메뉴 건너뛰기




Volumn 398, Issue 3, 2010, Pages 395-399

P70S6K 1 regulation of angiogenesis through VEGF and HIF-1α expression

Author keywords

HIF 1; P70S6K1; SiRNA; Tumor angiogenesis; VEGF

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P70 RIBOSOMAL S6 KINASE 1; S6 KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 77955272978     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.06.080     Document Type: Article
Times cited : (60)

References (34)
  • 1
    • 0028178928 scopus 로고
    • PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
    • Chung J., Grammer T.C., Lemon K.P., Kazlauskas A., Blenis J. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 1994, 370:71-75.
    • (1994) Nature , vol.370 , pp. 71-75
    • Chung, J.1    Grammer, T.C.2    Lemon, K.P.3    Kazlauskas, A.4    Blenis, J.5
  • 2
    • 0036385637 scopus 로고    scopus 로고
    • Coordinate regulation of translation by the PI 3-kinase and mTOR pathways
    • Martin K.A., Blenis J. Coordinate regulation of translation by the PI 3-kinase and mTOR pathways. Adv. Cancer Res. 2002, 86:1-39.
    • (2002) Adv. Cancer Res. , vol.86 , pp. 1-39
    • Martin, K.A.1    Blenis, J.2
  • 3
    • 0035793086 scopus 로고    scopus 로고
    • A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt
    • Aoki M., Blazek E., Vogt P.K. A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. Proc. Natl. Acad. Sci. USA 2001, 98:136-141.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 136-141
    • Aoki, M.1    Blazek, E.2    Vogt, P.K.3
  • 4
    • 0037295455 scopus 로고    scopus 로고
    • Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues
    • Miyakawa M., Tsushima T., Murakami H., Wakai K., Isozaki O., Takano K. Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues. Endocr. J. 2003, 50:77-83.
    • (2003) Endocr. J. , vol.50 , pp. 77-83
    • Miyakawa, M.1    Tsushima, T.2    Murakami, H.3    Wakai, K.4    Isozaki, O.5    Takano, K.6
  • 5
    • 77649268890 scopus 로고    scopus 로고
    • Inhibitors of the PI3K/Akt/mTOR pathway: new hope for breast cancer patients
    • Ghayad S.E., Cohen P.A. Inhibitors of the PI3K/Akt/mTOR pathway: new hope for breast cancer patients. Recent Pat. Anticancer Drug Discov. 2010, 5:29-57.
    • (2010) Recent Pat. Anticancer Drug Discov. , vol.5 , pp. 29-57
    • Ghayad, S.E.1    Cohen, P.A.2
  • 9
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J. What is the evidence that tumors are angiogenesis dependent?. J. Natl. Cancer Inst. 1990, 82:4-6.
    • (1990) J. Natl. Cancer Inst. , vol.82 , pp. 4-6
    • Folkman, J.1
  • 10
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • Folkman J., Watson K., Ingber D., Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 1989, 339:58-61.
    • (1989) Nature , vol.339 , pp. 58-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3    Hanahan, D.4
  • 14
    • 0032771247 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor in epithelial ovarian neoplasms: correlation with patient survival
    • Chen C.A., Cheng W.F., Lee C.N., Chen T.M., Kung C.C., Hsieh F.J., Hsieh C.Y. Serum vascular endothelial growth factor in epithelial ovarian neoplasms: correlation with patient survival. Gynecol. Oncol. 1999, 74:235-240.
    • (1999) Gynecol. Oncol. , vol.74 , pp. 235-240
    • Chen, C.A.1    Cheng, W.F.2    Lee, C.N.3    Chen, T.M.4    Kung, C.C.5    Hsieh, F.J.6    Hsieh, C.Y.7
  • 15
    • 3142729125 scopus 로고    scopus 로고
    • Isolation and purification of vascular endothelial growth factor (VEGF) from ascitic fluid of ovarian cancer patients
    • Ghosh S., Maity P. Isolation and purification of vascular endothelial growth factor (VEGF) from ascitic fluid of ovarian cancer patients. Pathol. Oncol. Res. 2004, 10:104-108.
    • (2004) Pathol. Oncol. Res. , vol.10 , pp. 104-108
    • Ghosh, S.1    Maity, P.2
  • 17
    • 0345060442 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
    • Byrne A.T., Ross L., Holash J., Nakanishi M., Hu L., Hofmann J.I., Yancopoulos G.D., Jaffe R.B. Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin. Cancer Res. 2003, 9:5721-5728.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5721-5728
    • Byrne, A.T.1    Ross, L.2    Holash, J.3    Nakanishi, M.4    Hu, L.5    Hofmann, J.I.6    Yancopoulos, G.D.7    Jaffe, R.B.8
  • 18
    • 0034925041 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
    • Jiang B.H., Jiang G., Zheng J.Z., Lu Z., Hunter T., Vogt P.K. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ. 2001, 12:363-369.
    • (2001) Cell Growth Differ. , vol.12 , pp. 363-369
    • Jiang, B.H.1    Jiang, G.2    Zheng, J.Z.3    Lu, Z.4    Hunter, T.5    Vogt, P.K.6
  • 19
    • 24344458927 scopus 로고    scopus 로고
    • Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells
    • Trisciuoglio D., Iervolino A., Zupi G., Del Bufalo D. Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells. Mol. Biol. Cell 2005, 16:4153-4162.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 4153-4162
    • Trisciuoglio, D.1    Iervolino, A.2    Zupi, G.3    Del Bufalo, D.4
  • 20
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics
    • Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M.M., Simons J.W., Semenza G.L. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 2000, 60:1541-1545.
    • (2000) Cancer Res. , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, J.W.7    Semenza, G.L.8
  • 22
    • 0037111665 scopus 로고    scopus 로고
    • BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin
    • Mayerhofer M., Valent P., Sperr W.R., Griffin J.D., Sillaber C. BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Blood 2002, 100:3767-3775.
    • (2002) Blood , vol.100 , pp. 3767-3775
    • Mayerhofer, M.1    Valent, P.2    Sperr, W.R.3    Griffin, J.D.4    Sillaber, C.5
  • 23
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar D.C., Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004, 23:3151-3171.
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 24
    • 4143111260 scopus 로고    scopus 로고
    • AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
    • Altomare D.A., Wang H.Q., Skele K.L., De Rienzo A., Klein-Szanto A.J., Godwin A.K., Testa J.R. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene 2004, 23:5853-5857.
    • (2004) Oncogene , vol.23 , pp. 5853-5857
    • Altomare, D.A.1    Wang, H.Q.2    Skele, K.L.3    De Rienzo, A.4    Klein-Szanto, A.J.5    Godwin, A.K.6    Testa, J.R.7
  • 25
    • 10244229652 scopus 로고    scopus 로고
    • In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model
    • Frost P., Moatamed F., Hoang B., Shi Y., Gera J., Yan H., Frost P., Gibbons J., Lichtenstein A. In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model. Blood 2004, 104:4181-4187.
    • (2004) Blood , vol.104 , pp. 4181-4187
    • Frost, P.1    Moatamed, F.2    Hoang, B.3    Shi, Y.4    Gera, J.5    Yan, H.6    Frost, P.7    Gibbons, J.8    Lichtenstein, A.9
  • 27
    • 0034652392 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
    • Jiang B.H., Zheng J.Z., Aoki M., Vogt P.K. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc. Natl. Acad. Sci. USA 2000, 97:1749-1753.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1749-1753
    • Jiang, B.H.1    Zheng, J.Z.2    Aoki, M.3    Vogt, P.K.4
  • 29
    • 15844391440 scopus 로고    scopus 로고
    • Mechanism of action of the immunosuppressant rapamycin
    • Dumont F.J., Su Q. Mechanism of action of the immunosuppressant rapamycin. Life Sci. 1996, 58:373-395.
    • (1996) Life Sci. , vol.58 , pp. 373-395
    • Dumont, F.J.1    Su, Q.2
  • 31
    • 0032498640 scopus 로고    scopus 로고
    • Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis
    • Eliceiri B.P., Klemke R., Stromblad S., Cheresh D.A. Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J. Cell Biol. 1998, 140:1255-1263.
    • (1998) J. Cell Biol. , vol.140 , pp. 1255-1263
    • Eliceiri, B.P.1    Klemke, R.2    Stromblad, S.3    Cheresh, D.A.4
  • 32
    • 0034234924 scopus 로고    scopus 로고
    • A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
    • Sekulic A., Hudson C.C., Homme J.L., Yin P., Otterness D.M., Karnitz L.M., Abraham R.T. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 2000, 60:3504-3513.
    • (2000) Cancer Res. , vol.60 , pp. 3504-3513
    • Sekulic, A.1    Hudson, C.C.2    Homme, J.L.3    Yin, P.4    Otterness, D.M.5    Karnitz, L.M.6    Abraham, R.T.7
  • 33
    • 0037293542 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible factor-1?
    • Burroughs K.D., Oh J., Barrett J.C., DiAugustine R.P. Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible factor-1?. Mol. Cancer Res. 2003, 1:312-322.
    • (2003) Mol. Cancer Res. , vol.1 , pp. 312-322
    • Burroughs, K.D.1    Oh, J.2    Barrett, J.C.3    DiAugustine, R.P.4
  • 34
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • Fukuda R., Hirota K., Fan F., Jung Y.D., Ellis L.M., Semenza G.L. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J. Biol. Chem. 2002, 277:38205-38211.
    • (2002) J. Biol. Chem. , vol.277 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.