Manganese (II) induces chemical hypoxia by inhibiting HIF-prolyl hydroxylase: Implication in manganese-induced pulmonary inflammation

Toxicology and Applied Pharmacology

Volumn 235, Issue 3, 2009, Pages 261-267

  Han, Jeongoh ^a   Lee, Jong Suk ^b   Choi, Daekyu ^a   Lee, Youna ^a   Hong, Sungchae ^a   Choi, Jungyun ^a   Han, Songyi ^a   Ko, Yujin ^b   Kim, Jung Ae ^b   Mi Kim, Young ^a   Jung, Yunjin ^a  

^a Pusan National University   (South Korea)

^b Yeungnam University   (South Korea)

Author keywords

HIF prolyl hydroxylase; Hypoxia inducible factor; Manganese; Pulmonary inflammation; Vascular endothelial growth factor

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; IRON; MANGANESE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; UNCLASSIFIED DRUG; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENVIRONMENTAL EXPOSURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROXYLATION; HYPOXIA; OCCUPATIONAL EXPOSURE; PNEUMONIA; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INDUCTION;

CELL HYPOXIA; CELL LINE, TUMOR; CHLORIDES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION MEDIATORS; MANGANESE COMPOUNDS; PNEUMONIA; PROCOLLAGEN-PROLINE DIOXYGENASE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 60749087846     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.01.003     Document Type: Article

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