Generation of hydrogen peroxide from mutant forms of the prion protein fragment PrP121-231

Biochemistry

Volumn 42, Issue 25, 2003, Pages 7675-7681

  Turnbull, Stuart ^a   Tabner, Brian J ^a   Brown, David R ^b   Allsop, David ^a  

^a LANCASTER UNIVERSITY   (United Kingdom)

^b University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSTS; ELECTRON SPIN RESONANCE SPECTROSCOPY; HYDROGEN PEROXIDE; TOXICITY;

SPIN TRAPPING;

PROTEINS;

ALPHA SYNUCLEIN; CATALASE; CHELATING AGENT; FERROUS ION; HYDROGEN PEROXIDE; HYDROXYL RADICAL; METAL; MUTANT PROTEIN; PRION PROTEIN; PROTEIN PRP121 231; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN CELL; CELL CULTURE; CELL LOSS; CEREBELLUM; CONTROLLED STUDY; CYTOTOXICITY; ELECTRON SPIN RESONANCE; FENTON REACTION; HUMAN; MOUSE; MUTATION; NERVE DEGENERATION; NONHUMAN; OXIDATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENCE HOMOLOGY; SPIN TRAPPING; WILD TYPE;

ANIMALS; CELL LINE; CEREBELLUM; ELECTRON SPIN RESONANCE SPECTROSCOPY; HYDROGEN PEROXIDE; MICE; MUTATION; PEPTIDE FRAGMENTS; PRIONS;

ANIMALIA;

EID: 0038001458     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi030036e     Document Type: Article

References (54)

1. Prusiner, S. B. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 13363-13383.
2. Prusiner, S. B. (1998) Brain Pathol. 8, 499-513.
3. Soto, C., and Saborio, G. P. (2001) Trends Mol. Med. 7, 109-114.
4. McKinley, M. P., Meyer, R. K., Kenaga, L., Rahbar, F., Cotter, R., Serban, A., and Prusiner, S. B. (1991) J. Virol. 65, 1340-1351.
5. Soto, C. (2003) Nat. Rev. Neurosci. 4, 49-60.
6. Brown, D. R. (2002) Mol. Neurobiol. 25, 287-302.
7. Janus, C., Phinney, A. L., Chishti, M. A., and Westaway, D. (2001) Curr. Neurol. Neurosci. Rep. 1, 451-457.
8. Beal, M. F. (2001) Nat. Rev. Neurosci. 2, 325-334.
9. Hutton, M., Lewis, J., Dickson, D., Yen, S. H., and McGowan, E. (2001) Trends Mol. Med. 7, 467-470.
10. Sipione, S., and Cattaneo, E. (2001) Mol. Neurobiol. 23, 21-51.
11. Aguzzi, A., Brandner, S., Fischer, M. B., Furukawa, H., Glatzel, M., Hawkins, C., Heppner, F. L., Montrasio, F., Navarro, B., Parizek, P., Pekarik, V., Prinz, M., Raeber, A. J., Rockl, C., and Klein, M. A. (2001) Adv. Virus Res. 56, 313-352.
12. Asante, E. A., and Collinge, J. (2001) Adv. Protein Chem. 57, 273-311.
13. Rottkamp, C. A., Nunomura, A., Raina, A. K., Sayre, L. M., Perry, G., and Smith, M. A. (2000) Alzheimer. Dis. Assoc. Disord. 14, S62-S66.
14. Jenner, P., and Olanow, C. W. (1996) Neurology 47, S161-S170.
15. Kim, J. I., Choi, S. I., Kim, N. H., Jin, J. K., Choi, E. K., Carp, R. I., and Kim, Y. S. (2001) Ann. N.Y. Acad. Sci. 928, 182-186.
16. Milhavet, O., and Lehmann, S. (2002) Brain Res. Rev. 38, 328-339.
17. Lehman, S. (2002) Curr. Opin. Chem. Biol. 6, 187-192.
18. Allsop, D. (2000) in Alzheimer's disease: methods and protocols (Hooper, N., Ed.) pp 1-21, Humana Press, Totawa, NJ.
19. Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) Nature 388, 839-840.
20. Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., and Goedert, M. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 6469-6473.
21. Duda, J. E., Giasson, B. I., Gur, T. L., Montine, T. J., Robertson, D., Biaggioni, I., Hurtig, H. I., Stern, M. B., Gollomp, S. M., Grossman, M., Lee, V. M., and Trojanowski, J. Q. (2000) J. Neuropathol. Exp. Neurol. 59, 830-841.
22. Turnbull, S., Tabner, B. J., El-Agnaf, O. M. A., Moore, S., Davies, Y., and Allsop, D. (2001) Free Radical Biol. Med. 30, 1163-1170.
23. Huang, X., Atwood, C. S., Hartshorn, M. A., Multhaup, G., Goldstein, L. E., Scarpa, R. C., Cuajungco, M. P., Gray, D. N., Lim, J., Moir, R. D., Tanzi, R. E., and Bush, A. I. (1999) Biochemistry 38, 7609-7616.
24. Turnbull, S., Tabner, B. J., Brown, D. R., and Allsop, D. (2003) Neurosci. Lett. 336, 159-162.
25. Jobling, M. F., Huang, X., Stewart, L. R., Barnham, K. J., Curtain, C., Volitakis, I., Perugini, M., White, A. R., Cherny, R. A., Masters, C. L., Barrow, C. J., Collins, S. J., Bush, A. I., and Cappai, R. Biochemistry 40, 8073-8084.
26. Brown, D. R. (2002) Biochem. Soc. Trans. 30, 742-745.
27. Brown, D. R., Qin, K. Herms, J. W., Madlung, A., Manson, J., Strome, R., Fraser, P. E., Kruck, T. A., von Bohlen, A., Schulz-Schaeffer, W., Giese, A., Westaway, D., and Kretzschmar, H. (1997) Nature 390, 684-687.
28. Burns, C. S., Aronoff-Spencer, E., Dunham, C. M., Lario, P., Avdievich, N. I., Antholine, W. E., Olmstead, M. M., Vrielink, A., Gerfen, G. J., Peisach, J., Scott W. G., and Millhauser, G. L. (2002) Biochemistry 41, 3991-4001.
29. Qin, K., Yang, Y., Mastrangelo, P., and Westaway, D. (2002) J. Biol. Chem. 277, 1981-1990.
30. Hasnain, S. S., Murphy, L. M., Strange, R. W., Grossmann, J. G., Clarke, A. R., Jackson, G. S., and Collinge, J. (2001) J. Mol. Biol. 311, 467-473.
31. Jackson, G. S., Murray, I., Hosszu, L. L., Gibbs, N., Waltho, J. P., Clarke, A. R., and Collinge, J. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 8531-8535.
32. Cereghetti, G. M., Schweiger, A., Glockshuber, R., and Van Doorslaer, S. (2001) Biophys. J. 81, 516-525.
33. Brown, D. R., Wong, B.-S., Hafiz, F., Clive, C., Haswell, S. J., and Jones, I. M. (1999) Biochem. J. 344, 1-5.
34. Tabner, B. J., Turnbull, S., El-Agnaf, O. M. A., and Allsop, D. (2001) Curr. Top. Med. Chem. 1, 483-493.
35. Tabner, B. J., Turnbull, S., El-Agnaf, O. M. A., and Allsop, D. (2002) Free Radical Biol. Med. 32, 1076-1083.
36. Shmerling, D., Hegy, I., Fischer, M., Blättler, T., Brandner, S., Götz, J., Rülicke, T., Flechsig, E., Cozzio, A., von Mering, C., Hangartner, C., Aguzzi, A., and Weissmann, C. (1998) Cell 93, 203-214.
37. Daniels, M., Cereghetti, G. M., and Brown, D. R. (2001) Eur. J. Biochem. 268, 6155-6164.
38. Liemann, S., and Glockshuber, R. (1999) Biochemistry 38, 3258-3267.
39. Wong, B.-S., Liu, T., Paisley, D., Li, R., Pan, T., Chen, S. G., Perry, G., Petersen, R. B., Smith, M. A., Melton, D. W., Gambetti, P., Brown, D. R., and Sy, M.-S. (2001) Mol. Cell Neurosci. 17, 768-775.
40. Brown, D. R., Schmidt, B., and Kretzschmar, H. A (1996) Nature 380, 345-347.
41. Zhang, Y., Swietnicki, W., Zagorski, M. G., Surewicz, W. K., and Sönnichsen, F. D. (2000) J. Biol. Chem. 275, 33650-33654.
42. Riek, R., Wider, G., Billeter, M., Hornemann, S., Glockshuber, R., and Wüthrich, K. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 11667-11672.
43. Cappai, R., Stewart, L., Jobling, M. F., Thyer, J. M., White, A. R., Beyreuther, K., Collins, S. J., Masters, C. L., and Barrow, C. J. (1999) Biochemistry 38, 3280-3284.
44. Inouye, H., Bond, J., Baldwin, M. A., Ball, H. L., Prusiner, S. B., and Kirschner, D. A. (2000) J. Mol. Biol. 300, 1283-1296.
45. Lehmann, S., and Harris, D. A. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 5610-5614.
46. Brown, D. R. (2000) Biochem. J. 346, 785-791.
47. Chen, S. G., Teplow, D. B., Parchi, P., Teller, J. K., Gambetti, P., and Autilio-Gambetti, L. (1995) J. Biol. Chem. 270, 19173-19180.
48. Monji, A., Utsumi, H., Yoshida, I., Hashioka, S., Tashiro, K. I., and Tashiro, N. (2001) Neurosci. Lett. 304, 65-68.
49. Guentchev, M., Siedlak, S. L., Jarius, C., Tagliavini, F., Castellani, R. J., Perry, G., Smith, M. A., and Budka, H. (2002) Neurobiol. Dis. 9, 275-281.
50. Behl, C., Davis, J. B., Lesley, R., and Schubert, D. (1994) Cell 77, 817-827.
51. Rottkamp, C., Raina, A. K., Zhu, X., Gaier, E., Bush, A. I., Atwood, C. S., Hevion, M., Perry, G., and Smith M. A. (2001) Free Radical Biol. Med. 30, 447-450.
52. Goldfarb, L. G., Hattia, M., Brown, P., Asher, D. M., Lin, S., Teener, J. W., Feinstone, S. M., Rubenstein, R., Kascsak, R. J., Boellaard, J. W., and Gajdusek, D. C. (1991) Lancet 337, 425.
53. Hsiao, K., Dlouhy, S. R., Farlow, M. R., Cass, C., Dacosta, M., Conneally, P. M., Hodes, M. E., Ghetti, B., and Prusiner, S. B. (1992) Nat. Genet. 1, 68-71.
54. Goldgaber, D., Goldfarb, L. G., Brown, P., Asher, D. M., Lin, S., Teener, J. W., Feinstone, S. M., Rubenstein, R., Kascsak, R. J., Boellaard, J. W., and Gajdusek, D. C. (1989) Exp. Neurol. 106, 204-206.