Several generations of chemoenzymatic synthesis of oseltamivir (Tamiflu): Evolution of strategy, quest for a process-quality synthesis, and evaluation of efficiency metrics

Journal of Organic Chemistry

Volumn 76, Issue 24, 2011, Pages 10050-10067

  Werner, Lukas ^a   Machara, Ales ^a   Sullivan, Bradford ^a   Carrera, Ignacio ^a   Moser, Michael ^a   Adams, David R ^a   Hudlicky, Tomas ^a   Andraos, John ^b  

^a BROCK UNIVERSITY   (Canada)

^b CareerChem   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOBENZENE; CHEMO-ENZYMATIC SYNTHESIS; CHEMOENZYMATIC APPROACHES; DOUBLE BONDS; E. COLI; ETHYL BENZOATE; FOURTH GENERATION; OSELTAMIVIR; OVERALL EFFICIENCY; SYMMETRY CONSIDERATION; TAMIFLU; THIRD GENERATION;

EFFICIENCY; ESCHERICHIA COLI;

QUALITY CONTROL;

ACRYLIC ACID; ALKADIENE; BENZOIC ACID; BROMOBENZENE; CYCLOHEXADIENE CIS DIOL; ETHYL BENZOATE; HYDROXYL GROUP; OSELTAMIVIR; UNCLASSIFIED DRUG;

ARTICLE; BIOMASS FERMENTATION; CHEMICAL BOND; CYCLOADDITION; DRUG SYNTHESIS; ENZYME CHEMISTRY; ESCHERICHIA COLI; HYDROGENATION; NONHUMAN; PRODUCTIVITY;

ANTIVIRAL AGENTS; BENZOATES; BROMOBENZENES; CYCLOHEXENES; ESCHERICHIA COLI; FERMENTATION; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; NEURAMINIDASE; OSELTAMIVIR; STEREOISOMERISM;

EID: 84055193839     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo2018872     Document Type: Article

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