No reduction of energy metabolism in Clk mutants

Mechanisms of Ageing and Development

Volumn 123, Issue 11, 2002, Pages 1447-1456

  Braeckman, Bart P ^a   Houthoofd, Koen ^a   Brys, Kristel ^a   Lenaerts, Isabelle ^a   De Vreese, Annemie ^a   Van Eygen, Sylvie ^a   Raes, Hilda ^a   Vanfleteren, Jacques R ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Ageing; Antioxidant defense; Caenorhabditis elegans; Clk; Metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATE; CATALASE; LIPOFUSCIN; LUCIGENIN; OXYGEN; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE DISMUTASE; 10,10' DIMETHYL 9,9' BIACRIDINIUM; 10,10'-DIMETHYL-9,9'-BIACRIDINIUM; ACRIDINE DERIVATIVE; CAENORHABDITIS ELEGANS PROTEIN; CLK 1 PROTEIN, C ELEGANS; CLK 2 PROTEIN, C ELEGANS; CLK 3 PROTEIN, C ELEGANS; CLK-1 PROTEIN, C ELEGANS; CLK-2 PROTEIN, C ELEGANS; CLK-3 PROTEIN, C ELEGANS; HELMINTH PROTEIN; TELOMERE BINDING PROTEIN; TRANSFER RIBONUCLEIC ACID ISOPENTENYLTRANSFERASE; TRANSFERASE;

AGING; ARTICLE; AUTOFLUORESCENCE; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; GENE MUTATION; LIFESPAN; METABOLIC RATE; MOLECULAR MODEL; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; THERMOGENESIS; WILD TYPE; WORM; ANIMAL; CAENORHABDITIS ELEGANS; FLUORESCENCE; GENETICS; LONGEVITY; LUMINESCENCE; METABOLISM; MUTATION; PHYSIOLOGY;

CAENORHABDITIS; CAENORHABDITIS ELEGANS;

ACRIDINES; ADENOSINE TRIPHOSPHATE; ALKYL AND ARYL TRANSFERASES; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CATALASE; ENERGY METABOLISM; FLUORESCENCE; HELMINTH PROTEINS; LIPOFUSCIN; LONGEVITY; LUMINESCENT MEASUREMENTS; MUTATION; OXYGEN CONSUMPTION; SUPEROXIDE DISMUTASE; TELOMERE-BINDING PROTEINS; THERMOGENESIS;

EID: 0036757226     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(02)00085-4     Document Type: Article

References (30)

1. Aebi H. Catalase in vitro. Methods Enzymol. 105:1984;121-126.
2. Ahmed S., Alpi A., Hengartner M.O., Gartner A. C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein. Curr. Biol. 11:2001;1934-1944.
3. Bénard C., McCright B., Zhang Y., Felkai S., Lakowski B., Hekimi S. The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. Development. 128:2001;4045-4055.
4. Björk G.R., Durand J.M., Hagervall T.G., Leipuviene R., Lundgren H.K., Nilsson K., Chen P., Qian Q., Urbonavicius J. Transfer RNA modification: influence on translational frameshifting and metabolism. FEBS Lett. 452:1999;47-51.
5. Braeckman B.P., Houthoofd K., De Vreese A., Vanfleteren J.R. Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans. Curr. Biol. 9:1999;493-496.
6. Braeckman B.P., Houthoofd K., De Vreese A., Vanfleteren J.R. Assaying metabolic activity in ageing Caenorhabditis elegans. Mech. Ageing Dev. 123:2002;105-119.
7. Branicky R., Shibata Y., Feng J., Hekimi S. Phenotypic and suppressor analysis of defecation in clk-1 mutants reveals that reaction to changes in temperature is an active process in Caenorhabditis elegans. Genetics. 159:2001;997-1006.
8. Corbisier P., Houbion A., Remacle J. A new technique for highly sensitive detection of superoxide dismutase activity by chemiluminescence. Anal. Biochem. 164:1987;240-247.
9. Ewbank J.J., Barnes T.M., Lakowski B., Lussier M., Bussey H., Hekimi S. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Science. 275:1997;980-983.
10. Fabian T.J., Johnson T.E. Production of age-synchronous mass-cultures of Caenorhabditis elegans. J. Gerontol. 49:1994;B145-B156.
11. Felkai S., Ewbank J.J., Lemieux J., Labbe J.C., Brown G.G., Hekimi S. CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. EMBO J. 18:1999;1783-1792.
12. Feng J., Bussière F., Hekimi S. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev. Cell. 1:2001;633-644.
13. Gorbunova V., Seluanov A. CLK-1 protein has DNA binding activity specific to OL region of mitochondrial DNA. FEBS Lett. 516:2002;279-284.
14. Harman D. Aging: a theory based on free radical radiation chemistry. J. Gerontol. 11:1956;298-300.
15. Hekimi S., Lakowski B., Barnes T.M., Ewbank J.J. Molecular genetics of life span in C. elegans: how much does it teach us. Trends Genet. 14:1998;14-20.
16. Hekimi S., Burgess J., Bussiere F., Meng Y., Benard C. Genetics of lifespan in C. elegans: molecular diversity, physiological complexity, mechanistic simplicity. Trends Genet. 17:2001;712-718.
17. Hekimi S., Benard C., Branicky R., Burgess J., Hihi A.K., Rea S. Why only time will tell. Mech. Ageing Dev. 122:2001;571-594.
18. Hihi A.K., Gao Y., Hekimi S. Ubiquinone is necessary for Caenorhabditis elegans development at mitochondrial and non-mitochondrial sites. J. Biol. Chem. 277:2002;2202-2206.
19. Johnson T.E., de Castro E., Hegi de Castro S., Cypser J., Henderson S., Tedesco P. Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans. Exp. Gerontol. 36:2001;1609-1617.
20. Jonassen T., Larsen P.L., Clarke C.F. A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants. Proc. Natl. Acad. Sci. USA. 98:2001;421-426.
21. Kota R.S., Runge K.W. Tel2p, a regulator of yeast telomeric length in vivo, binds to single-stranded telomeric DNA in vitro. Chromosoma. 108:1999;278-290.
22. Lakowski B., Hekimi S. Determination of life-span in Caenorhabditis elegans by four clock genes. Science. 272:1996;1010-1013.
23. Larsen P.L., Clarke C.F. Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q. Science. 295:2002;120-123.
24. Lemieux J., Lakowski B., Webb A., Meng Y., Ubach A., Bussiere F., Barnes T., Hekimi S. Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria. Genetics. 159:2001;147-157.
25. Lim C.S., Mian I.S., Dernburg A.F., Campisi J. C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p. Curr. Biol. 11:2001;1706-1710.
26. Miyadera H., Amino H., Hiraishi A., Taka H., Murayama K., Miyoshi H., Sakamoto K., Ishii N., Hekimi S., Kita K. Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans. J. Biol. Chem. 276:2001;7713-7716.
27. Pearl R. The Rate of Living. 1928;University of London Press, London.
28. Runge K.W., Zakian V.A. TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:1996;3094-3105.
29. Sulston J., Hodgkin J. Methods. Wood W.B., et al. The Nematode Caenorhabditis elegans. 1988;587-606 Cold Spring Harbor Laboratory Press, Plainview, NY.
30. Wong A., Boutis P., Hekimi S. Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics. 139:1995;1247-1259.