A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 44, 2009, Pages 18668-18673

  Hammell, Christopher M ^a   Karp, Xantha ^a   Ambros, Victor ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Gene regulation; microRNA; Nuclear hormone receptor

Indexed keywords

MICRORNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DAF 12; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DEVELOPMENTAL SCREENING; ENVIRONMENTAL FACTOR; FEEDBACK SYSTEM; LINEAR ENERGY TRANSFER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; ENVIRONMENT; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LIGANDS; MICRORNAS; MODELS, BIOLOGICAL; MUTATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TIME FACTORS;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 73249148097     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908131106     Document Type: Article

References (28)

1. Braendle C, Felix MA (2008) Plasticity and errors of a robust developmental system in different environments. Dev Cell 15:714-724.
2. Golden JW, Riddle DL (1984) The Caenorhabditis elegans dauer larva: Developmental effects of pheromone, food, and temperature. Dev Biol 102:368-378.
3. Hu PJ (2007) Dauer (August 8). WormBook: The C. elegans Research Community. Available at http://wormbook.org/chapters/www-dauer/dauer.html. Accessed October 1, 2009.
4. Sulston JE, Horvitz HR (1977) Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol 56:110-156.
5. Fielenbach N, Antebi A (2008) C. elegans dauer formation and the molecular basis of plasticity. Genes Dev 22:2149-2165.
6. Liu X, Ambros V (1991) Alternative temporal control systems for hypodermal cell differentiation in Caenorhabditis elegans. Nature 350:162-165.
7. Rougvie AE (2001) Control of developmental timing in animals. Nat Rev Genet 2:690-701.
8. Abbott AL, et al. (2005) The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell 9:403-414.
9. Antebi A, Culotti JG, Hedgecock EM (1998) daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans. Development 125:1191-1205.
10. Motola DL, et al. (2006) Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Cell 124:1209-1223.
11. Ludewig AH, et al. (2004) A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging. Genes Dev 18:2120-2133.
12. Bethke A, Fielenbach N, Wang Z, Mangelsdorf DJ, Antebi A (2009) Nuclear hormone receptor regulation of microRNAs controls developmental progression. Science 324:95-98.
13. Antebi A, Yeh WH, Tait D, Hedgecock EM, Riddle DL (2000) daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans. Genes Dev 14:1512-1527.
14. Hammell CM, Lubin I, Boag PR, Blackwell TK, Ambros V (2009) nhl-2 modulates microRNA activity in Caenorhabditis elegans. Cell 136:926-938.
15. Lin SY, et al. (2003) The C. elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable MicroRNA target. Dev Cell 4:639-650.
16. Abrahante JE, et al. (2003) The Caenorhabditis elegans hunchback-like gene lin-57/ hbl-1 controls developmental time and is regulated by microRNAs. Dev Cell 4:625-637.
17. Moss EG, Lee RC, Ambros V (1997) The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell 88:637-646.
18. Pepper AS, et al. (2004) The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin. Development 131:2049-2059.
19. Grosshans H, Johnson T, Reinert KL, Gerstein M, Slack FJ (2005) The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans. Dev Cell 8:321-330.
20. Kimble J, Hirsh D (1979) The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans. Dev Biol 70:396-417.
21. Gerisch B, Weitzel C, Kober-Eisermann C, Rottiers V, Antebi A (2001) A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. Dev Cell 1:841-851.
22. Martinez NJ, et al. (2008) A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity. Genes Dev 22:2535-2549.
23. Turner MJ, Slack FJ (2009) Transcriptional control of microRNA expression in C. elegans: Promoting better understanding. RNA Biol 6:49-53.
24. Li X, Cassidy JJ, Reinke CA, Fischboeck S, Carthew RW (2009) A microRNA imparts robustness against environmental fluctuation during development. Cell 137:273-282.
25. Marson A, et al. (2008) Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 134:521-533.
26. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71-94.
27. Mello CC, Kramer JM, Stinchcomb D, Ambros V (1991) Efficient gene transfer in C. elegans: Extrachromosomal maintenance and integration of transforming sequences. EMBO J 10:3959-3970.
28. Pradervand S, et al. (2009) Impact of normalization on miRNA microarray expression profiling. RNA 15:493-501.