Possible neuroprotective role of clusterin in Alzheimer's disease: A quantitative immunocytochemical study

Acta Neuropathologica

Volumn 95, Issue 4, 1998, Pages 387-394

  Giannakopoulos, P ^a,b   Kovari E ^a   French, L E ^a   Viard, I ^a   Hof, P R ^d   Bouras, C ^a,c  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b Psychiatric Clinic 1   (Switzerland)

^c Division of Neuropsychiatry   (Switzerland)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Cerebral cortex; Clusterin; Neurofibrillary tangle; Neuronal loss

Indexed keywords

CELL PROTEIN; CLUSTERIN; MESSENGER RNA;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; ENTORHINAL CORTEX; FEMALE; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NEUROFIBRILLARY TANGLE; NEUROPIL; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; QUANTITATIVE ASSAY; SENILE PLAQUE; TEMPORAL CORTEX;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIBODIES, MONOCLONAL; BRAIN; BRAIN CHEMISTRY; CEREBRAL CORTEX; CLUSTERIN; FEMALE; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR CHAPERONES; NERVE TISSUE PROTEINS; NEUROFIBRILLARY TANGLES; TAU PROTEINS;

EID: 2642684569     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050815     Document Type: Article

References (66)

1. Bandyk MG, Sawczuk IS, Olsson CA, Katz AE, Buttyan R (1990) Characterization of the products of a gene expressed during androgen-programmed cell death and their potential use as a marker of urogenital injury. J Urol 143: 407-413
2. Benzi G, Moretti A (1995) Are reactive oxygen species involved in Alzheimer's disease? Neurobiol Aging 16: 661-674
3. Blaschuk O, Burdzy K, Fritz IB (1983) Purification and characterization of a cell-aggregating factor (clusterin), the major glycoprotein in ram rete testis fluid. J Biol Chem 258: 7714-7720
4. Blatter MC, James RW, Messmer S, Barja F, Pometta D (1993) Identification of a distinct human high-density lipoprotein subspecies defined by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase. Eur J Biochem 211: 871-879
5. Boggs LN, Fuson KS, Baez M, Churgay L, McClure D, Becker G, May PC (1996) Clusterin (Apo J) protects against in vitro amyloid β (1-40) neurotoxicity. J Neurochem 67: 1324-1327
6. Cheng CY, Mathur PP, Grima J (1988) Structural analysis of clusterin and its subunits in ram rete testis fluid. Biochemistry 27: 4079-4088
7. Cheng HW, Jian T, Brown SA, Pasinetti GM, Finch CE, McNeill TH (1994) Response of striatal astrocytes to neuronal deafferentation: an immunocytochemical and ultrastructural study. Neuroscience 62: 425-439
8. Choi-Miura NH, Oda T (1996) Relationship between multifunctional protein "clusterin" and Alzheimer's disease. Neurobiol Aging 17: 717-722
9. Choi-Miura NH, Ihara Y, Fukuchi K, Takeda M, Nakano Y, Tobe T, Tomita M (1992) SP-40, 40 is a constituent of Alzheimer's amyloid. Acta Neuropathol 83: 260-264
10. Collard MW, Griswold MD (1987) Biosynthesis and molecular cloning of sulphated glycoprotein 2 secreted by rat Sertoli cells. Biochemistry 26: 3297-3303
11. Connor J, Buttyan R, Olsson CA, D' Agati V, O' Toole K, Sawczuk IS (1991) SGP-2 expression as a genetic marker of progressive cellular pathology in experimental hydronephrosis. Kidney Int 39: 1098-1103
12. Coyle JT, Puttfarken P (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262: 689-695
13. Day JR, Laping NJ, McNeill TH, Schreiber SS, Pasinetti CM, Finch CE (1990) Castration enhances expression of glial fibrillary acidic protein sulfated glycoprotein-2 in the intact and lesion-altered hippocampus of the adult male rat. Mol Endocrinol 4: 1995-2002
14. De Suva HV, Stuart WD, Duvic CR, Wetterau JR, Ray MJ, Ferguson DG, Albers HW, Smith JR, Harmony JA (1990) A 70-kDa apolipoprotein designated ApoJ is a marker for subclasses of human plasma high density lipoproteins. J Biol Chem 265: 13240-13247
15. De Silva HV, Stuart WD, Park YB, Mao SJ, Gil CM, Wetterau JR, Busch SJ, Harmony JA (1990) Purification and characterization of apolipoprotein J. J Biol Chem 265: 14292-14297
16. Duguid JR, Boumont CW, Liu N, Tourtellotte W (1989) Changes in brain gene expression shared by scrapie and Alzheimer disease. Proc Natl Acad Sci USA 86: 7260-7264
17. Evans DA, Scherr PA, Cook NA, Albert MS, Funkenstein HH, Beckett LA, Hebert LE, Wetle TT, Branch LG, Chown MJ, Hennekens CH, Taylor JO (1992) The impact of Alzheimer's disease in the United States population. In: Suzman RM, Willis DP, Manton KG (eds) The oldest-old. Oxford University Press, New York, pp 283-299
18. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189-198
19. French LE, Chonn A, Ducrest D, Baumann B, Belin D, Wohlwend A, Kiss JZ, Sappino AP, Tschopp J, Schifferli JA (1993) Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis. J Cell Biol 122: 1119-1130
20. French LE, Wohlwend A, Sappino AP, Tschopp J, Schifferli JA (1994) Human clusterin gene expression is confined to surviving cells during in vitro programmed cell death. J Clin Invest 93: 877-884
21. Garden GA, Bothwell M, Rubel EW (1991) Lack of correspondence between mRNA expression for a putative cell death molecule (SGP-2) and neuronal cell death in the central nervous system. J Neurobiol 22: 590-604
22. Giannakopoulos P, Hof PR, Giannakopoulos AS, Buée-Scherrer V, Surini M, Delacourte A, Bouras C (1994) Dementia in the oldest-old: quantitative analysis of 12 cases from a psychiatric hospital. Dementia 5: 348-356
23. Giannakopoulos P, Hof PR, Kövari E, Vallet PG, Bouras C (1996) Distinct patterns of neuronal loss and Alzheimer's disease lesion distribution in elderly individuals older than 90 years. J Neuropathol Exp Neurol 55: 1210-1120
24. Giannakopoulos P, Bouras C, Kövari E, Shioi J, Tezapsidis N, Hof PR, Robakis NK (1997) Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer disease. Am J Pathol 150: 429-436
25. Gómez-Isla T, Price JL, McKeel DW Jr, Morris JC, Growdon JH, Hyman BT (1996) Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci 16: 4491-4500
26. Good PF, Werner P, Hsu A, Olanow CW, Perl DP (1996) Evidence for neuronal oxidative damage in Alzheimer's disease. Am J Pathol 149: 21-28
27. Grima J, Zwain I, Lockshin RA, Bardin CW, Cheng CY (1990) Diverse secretory patterns of clusterin by epididymis and prostate/seminal vesicles undergoing cell regression after orchiectomy. Endocrinology 126: 2989-2997
28. Harr SD, Uint L, Hollister R, Hyman BT, Mendez AJ (1996) Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease. J Neurochem 66: 2429-2435
29. Heyman A, Wilkinson WE, Hurwitz BL, Helms MJ, Haynes CS, Utley CM, Gwyther LP (1987) Early-onset Alzheimer's disease: clinical predictors of institutionalization and death. Neurology 83: 170-178
30. Jenne DE, Tschopp J (1989) Molecular structure and functional characterization of a novel human cytolysis inhibitor (CLI) found in blood and seminal plasma. Identity to sulfated glycoprotein 2 (SGP-2), a constituent of rat testis fluid. Proc Natl Acad Sci USA 86: 7123-7127
31. Jenne DE, Tschopp J (1992) Clusterin: the intriguing guises of a widely expressed glycoprotein. Trends Biochem Sci 17: 154-159
32. Johnson SA, Young-Chan CS, Laping NJ, Finch CE (1996) Perforant path transection induces complement C9 deposition in hippocampus. Exp Neurol 138: 198-205
33. Kelso GJ, Stuart WD, Richter RJ, Furlong CE, Jordan STC, Harmony JA (1994) Apolipoprotein J is associated with paraoxonase in human plasma. Biochemistry 33: 832-839
34. Matsubara E, Soto C, Governale S, Frangione B, Ghiso J (1996) Apolipoprotein J and Alzheimer's amyloid β solubility. Biochem J 316: 671-679
35. May PC, Finch CE (1992) Sulfated glycoprotein 2: new relationships of this multifunctional protein to neurodegeneration. Trends Neurosci 15: 391-396
36. May PC, Johnson SA, Poirier J, Lampert-Etchells M, Finch CE (1989) Altered gene expression in Alzheimer's disease brain tissue. Can J Neurol Sci 16: 473-476
37. May PC, Lampert EM, Johnson SA, Poirier J, Masters JN, Finch CE (1990) Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat. Neuron 5: 831-839
38. McGeer PL, Rogers J (1992) Anti-inflammatory agents as a therapeutic approach to Alzheimer's disease. Neurology 42: 447-449
39. McGeer PL, Kawamata T, Walker DG (1992) Distribution of clusterin in Alzheimer brain tissue. Brain Res 579: 337-341
40. McGeer PL, Kawamata T, Walker DG, Akiyama H, Tooyama I, McGeer EG (1993) Microglia in neurodegenerative neurological disease. Glia 7: 84-92
41. McMillan PJ, Leverenz JB, Poorkaj P, Schellenberg GD, Dorsa DM (1996) Neuronal expression of STM2 mRNA in human brain is reduced in Alzheimer's disease. J Histochem Cytochem 44: 1215-1222
42. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, Van Belle G, Berg L (1991) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41: 479-486
43. Moss M, Albert M (1988) Alzheimer's disease and other dementing disorders. In: Albert M, Moss M (eds) Geriatric neuropsycholoey. Guilford Press, New York, pp 145-177
44. Murphy BF, Kirszbaum L, Walker ID, D'Apice JF (1988) SP40,40 a newly identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis. J Clin Invest 81: 1858-1864
45. Murphy BF, Saunders JR, O'Bryan MK, Kirszbaum L, Walker ID, D'Apice AJF (1989) SP-40, 40 is an inhibitor of C5b-6 initiated hemolysis. Int Immunol 1: 551-554
46. Oda T, Pasinetti GM, Osterburg HH, Andersen C, Johnson SA, Finch CE (1994) Purification and characterization of brain clusterin. Biochem Biophys Res Commun 204: 1131-1136
47. Oda T, Wals P, Osterburg HH, Johnson SA, Pasinetti GM, Morgan TE, Rozovsky I, Stine WB, Synder SW, Holzman TF, Krafft GA, Finch CE (1995) Clusterin (apoJ) alters the aggregation of amyloid β peptide (Aβ 1-42) and forms slowly sedimenting Aβ complexes that cause oxidative stress. Exp Neurol 136: 22-31
48. Pasinetti GM, Finch CE (1991) Sulfated glycoprotein-2 (SGP-2) mRNA is expressed in rat striatal astrocytes following ibotenic acid lesions. Neurosci Lett 130: 1-4
49. Pasinetti GM, Johnson SA, Oda T, Rozovsky I, Finch CE (1994) Clusterin (SGP-2): a multifunctional glycoprotein with regional expression in astrocytes and neurons of the adult rat brain. J Comp Neurol 339: 387-400
50. Pearse MJ, O'Bryan M, Fisicaro N, Rogers L, Murphy B, D'Apice AJ (1992) Differential expression of clusterin in inducible models of apoptosis. Int Immunol 4: 1225-1231
51. Polihronis M, Paizis K, Carter G, Sedal L, Murphy B (1993) Elevation of human cerebrospinal fluid clusterin concentration is associated with acute neuropathology. J Neurol Sci 115: 230-233
52. Rozovsky I, Morgan TE, Willoughby DA, Dugich-Djordjevich MM, Pasinetti GM, Johnson SA, Finch CE (1994) Selective expression of clusterin (SGP-2) and complement C1qB and C4 during responses to neurotoxins in vivo and in vitro. Neuroscience 62: 741-758
53. Simonian NA, Coyle JT (1996) Oxidative stress in neurode-generative diseases. Annu Rev Pharmacol Toxicol 36: 83-106
54. Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S (1997) Skeletal and CNS defects in presenilin-1-deficient mice. Cell 89: 629-639
55. Smith MA, Perry G, Richey PL, Sayre LM, Anderson VE, Beal MF, Kowall N (1996) Oxidative damage in Alzheimer's disease. Nature 382: 120-121
56. Sterio DC (1984) The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 134: 127-136
57. Sylvester S, Skinner MK, Griswold MD (1984) A sulfated glycoprotein synthesized by Sertoli cells and by epididymal cells is a component of the sperm membrane. Biol Reprod 31: 1087-1101
58. Tschopp J, Chonn A, Hertig S, French LE (1993) Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9. J Immunol 151: 2159-2165
59. Vallet PG, Guntern R, Hof PR, Golaz J, Delacourte A, Robakis NK, Bouras C (1992) A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease. Acta Neuropathol 83: 170-178
60. 2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science 271: 521-525
61. West MJ (1993) Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging 14: 287-293
62. West MJ, Coleman PD, Flood DG, Troncoso JC (1994) Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344: 769-772
63. Yasuhara O, Aimi Y, McGeer EG, McGeer PL (1994) Expression of the complement membrane attack complex and its inhibitors in Pick disease brain. Brain Res 652: 346-349
64. Zabludoff SD, Erickson-Lawrence M, Wright WW (1990) Sertoli cells, proximal convoluted tubules in the kidney, and neurons in the brain contain cyclic protein-2. Biol Reprod 43: 15-24
65. Zoli M, Ferraguti F, Zini I, Bettuzzi S, Agnati LF (1993) Increases in sulphated glycoprotein-2 mRNA levels in the rat brain after transient forebrain ischemia or partial mesodiencephalic hemitransection. Mol Brain Res 18: 163-177
66. Zwain IH, Grima J, Cheng CY (1994) Regulation of clusterin secretion and mRNA expression in astrocytes by cytokines. Mol Cell Neurosci 5: 229-237