메뉴 건너뛰기




Volumn 217, Issue 2, 2012, Pages 204-215

Complement activation as a biomarker for Alzheimer's disease

Author keywords

Alzheimer's disease; Biomarker; Blood; Complement; Genetic risk factors; Inflammation; Plasma

Indexed keywords

ALPHA 2 MACROGLOBULIN; AMYLOID; AMYLOID BETA PROTEIN; BIOLOGICAL MARKER; BRAIN PROTEIN; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; CLUSTERIN; COMPLEMENT; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C4B; INTERLEUKIN 1; INTERLEUKIN 6; ROSIGLITAZONE; TAU PROTEIN;

EID: 84855260469     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2011.07.023     Document Type: Review
Times cited : (57)

References (158)
  • 3
    • 0029021217 scopus 로고
    • Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam Study
    • Andersen K., Launer L.J., Ott A., Hoes A.W., Breteler M.M., Hofman A. Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam Study. Neurology 1995, 45:1441-1445.
    • (1995) Neurology , vol.45 , pp. 1441-1445
    • Andersen, K.1    Launer, L.J.2    Ott, A.3    Hoes, A.W.4    Breteler, M.M.5    Hofman, A.6
  • 4
    • 0036741098 scopus 로고    scopus 로고
    • A role for local inflammation in the formation of drusen in the aging eye
    • Anderson D.H., Mullins R.F., Hageman G.S., Johnson L.V. A role for local inflammation in the formation of drusen in the aging eye. Am. J. Ophthalmol. 2002, 134:411-431.
    • (2002) Am. J. Ophthalmol. , vol.134 , pp. 411-431
    • Anderson, D.H.1    Mullins, R.F.2    Hageman, G.S.3    Johnson, L.V.4
  • 5
    • 0028810838 scopus 로고
    • Association of polyclonal anti-GM1 IgM and anti-neurofilament antibodies with CSF oligoclonal bands in a young with amyotrophic lateral sclerosis
    • Annunziata P., Maimone D., Guazzi G.C. Association of polyclonal anti-GM1 IgM and anti-neurofilament antibodies with CSF oligoclonal bands in a young with amyotrophic lateral sclerosis. Acta Neurol. Scand. 1995, 92:387-393.
    • (1995) Acta Neurol. Scand. , vol.92 , pp. 387-393
    • Annunziata, P.1    Maimone, D.2    Guazzi, G.C.3
  • 11
    • 79952273376 scopus 로고    scopus 로고
    • Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression
    • Benoit M.E., Tenner A.J. Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression. J. Neurosci. 2011, 31:3459-3469.
    • (2011) J. Neurosci. , vol.31 , pp. 3459-3469
    • Benoit, M.E.1    Tenner, A.J.2
  • 12
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    • Bertram L., McQueen M.B., Mullin K., Blacker D., Tanzi R.E. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 2007, 39:17-23.
    • (2007) Nat. Genet. , vol.39 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3    Blacker, D.4    Tanzi, R.E.5
  • 14
    • 25144513449 scopus 로고    scopus 로고
    • CSF biomarkers for Alzheimer's disease: use in early diagnosis and evaluation of drug treatment
    • Blennow K. CSF biomarkers for Alzheimer's disease: use in early diagnosis and evaluation of drug treatment. Expert. Rev. Mol. Diagn. 2005, 5:661-672.
    • (2005) Expert. Rev. Mol. Diagn. , vol.5 , pp. 661-672
    • Blennow, K.1
  • 15
    • 77949423619 scopus 로고    scopus 로고
    • Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
    • Blennow K., Hampel H., Weiner M., Zetterberg H. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat. Rev. Neurol. 2010, 6:131-144.
    • (2010) Nat. Rev. Neurol. , vol.6 , pp. 131-144
    • Blennow, K.1    Hampel, H.2    Weiner, M.3    Zetterberg, H.4
  • 29
    • 73849090193 scopus 로고    scopus 로고
    • Complement and its role in innate and adaptive immune responses
    • Dunkelberger J.R., Song W.C. Complement and its role in innate and adaptive immune responses. Cell Res. 2010, 20:34-50.
    • (2010) Cell Res. , vol.20 , pp. 34-50
    • Dunkelberger, J.R.1    Song, W.C.2
  • 30
    • 0006697033 scopus 로고    scopus 로고
    • Relationship between á1-antichymotypsin micro-satelletie and apolipoprotein E in Alzheimer's disease
    • Durany,N., K. Morgan, J. Thome, L. Tilley, N. Kalsheker, G. Munch, P. Riederer, Cruz-Sanchez, F., 1998. Relationship between á1-antichymotypsin micro-satelletie and apolipoprotein E in Alzheimer's disease, pp. 315-320.
    • (1998) , pp. 315-320
    • Durany, N.1    Morgan, K.2    Thome, J.3    Tilley, L.4    Kalsheker, N.5    Munch, G.6    Riederer, P.7    Cruz-Sanchez, F.8
  • 35
    • 0032498132 scopus 로고    scopus 로고
    • Alpha-antichymotrypsin gene polymorphism and risk for Alzheimer's disease in the Spanish population
    • Ezquerra M., Blesa R., Tolosa E., Ballesta F., Oliva R. Alpha-antichymotrypsin gene polymorphism and risk for Alzheimer's disease in the Spanish population. Neurosci. Lett. 1998, 240:107-109.
    • (1998) Neurosci. Lett. , vol.240 , pp. 107-109
    • Ezquerra, M.1    Blesa, R.2    Tolosa, E.3    Ballesta, F.4    Oliva, R.5
  • 37
    • 21044455621 scopus 로고    scopus 로고
    • Complement protein isoforms in CSF as possible biomarkers for neurodegenerative disease
    • Finehout E.J., Franck Z., Lee K.H. Complement protein isoforms in CSF as possible biomarkers for neurodegenerative disease. Dis. Markers 2005, 21:93-101.
    • (2005) Dis. Markers , vol.21 , pp. 93-101
    • Finehout, E.J.1    Franck, Z.2    Lee, K.H.3
  • 44
    • 0032055127 scopus 로고    scopus 로고
    • Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function?
    • Gelissen I.C., Hochgrebe T., Wilson M.R., Easterbrook-Smith S.B., Jessup W., Dean R.T., Brown A.J. Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function?. Biochem. J. 1998, 331(Pt 1):231-237.
    • (1998) Biochem. J. , vol.331 , Issue.PART 1 , pp. 231-237
    • Gelissen, I.C.1    Hochgrebe, T.2    Wilson, M.R.3    Easterbrook-Smith, S.B.4    Jessup, W.5    Dean, R.T.6    Brown, A.J.7
  • 45
    • 2642684569 scopus 로고    scopus 로고
    • Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study
    • Giannakopoulos P., Kovari E., French L.E., Viard I., Hof P.R., Bouras C. Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study. Acta Neuropathol. 1998, 95:387-394.
    • (1998) Acta Neuropathol. , vol.95 , pp. 387-394
    • Giannakopoulos, P.1    Kovari, E.2    French, L.E.3    Viard, I.4    Hof, P.R.5    Bouras, C.6
  • 49
    • 0033551794 scopus 로고    scopus 로고
    • C1qB and clusterin mRNA increase in association with neurodegeneration in sporadic amyotrophic lateral sclerosis
    • Grewal R.P., Morgan T.E., Finch C.E. C1qB and clusterin mRNA increase in association with neurodegeneration in sporadic amyotrophic lateral sclerosis. Neurosci. Lett. 1999, 271:65-67.
    • (1999) Neurosci. Lett. , vol.271 , pp. 65-67
    • Grewal, R.P.1    Morgan, T.E.2    Finch, C.E.3
  • 51
    • 0034832029 scopus 로고    scopus 로고
    • An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration
    • Hageman G.S., Luthert P.J., Victor Chong N.H., Johnson L.V., Anderson D.H., Mullins R.F. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog. Retin. Eye Res. 2001, 20:705-732.
    • (2001) Prog. Retin. Eye Res. , vol.20 , pp. 705-732
    • Hageman, G.S.1    Luthert, P.J.2    Victor Chong, N.H.3    Johnson, L.V.4    Anderson, D.H.5    Mullins, R.F.6
  • 57
    • 0030610931 scopus 로고    scopus 로고
    • No association between alpha1-antichymotrypsin polymorphism, apolipoprotein E and patients with late-onset Alzheimer's disease
    • Helisalmi S., Mannermaa A., Lehtovirta M., Ryynanen M., Riekkinen P., Soininen H. No association between alpha1-antichymotrypsin polymorphism, apolipoprotein E and patients with late-onset Alzheimer's disease. Neurosci. Lett. 1997, 231:56-58.
    • (1997) Neurosci. Lett. , vol.231 , pp. 56-58
    • Helisalmi, S.1    Mannermaa, A.2    Lehtovirta, M.3    Ryynanen, M.4    Riekkinen, P.5    Soininen, H.6
  • 60
    • 79954630189 scopus 로고    scopus 로고
    • A Review and meta-analysis of the association between C-reactive protein and age-related macular degeneration
    • Hong T., Tan A.G., Mitchell P., Wang J.J. A Review and meta-analysis of the association between C-reactive protein and age-related macular degeneration. Surv. Ophthalmol. 2011, 56:184-194.
    • (2011) Surv. Ophthalmol. , vol.56 , pp. 184-194
    • Hong, T.1    Tan, A.G.2    Mitchell, P.3    Wang, J.J.4
  • 61
    • 0037059776 scopus 로고    scopus 로고
    • Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb
    • Hourcade D.E., Mitchell L., Kuttner-Kondo L.A., Atkinson J.P., Medof M.E. Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb. J. Biol. Chem. 2002, 277:1107-1112.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1107-1112
    • Hourcade, D.E.1    Mitchell, L.2    Kuttner-Kondo, L.A.3    Atkinson, J.P.4    Medof, M.E.5
  • 63
    • 0032081298 scopus 로고    scopus 로고
    • Absence of association of alpha1-antichymotrypsin polymorphisms with Alzheimer's disease: a report on autopsy-confirmed cases
    • Itabashi S., Arai H., Matsui T., Matsushita S., Muramatsu T., Higuchi S., Trojanowski J.Q., Sasaki H. Absence of association of alpha1-antichymotrypsin polymorphisms with Alzheimer's disease: a report on autopsy-confirmed cases. Exp. Neurol. 1998, 151:237-240.
    • (1998) Exp. Neurol. , vol.151 , pp. 237-240
    • Itabashi, S.1    Arai, H.2    Matsui, T.3    Matsushita, S.4    Muramatsu, T.5    Higuchi, S.6    Trojanowski, J.Q.7    Sasaki, H.8
  • 65
    • 48249096770 scopus 로고    scopus 로고
    • C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes
    • Jakobsdottir J., Conley Y.P., Weeks D.E., Ferrell R.E., Gorin M.B. C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes. PLoS One 2008, 3:e2199.
    • (2008) PLoS One , vol.3
    • Jakobsdottir, J.1    Conley, Y.P.2    Weeks, D.E.3    Ferrell, R.E.4    Gorin, M.B.5
  • 68
    • 0035699547 scopus 로고    scopus 로고
    • Complement activation and inflammatory processes in Drusen formation and age related macular degeneration
    • Johnson L.V., Leitner W.P., Staples M.K., Anderson D.H. Complement activation and inflammatory processes in Drusen formation and age related macular degeneration. Exp. Eye Res. 2001, 73:887-896.
    • (2001) Exp. Eye Res. , vol.73 , pp. 887-896
    • Johnson, L.V.1    Leitner, W.P.2    Staples, M.K.3    Anderson, D.H.4
  • 74
    • 0028990941 scopus 로고
    • APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism
    • Kamboh M.I., Sanghera D.K., Ferrell R.E., DeKosky S.T. APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism. Nat. Genet. 1995, 10:486-488.
    • (1995) Nat. Genet. , vol.10 , pp. 486-488
    • Kamboh, M.I.1    Sanghera, D.K.2    Ferrell, R.E.3    DeKosky, S.T.4
  • 76
    • 77951916610 scopus 로고    scopus 로고
    • The molecular genetic basis of age-related macular degeneration: an overview
    • Katta S., Kaur I., Chakrabarti S. The molecular genetic basis of age-related macular degeneration: an overview. J. Genet. 2009, 88:425-449.
    • (2009) J. Genet. , vol.88 , pp. 425-449
    • Katta, S.1    Kaur, I.2    Chakrabarti, S.3
  • 77
    • 59249097049 scopus 로고    scopus 로고
    • Complement Receptor 1: disease associations and therapeutic implications
    • Khera R., Das N. Complement Receptor 1: disease associations and therapeutic implications. Mol. Immunol. 2009, 46:761-772.
    • (2009) Mol. Immunol. , vol.46 , pp. 761-772
    • Khera, R.1    Das, N.2
  • 79
    • 0031934335 scopus 로고    scopus 로고
    • Apolipoprotein E and alpha-1 antichymotrypsin polymorphism genotyping in Alzheimer's disease and in dementia with Lewy bodies distinctions between diseases
    • Lamb H., Christie J., Singleton A.B., Leake A., Perry R.H., Ince P.G., McKeith I.G., Melton L.M., Edwardson J.A., Morris C.M. Apolipoprotein E and alpha-1 antichymotrypsin polymorphism genotyping in Alzheimer's disease and in dementia with Lewy bodies distinctions between diseases. Neurology 1998, 50:388-391.
    • (1998) Neurology , vol.50 , pp. 388-391
    • Lamb, H.1    Christie, J.2    Singleton, A.B.3    Leake, A.4    Perry, R.H.5    Ince, P.G.6    McKeith, I.G.7    Melton, L.M.8    Edwardson, J.A.9    Morris, C.M.10
  • 82
    • 50949095168 scopus 로고    scopus 로고
    • Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data
    • Li B., Leal S.M. Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am. J. Hum. Genet. 2008, 83:311-321.
    • (2008) Am. J. Hum. Genet. , vol.83 , pp. 311-321
    • Li, B.1    Leal, S.M.2
  • 84
    • 0037336701 scopus 로고    scopus 로고
    • Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway
    • Li Y., Liu L., Barger S.W., Griffin W.S. Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. J. Neurosci. 2003, 23:1605-1611.
    • (2003) J. Neurosci. , vol.23 , pp. 1605-1611
    • Li, Y.1    Liu, L.2    Barger, S.W.3    Griffin, W.S.4
  • 86
    • 0033966340 scopus 로고    scopus 로고
    • Increased plasma levels of interleukin-1, interleukin-6 and [alpha]-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?
    • Licastro F., Pedrini S., Caputo L., Annoni G., Davis L.J., Ferri C., Casadei V., Grimaldi L.M.E. Increased plasma levels of interleukin-1, interleukin-6 and [alpha]-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?. J. Neuroimmunol. 2000, 103:97-102.
    • (2000) J. Neuroimmunol. , vol.103 , pp. 97-102
    • Licastro, F.1    Pedrini, S.2    Caputo, L.3    Annoni, G.4    Davis, L.J.5    Ferri, C.6    Casadei, V.7    Grimaldi, L.M.E.8
  • 87
    • 33344454373 scopus 로고    scopus 로고
    • The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool
    • Liew C.C., Ma J., Tang H.C., Zheng R., Dempsey A.A. The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J. Lab. Clin. Med. 2006, 147:126-132.
    • (2006) J. Lab. Clin. Med. , vol.147 , pp. 126-132
    • Liew, C.C.1    Ma, J.2    Tang, H.C.3    Zheng, R.4    Dempsey, A.A.5
  • 88
    • 78449245227 scopus 로고    scopus 로고
    • A novel adaptive method for the analysis of next-generation sequencing data to detect complex trait associations with rare variants due to gene main effects and interactions
    • Liu D.J., Leal S.M. A novel adaptive method for the analysis of next-generation sequencing data to detect complex trait associations with rare variants due to gene main effects and interactions. PLoS Genet. 2010, 6:e1001156.
    • (2010) PLoS Genet. , vol.6
    • Liu, D.J.1    Leal, S.M.2
  • 89
    • 42349104349 scopus 로고    scopus 로고
    • Plaque complement activation and cognitive loss in Alzheimer's disease
    • Loeffler D.A., Camp D.M., Bennett D.A. Plaque complement activation and cognitive loss in Alzheimer's disease. J. Neuroinflamm. 2008, 5:9.
    • (2008) J. Neuroinflamm. , vol.5 , pp. 9
    • Loeffler, D.A.1    Camp, D.M.2    Bennett, D.A.3
  • 91
  • 93
    • 35148814074 scopus 로고    scopus 로고
    • Transcriptional profiling of Alzheimer blood mononuclear cells by microarray
    • Maes O.C., Xu S., Yu B., Chertkow H.M., Wang E., Schipper H.M. Transcriptional profiling of Alzheimer blood mononuclear cells by microarray. Neurobiol. Aging 2007, 28:1795-1809.
    • (2007) Neurobiol. Aging , vol.28 , pp. 1795-1809
    • Maes, O.C.1    Xu, S.2    Yu, B.3    Chertkow, H.M.4    Wang, E.5    Schipper, H.M.6
  • 94
    • 55549147191 scopus 로고    scopus 로고
    • Personal genomes: the case of the missing heritability
    • Maher B. Personal genomes: the case of the missing heritability. Nature 2008, 456:18-21.
    • (2008) Nature , vol.456 , pp. 18-21
    • Maher, B.1
  • 95
    • 33748309136 scopus 로고    scopus 로고
    • Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration
    • Maller J., George S., Purcell S., Fagerness J., Altshuler D., Daly M.J., Seddon J.M. Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat. Genet. 2006, 38:1055-1059.
    • (2006) Nat. Genet. , vol.38 , pp. 1055-1059
    • Maller, J.1    George, S.2    Purcell, S.3    Fagerness, J.4    Altshuler, D.5    Daly, M.J.6    Seddon, J.M.7
  • 96
    • 34748819371 scopus 로고    scopus 로고
    • Variation in complement factor 3 is associated with risk of age-related macular degeneration
    • Maller J.B., Fagerness J.A., Reynolds R.C., Neale B.M., Daly M.J., Seddon J.M. Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nat. Genet. 2007, 39:1200-1201.
    • (2007) Nat. Genet. , vol.39 , pp. 1200-1201
    • Maller, J.B.1    Fagerness, J.A.2    Reynolds, R.C.3    Neale, B.M.4    Daly, M.J.5    Seddon, J.M.6
  • 97
    • 34547794674 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers for diagnosis of Alzheimer's disease: beta-amyloid(1-42), tau, phospho-tau-181 and total protein
    • Marksteiner J., Hinterhuber H., Humpel C. Cerebrospinal fluid biomarkers for diagnosis of Alzheimer's disease: beta-amyloid(1-42), tau, phospho-tau-181 and total protein. Drugs Today (Barc.) 2007, 43:423-431.
    • (2007) Drugs Today (Barc.) , vol.43 , pp. 423-431
    • Marksteiner, J.1    Hinterhuber, H.2    Humpel, C.3
  • 100
    • 85043724153 scopus 로고    scopus 로고
    • Expression profiles of cytokines in the brains of Alzheimer's Disease (AD) patients compared to the brains of non-demented patients with and without increasing ad pathology
    • (Epub ahead of print)
    • Morimoto K., Horio J., Satoh H., Sue L., Beach T., Arita S., Tooyama I., Konishi Y. Expression profiles of cytokines in the brains of Alzheimer's Disease (AD) patients compared to the brains of non-demented patients with and without increasing ad pathology. J. Alzheimers. Dis. 2011, 2(March). (Epub ahead of print).
    • (2011) J. Alzheimers. Dis. , vol.2
    • Morimoto, K.1    Horio, J.2    Satoh, H.3    Sue, L.4    Beach, T.5    Arita, S.6    Tooyama, I.7    Konishi, Y.8
  • 102
    • 0029753030 scopus 로고    scopus 로고
    • Lack of association between alpha 1-antichymotrypsin polymorphism. Alzheimer's disease, and allele epsilon 4 of apolipoprotein E
    • Muller U., Bodeker R.H., Gerundt I., Kurz A. Lack of association between alpha 1-antichymotrypsin polymorphism. Alzheimer's disease, and allele epsilon 4 of apolipoprotein E. Neurology 1996, 47:1575-1577.
    • (1996) Neurology , vol.47 , pp. 1575-1577
    • Muller, U.1    Bodeker, R.H.2    Gerundt, I.3    Kurz, A.4
  • 106
    • 27944511120 scopus 로고    scopus 로고
    • Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis
    • Nath S.K., Harley J.B., Lee Y.H. Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis. Hum. Genet. 2005, 118:225-234.
    • (2005) Hum. Genet. , vol.118 , pp. 225-234
    • Nath, S.K.1    Harley, J.B.2    Lee, Y.H.3
  • 107
    • 65249131713 scopus 로고    scopus 로고
    • Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    • Nejentsev S., Walker N., Riches D., Egholm M., Todd J.A. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 2009, 324:387-389.
    • (2009) Science , vol.324 , pp. 387-389
    • Nejentsev, S.1    Walker, N.2    Riches, D.3    Egholm, M.4    Todd, J.A.5
  • 108
    • 0021345176 scopus 로고
    • HLA-linked complement markers in Alzheimer's and Parkinson's disease: C4 variant (C4B2) a possible marker for senile dementia of the Alzheimer type
    • Nerl C., Mayeux R., O'Neill G.J. HLA-linked complement markers in Alzheimer's and Parkinson's disease: C4 variant (C4B2) a possible marker for senile dementia of the Alzheimer type. Neurology 1984, 34:310-314.
    • (1984) Neurology , vol.34 , pp. 310-314
    • Nerl, C.1    Mayeux, R.2    O'Neill, G.J.3
  • 110
    • 33750582958 scopus 로고    scopus 로고
    • Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons
    • Padmanabhan J., Levy M., Dickson D.W., Potter H. Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain 2006, 129:3020-3034.
    • (2006) Brain , vol.129 , pp. 3020-3034
    • Padmanabhan, J.1    Levy, M.2    Dickson, D.W.3    Potter, H.4
  • 112
    • 77956567560 scopus 로고    scopus 로고
    • Clinical assessment incorporating a personal genome
    • Pierce B.L., Ahsan H. Clinical assessment incorporating a personal genome. Lancet 2010, 376:869-870.
    • (2010) Lancet , vol.376 , pp. 869-870
    • Pierce, B.L.1    Ahsan, H.2
  • 113
    • 60349125886 scopus 로고    scopus 로고
    • Reassessing the amyloid cascade hypothesis of Alzheimer's disease
    • Pimplikar S.W. Reassessing the amyloid cascade hypothesis of Alzheimer's disease. Int. J. Biochem. Cell Biol. 2008, 41(6):1261-1268.
    • (2008) Int. J. Biochem. Cell Biol. , vol.41 , Issue.6 , pp. 1261-1268
    • Pimplikar, S.W.1
  • 118
    • 73349112242 scopus 로고    scopus 로고
    • Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes
    • Reynolds R., Hartnett M.E., Atkinson J.P., Giclas P.C., Rosner B., Seddon J.M. Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Invest. Ophthalmol. Vis. Sci. 2009, 50:5818-5827.
    • (2009) Invest. Ophthalmol. Vis. Sci. , vol.50 , pp. 5818-5827
    • Reynolds, R.1    Hartnett, M.E.2    Atkinson, J.P.3    Giclas, P.C.4    Rosner, B.5    Seddon, J.M.6
  • 120
    • 27744462212 scopus 로고    scopus 로고
    • Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk
    • Rivera A., Fisher S.A., Fritsche L.G., Keilhauer C.N., Lichtner P., Meitinger T., Weber B.H. Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. Hum. Mol. Genet. 2005, 14:3227-3236.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 3227-3236
    • Rivera, A.1    Fisher, S.A.2    Fritsche, L.G.3    Keilhauer, C.N.4    Lichtner, P.5    Meitinger, T.6    Weber, B.H.7
  • 121
    • 77957591829 scopus 로고    scopus 로고
    • C-reactive protein levels and complement factor H polymorphism interaction in age-related macular degeneration and its progression
    • Robman L., Baird P.N., Dimitrov P.N., Richardson A.J., Guymer R.H. C-reactive protein levels and complement factor H polymorphism interaction in age-related macular degeneration and its progression. Ophthalmology 2010, 117:1982-1988.
    • (2010) Ophthalmology , vol.117 , pp. 1982-1988
    • Robman, L.1    Baird, P.N.2    Dimitrov, P.N.3    Richardson, A.J.4    Guymer, R.H.5
  • 127
    • 0036942998 scopus 로고    scopus 로고
    • Increased clusterin (apolipoprotein J) expression in human and mouse brains infected with transmissible spongiform encephalopathies
    • Sasaki K., Doh-ura K., Ironside J.W., Iwaki T. Increased clusterin (apolipoprotein J) expression in human and mouse brains infected with transmissible spongiform encephalopathies. Acta Neuropathol. 2002, 103:199-208.
    • (2002) Acta Neuropathol. , vol.103 , pp. 199-208
    • Sasaki, K.1    Doh-ura, K.2    Ironside, J.W.3    Iwaki, T.4
  • 131
  • 132
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 2001, 81:741-766.
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 139
    • 70449435231 scopus 로고    scopus 로고
    • Identifying early markers of Alzheimer's disease using quantitative multiplex proteomic immunoassay panels
    • Soares H.D., Chen Y., Sabbagh M., Roher A., Schrijvers E., Breteler M. Identifying early markers of Alzheimer's disease using quantitative multiplex proteomic immunoassay panels. Ann. N.Y. Acad. Sci. 2009, 1180:56-67.
    • (2009) Ann. N.Y. Acad. Sci. , vol.1180 , pp. 56-67
    • Soares, H.D.1    Chen, Y.2    Sabbagh, M.3    Roher, A.4    Schrijvers, E.5    Breteler, M.6
  • 141
    • 0030897133 scopus 로고    scopus 로고
    • Risk of Alzheimer's disease and duration of NSAID use
    • Stewart W.F., Kawas C., Corrada M., Metter E.J. Risk of Alzheimer's disease and duration of NSAID use. Neurology 1997, 48:626-632.
    • (1997) Neurology , vol.48 , pp. 626-632
    • Stewart, W.F.1    Kawas, C.2    Corrada, M.3    Metter, E.J.4
  • 142
    • 0035575742 scopus 로고    scopus 로고
    • Beta-amyloid fibrils activate the C1 complex of complement under physiological conditions: evidence for a binding site for A beta on the C1q globular regions
    • Tacnet-Delorme P., Chevallier S., Arlaud G.J. Beta-amyloid fibrils activate the C1 complex of complement under physiological conditions: evidence for a binding site for A beta on the C1q globular regions. J. Immunol. 2001, 167:6374-6381.
    • (2001) J. Immunol. , vol.167 , pp. 6374-6381
    • Tacnet-Delorme, P.1    Chevallier, S.2    Arlaud, G.J.3
  • 144
    • 69449103057 scopus 로고    scopus 로고
    • HTRA1 promoter polymorphism and risk of age-related macular degeneration: a meta-analysis
    • Tang N.P., Zhou B., Wang B., Yu R.B. HTRA1 promoter polymorphism and risk of age-related macular degeneration: a meta-analysis. Ann. Epidemiol. 2009, 19:740-745.
    • (2009) Ann. Epidemiol. , vol.19 , pp. 740-745
    • Tang, N.P.1    Zhou, B.2    Wang, B.3    Yu, R.B.4
  • 145
    • 58549087156 scopus 로고    scopus 로고
    • Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease
    • Thambisetty M., Hye A., Foy C., Daly E., Glover A., Cooper A., Simmons A., Murphy D., Lovestone S. Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease. J. Neurol. 2008, 255:1712-1720.
    • (2008) J. Neurol. , vol.255 , pp. 1712-1720
    • Thambisetty, M.1    Hye, A.2    Foy, C.3    Daly, E.4    Glover, A.5    Cooper, A.6    Simmons, A.7    Murphy, D.8    Lovestone, S.9
  • 149
    • 65249084947 scopus 로고    scopus 로고
    • Imaging and biomarkers will be used for detection and monitoring progression of early Alzheimer's disease
    • Weiner M.W. Imaging and biomarkers will be used for detection and monitoring progression of early Alzheimer's disease. J. Nutr. Health Aging 2009, 13:332.
    • (2009) J. Nutr. Health Aging , vol.13 , pp. 332
    • Weiner, M.W.1
  • 153
    • 0033061855 scopus 로고    scopus 로고
    • Up-regulated production and activation of the complement system in Alzheimer's disease brain
    • Yasojima K., Schwab C., McGeer E.G., McGeer P.L. Up-regulated production and activation of the complement system in Alzheimer's disease brain. Am. J. Pathol. 1999, 154:927-936.
    • (1999) Am. J. Pathol. , vol.154 , pp. 927-936
    • Yasojima, K.1    Schwab, C.2    McGeer, E.G.3    McGeer, P.L.4
  • 155
    • 34547823043 scopus 로고    scopus 로고
    • The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures
    • Yerbury J.J., Poon S., Meehan S., Thompson B., Kumita J.R., Dobson C.M., Wilson M.R. The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures. FASEB J. 2007, 21:2312-2322.
    • (2007) FASEB J. , vol.21 , pp. 2312-2322
    • Yerbury, J.J.1    Poon, S.2    Meehan, S.3    Thompson, B.4    Kumita, J.R.5    Dobson, C.M.6    Wilson, M.R.7
  • 158
    • 77955709299 scopus 로고    scopus 로고
    • Complement receptor 1 polymorphisms and risk of late-onset Alzheimer's disease
    • Zhang Q., Yu J.T., Zhu Q.X., Zhang W., Wu Z.C., Miao D., Tan L. Complement receptor 1 polymorphisms and risk of late-onset Alzheimer's disease. Brain Res. 2010, 1348:216-221.
    • (2010) Brain Res. , vol.1348 , pp. 216-221
    • Zhang, Q.1    Yu, J.T.2    Zhu, Q.X.3    Zhang, W.4    Wu, Z.C.5    Miao, D.6    Tan, L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.