Regulation of hSos1 activity is a system-level property generated by its multi-domain structure

Biotechnology Advances

Volumn 30, Issue 1, 2012, Pages 154-168

  Sacco, Elena ^a   Farina, Marcello ^b   Greco, Claudio ^a   Lamperti, Stefano ^a   Busti, Stefano ^a   DeGioia, Luca ^a   Alberghina, Lilia ^a   Liberati, Diego ^c   Vanoni, Marco ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b POLITECNICO DI MILANO   (Italy)

^c CNR   (Italy)

Author keywords

BIAcore; Complementation of cdc25ts yeast; HSos1; Inter domain interactions; Intra molecular regulation; Monte Carlo simulation; Ras specific GEF; Sensitivity analysis; Stochastic mathematical model

Indexed keywords

BIACORE; COMPLEMENTATION; HSOS1; INTER-DOMAIN; INTRA-MOLECULAR REGULATION; MONTE CARLO SIMULATION; RAS-SPECIFIC GEF;

ACTIVATION ANALYSIS; COMPUTER SIMULATION; CRYSTALS; MOLECULAR STRUCTURE; MONTE CARLO METHODS; NUCLEOTIDES; PHYSIOLOGICAL MODELS; POSITIVE IONS; SENSITIVITY ANALYSIS; STOCHASTIC SYSTEMS; SYSTEMS ENGINEERING; YEAST;

STOCHASTIC MODELS;

GUANINE NUCLEOTIDE EXCHANGE FACTOR; SOS PROTEIN;

DATA SET; MONTE CARLO ANALYSIS; NUMERICAL MODEL; SENSITIVITY ANALYSIS; STOCHASTICITY; YEAST;

ARTICLE; BIOLOGICAL MODEL; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; GENE INACTIVATION; GENETIC COMPLEMENTATION; GENETICS; HUMAN; METABOLISM; MONTE CARLO METHOD; PROTEIN DOMAIN; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TWO HYBRID SYSTEM;

COMPUTATIONAL BIOLOGY; GENE KNOCKOUT TECHNIQUES; GENETIC COMPLEMENTATION TEST; HUMANS; MODELS, GENETIC; MODELS, MOLECULAR; MONTE CARLO METHOD; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, TERTIARY; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SOS1 PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; TWO-HYBRID SYSTEM TECHNIQUES;

SACCHAROMYCES CEREVISIAE;

EID: 84855735965     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2011.07.017     Document Type: Article

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