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34547491300
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The main by-product was benzyl (5-formylcyclohexa-2,4-dienyl) methylcarbamate, which was isolated as the corresponding alcohol after reduction of the crude mixture of aldehydes (see the Supporting Information). The exo isomer was not detected.
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The main by-product was benzyl (5-formylcyclohexa-2,4-dienyl) methylcarbamate, which was isolated as the corresponding alcohol after reduction of the crude mixture of aldehydes (see the Supporting Information). The exo isomer was not detected.
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34547480919
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In an experiment with 4.5 g of 14, 93, of the RuO 2·n H2O used could be recovered by the addition of isopropanol to the reaction mixture followed by filtration. The recovered material could be reused and showed no sign of deterioration (see the Supporting Information, Oxone could also be used as a cooxidant 90% over 2 steps, Quite recently, we found that n-propyl acetate, a safer solvent than dichloroethane, could be used with similar results
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2O used could be recovered by the addition of isopropanol to the reaction mixture followed by filtration. The recovered material could be reused and showed no sign of deterioration (see the Supporting Information). Oxone could also be used as a cooxidant (90% over 2 steps). Quite recently, we found that n-propyl acetate, a safer solvent than dichloroethane, could be used with similar results.
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0001453706
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The relatively low yield of 20 was attributed to the concomitant formation of oxazolidinone 22. The mixture was readily separable by chromatography on silica gel. (Chemical Equation Presented)
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The relatively low yield of 20 was attributed to the concomitant formation of oxazolidinone 22. The mixture was readily separable by chromatography on silica gel. (Chemical Equation Presented)
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