Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 8, 2010, Pages 3430-3435

  Gureasko, Jodi ^a   Kuchment, Olga ^a   Makino, Debora Lika ^a,d   Sondermann, Holger ^a,e   Bar Sagi, Dafna ^b   Kuriyan, John ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^e Department of Obstetrics Gynecology   (United States)

Author keywords

Crystal structure; Membrane binding; PIP2 dependent; SOS

Indexed keywords

HISTONE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; RAS PROTEIN; SOS PROTEIN;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; DISEASE ASSOCIATION; ELECTRICITY; GENE MUTATION; HUMAN; INHIBITION KINETICS; KINETICS; MUTANT; NOONAN SYNDROME; PRIORITY JOURNAL; PROTEIN CONFORMATION;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HISTONES; HUMANS; PROTEIN STRUCTURE, TERTIARY; SOS1 PROTEIN;

EID: 77649241353     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0913915107     Document Type: Article

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