Catalytic competence of the Ras-GEF domain of hSos1 requires intra-REM domain interactions mediated by Phenylalanine 577

FEBS Letters

Volumn 580, Issue 27, 2006, Pages 6322-6328

  Sacco, Elena ^a   Metalli, David ^a   Busti, Stefano ^a   Fantinato, Sonia ^a   D'Urzo, Annalisa ^a   Mapelli, Valeria ^a   Alberghina, Lilia ^a   Vanoni, Marco ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Biacore; Catalytic region; Guanine nucleotide exchange factor; Intramolecular interaction; Mutagenesis

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHENYLALANINE; RAS PROTEIN;

ARTICLE; CATALYSIS; CONFORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF;

AMINO ACID MOTIFS; BINDING SITES; HUMANS; PHENYLALANINE; PROTEIN STRUCTURE, TERTIARY; SOS1 PROTEIN;

EID: 33750970285     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.10.040     Document Type: Article

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