New, azide-free transformation of epoxides into 1,2-diamino compounds: Synthesis of the anti-influenza neuraminidase inhibitor oseltamivir phosphate (Tamiflu)

Journal of Organic Chemistry

Volumn 66, Issue 6, 2001, Pages 2044-2051

  Karpf, M ^a   Trussardi, R ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATOGRAPHIC PURIFICATION;

ACETYLATION; ANTIBIOTICS; CATALYSIS; ENZYME INHIBITION; ORGANIC COMPOUNDS; PURIFICATION;

PHOSPHATES;

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; ALLYLAMINE DERIVATIVE; AZIDE; DIAMINE; EPOXIDE; ETHYLENE OXIDE; OSELTAMIVIR; PALLADIUM; QUINIC ACID; SHIKIMIC ACID; SIALIDASE INHIBITOR; ZANAMIVIR;

ARTICLE; CATALYST; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGENATION; REACTION ANALYSIS; REDUCTION; REPRODUCIBILITY;

ACETAMIDES; AMINES; ANTIVIRAL AGENTS; AZIDES; ENZYME INHIBITORS; EPOXY COMPOUNDS; MOLECULAR STRUCTURE; NEURAMINIDASE; ORTHOMYXOVIRIDAE; OSELTAMIVIR; SPECTRUM ANALYSIS;

EID: 0035937274     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo005702l     Document Type: Article

References (28)