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Volumn 277, Issue 1-3, 2010, Pages 66-73

Monolayer cultivation of osteoprogenitors shortens duration of the embryonic stem cell test while reliably predicting developmental osteotoxicity

Author keywords

Developmental osteotoxicity; Embryonic stem cell test; Embryonic stem cells; Embryotoxicity; Osteogenesis; Retinoic acid

Indexed keywords

FLUOROURACIL; OSTEOCALCIN; PENICILLIN G; RETINOIC ACID;

EID: 77957863307     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.08.016     Document Type: Article
Times cited : (25)

References (27)
  • 2
    • 0032856081 scopus 로고    scopus 로고
    • The relative semi-quantification of mRNA expression as a useful toxicological endpoint for the identification of embryotoxic/teratogenic substances
    • Bigot K., De Lange J., Archer J., Clothier R., Bremer S. The relative semi-quantification of mRNA expression as a useful toxicological endpoint for the identification of embryotoxic/teratogenic substances. Toxicol. In Vitro 1999, 13:619-623.
    • (1999) Toxicol. In Vitro , vol.13 , pp. 619-623
    • Bigot, K.1    De Lange, J.2    Archer, J.3    Clothier, R.4    Bremer, S.5
  • 5
    • 33751563297 scopus 로고    scopus 로고
    • Expansion of undifferentiated murine embryonic stem cells as aggregates in suspension culture bioreactors
    • Cormier J.T., zur Nieden N.I., Rancourt D.E., Kallos M.S Expansion of undifferentiated murine embryonic stem cells as aggregates in suspension culture bioreactors. Tissue Eng. 2006, 12(11):3233-3245.
    • (2006) Tissue Eng. , vol.12 , Issue.11 , pp. 3233-3245
    • Cormier, J.T.1    zur Nieden, N.I.2    Rancourt, D.E.3    Kallos, M.S.4
  • 6
    • 0003131638 scopus 로고
    • Sensitive stages for the production of developmental abnormalities in mice with 5-fluorouracil
    • Dagg C.P. Sensitive stages for the production of developmental abnormalities in mice with 5-fluorouracil. Am. J. Anat. 1960, 106:89-96.
    • (1960) Am. J. Anat. , vol.106 , pp. 89-96
    • Dagg, C.P.1
  • 8
    • 0036098620 scopus 로고    scopus 로고
    • The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods
    • Genschow E., Spielmann H., Scholz G., Seiler A., Brown N., Piersma A., Brady M., Clemann N., Huuskonen H., Paillard F., Bremer S., Becker K. The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods. Altern. Lab. Anim. 2002, 30(2):151-176.
    • (2002) Altern. Lab. Anim. , vol.30 , Issue.2 , pp. 151-176
    • Genschow, E.1    Spielmann, H.2    Scholz, G.3    Seiler, A.4    Brown, N.5    Piersma, A.6    Brady, M.7    Clemann, N.8    Huuskonen, H.9    Paillard, F.10    Bremer, S.11    Becker, K.12
  • 9
    • 0342965855 scopus 로고
    • Culture system for the differentiation of murine embryonic stem cells-a new approach to in vitro testing for embryotoxicity and for developmental immunotoxicology
    • IOS Press, Amsterdam, G.N. Fracchia (Ed.)
    • Heuer J., Graeber I.M., Pohl I., Spielmann H. Culture system for the differentiation of murine embryonic stem cells-a new approach to in vitro testing for embryotoxicity and for developmental immunotoxicology. European Medicines Research 1994, 134-145. IOS Press, Amsterdam. G.N. Fracchia (Ed.).
    • (1994) European Medicines Research , pp. 134-145
    • Heuer, J.1    Graeber, I.M.2    Pohl, I.3    Spielmann, H.4
  • 10
    • 0034176844 scopus 로고    scopus 로고
    • Embryonic stem cell-derived chondrogenic differentiation in vitro: activation by BMP-2 and BMP-4
    • Kramer J., Hegert C., Guan K., Wobus A.M., Müller P.K., Rohwedel J. Embryonic stem cell-derived chondrogenic differentiation in vitro: activation by BMP-2 and BMP-4. Mech. Dev. 2000, 92(2):193-205.
    • (2000) Mech. Dev. , vol.92 , Issue.2 , pp. 193-205
    • Kramer, J.1    Hegert, C.2    Guan, K.3    Wobus, A.M.4    Müller, P.K.5    Rohwedel, J.6
  • 11
    • 0026365921 scopus 로고
    • Cytotoxicity test using blastocyst-derived euploid embryonal stem cells: a new approach to in vitro teratogenesis screening
    • Laschinski G., Vogel R., Spielmann H. Cytotoxicity test using blastocyst-derived euploid embryonal stem cells: a new approach to in vitro teratogenesis screening. Reprod. Toxicol. 1991, 5:57-64.
    • (1991) Reprod. Toxicol. , vol.5 , pp. 57-64
    • Laschinski, G.1    Vogel, R.2    Spielmann, H.3
  • 12
    • 0026537256 scopus 로고
    • Concepts of osteoblast growth and differentiation: basis for modulation of bone cell development and tissue formation
    • Lian J.B., Stein G.S. Concepts of osteoblast growth and differentiation: basis for modulation of bone cell development and tissue formation. Crit. Rev. Oral Biol. Med. 1992, 3(3):269-305.
    • (1992) Crit. Rev. Oral Biol. Med. , vol.3 , Issue.3 , pp. 269-305
    • Lian, J.B.1    Stein, G.S.2
  • 14
    • 0003040388 scopus 로고    scopus 로고
    • Results of the first phase of the ECVAM project “prevalidation and validation of three in vitro embryotoxicity tests”
    • (in German)
    • Scholz G., Pohl I., Seiler A., Bremer S., Brown N.A., Piersma A.H., Holzhütter H.G., Spielmann H. Results of the first phase of the ECVAM project “prevalidation and validation of three in vitro embryotoxicity tests”. ALTEX 1998, 15(1):3-8. (in German).
    • (1998) ALTEX , vol.15 , Issue.1 , pp. 3-8
    • Scholz, G.1    Pohl, I.2    Seiler, A.3    Bremer, S.4    Brown, N.A.5    Piersma, A.H.6    Holzhütter, H.G.7    Spielmann, H.8
  • 15
    • 0032745067 scopus 로고    scopus 로고
    • Embryotoxicity screening using embryonic stem cells in vitro: correlation to in vivo teratogenicity
    • Scholz G., Pohl I., Genschow E., Klemm M., Spielmann H. Embryotoxicity screening using embryonic stem cells in vitro: correlation to in vivo teratogenicity. Cells Tissues Organs 1999, 165(3-4):203-211.
    • (1999) Cells Tissues Organs , vol.165 , Issue.3-4 , pp. 203-211
    • Scholz, G.1    Pohl, I.2    Genschow, E.3    Klemm, M.4    Spielmann, H.5
  • 16
    • 1542618024 scopus 로고    scopus 로고
    • Improvement of an in vitro stem cell assay for developmental toxicity: the use of molecular endpoints in the embryonic stem cell test
    • Seiler A., Visan A., Buesen R., Genschow E., Spielmann H. Improvement of an in vitro stem cell assay for developmental toxicity: the use of molecular endpoints in the embryonic stem cell test. Reprod. Toxicol. 2004, 18:231-240.
    • (2004) Reprod. Toxicol. , vol.18 , pp. 231-240
    • Seiler, A.1    Visan, A.2    Buesen, R.3    Genschow, E.4    Spielmann, H.5
  • 18
    • 0030917962 scopus 로고    scopus 로고
    • The embryonic stem cell test (EST), an in vitro embryotoxicity test using two permanent mouse cell lines: 3T3 fibroblasts and embryonic stem cells
    • Spielmann H., Pohl I., Döring B., Liebsch M., Moldenhauer F. The embryonic stem cell test (EST), an in vitro embryotoxicity test using two permanent mouse cell lines: 3T3 fibroblasts and embryonic stem cells. In Vitro Toxicol. 1997, 10:119.
    • (1997) In Vitro Toxicol. , vol.10 , pp. 119
    • Spielmann, H.1    Pohl, I.2    Döring, B.3    Liebsch, M.4    Moldenhauer, F.5
  • 20
  • 22
    • 0041396065 scopus 로고    scopus 로고
    • In vitro differentiation of embryonic stem cells into mineralized osteoblasts
    • zur Nieden N.I., Kempka G., Ahr H.J. In vitro differentiation of embryonic stem cells into mineralized osteoblasts. Differentiation 2003, 71(1):18-27.
    • (2003) Differentiation , vol.71 , Issue.1 , pp. 18-27
    • zur Nieden, N.I.1    Kempka, G.2    Ahr, H.J.3
  • 23
    • 0842264755 scopus 로고    scopus 로고
    • Molecular multiple endpoint embryonic stem cell test-a possible approach to test for the teratogenic potential of compounds
    • zur Nieden N.I., Kempka G., Ahr H.J. Molecular multiple endpoint embryonic stem cell test-a possible approach to test for the teratogenic potential of compounds. Toxicol. Appl. Pharmacol. 2004, 194(3):257-269.
    • (2004) Toxicol. Appl. Pharmacol. , vol.194 , Issue.3 , pp. 257-269
    • zur Nieden, N.I.1    Kempka, G.2    Ahr, H.J.3
  • 24
    • 14644429806 scopus 로고    scopus 로고
    • Induction of chondro-, osteo-and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: effect of cofactors on differentiating lineages
    • zur Nieden N.I., Kempka G., Rancourt D.E., Ahr H.J. Induction of chondro-, osteo-and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: effect of cofactors on differentiating lineages. BMC Dev. Biol. 2005, 5:1.
    • (2005) BMC Dev. Biol. , vol.5 , pp. 1
    • zur Nieden, N.I.1    Kempka, G.2    Rancourt, D.E.3    Ahr, H.J.4
  • 25
    • 33847233594 scopus 로고    scopus 로고
    • Gene profiling on mixed embryonic stem cell populations reveals a biphasic role for beta-catenin in osteogenic differentiation
    • zur Nieden N.I., Price F.D., Davis L.A., Everitt R.E., Rancourt D.E. Gene profiling on mixed embryonic stem cell populations reveals a biphasic role for beta-catenin in osteogenic differentiation. Mol. Endocrinol. 2007, 21(3):674-685.
    • (2007) Mol. Endocrinol. , vol.21 , Issue.3 , pp. 674-685
    • zur Nieden, N.I.1    Price, F.D.2    Davis, L.A.3    Everitt, R.E.4    Rancourt, D.E.5
  • 26
    • 77957861520 scopus 로고    scopus 로고
    • Embryonic stem cells for the prediction of developmental toxicity in pharmacological screening
    • Pabst Science Publishers, Lengerich, K. Conrad, W. Lehman, U. Sack, U. Schedler (Eds.)
    • zur Nieden N.I. Embryonic stem cells for the prediction of developmental toxicity in pharmacological screening. Multiparameteranalytics-Methods, Applications, Perspectives 2008, 198-220. Pabst Science Publishers, Lengerich. K. Conrad, W. Lehman, U. Sack, U. Schedler (Eds.).
    • (2008) Multiparameteranalytics-Methods, Applications, Perspectives , pp. 198-220
    • zur Nieden, N.I.1
  • 27
    • 77955278895 scopus 로고    scopus 로고
    • Comparing three novel endpoints for developmental osteotoxicity in the embryonic stem cell test
    • zur Nieden N.I., Davis L.A., Rancourt D.E. Comparing three novel endpoints for developmental osteotoxicity in the embryonic stem cell test. Toxicol. Appl. Pharmacol. 2010, 247(2):91-97.
    • (2010) Toxicol. Appl. Pharmacol. , vol.247 , Issue.2 , pp. 91-97
    • zur Nieden, N.I.1    Davis, L.A.2    Rancourt, D.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.