Re-establishing immunological self-tolerance in autoimmune disease

Nature Medicine

Volumn 18, Issue 1, 2012, Pages 54-58

  Sakaguchi, Shimon ^a,b   Powrie, Fiona ^c,d   Ransohoff, Richard M ^e  

^a OSAKA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

AUTOIMMUNE DISEASE; EFFECTOR CELL; HUMAN; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW;

ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; CELL DIFFERENTIATION; FORKHEAD TRANSCRIPTION FACTORS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MICE; SELF TOLERANCE; T-LYMPHOCYTES, REGULATORY; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84855548027     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2622     Document Type: Review

References (72)

1. Korn, T., Bettelli, E., Oukka, M. & Kuchroo, V.K. Annu. Rev. Immunol. 27, 485-517 (2009).
2. Sakaguchi, S. Nat. Immunol. 6, 345-352 (2005).
3. Mathis, D. & Benoist, C. Annu. Rev. Immunol. 27, 287-312 (2009).
4. The Wellcome Trust Case Control Consortium. Nature 447, 661-678 (2007).
5. Bottini, N., Vang, T., Cucca, F. & Mustelin, T. Semin. Immunol. 18, 207-213 (2006).
6. von Boehmer, H. et al. Immunol. Rev. 191, 62-78 (2003).
7. Mueller, D.L. Nat. Immunol. 11, 21-27 (2010).
8. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. J. Immunol. 155, 1151-1164 (1995).
9. Danke, N.A., Koelle, D.M., Yee, C., Beheray, S. & Kwok, W.W. J. Immunol. 172, 5967-5972 (2004).
10. Danke, N.A., Yang, J., Greenbaum, C. & Kwok, W.W. J. Autoimmun. 25, 303-311 (2005).
11. Wing, K. & Sakaguchi, S. Nat. Immunol. 11, 7-13 (2010).
12. Fife, B.T. & Bluestone, J.A. Immunol. Rev. 224, 166-182 (2008).
13. Starr, T.K., Jameson, S.C. & Hogquist, K.A. Annu. Rev. Immunol. 21, 139-176 (2003).
14. Werlen, G., Hausmann, B., Naeher, D. & Palmer, E. Science 299, 1859-1863 (2003).
15. Kyewski, B. & Klein, L. Annu. Rev. Immunol. 24, 571-606 (2006).
16. Herman, A., Kappler, J.W., Marrack, P. & Pullen, A.M. Annu. Rev. Immunol. 9, 745-772 (1991).
17. Jordan, M.S. et al. Nat. Immunol. 2, 301-306 (2001).
18. Liston, A. & Rudensky, A.Y. Curr. Opin. Immunol. 19, 176-185 (2007).
19. Sakaguchi, S., Yamaguchi, T., Nomura, T. & Ono, M. Cell 133, 775-787 (2008).
20. Kekäläinen, E. et al. J. Immunol. 178, 1208-1215 (2007).
21. Laakso, S.M. et al. J. Autoimmun. 35, 351-357 (2010).
22. Anderson, M.S. et al. Immunity 23, 227-239 (2005).
23. Liston, A., Lesage, S., Wilson, J., Peltonen, L. & Goodnow, C.C. Nat. Immunol. 4, 350-354 (2003).
24. Daniel, C., Weigmann, B., Bronson, R. & von Boehmer, H. J. Exp. Med. 208, 1501-1510 (2011).
25. Tanaka, S. et al. J. Immunol. 185, 2295-2305 (2010).
26. Powrie, F., Leach, M.W., Mauze, S., Caddle, L.B. & Coffman, R.L. Int. Immunol. 5, 1461-1471 (1993).
27. Takahashi, T. et al. Int. Immunol. 10, 1969-1980 (1998).
28. Thornton, A.M. & Shevach, E.M. J. Exp. Med. 188, 287-296 (1998).
29. Vignali, D.A., Collison, L.W. & Workman, C.J. Nat. Rev. Immunol. 8, 523-532 (2008).
30. Shevach, E.M. Immunity 30, 636-645 (2009).
31. Yamaguchi, T., Wing, J.B. & Sakaguchi, S. Semin. Immunol. 23, 424-430 (2011).
32. Wing, K. et al. Science 322, 271-275 (2008).
33. Wing, K., Yamaguchi, T. & Sakaguchi, S. Trends Immunol. 32, 428-433 (2011).
34. Uhlig, H.H. et al. J. Immunol. 177, 5852-5860 (2006).
35. Asseman, C., Mauze, S., Leach, M.W., Coffman, R.L. & Powrie, F. J. Exp. Med. 190, 995-1004 (1999).
36. Strober, W., Fuss, I.J. & Blumberg, R.S. Annu. Rev. Immunol. 20, 495-549 (2002).
37. Suri-Payer, E. & Cantor, H. J. Autoimmun. 16, 115-123 (2001).
38. Barnes, M.J. & Powrie, F. Immunity 31, 401-411 (2009).
39. Glocker, E.O. et al. N. Engl. J. Med. 361, 2033-2045 (2009).
40. Koch, M.A. et al. Nat. Immunol. 10, 595-602 (2009).
41. Zheng, Y. et al. Nature 458, 351-356 (2009).
42. Chaudhry, A. et al. Science 326, 986-991 (2009).
43. Campbell, D.J. & Koch, M.A. Nat. Rev. Immunol. 11, 119-130 (2011).
44. Tang, Q. & Bluestone, J.A. Immunol. Rev. 212, 217-237 (2006).
45. Sakaguchi, S., Miyara, M., Costantino, C.M. & Hafler, D.A. Nat. Rev. Immunol. 10, 490-500 (2010).
46. Grazia Roncarolo, M. et al. Immunol. Rev. 212, 28-50 (2006).
47. Collison, L.W. et al. Nat. Immunol. 11, 1093-1101 (2010).
48. Zheng, S.G., Gray, J.D., Ohtsuka, K., Yamagiwa, S. & Horwitz, D.A. J. Immunol. 169, 4183-4189 (2002).
49. Chen, W. et al. J. Exp. Med. 198, 1875-1886 (2003).
50. Laurence, A. et al. Immunity 26, 371-381 (2007).
51. Hall, J.A., Grainger, J.R., Spencer, S.P. & Belkaid, Y. Immunity 35, 13-22 (2011).
52. Huehn, J., Polansky, J.K. & Hamann, A. Nat. Rev. Immunol. 9, 83-89 (2009).
53. Duarte, J.H., Zelenay, S., Bergman, M.L., Martins, A.C. & Demengeot, J. Eur. J. Immunol. 39, 948-955 (2009).
54. Komatsu, N. et al. Proc. Natl. Acad. Sci. USA 106, 1903-1908 (2009).
55. Zhou, X. et al. Nat. Immunol. 10, 1000-1007 (2009).
56. Tsuji, M. et al. Science 323, 1488-1492 (2009).
57. Rubtsov, Y.P. et al. Science 329, 1667-1671 (2010).
58. Tran, D.Q., Ramsey, H. & Shevach, E.M. Blood 110, 2983-2990 (2007).
59. Baecher-Allan, C., Brown, J.A., Freeman, G.J. & Hafler, D.A. J. Immunol. 167, 1245-1253 (2001).
60. Yagi, H. et al. Int. Immunol. 16, 1643-1656 (2004).
61. Miyara, M. et al. Immunity 30, 899-911 (2009).
62. Ahern, P.P. et al. Immunity 33, 279-288 (2010).
63. Hirota, K. et al. J. Exp. Med. 204, 41-47 (2007).
64. Chen, Y. et al. Immunity 34, 409-421 (2011).
65. Anderson, C.F., Oukka, M., Kuchroo, V.J. & Sacks, D. J. Exp. Med. 204, 285-297 (2007).
66. Jankovic, D. et al. J. Exp. Med. 204, 273-283 (2007).
67. Pot, C., Apetoh, L., Awasthi, A. & Kuchroo, V.K. Semin. Immunol. 23, 438-445 (2011).
68. Nadkarni, S., Mauri, C. & Ehrenstein, M.R. J. Exp. Med. 204, 33-39 (2007).
69. Sakaguchi, S. & Sakaguchi, N. Curr. Opin. Immunol. 17, 589-594 (2005).
70. Keffer, J. et al. EMBO J. 10, 4025-4031 (1991).
71. Cua, D.J. & Tato, C.M. Nat. Rev. Immunol. 10, 479-489 (2010).
72. Buonocore, S. et al. Nature 464, 1371-1375 (2010).