Palladium-catalysed allylic amination for the direct synthesis of epi-4-alkylamino-N-acetylneuraminic acid derivatives

Tetrahedron Letters

Volumn 50, Issue 28, 2009, Pages 4009-4011

  Resende, Ricardo ^a   Glover, Christian ^a   Watts, Andrew G ^a  

^a University of Bath   (United Kingdom)

Author keywords

4 epi Alkylamino N acetylneuraminic acids; Allylic amination; Neuraminidase inhibitors; Palladium

Indexed keywords

4 EPI DIETHYLAMINO N ACETYLNEURAMINIC ACID; 4 EPI ETHYLAMINO N ACETYLNEURAMINIC ACID; 4 EPI METHYLAMINO N ACETYLNEURAMINIC ACID; METHYLAMINE; N ACETYLNEURAMINIC ACID DERIVATIVE; OXAZOLINE DERIVATIVE; PALLADIUM; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; CATALYSIS; CATALYST; DRUG SYNTHESIS; STEREOCHEMISTRY;

EID: 66049107619     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.03.166     Document Type: Article

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9. 3N) of the evaporated residue gave the required products.
10. +]: m/z = 467.1636, found: m/z = 467.1631.
11. +]: m/z = 621.1730, found: m/z = 621.1709.
12. +]: m/z = 481.1798, found: m/z = 481.1785.
13. +]: m/z = 509.2106, found: m/z = 509.2106.