An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine

Journal of Cell Biology

Volumn 154, Issue 5, 2001, Pages 1031-1044

  Scita, Giorgio ^a   Tenca, Pierluigi ^a   Areces, Liliana B ^a   Tocchetti, Arianna ^a   Frittoli, Emanuela ^a   Giardina, Giuseppina ^a   Ponzanelli, Isabella ^a   Sini, Patrizia ^a   Innocenti, Metello ^a   Di Fiore, Pier Paolo ^a,b,c  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Cytoskeleton; Eps8; GEF; Rac; Sos 1

Indexed keywords

BINDING PROTEIN; F ACTIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEIN EPS8; RAC PROTEIN; RAS PROTEIN; SOS PROTEIN; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; EFFECTOR CELL; MOLECULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SIGNAL PROCESSING;

ACTINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; CDC42 GTP-BINDING PROTEIN; CELL FRACTIONATION; CELL SURFACE EXTENSIONS; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; CYTOCHALASIN D; CYTOSKELETAL PROTEINS; EMBRYO; FIBROBLASTS; GENES, REPORTER; HUMANS; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; NUCLEIC ACID SYNTHESIS INHIBITORS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RAC GTP-BINDING PROTEINS; RAS PROTEINS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SOS1 PROTEIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSFECTION;

ANIMALIA;

EID: 0035802118     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200103146     Document Type: Article

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