Efficient short step synthesis of corey's tamiflu intermediate

Organic Letters

Volumn 10, Issue 5, 2008, Pages 815-816

  Kipassa, Nsiama Tienabe ^a   Okamura, Hiroaki ^a   Kina, Kengo ^a   Hamada, Toshiyuki ^a   Iwagawa, Tetsuo ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DERIVATIVE; ENZYME INHIBITOR; OSELTAMIVIR; SIALIDASE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; SYNTHESIS;

CATALYSIS; ENZYME INHIBITORS; MOLECULAR STRUCTURE; NEURAMINIDASE; OSELTAMIVIR;

EID: 43549123603     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol7029646     Document Type: Article

References (19)

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19. As a preliminary examination, we found that the asymmetric DA reaction of 3a and chiral acrylate derivative gave optically active product up to 91% de. Further optimization of the reaction conditions is currently being investigated.