Conformational and functional characterization of trapped complexes of the P-glycoprotein multidrug transporter

Biochemical Journal

Volumn 399, Issue 2, 2006, Pages 315-323

  Russell, Paula L ^a   Sharom, Frances J ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

ATP binding cassette superfamily (ABC superfamily); Fluorescence quenching; Multidrug resistance; Nucleotide binding domain; P glycoprotein (Pgp); Transition state

Indexed keywords

ATP-BINDING CASSETTE SUPERFAMILY (ABC SUPERFAMILY); FLUORESCENCE QUENCHING; MULTIDRUG RESISTANCE; NUCLEOTIDE-BINDING DOMAIN; P-GLYCOPROTEIN (PGP); TRANSITION STATE;

CATALYSIS; COMPLEXATION; CONFORMATIONS; CYTOLOGY; HYDROPHOBICITY; PROTEINS;

DRUG PRODUCTS;

ACRYLAMIDE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALLOGRAFT INFLAMMATORY FACTOR 1; ALUMINUM FLUORIDE; BERYLLIUM FLUORIDE; CESIUM CHLORIDE; COBALT; GLYCOPROTEIN P; INORGANIC SALT; MAGNESIUM; MEMBRANE PROTEIN; POTASSIUM IODIDE; TRINITROPHENYL; TRYPTOPHAN; UNCLASSIFIED DRUG; VANADIC ACID;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN INTERACTION;

ACRYLAMIDE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; CESIUM; CHO CELLS; CRICETINAE; CRICETULUS; FLUORESCENCE; IODINE; KINETICS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PROTEIN CONFORMATION; TRINITROBENZENES; TRYPTOPHAN;

EID: 33749994338     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060015     Document Type: Article

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