Transcriptomics analysis of retinoic acid embryotoxicity in rat postimplantation whole embryo culture

Reproductive Toxicology

Volumn 30, Issue 2, 2010, Pages 333-340

  Luijten, Mirjam ^a   van Beelen, Vincent A ^a   Verhoef, Aart ^a   Renkens, Marc F J ^a   van Herwijnen, Marcel H M ^b   Westerman, Anja ^a   van Schooten, Frederik J ^b   Pennings, Jeroen L A ^a   Piersma, Aldert H ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Bovine serum; Embryotoxicity; Microarray analysis; Rat serum; Retinoic acid; Whole embryo culture

Indexed keywords

RETINOIC ACID;

ARTICLE; BRANCHIAL DEFECT; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; CULTURE MEDIUM; DEVELOPMENTAL STAGE; EMBRYO; EMBRYO CULTURE; EMBRYOTOXICITY; EYE MALFORMATION; GENE EXPRESSION REGULATION; MICROARRAY ANALYSIS; NEURAL TUBE DEFECT; NIDATION; NONHUMAN; RAT; REAL TIME POLYMERASE CHAIN REACTION; TOXICITY TESTING; TRANSCRIPTOMICS;

BOVINAE; RATTUS; RODENTIA;

EID: 77955270390     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2010.05.013     Document Type: Article

References (39)

1. van der Jagt K., Munn S., Tørsløv J., de Bruijn J. Alternative approaches can reduce the use of test animals under REACH. Addendum to Assessment of additional testing needs under REACH effects of (Q)SARS risk based testing and voluntary industry initiatives 2004.
2. Genschow E., Spielmann H., Scholz G., Seiler A., Brown N., Piersma A., et al. The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods. Altern Lab Anim 2002, 30:151-176.
3. New D.A., Coppola P.T., Cockroft D.L. Comparison of growth in vitro and in vivo of post-implantation rat embryos. J Embryol Exp Morphol 1976, 36:133-144.
4. Piersma A.H., Genschow E., Verhoef A., Spanjersberg M.Q., Brown N.A., Brady M., et al. Validation of the postimplantation rat whole-embryo culture test in the international ECVAM validation study on three in vitro embryotoxicity tests. Altern Lab Anim 2004, 32:275-307.
5. Morriss-Kay G.M., Murphy P., Hill R.E., Davidson D.R. Effects of retinoic acid excess on expression of Hox-2.9 and Krox-20 and on morphological segmentation in the hindbrain of mouse embryos. EMBO J 1991, 10:2985-2995.
6. Zhang Q.J., Chadderton A., Clark R.L., Augustine-Rauch K.A. Selection of normalizer genes in conducting relative gene expression analysis of embryos. Birth Defects Res A: Clin Mol Teratol 2003, 67:533-544.
7. Menegola E., Broccia M.L., Di Renzo F., Massa V., Giavini E. Relationship between hindbrain segmentation, neural crest cell migration and branchial arch abnormalities in rat embryos exposed to fluconazole and retinoic acid in vitro. Reprod Toxicol 2004, 18:121-130.
8. New D.A. Whole-embryo culture and the study of mammalian embryos during organogenesis. Biol Rev Camb Philos Soc 1978, 53:81-122.
9. Brown N.A., Fabro S. Quantitation of rat embryonic development in vitro: a morphological scoring system. Teratology 1981, 24:65-78.
10. Kakinoki R., Bishop A.T., Tu Y.K., Matsui N. Detection of the proliferated donor cells in bone grafts in rats, using a PCR for a Y-chromosome-specific gene. J Orthop Sci 2002, 7:252-257.
11. Irizarry R.A., Bolstad B.M., Collin F., Cope L.M., Hobbs B., Speed T.P. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 2003, 31:e15.
12. de Leeuw W.C., Rauwerda H., Jonker M.J., Breit T.M. Salvaging Affymetrix probes after probe-level re-annotation. BMC Res Notes 2008, 1:66.
13. Dai M., Wang P., Boyd A.D., Kostov G., Athey B., Jones E.G., et al. Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res 2005, 33:e175.
14. R: A language and environment for statistical computing 2005, R. Development Core Team.
15. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc Ser B: Method 1995, 57:289-300.
16. Huang dW, Sherman B.T., Lempicki R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009, 4:44-57.
17. Dennis G., Sherman B.T., Hosack D.A., Yang J., Gao W., Lane H.C., et al. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol 2003, 4:3.
18. Daftary G.S., Taylor H.S. Endocrine regulation of HOX genes. Endocr Rev 2006, 27:331-355.
19. Williams S.S., Mear J.P., Liang H.C., Potter S.S., Aronow B.J., Colbert M.C. Large-scale reprogramming of cranial neural crest gene expression by retinoic acid exposure. Physiol Genomics 2004, 19:184-197.
20. Loudig O., Babichuk C., White J., Abu-Abed S., Mueller C., Petkovich M. Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism. Mol Endocrinol 2000, 14:1483-1497.
21. Cerignoli F., Guo X., Cardinali B., Rinaldi C., Casaletto J., Frati L., et al. retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines. Cancer Res 2002, 62:1196-1204.
22. Thatcher J.E., Isoherranen N. The role of CYP26 enzymes in retinoic acid clearance. Expert Opin Drug Metab Toxicol 2009, 5:875-886.
23. Li J.Y., Joyner A.L. Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression. Development 2001, 128:4979-4991.
24. Mavilio F. Regulation of vertebrate homeobox-containing genes by morphogens. Eur J Biochem 1993, 212:273-288.
25. Conlon R.A. Retinoic acid and pattern formation in vertebrates. Trends Genet 1995, 11:314-319.
26. Barrow J.R., Stadler H.S., Capecchi M.R. Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse. Development 2000, 127:933-944.
27. Grapin-Botton A., Bonnin M.A., Sieweke M., Le Douarin N.M. Defined concentrations of a posteriorizing signal are critical for MafB/Kreisler segmental expression in the hindbrain. Development 1998, 125:1173-1181.
28. Houle M., Prinos P., Iulianella A., Bouchard N., Lohnes D. Retinoic acid regulation of Cdx1: an indirect mechanism for retinoids and vertebral specification. Mol Cell Biol 2000, 20:6579-6586.
29. Lohnes D. The Cdx1 homeodomain protein: an integrator of posterior signaling in the mouse. Bioessays 2003, 25:971-980.
30. Qin P., Cimildoro R., Kochhar D.M., Soprano K.J., Soprano D.R. PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects. Teratology 2002, 66:224-234.
31. Capellini T.D., Di Giacomo G., Salsi V., Brendolan A., Ferretti E., Srivastava D., et al. Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development 2006, 133:2263-2273.
32. Balmer J.E., Blomhoff R. Gene expression regulation by retinoic acid. J Lipid Res 2002, 43:1773-1808.
33. Jeong J., Li X., McEvilly R.J., Rosenfeld M.G., Lufkin T., Rubenstein J.L. Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development 2008, 135:2905-2916.
34. Mechta-Grigoriou F., Garel S., Charnay P. Nab proteins mediate a negative feedback loop controlling Krox-20 activity in the developing hindbrain. Development 2000, 127:119-128.
35. Schmid B.P., Trippmacher A., Bianchi A. Validation of the whole-embryo culture method for in vitro teratogenicity testing. Dev Toxicol Environ Sci 1983, 11:563-566.
36. New D.A. The use and misuse of mammalian culture systems for estimating teratologic and embryotoxic risks. Cong Anom 1988, 28:S27-S40.
37. Piersma A.H., Bechter R., Krafft N., Schmid B.P., Stadler J., Verhoef A., et al. Interlaboratory evaluation of five pairs of (non-)teratogens in post-implantation rat embryo culture. Altern Lab Anim 1996, 24:201-209.
38. Morriss G.M. Morphogenesis of the malformations induced in rat embryos by maternal hypervitaminosis A. J Anat 1972, 113:241-250.
39. Flick B., Talsness C.E., Jackh R., Buesen R., Klug S. Embryotoxic potential of N-methyl-pyrrolidone (NMP) and three of its metabolites using the rat whole embryo culture system. Toxicol Appl Pharmacol 2009, 237:154-167.