The fruit juice of Morinda citrifolia (noni) downregulates HIF-1α protein expression through inhibition of PKB, ERK-1/2, JNK-1 and S6 in manganese-stimulated A549 human lung cancer cells

International Journal of Molecular Medicine

Volumn 29, Issue 3, 2012, Pages 499-504

  Jang, Byeong Churl ^a  

^a Keimyung University   (South Korea)

Author keywords

A549 cells; c Jun N terminal kinase 1; Extracellular regulated protein kinase 1 2; HIF 1 ; Manganese; Noni fruit juice; Protein kinase B; S6

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; DEFEROXAMINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1BETA; MANGANESE CHLORIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NATURAL PRODUCT; PROTEIN KINASE B; PROTEIN S6; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE 1;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EUKARYOTE; FRUIT JUICE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG CANCER; MORINDA CITRIFOLIA; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSLATION REGULATION; UPREGULATION;

CELL LINE, TUMOR; DOWN-REGULATION; EUKARYOTIC INITIATION FACTOR-2; FRUIT; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG NEOPLASMS; MANGANESE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 8; MORINDA; PHOSPHORYLATION; PLANT EXTRACTS; PROTEIN STABILITY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION;

EID: 84856135046     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.860     Document Type: Article

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