Acetaldehyde promotes rapamycin-dependent activation of p70S6K and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human neuroblastoma cells

Experimental Neurology

Volumn 203, Issue 1, 2007, Pages 196-204

  Fang, Cindy X ^a   Yang, Xiaoping ^a   Sreejayan, Nair ^a   Ren, Jun ^a  

^a UNIVERSITY OF WYOMING   (United States)

Author keywords

4E BP1; Acetaldehyde; Akt; Glucose uptake; IRS 2; mTOR; p70S6K

Indexed keywords

ACETALDEHYDE; CASPASE 3; DEOXYGLUCOSE; GLUCOSE; INITIATION FACTOR 4E BINDING PROTEIN 1; INSULIN RECEPTOR SUBSTRATE 2; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; TRITIUM;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ACETALDEHYDE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALCOHOL-INDUCED DISORDERS, NERVOUS SYSTEM; APOPTOSIS; CELL LINE, TUMOR; DIABETES MELLITUS, TYPE 2; DOPAMINE; GLUCOSE; HUMANS; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; METABOLIC SYNDROME X; NEURONS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 33751415082     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2006.08.002     Document Type: Article

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