Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts

Molecular Pharmacology

Volumn 68, Issue 4, 2005, Pages 1061-1073

  Men, Luh Yen ^a   Jen, Liang Su ^b   Chung, Liang Chien ^b   Kuang, Wen Tseng ^b   Ching, Yao Ying ^a,b   Wei, Fang Chen ^b   Chiao, Chia Chang ^b   Min, Liang Kuo ^b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DIOSGENIN; ESTRADIOL; ESTROGEN RECEPTOR; FULVESTRANT; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; TAMOXIFEN; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; BINDING ASSAY; CELL CULTURE; CELL LINE; CONCENTRATION RESPONSE; CULTURE MEDIUM; EX VIVO STUDY; GENETIC TRANSFECTION; HORMONE ACTION; HORMONE BINDING; HYPOXIA; IC 50; IN VITRO STUDY; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANIMALS; BASE SEQUENCE; CULTURE MEDIA, CONDITIONED; DIOSGENIN; DNA PRIMERS; DNA-BINDING PROTEINS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, INBRED BALB C; NEOVASCULARIZATION, PHYSIOLOGIC; NUCLEAR PROTEINS; OSTEOBLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ESTROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 25144462239     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.010082     Document Type: Article

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