-
1
-
-
0028178928
-
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
-
Chung J., Grammer T.C., Lemon K.P., Kazlauskas A., Blenis J. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 1994, 370:71-75.
-
(1994)
Nature
, vol.370
, pp. 71-75
-
-
Chung, J.1
Grammer, T.C.2
Lemon, K.P.3
Kazlauskas, A.4
Blenis, J.5
-
2
-
-
0036385637
-
Coordinate regulation of translation by the PI 3-kinase and mTOR pathways
-
Martin K.A., Blenis J. Coordinate regulation of translation by the PI 3-kinase and mTOR pathways. Adv. Cancer Res. 2002, 86:1-39.
-
(2002)
Adv. Cancer Res.
, vol.86
, pp. 1-39
-
-
Martin, K.A.1
Blenis, J.2
-
3
-
-
0035793086
-
A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt
-
Aoki M., Blazek E., Vogt P.K. A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. Proc. Natl. Acad. Sci. USA 2001, 98:136-141.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 136-141
-
-
Aoki, M.1
Blazek, E.2
Vogt, P.K.3
-
4
-
-
0037295455
-
Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues
-
Miyakawa M., Tsushima T., Murakami H., Wakai K., Isozaki O., Takano K. Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues. Endocr. J. 2003, 50:77-83.
-
(2003)
Endocr. J.
, vol.50
, pp. 77-83
-
-
Miyakawa, M.1
Tsushima, T.2
Murakami, H.3
Wakai, K.4
Isozaki, O.5
Takano, K.6
-
5
-
-
77649268890
-
Inhibitors of the PI3K/Akt/mTOR pathway: new hope for breast cancer patients
-
Ghayad S.E., Cohen P.A. Inhibitors of the PI3K/Akt/mTOR pathway: new hope for breast cancer patients. Recent Pat. Anticancer Drug Discov. 2010, 5:29-57.
-
(2010)
Recent Pat. Anticancer Drug Discov.
, vol.5
, pp. 29-57
-
-
Ghayad, S.E.1
Cohen, P.A.2
-
6
-
-
62549099008
-
The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer
-
Trinh X.B., Tjalma W.A., Vermeulen P.B., Van den E.G., Van der Auwera I., Van Laere S.J., Helleman J., Berns E.M., Dirix L.Y., van Dam P.A. The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer. Br. J. Cancer 2009, 100:971-978.
-
(2009)
Br. J. Cancer
, vol.100
, pp. 971-978
-
-
Trinh, X.B.1
Tjalma, W.A.2
Vermeulen, P.B.3
Van den, E.G.4
Van der Auwera, I.5
Van Laere, S.J.6
Helleman, J.7
Berns, E.M.8
Dirix, L.Y.9
van Dam, P.A.10
-
7
-
-
17944368972
-
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten mice
-
Podsypanina K., Lee R.T., Politis C., Hennessy I., Crane A., Puc J., Neshat M., Wang H., Yang L., Gibbons J., Frost P., Dreisbach V., Blenis J., Gaciong Z., Fisher P., Sawyers C., Hedrick-Ellenson L., Parsons R. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten mice. Proc. Natl. Acad. Sci. USA 2001, 98:10320-10325.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10320-10325
-
-
Podsypanina, K.1
Lee, R.T.2
Politis, C.3
Hennessy, I.4
Crane, A.5
Puc, J.6
Neshat, M.7
Wang, H.8
Yang, L.9
Gibbons, J.10
Frost, P.11
Dreisbach, V.12
Blenis, J.13
Gaciong, Z.14
Fisher, P.15
Sawyers, C.16
Hedrick-Ellenson, L.17
Parsons, R.18
-
8
-
-
17944377486
-
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
-
Neshat M.S., Mellinghoff I.K., Tran C., Stiles B., Thomas G., Petersen R., Frost P., Gibbons J.J., Wu H., Sawyers C.L. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc. Natl. Acad. Sci. USA 2001, 98:10314-10319.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10314-10319
-
-
Neshat, M.S.1
Mellinghoff, I.K.2
Tran, C.3
Stiles, B.4
Thomas, G.5
Petersen, R.6
Frost, P.7
Gibbons, J.J.8
Wu, H.9
Sawyers, C.L.10
-
9
-
-
0025141337
-
What is the evidence that tumors are angiogenesis dependent?
-
Folkman J. What is the evidence that tumors are angiogenesis dependent?. J. Natl. Cancer Inst. 1990, 82:4-6.
-
(1990)
J. Natl. Cancer Inst.
, vol.82
, pp. 4-6
-
-
Folkman, J.1
-
10
-
-
0024549349
-
Induction of angiogenesis during the transition from hyperplasia to neoplasia
-
Folkman J., Watson K., Ingber D., Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 1989, 339:58-61.
-
(1989)
Nature
, vol.339
, pp. 58-61
-
-
Folkman, J.1
Watson, K.2
Ingber, D.3
Hanahan, D.4
-
11
-
-
0035206981
-
Angiogenesis as a biomarker and target in cancer chemoprevention
-
Sharma R.A., Harris A.L., Dalgleish A.G., Steward W.P., O'Byrne K.J. Angiogenesis as a biomarker and target in cancer chemoprevention. Lancet Oncol. 2001, 2:726-732.
-
(2001)
Lancet Oncol.
, vol.2
, pp. 726-732
-
-
Sharma, R.A.1
Harris, A.L.2
Dalgleish, A.G.3
Steward, W.P.4
O'Byrne, K.J.5
-
13
-
-
3242658330
-
Correlation of serum VEGF levels with clinical stage, therapy efficacy, tumor metastasis and patient survival in ovarian cancer
-
Li L., Wang L., Zhang W., Tang B., Zhang J., Song H., Yao D., Tang Y., Chen X., Yang Z., Wang G., Li X., Zhao J., Ding H., Reed E., Li Q.Q. Correlation of serum VEGF levels with clinical stage, therapy efficacy, tumor metastasis and patient survival in ovarian cancer. Anticancer Res. 2004, 24:1973-1979.
-
(2004)
Anticancer Res.
, vol.24
, pp. 1973-1979
-
-
Li, L.1
Wang, L.2
Zhang, W.3
Tang, B.4
Zhang, J.5
Song, H.6
Yao, D.7
Tang, Y.8
Chen, X.9
Yang, Z.10
Wang, G.11
Li, X.12
Zhao, J.13
Ding, H.14
Reed, E.15
Li, Q.Q.16
-
14
-
-
0032771247
-
Serum vascular endothelial growth factor in epithelial ovarian neoplasms: correlation with patient survival
-
Chen C.A., Cheng W.F., Lee C.N., Chen T.M., Kung C.C., Hsieh F.J., Hsieh C.Y. Serum vascular endothelial growth factor in epithelial ovarian neoplasms: correlation with patient survival. Gynecol. Oncol. 1999, 74:235-240.
-
(1999)
Gynecol. Oncol.
, vol.74
, pp. 235-240
-
-
Chen, C.A.1
Cheng, W.F.2
Lee, C.N.3
Chen, T.M.4
Kung, C.C.5
Hsieh, F.J.6
Hsieh, C.Y.7
-
15
-
-
3142729125
-
Isolation and purification of vascular endothelial growth factor (VEGF) from ascitic fluid of ovarian cancer patients
-
Ghosh S., Maity P. Isolation and purification of vascular endothelial growth factor (VEGF) from ascitic fluid of ovarian cancer patients. Pathol. Oncol. Res. 2004, 10:104-108.
-
(2004)
Pathol. Oncol. Res.
, vol.10
, pp. 104-108
-
-
Ghosh, S.1
Maity, P.2
-
16
-
-
77950519933
-
Peritoneal VEGF burden as a predictor of cytoreductive surgery outcome in women with epithelial ovarian cancer
-
Diniz Bizzo S.M., Meira D.D., Lima J.M., Mororo J.S., Casali-da-Rocha J.C., Ornellas M.H. Peritoneal VEGF burden as a predictor of cytoreductive surgery outcome in women with epithelial ovarian cancer. Int. J. Gynaecol. Obstet. 2010, 109:113-117.
-
(2010)
Int. J. Gynaecol. Obstet.
, vol.109
, pp. 113-117
-
-
Diniz Bizzo, S.M.1
Meira, D.D.2
Lima, J.M.3
Mororo, J.S.4
Casali-da-Rocha, J.C.5
Ornellas, M.H.6
-
17
-
-
0345060442
-
Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
-
Byrne A.T., Ross L., Holash J., Nakanishi M., Hu L., Hofmann J.I., Yancopoulos G.D., Jaffe R.B. Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin. Cancer Res. 2003, 9:5721-5728.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 5721-5728
-
-
Byrne, A.T.1
Ross, L.2
Holash, J.3
Nakanishi, M.4
Hu, L.5
Hofmann, J.I.6
Yancopoulos, G.D.7
Jaffe, R.B.8
-
18
-
-
0034925041
-
Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
-
Jiang B.H., Jiang G., Zheng J.Z., Lu Z., Hunter T., Vogt P.K. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ. 2001, 12:363-369.
-
(2001)
Cell Growth Differ.
, vol.12
, pp. 363-369
-
-
Jiang, B.H.1
Jiang, G.2
Zheng, J.Z.3
Lu, Z.4
Hunter, T.5
Vogt, P.K.6
-
19
-
-
24344458927
-
Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells
-
Trisciuoglio D., Iervolino A., Zupi G., Del Bufalo D. Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells. Mol. Biol. Cell 2005, 16:4153-4162.
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 4153-4162
-
-
Trisciuoglio, D.1
Iervolino, A.2
Zupi, G.3
Del Bufalo, D.4
-
20
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics
-
Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M.M., Simons J.W., Semenza G.L. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 2000, 60:1541-1545.
-
(2000)
Cancer Res.
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.M.6
Simons, J.W.7
Semenza, G.L.8
-
21
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
Hudson C.C., Liu M., Chiang G.G., Otterness D.M., Loomis D.C., Kaper F., Giaccia A.J., Abraham R.T. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol. Cell. Biol. 2002, 22:7004-7014.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
Otterness, D.M.4
Loomis, D.C.5
Kaper, F.6
Giaccia, A.J.7
Abraham, R.T.8
-
22
-
-
0037111665
-
BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin
-
Mayerhofer M., Valent P., Sperr W.R., Griffin J.D., Sillaber C. BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Blood 2002, 100:3767-3775.
-
(2002)
Blood
, vol.100
, pp. 3767-3775
-
-
Mayerhofer, M.1
Valent, P.2
Sperr, W.R.3
Griffin, J.D.4
Sillaber, C.5
-
23
-
-
2342545519
-
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
Fingar D.C., Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004, 23:3151-3171.
-
(2004)
Oncogene
, vol.23
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
24
-
-
4143111260
-
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
-
Altomare D.A., Wang H.Q., Skele K.L., De Rienzo A., Klein-Szanto A.J., Godwin A.K., Testa J.R. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene 2004, 23:5853-5857.
-
(2004)
Oncogene
, vol.23
, pp. 5853-5857
-
-
Altomare, D.A.1
Wang, H.Q.2
Skele, K.L.3
De Rienzo, A.4
Klein-Szanto, A.J.5
Godwin, A.K.6
Testa, J.R.7
-
25
-
-
10244229652
-
In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model
-
Frost P., Moatamed F., Hoang B., Shi Y., Gera J., Yan H., Frost P., Gibbons J., Lichtenstein A. In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model. Blood 2004, 104:4181-4187.
-
(2004)
Blood
, vol.104
, pp. 4181-4187
-
-
Frost, P.1
Moatamed, F.2
Hoang, B.3
Shi, Y.4
Gera, J.5
Yan, H.6
Frost, P.7
Gibbons, J.8
Lichtenstein, A.9
-
26
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe J.A., Jiang B.H., Iyer N.V., Agani F., Leung S.W., Koos R.D., Semenza G.L. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 1996, 16:4604-4613.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
Semenza, G.L.7
-
27
-
-
0034652392
-
Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
-
Jiang B.H., Zheng J.Z., Aoki M., Vogt P.K. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc. Natl. Acad. Sci. USA 2000, 97:1749-1753.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 1749-1753
-
-
Jiang, B.H.1
Zheng, J.Z.2
Aoki, M.3
Vogt, P.K.4
-
28
-
-
0030915898
-
Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k
-
Jefferies H.B., Fumagalli S., Dennis P.B., Reinhard C., Pearson R.B., Thomas G. Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k. EMBO J. 1997, 16:3693-3704.
-
(1997)
EMBO J.
, vol.16
, pp. 3693-3704
-
-
Jefferies, H.B.1
Fumagalli, S.2
Dennis, P.B.3
Reinhard, C.4
Pearson, R.B.5
Thomas, G.6
-
29
-
-
15844391440
-
Mechanism of action of the immunosuppressant rapamycin
-
Dumont F.J., Su Q. Mechanism of action of the immunosuppressant rapamycin. Life Sci. 1996, 58:373-395.
-
(1996)
Life Sci.
, vol.58
, pp. 373-395
-
-
Dumont, F.J.1
Su, Q.2
-
30
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
-
Guba M., von Breitenbuch P., Steinbauer M., Koehl G., Flegel S., Hornung M., Bruns C.J., Zuelke C., Farkas S., Anthuber M., Jauch K.W., Geissler E.K. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat. Med. 2002, 8:128-135.
-
(2002)
Nat. Med.
, vol.8
, pp. 128-135
-
-
Guba, M.1
von Breitenbuch, P.2
Steinbauer, M.3
Koehl, G.4
Flegel, S.5
Hornung, M.6
Bruns, C.J.7
Zuelke, C.8
Farkas, S.9
Anthuber, M.10
Jauch, K.W.11
Geissler, E.K.12
-
31
-
-
0032498640
-
Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis
-
Eliceiri B.P., Klemke R., Stromblad S., Cheresh D.A. Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J. Cell Biol. 1998, 140:1255-1263.
-
(1998)
J. Cell Biol.
, vol.140
, pp. 1255-1263
-
-
Eliceiri, B.P.1
Klemke, R.2
Stromblad, S.3
Cheresh, D.A.4
-
32
-
-
0034234924
-
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
-
Sekulic A., Hudson C.C., Homme J.L., Yin P., Otterness D.M., Karnitz L.M., Abraham R.T. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 2000, 60:3504-3513.
-
(2000)
Cancer Res.
, vol.60
, pp. 3504-3513
-
-
Sekulic, A.1
Hudson, C.C.2
Homme, J.L.3
Yin, P.4
Otterness, D.M.5
Karnitz, L.M.6
Abraham, R.T.7
-
33
-
-
0037293542
-
Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible factor-1?
-
Burroughs K.D., Oh J., Barrett J.C., DiAugustine R.P. Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible factor-1?. Mol. Cancer Res. 2003, 1:312-322.
-
(2003)
Mol. Cancer Res.
, vol.1
, pp. 312-322
-
-
Burroughs, K.D.1
Oh, J.2
Barrett, J.C.3
DiAugustine, R.P.4
-
34
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
Fukuda R., Hirota K., Fan F., Jung Y.D., Ellis L.M., Semenza G.L. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J. Biol. Chem. 2002, 277:38205-38211.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
Hirota, K.2
Fan, F.3
Jung, Y.D.4
Ellis, L.M.5
Semenza, G.L.6
|