A proposal in relation to a genetic control of lifespan in mammals

Ageing Research Reviews

Volumn 9, Issue 4, 2010, Pages 437-446

  Neill, David ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Behaviour; Gene regulatory networks; Heterochronic genes; Hominin; Senescence; Stem cells

Indexed keywords

MICRORNA;

BEHAVIOR; BEHAVIOR CONTROL; BRAIN SIZE; GENE MUTATION; GENETIC REGULATION; LIFESPAN; NEOCORTEX; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SENESCENCE; TISSUE REGENERATION;

ANIMALS; BIOLOGICAL EVOLUTION; CAENORHABDITIS ELEGANS; DEVELOPMENTAL BIOLOGY; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENOTYPE; HUMANS; LIFE EXPECTANCY; LONGEVITY; MAMMALS; NEOCORTEX; NEURONS; PHENOTYPE;

MAMMALIA;

EID: 83855165302     PISSN: 15681637     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arr.2010.05.004     Document Type: Review

References (192)

1. Abbott A.L., Alvarez-Saavedra E., Miska E.A., Lau N.C., Bartel D.P., Horvitz H.R., Ambros V. The let-7 microRNA family members mir-48, mir-84 and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev. Cell 2005, 9:403-414.
2. Adoutte A., Balavoine G., Lartillot N., Lespenet O., Prud'homme B., De Rosa R. The new animal phylogeny: reliability and implications. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:4453-4456.
3. Agata K., Nakajima E., Funayama N., Shibata N., Saito Y., Umesono Y. Two different evolutionary origins of stem cell systems and their molecular basis. Semin. Cell Dev. Biol. 2006, 17:503-509.
4. Allman J.M., McLaughlin T., Hakeem A. Brain weight and life-span in primate species. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:118-122.
5. Allman J.M., McLaughlin T., Hakeem A. Brain structures and life-span in primate species. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:3559-3563.
6. Alroy J. The fossil record of North American mammals: evidence for a Paleocene evolutionary radiation. Syst. Biol. 1999, 48:107-118.
7. Ambros V. Control of developmental timing in Caenorhabditis elegans. Curr. Opin. Genet. Dev. 2000, 10:428-433.
8. Ambros V., Horvitz H.R. Heterochronic mutants of the nematode Caenorhabditis elegans. Science 1984, 226:409-416.
9. Antebi A., Yeh W.H., Tait D., Hedgecock E.M., Riddle D.L. daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans. Genes Dev. 2000, 14:1512-1527.
10. Archibald J.D., Deutschman D.H. Quantitative analysis of the timing of the origin and diversification of extant placental orders. J. Mammal. Evol. 2001, 8:107-124.
11. Arnone M.I., Davidson E.H. The hardwiring of development: organization and function of genomic regulatory systems. Development 1997, 124:1851-1864.
12. Austad S.N. Is aging programmed?. Aging Cell 2004, 3:249-251.
13. Baguna J., Garcia-Fernandez J. Evo-Devo: the long and winding road. Int. J. Dev. Biol. 2003, 47:705-713.
14. Baguna J., Riutort M. The dawn of bilaterian animals: the case of the acoelomorph flatworms. Bioessays 2004, 26:1046-1057.
15. Baguna J., Martinez P., Paps J., Riutort M. Back in time: a new systematic proposal for the Bilateria. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2008, 363:1481-1491.
16. Banerjee D., Slack F. Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression. Bioessays 2002, 24:119-129.
17. Banerjee D., Kwok A., Lin S.Y., Slack F.J. Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes. Dev. Cell 2005, 8:287-295.
18. Benard C., McCright B., Zhang Y., Felkai S., Lakowski B., Hekimi S. The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. Development 2001, 128:4045-4055.
19. Bethke A., Fielenbach N., Wang Z., Mangelsdorf D.J., Antebi A. Nuclear hormone receptor regulation of microRNAs controls developmental progression. Science 2009, 324:95-98.
20. Bettinger J.C., Lee K., Rougvie A.E. Stage-specific accumulation of the terminal differentiation factor LIN-29 during Caenorhabditis elegans development. Development 1996, 122:2517-2527.
21. Bininda-Emonds O.R.P., Cardillo M., Jones K.E., MacPhee R.D.E., Beck R.M.D., Grenyer R., Price S.A., Vos R.A., Gittleman J.L., Purvis A. The delayed rise of present-day mammals. Nature 2007, 446:507-512.
22. Boehm M., Slack F. A developmental timing microRNA and its target regulate life span in C. elegans. Science 2005, 310:1954-1957.
23. Bradshaw W.E. Pervasive themes in insect life cycle strategies. The Evolution of Insect Life Cylces 1986, 261-275. Springer Verlag, Berlin. F. Taylor, R. Karban (Eds.).
24. Braeckman B.P., Vanfleteren J.R. Genetic control of longevity in C. elegans. Exp. Gerontol. 2007, 42:90-98.
25. Braeckman B.P., Houthoofdt K., Brys K., Lenaerts I., De Vreese A., Van Eygen S., Raes H., Vanfleteren J.R. No reduction of energy metabolism in Clk mutants. Mech. Ageing Dev. 2002, 123:1447-1456.
26. Braeckman B.P., Houthoofd K., Vanfleteren J.R. Intermediary metabolism. WormBook 2009, (February):1-24.
27. Branicky R., Benard C., Hekimi S. Clk-1, mitochondria, and physiological rates. Bioessays 2000, 22:48-56.
28. Brunet-Rossinni A.K., Austad S.N. Ageing studies on bats: a review. Biogernotology 2004, 5:211-222.
29. Brys K., Vanfleteren J.R., Braeckman B.P. Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans. Exp. Gerontol. 2007, 42:845-851.
30. Burgess J., Hihi A.K., Benard C.Y., Branicky R., Hekimi S. Molecular mechanism of maternal rescue in the clk-1 mutants of Caenorhabditis elegans. J. Biol. Chem. 2003, 278:49555-49562.
31. Campbell R.D. Tissue dynamics of steady state growth in Hydra littoralis. II. Patterns of tissue movement. J. Morphol. 1967, 121:19-28.
32. Carroll S.B. Evo-Devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Cell 2008, 134:25-36.
33. Charnov E.L. Life History Invariants: Some Explorations of Symmetry in Evolutionary Ecology 1993, Oxford University Press, Oxford.
34. Chen J., Li X., Greenwald I. sel-7, a positive regulator of lin-12 activity, encodes a novel nuclear protein in Caenorhabditis elegans. Genetics 2004, 166:151-160.
35. Cifelli R. Early mammalian radiations. J. Paleontol. 2001, 75:1214-1226.
36. Clark D.A., Mitra P.P., Wang S.S.-H. Scalable architecture in mammalian brains. Nature 2001, 411:189-193.
37. Comfort A. The biology of ageing. Lancet 1956, 268:772-778.
38. Comfort A. The life span of animals. Sci. Am. 1961, 205:108-119.
39. Comfort A. Ageing: The Biology of Senescence 1964, Holt, Rinehart and Winston, New York.
40. Comfort A. Biology of Senescence 1979, Churchill and Livingstone, London.
41. Corona M., Velarde R.A., Remolina S., Moran-Lauter A., Wang Y., Hughes K.A., Robinson G.E. Vitellogenin, juvenile hormone, insulin signalling, and queen honey bee longevity. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:7128-7133.
42. Covey E. Neurobiological specilizations in echolocating bats. Anat. Rec. A 2005, 287:1103-1116.
43. Cronin J.E., Boaz N.T., Stringer C.B., Rak Y. Tempo and mode in hominid evolution. Nature 1981, 292:113-122.
44. Curran S.P., Ruvkun G. Lifespan regulation by evolutionary conserved genes essential for viability. PLoS Genet. 2007, 3:479-487.
45. Cutler R.G. Evolution of human longevity and the genetic complexity governing aging rate. Proc. Natl. Acad. Sci. U.S.A. 1975, 72:4664-4668.
46. Cutler R.G. Evolution of longevity in primates. J. Hum. Evol. 1976, 5:169-202.
47. Cutler R.G. On the nature of aging and life maintenance processes. Interdisciplinary Topics in Gerontology 1976, vol. 9:83-133. Karger Press, Basel.
48. Cutler R.G. Evolution of human longevity: a critical overview. Mech. Ageing Dev. 1979, 9:337-354.
49. Cutler R.G. Evolution of longevity in ungulates and carnivores. Gerontology 1979, 25:69-86.
50. Davidson E.H., Erwin D.H. Gene regulatory networks and the evolution of animal body plans. Science 2006, 311:796-800.
51. Deacon T.W. The Symbolic Species 1997, W.W. Norton and Co., New York.
52. Deacon T.W. What makes the human brain different. Annu. Rev. Anthropol. 1997, 26:337-357.
53. Dean C.M., Lucas V.S. Dental and skeletal growth in early fossil hominins. Ann. Hum. Biol. 2009, 36:545-561.
54. De Heinzelin J., Clark J.D., White T., Hart W., Renne P., WoldeGabriel G., Beyene Y., Vrba E. Environmental and behaviour of 2.5-million-year-old Bouri hominids. Science 1999, 284:625-629.
55. De Magalhaes J.P., Costa J. A database of vertebrate longevity records and their relation to other life-history traits. J. Evol. Biol. 2009, 22:1770-1774.
56. De Magalhaes J.P., Costa J., Toussaint O. HAGR: the human ageing genomic resource. Nucleic Acids Res. 2005, 33:D537-D543.
57. De Magalhaes J.P., Costa J., Church G.M. An analysis of the relationship between metabolism, developmental schedules and longevity using phylogentic independent contrasts. J. Gerontol. A: Biol. Sci. Med. Sci. 2007, 62:149-160.
58. Denis H., Lacroix J.C. The dichotomy between germ line and somatic line, and the origin of cell mortality. Trends Genet. 1993, 9:7-11.
59. Denlinger D.L. Regulation of diapause. Annu. Rev. Entomol. 2002, 47:93-122.
60. Dickinson W.J. Molecules and morphology: where's the homology?. Trends Genet. 1995, 11:119-121.
61. Dillin A., Crawford D.K., Kenyon C. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 2002, 298:830-834.
62. Dillin A., Hsu A.-L., Arantes-Oliveira N., Lehrer-Graiwer J., Hsin H., Fraser A.G., Kamath R.S., Ahringer J., Kenyon C. Rates of behaviour and aging specified by mitochondrial function during development. Science 2002, 298:2398-2401.
63. Dunn C.W., Hejinol A., Matus D.Q., Pang K., Browne W.E., Smith S.A., Seaver E., Rouse G.W., Obst M., Edgocombe G.D., Sorensen M.V., Haddock S.H., Schmidt-Rhaesa A., Okusu A., Kristensen R.M., Wheeler W.C., Martindale M.Q., Giribet G. Broad phylogenomic sampling improves resolution of the animal tree of life. Nature 2008, 452:745-749.
64. Economos A.C. Brain-lifespan conjecture: a reevaluation of the evidence. Gerontology 1980, 26:82-89.
65. Egger B., Gschwentner R., Reinhard R. Free-living flatworms under the knife: past and present. Dev. Genes Evol. 2007, 217:89-104.
66. Egger B., Steinke D., Tarui H., De Mulder K., Arendt D., Borgonie G., Funayama N., Gschwentner R., Hartenstein V., Hobmayer B., Hooge M., Hrouda M., Ishida S., Kobayashi C., Kuales G., Nishimura O., Pfister D., Rieger R., Salvenmoser W., Smith J., Technau U., Tyler S., Agata K., Salzburger W., Ladurner P. To be or not to be a flatworm: the acoel controversy. PLoS One 2009, 4:e5502.
67. Erwin D.H., Davidson E.H. The evolution of hierarchical gene regulatory networks. Nat. Rev. Genet. 2009, 10:141-148.
68. Falk D. Hominin brain evolution-new century new directions. Coll. Antropol. 2004, 28(Suppl. 2):59-65.
69. Falk D., Redmond J.C., Guyer J., Conroy G.C., Recheis W., Weber G.W., Seidler H. Early hominid brain evolution: a new look at old endocasts. J. Hum. Evol. 2000, 38:695-717.
70. Fay D.S., Stanley H.M., Han M., Wood W.B. A Caenorhabditis elegans homologue of hunchback is required for late stages of stages of development but not early embryonic patterning. Dev. Biol. 1999, 205:240-253.
71. Feinbaum R., Ambros V. The timing of lin-4 RNA accumulation controls the timing of postembryonic developmental events in Caenorhabditis elegans. Dev. Biol. 1999, 210:87-95.
72. Feng J., Bussiere F., Hekimi S. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev. Cell 2001, 1:633-644.
73. Finlay B.L., Darlington R.B. Linked regularities in the development and evolution of mammalian brains. Science 1995, 268:1578-1584.
74. Finlay B.L., Hersman M.N., Darlington R.B. Patterns of vertebrate neurogenesis and the paths of vertebrate evolution. Brain Behav. Evol. 1998, 52:232-242.
75. Galliot B., Miljkovic-Licina M., De Rosa R., Chera S. Hydra, a niche for cell and developmetal plasticity. Semin. Cell Dev. Biol. 2006, 17:492-502.
76. Gems D., Sutton A.J., Sundermeyer M.L., Albert P.S., King K.V., Edgley M.L., Larsen P.L., Riddle D.L. Two pleiotropic classes of daf-2 mutations affect larval arrest, adult behaviour, reproduction and longevity in Caenorhabditis elegans. Genetics 1998, 150:129-155.
77. Gibbon R.J., Granger D.E., Kuman K., Patridge T.C. Eary Acheulean technology in the Rietputs Fromation, South Africa, dated with cosmogenic nuclides. J. Hum. Evol. 2009, 56:152-160.
78. Graham A. Animal phylogeny: root and branch surgery. Curr. Biol. 2000, 10:R36-R38.
79. Grobhans H., Johnson T., Reinert K.L., Gerstein M., Slack F.J. The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans. Dev. Cell 2005, 8:321-330.
80. Gschwentner R., Ladurner P., Nimeth K., Rieger R. Stem cells in a basal bilaterian. Cell Tissue Res. 2001, 304:401-408.
81. Halanych K.M. The new view of animal phylogeny. Annu. Rev. Ecol. Evol. Syst. 2004, 35:229-256.
82. Hall K.H. Evo-devo: evolutionary developmental mechanisms. Int. J. Dev. Biol. 2003, 47:491-495.
83. Hammell C.M., Xantha K., Ambros V. A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:18668-18673.
84. Harfe B.D. MicroRNAs in vertebrate development. Curr. Opin. Genet. Dev. 2005, 15:410-415.
85. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 1956, 11:298-300.
86. Harvey P.H., Zammuto R.M. Patterns of mortality and age at first reproduction in natural populations of mammals. Nature 1985, 315:319-320.
87. Hejnol A., Martindale M.Q. Acoel development supports a simple planula-like urbilaterian. Phil. Trans. R. Soc. Lond. B: Biol. Sci. 2008, 363:1493-1501.
88. Hofman M.A. Encephalization in hominids: evidence for the model of punctuationalism. Brain Behav. Evol. 1983, 22:102-117.
89. Holstein T.W., Hobmayer E., Technau U. Cnidarians: an evolutionary conserved model system for regeneration?. Dev. Dyn. 2003, 226:257-267.
90. Holzenberger M., Dupont J., Ducos B., Leneuve P., Geloen A., Even P.C., Cervera P., Le Bouc Y. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003, 421:182-187.
91. Howard M.L., Davidson E.H. cis-Regulatory control circuits in development. Dev. Biol. 2004, 271:109-118.
92. Huang Z.J., Edery I., Rosbash M. PAS is a dimerization domain common to Drosophila period and several transcription factors. Nature 1993, 364:259-262.
93. Hulbert A.J., Clancy D.J., Mair W., Braeckman B.P., Gems D., Partridge L. Metabolic rate is not reduced by dietary-restriction or by lowered isulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. Exp. Gerontol. 2004, 39:1137-1143.
94. Ibanez-Ventoso C., Yang M., Guo S., Robins H., Padgett R.W., Driscoll M. Modulated microRNA expression during adult lifespan in Caenorhabditis elegans. Aging Cell 2006, 5:235-246.
95. Jensen V.L., Gallo M., Riddle D.L. Targets of DAF-16 involved in Caenorhabditis elegans adult longevity and dauer formation. Exp. Gerontol. 2006, 41:922-927.
96. Jeon M., Gardner H.F., Miller E.A., Deshler J., Rougvie A.E. Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins. Science 1999, 286:1141-1146.
97. Jiang N., Benard C.Y., Kebir H., Shoubridge E.A., Hekimi S. Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation. J. Biol. Chem. 2003, 278:21678-21684.
98. Johnson S.M., Lin S.-Y., Slack F.J. The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter. Dev. Biol. 2003, 259:364-379.
99. Jordan P. Neanderthals 1999, J.H. Haynes, Sparkford.
100. Kappelman J.K. The evolution of body mass and relative brain size in fossil hominids. J. Hum. Evol. 1996, 30:243-276.
101. Kenyon C. A conserved regulatory system for aging. Cell 2001, 105:165-168.
102. Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell 2005, 120:449-460.
103. Kenyon C., Chang J., Gensch E., Rudner A., Tabtiang A. C. elegans mutant that lives twice as long as wild type. Nature 1993, 366:461-464.
104. Khazaeli A.A., Van Voorhies W., Curtsinger J.W. Longevity and metabolism in Drosophila melanogaster: genetic correlations between lifespan and age-specific metabolic rate in populations artificially selected for long life. Genetics 2005, 169:231-242.
105. Kirkwood T.B.L. Evolution of aging. Nature 1977, 270:301-304.
106. Kirkwood T.B.L. Comparative life spans of species: why do species have the life spans they do?. Am. J. Clin. Nutr. 1992, 55:1191S-1195S.
107. Klein R.G. Middle Paleolithic people. Science 1996, 272:822-823.
108. Klein R.G. Wither the Neanderthals. Science 2003, 299:822-823.
109. Kornack D.R. Neurogenesis and the evolution of cortical diversity: mode, tempo, and partitioning during development and persistence in adulthood. Brain Behav. Evol. 2000, 55:336-344.
110. Koziol C., Borojevic R., Steffen R., Muller W.E.G. Sponges (Porifera) model systems to study the shift from immortal to senescent somatic cells: the telomerase activity in somatic cells. Mech. Ageing Dev. 1998, 100:107-120.
111. Lagos-Quintana M., Rauhut R., Yalcin A., Meyer J. Identification of tissue-specific microRNAs from mouse. Curr. Biol. 2002, 12:735-739.
112. Lakowski B., Hekimi S. Determination of life-span in Caenorhabditis elegans by four clock genes. Science 1996, 272:1010-1013.
113. Larsen P.L. Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:8905-8909.
114. Larsen P.L., Albert P.S., Riddle D.L. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 1995, 139:1567-1583.
115. Lau N.C., Lim L.P., Weinstein E.G., Bartel D.P. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 2001, 294:858-862.
116. Lee R.C., Feinbaun R., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75:843-854.
117. Lee C.T., Rison T., Strauss W.M. MicroRNAs in mammalian development. Birth Defects Res. C: Embryo Today 2006, 78:129-139.
118. Lemieux J., Lakowski B., Webb A., Meng Y., Ubach A., Bussiere F., Barnes T., Hekimi S. Regulation of physiological rates in Caenorhabditis elegans by a t RNA-modifying enzyme in the mitochondria. Genetics 2001, 159:147-157.
119. Leung A.K., Sharp P.A. Function and localization of microRNAs in mammalian cells. Cold Spring Harb. Symp. Quant. Biol. 2006, 71:29-38.
120. Levavasseur F., Miyadera H., Sirois J., Tremblay M.L., Kita K., Shoubridge E., Hekimi S. Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration. J. Biol. Chem. 2001, 276:46160-46164.
121. Levine M., Davidson E.H. Gene regulatory networks for development. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:4936-4942.
122. Lim L.P., Lau N.C., Weinstein E.G., Abdelhakim A., Yetka S., Rhoades M.W., Burge C.B., Bartel D.P. The microRNAs of Caenorhabditis elegans. Genes Dev. 2003, 17:991-1008.
123. Liu X., Jiang N., Hughes B., Bigras E., Shoubridge E., Hekimi S. Evolutionary conservation of the clk-1 dependent mechanism of longevity: loss of mclk-1 increases cellular fitness and lifespan in mice. Genes Dev. 2005, 19:2424-2434.
124. Luo Z.-X. Transformation and diversification in early mammal evolution. Nature 2007, 450:1011-1019.
125. Martinez D.E. Mortality patterns suggest lack of senescence in hydra. Exp. Gerontol. 1998, 33:217-225.
126. McHenry H.M. Tempo and mode in human evolution. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:6780-6786.
127. McHenry H.M., Coffing K. Australopithecus to Homo: transformations in body and mind. Annu. Rev. Anthropol. 2000, 29:125-146.
128. McLaren A. The quest for immortality. Nature 1992, 359:482-483.
129. Medawar P.B. An Unsolved Problem of Biology 1952, H.K. Lewis, London.
130. Mellars P., Stringer C. The Human Revolution 1989, Edinburgh University Press, Edinburgh, UK.
131. Miller R.A., Harper J.M., Dysko R.C., Durkee S.J., Austad S.N. Longer lifespans and delayed maturation in wild-derived mice. Exp. Biol. Med. (Maywood) 2002, 227:500-508.
132. Moller A.P. Sociality, age a first reproduction and senescence: comparative analysis of birds. J. Evol. Biol. 2006, 19:682-689.
133. Morita K., Han M. Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in Caenorhabditis elegans. EMBO J. 2006, 25:5794-5804.
134. Morris J.Z., Tissenbaum H.A., Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 1996, 382:536-539.
135. Morrison S.J., Shah N.M., Anderson D.J. Regulatory mechanisms in stem cell biology. Cell 1997, 88:287-298.
136. Moss E.G. Heterochronic genes and the nature of developmental time. Curr. Biol. 2007, 17:R425-R434.
137. Moss E.G., Lee R.C., Ambros V. The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell 1997, 88:637-646.
138. Muller W.E.G. The stem cell concept in sponges (Porifera): Metazoan traits. Semin. Cell Dev. Biol. 2006, 17:481-491.
139. Muller G.B. Evo-devo: extending the evolutionary synthesis. Nat. Rev. Genet. 2007, 8:943-949.
140. Myohara M. Differential tissue development during embryogenesis and regeneration in an Annelid. Dev. Dyn. 2004, 231:349-358.
141. Myohara M., Yoshida-Noro C., Kobari F., Tochinai S. Fragmenting oligochaete Enchytraeus japonsnsis: a new material for regeneration study. Dev. Growth Differ. 1999, 41:549-555.
142. Nakauchi M., Takeshita T. Ascidian one-half embryos can develop into functional adult ascidians. J. Exp. Zool. 1983, 227:155-161.
143. Neill D. Cortical evolution and human behaviour. Brain Res. Bull. 2007, 74:191-205.
144. O'Rourke J.R., Swanson M.S., Harfe B.D. MicroRNAs in mammalian development and tumorigenesis. Birth Defects Res. C: Embryo Today 2006, 78:172-179.
145. Pasquinelli A.E., Ruvkun G. Control of developmental timing by micrornas and their targets. Annu. Rev. Cell Dev. Biol. 2002, 18:495-513.
146. Pearl R. The Rate of Living 1928, University of London press, London.
147. Pepper A.S., McCane J.E., Kemper K., Yeung D.A., Lee R.C., Ambros V., Moss E.G. The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin. Development 2004, 131:2049-2059.
148. Peterson K.J., Davidson E.H. Regulatory evolution and the origin of the bilaterians. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:4430-4433.
149. Peterson K.J., Eernisse D.J. Animal phylogeny and the ancestor of bilaterians: inferences from morphology and 18S r DNA gene sequences. Evol. Dev. 2001, 3:170-205.
150. Plummer T. Flaked stones and old bones: biological and cultural evolution at the dawn of technology. Am. J. Phys. Anthropol. 2004, 39:118-164.
151. Promislow D.E.L. On size and survival: progress and pitfalls in the allometry of lifespan. J. Gernontol. 1993, 48:B115-B123.
152. Prothero J. Adult life span as a function of age at maturity. Exp. Gerontol. 1993, 28:529-536.
153. Raff R.A. Evo-devo: the evolution of a new discipline. Nat. Rev. Genet. 2000, 1:74-79.
154. Reinhart B.J., Slack F.J., Basson M., Pasquinelli A.E., Bettinger J.C., Rougvie A.E., Horvitz H.R., Ruvkun G. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 2000, 403:901-906.
155. Riddle D.L., Albert P.S. Genetic and environmental regulation of dauer larva development. C. elegans II 1997, 739-768. Cold Spring Harbour Laboratory Press, New York. D.L. Riddle, T. Blumenthal, B. Meyer, J. Priess (Eds.).
156. Rightmire G.P. Brain size and encephalisation in early to mid Pleistocene Homo. Am. J. Phys. Anthropol. 2004, 124:109-123.
157. Robson S.L., Wood B. Hominin life history: reconstruction and evolution. J. Anat. 2008, 212:394-425.
158. Rossi L., Salvetti A., Batistoni R., Deri P., Gremigni V. Planarians, a tale of stem cells. Cell. Mol. Life Sci. 2008, 65:16-23.
159. Rougvie A.E. Control of developmental timing in animals. Nat. Rev. Genet. 2001, 2:690-701.
160. Roush S.F., Slack F.J. Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1. Dev. Biol. 2009, 334:523-534.
161. Rowe T. Definition, diagnosis, and origin of Mammalia. J. Vert. Paleontol. 1988, 8:241-264.
162. Ruff C.B., Trinkaus T.W., Holliday T.W. Body mass and encephalization in Pleistocene Homo. Nature 1997, 387:173-176.
163. Ruiz-Trillo I., Riutort M., Littlewood D.T.J., Herniou E.A., Baguna J. Acoel flatworms: earliest extant bilaterian metazoans, not members of Platyhelminthes. Science 1999, 283:1919-1923.
164. Ruvkun G., Giusto J. The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch. Nature 1989, 338:313-319.
165. Sacher G.A. Relationship of lifespan to brain weight and body weight in mammals. The Lifespan of animals, Ciba Foundation Colloquia on Aging 1959, vol. 5:115-133. Churchill Press, London.
166. Sacher G.A. Maturation and longevity in relation of cranial capacity in hominid evolution. Primate Functional Morphology and Evolution 1975, 417-441. Mouton Publishers, The Hague, Paris. R.H. Tuttle (Ed.).
167. Salo E. The power of regeneration and the stem-cell kingdom: freshwater planarians (Platyhelminthes). Bioessays 2006, 28:546-559.
168. Salvini-Plawen L.V. On the origin and evolution of the lower metazoan. Z. Zool. Syst. Evolutionsforsch. 1978, 16:40-88.
169. Scott G.R., Gibert L. The oldest hand-axes in Europe. Nature 2009, 461:82-85.
170. Shea J.J. A functional study of the lithic industries associated with hominid fossils in the Kebara and Qafzeh caves. The Human Revolution 1989, 611-625. Edinburgh University Press, Edinburgh. P. Mellars, C. Stringer (Eds.).
171. Sim C., Denlinger D.L. Insulin signalling and FOXO regulate the overwintering diapause of the mosquito Culex pipiens. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:6777-6781.
172. Sisk M.L., Shea J.J. Intrasite spatial variation of the Omo Kibish Middle Stone Age assemblages: artefact refitting and distribution patterns. J. Hum. Evol. 2008, 55:486-500.
173. Slack F.J., Basson M., Liu Z., Ambros V., Horvitz H.R., Ruvkun G. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol. Cell 2000, 5:659-669.
174. Sohal R.S. Oxidative stress hypothesis of aging. Free Radic. Biol. Med. 2002, 33:573-574.
175. Song L., Tuan R.S. MicroRNAs and cell differentiation in mammalian development. Birth Defects Res. C: Embryo Today 2006, 78:140-149.
176. Speakman J.R., Talbot D.A., Selman C., Snart S., Mclaren J.S., Redman P., Krol E., Jackson D.M., Johnson M.S., Brand M.D. Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. Aging Cell 2004, 3:87-95.
177. Stearns S.C. The Evolution of Life Histories 1992, Oxford University Press, Oxford.
178. Stout D., Quade J., Semaw S., Rogers M.J., Levin N.E. Raw material selectivity of the earliest stone toolmakers at Gona, Afar, Ethiopia. J. Hum. Evol. 2005, 48:365-380.
179. Stringer C.B., Gamble C. In Search of the Neanderthals 1993, Thomas and Hudson, New York.
180. Tatar A., Kopelman A., Epstein D., Tu M.P., Yin C.M., Garofalo R.S. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 2001, 292:107-110.
181. Tattersall I., Schwartz J.H. Hominids and hybrids: the place of the Neanderthals in human evolution. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:7117-7119.
182. Terman A., Brunk U.T. Is aging the price for memory?. Biogerontology 2005, 6:205-210.
183. Tissenbaum H.A., Ruvkun G. An insulin-like signalling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics 1998, 148:703-717.
184. Tryon C.A., McBrearty S. Tephrostratigraphy and the Acheulian to Middle Stone Age transition in the Kapthurin Formation, Kenya. J. Hum. Evol. 2002, 42:211-235.
185. Turner M.J., Slack F.J. Transcriptional control of microRNA expression in C. elegans: promoting better understanding. RNA Biol. 2009, 6:49-53.
186. Vanfleteren J.R. Oxidative stress and ageing in Caenorhabditis elegans. Biochem. J. 1993, 292:605-608.
187. Weisblat D.A. Germline regeneration: the worms turn. Curr. Biol. 2006, 16:R453-R455.
188. Whiten A., Goodall J., McGrew W.C., Nishida T., Reynolds V., Sugiyama Y., Tutin C.E.G. Cultures in chimpanzees. Nature 1999, 399:682-685.
189. Williams G.C. Pleiotrophy, natural selection, and the evolution of senescence. Evolution 1957, 11:398-411.
190. Wong A., Boutis P., Hekimi S. Mutations in the clk-1 gene of Caenorhabditis elegans affect development and behavioural timing. Genetics 1995, 139:1247-1259.
191. Wray G.A. The evolutionary significance of cis-regulatory mutations. Nat. Rev. Genet. 2007, 8:206-216.
192. Xia D., Huang X., Zhang H. The temporally regulated transcription factor SEL-7 controls developmental timing in C. elegans. Dev. Biol. 2009, 332:246-257.