Evaluation and interpretation of maternal toxicity in Segment II studies: Issues, some answers, and data needs

Toxicology and Applied Pharmacology

Volumn 207, Issue 2 SUPPL., 2005, Pages 367-374

  Rogers, John M ^a   Chernoff, Neil ^a   Keen, Carl L ^b   Daston, George P ^c  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Fetal toxicity; Hazard evaluation; Maternal stress; Maternal toxicity; Teratology

Indexed keywords

2 ETHYLHEXANOIC ACID; ACETAZOLAMIDE; ADENOSINE TRIPHOSPHATE; ALCOHOL; ALPHA HEDERIN; AMILORIDE; BENOMYL; CAFFEINE; CORTICOSTERONE; DIAZEPAM; DIFLUNISAL; HYDROXYUREA; INDACRINONE; MERCAPTOPURINE; METALLOTHIONEIN; NITROFEN; NORFLOXACIN; PHENYTOIN; TOXIC SUBSTANCE; TRANQUILIZER; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; URETHAN; VALPROIC ACID; XENOBIOTIC AGENT; ZINC;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ABNORMALLY LOW SUBSTRATE CONCENTRATION IN BLOOD; ABORTION; ANEMIA; BIOASSAY; BIRTH DEFECT; BLINDNESS; BODY WEIGHT DISORDER; BRADYCARDIA; CARDIOVASCULAR MALFORMATION; CENTRAL NERVOUS SYSTEM; CHORIORETINITIS; CLEFT LIP; CLEFT PALATE; CONFERENCE PAPER; CONGENITAL MALFORMATION; CORTICOSTERONE BLOOD LEVEL; CYTOMEGALOVIRUS INFECTION; DEVELOPMENTAL DISORDER; EAR MALFORMATION; ECTRODACTYLY; EMBRYO DEATH; EMBRYOTOXICITY; EMOTIONAL STRESS; ENCEPHALOCELE; ENZYME DEFICIENCY; ERYTHROCYTE LEVEL; EYE MALFORMATION; FETOTOXICITY; FETUS DEATH; FETUS MALFORMATION; FETUS WASTAGE; FETUS WEIGHT; FEVER; FOOD INTAKE; GROWTH RETARDATION; HEALTH CARE POLICY; HEARING IMPAIRMENT; HEART OUTPUT; HEART RATE; HEMOPERICARDIUM; HUMAN; HYDROCEPHALUS; HYPERCAPNIA; HYPERTENSION; HYPERTHERMIA; HYPOKALEMIA; HYPOXIA; LABORATORY; LAW; LIVER LEVEL; LOW BIRTH WEIGHT; MATERNAL DISEASE; MATERNAL MORTALITY; MENTAL DEFICIENCY; MICROCEPHALY; NERVOUS SYSTEM MALFORMATION; NEURAL CREST; NONHUMAN; NUTRITIONAL DEFICIENCY; PERINATAL DEATH; POPULATION; POSTNATAL DEVELOPMENT; PREGNANCY COMPLICATION; PREMATURITY; PROTEIN CALORIE MALNUTRITION; RIB MALFORMATION; RISK ASSESSMENT; RUBELLA; SKELETON MALFORMATION; TERATOGENICITY; TOXOPLASMA GONDII; TOXOPLASMOSIS; UTERUS BLOOD FLOW; VASCULAR RESISTANCE; VITAMIN DEFICIENCY; WEIGHT REDUCTION; ZINC DEFICIENCY;

RODENTIA;

EID: 24644459507     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.03.026     Document Type: Conference Paper

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