Industrial synthesis of the key precursor in the synthesis of the anti-influenza drug oseltamivir phosphate (Ro 64-0796/002, GS-4104-02): Ethyl (3R,4S,5S)-4,5-epoxy-3-(1-ethyl-propoxy)-cyclohex-1 -ene-1 -carboxylate

Organic Process Research and Development

Volumn 3, Issue 4, 1999, Pages 266-274

  Federspiel, Muriel ^a   Fischer, Rolf ^a   Hennig, Michael ^a   Mair, Hans Jürgen ^a   Oberhauser, Thomas ^a   Rimmler, Gösta ^a   Albiez, Thomas ^a   Bruhin, Jürg ^a   Estermann, Heinrich ^a   Gandert, Carsten ^a   Göckel, Volker ^a   Götzö, Stephan ^a   Hoffmann, Ursula ^a   Huber, Gabriel ^a   Janatsch, Günter ^a   Lauper, Stephan ^a   Röckel Stäbler, Odette ^a   Trussardi, Rene ^a   Zwahlen, Andreas G ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033435755     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op9900176     Document Type: Article

References (3)

1. (a) Kim, C. U.; Lew, W.; Williams, M. A.; Wu, H.; Zhang, L. N.; Chen, X.; Escarpe, P. A.; Mendel, D. B.; Laver, W. G.; Stevens, R. C. J. Med. Chem. 1998, 41, 2451.
2. (b) Kim, C. U.; Lew, W.; Williams, M. A.; Liu, H.; Zhang, L.; Swaminathan, S.; Bischofberger, N.; Chen, M. S.; Mendel, D. B.; Tai, C. Y.; Laver, W. G.; Stevens, R. C. J. Am. Chem. Soc. 1997, 119, 681.
3. Rohloff, J. C.; Kent, K. M.; Postich, M. J.; Becker, M. W.; Chapman, H. H.; Kelly, D. E.; Lew, W.; Louie, M. S.; McGee, L. R.; Prisbe, E. J.; Schultze, L. M.; Yu, R. H.; Zhang, L. J. Org. Chem. 1998, 63, 4545.