In vitro and in vivo aggregation of a fragment of huntingtin protein directly causes free radical production

Journal of Biological Chemistry

Volumn 286, Issue 52, 2011, Pages 44512-44520

  Hands, Sarah ^a   Sajjad, Mohammad U ^a   Newton, Michael J ^a   Wyttenbach, Andreas ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABNORMAL PRODUCTION; CAUSAL RELATIONSHIPS; EXTRACELLULAR PROTEINS; FLANKING SEQUENCE; FREE RADICAL PRODUCTIONS; HUNTINGTIN; HUNTINGTON DISEASE; IN-VITRO; INTRACELLULAR PROTEINS; OXIDATIVE DAMAGE; POLYGLUTAMINE; PROTEIN AGGREGATION; REACTIVE OXYGEN SPECIES; SINGLE-CHAIN ANTIBODIES; THERAPEUTIC TARGETS;

ATOMIC FORCE MICROSCOPY; CELL DEATH; ENZYME ACTIVITY; HYDROGEN; HYDROGEN PEROXIDE; NEURODEGENERATIVE DISEASES; OLIGOMERIZATION; OLIGOMERS; PATHOLOGY; PROTEINS;

FREE RADICALS;

DNA; FREE RADICAL; HUNTINGTIN; HYDROGEN PEROXIDE; POLYGLUTAMINE; REACTIVE OXYGEN METABOLITE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ARTICLE; ATOMIC FORCE MICROSCOPY; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DNA FLANKING REGION; EXON; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IN VITRO STUDY; IN VIVO CULTURE; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION;

CELL DEATH; CELL LINE; HUMANS; HUNTINGTON DISEASE; HYDROGEN PEROXIDE; MICROSCOPY, ATOMIC FORCE; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SINGLE-CHAIN ANTIBODIES;

EID: 84455173005     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.307587     Document Type: Article

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