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Volumn 245, Issue 1, 2012, Pages 164-176

Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases

Author keywords

Epithelium; GPR43; Microbiota; Short chain fatty acids

Indexed keywords

ALPHA DEFENSIN; ANTIBIOTIC AGENT; B7 ANTIGEN; BETA DEFENSIN; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CD86 ANTIGEN; CRYOPYRIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 120; G PROTEIN COUPLED RECEPTOR 41; G PROTEIN COUPLED RECEPTOR 43; GAMMA INTERFERON; HEAT SHOCK PROTEIN 25; HEAT SHOCK PROTEIN 72; HISTONE DEACETYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 17; INTERLEUKIN 18 RECEPTOR ALPHA; INTERLEUKIN 33; INTERLEUKIN 4; MUCIN; MUCIN 13; MUCIN 2; PREBIOTIC AGENT; PROBIOTIC AGENT; RECOMBINANT P40 PROTEIN; RECOMBINANT PROTEIN; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; VSL3;

EID: 83655193494     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2011.01080.x     Document Type: Review
Times cited : (190)

References (119)
  • 1
    • 77957075815 scopus 로고    scopus 로고
    • Impact of diet in shaping gut microbiota revealed by a comparative study in children from europe and rural africa
    • De Filippo C, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from europe and rural africa. Proc Natl Acad Sci USA 2010;107:14691-14696.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14691-14696
    • De Filippo, C.1
  • 2
    • 79956301905 scopus 로고    scopus 로고
    • Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans
    • Muegge BD, et al. Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science 2011;332:970-974.
    • (2011) Science , vol.332 , pp. 970-974
    • Muegge, B.D.1
  • 3
    • 79959855078 scopus 로고    scopus 로고
    • Predicting a human gut microbiota response to diet in gnotobiotic mice
    • Faith JJ, McNulty MP, Rey FE, Gordon JI. Predicting a human gut microbiota response to diet in gnotobiotic mice. Science 2011;333:101-104.
    • (2011) Science , vol.333 , pp. 101-104
    • Faith, J.J.1    McNulty, M.P.2    Rey, F.E.3    Gordon, J.I.4
  • 4
    • 78650408264 scopus 로고    scopus 로고
    • Diet, gut microbiota and immune responses
    • Maslowski KM, Mackay CR. Diet, gut microbiota and immune responses. Nat Immunol 2011;12:5-9.
    • (2011) Nat Immunol , vol.12 , pp. 5-9
    • Maslowski, K.M.1    Mackay, C.R.2
  • 5
    • 77956165390 scopus 로고    scopus 로고
    • Gpr120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
    • Oh DY, et al. Gpr120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 2010;142:687-698.
    • (2010) Cell , vol.142 , pp. 687-698
    • Oh, D.Y.1
  • 6
    • 79955935457 scopus 로고    scopus 로고
    • Intestinal microbiota in inflammatory bowel disease: friend of foe?
    • Fava F, Danese S. Intestinal microbiota in inflammatory bowel disease: friend of foe? World J Gastroenterol 2011;17:557-566.
    • (2011) World J Gastroenterol , vol.17 , pp. 557-566
    • Fava, F.1    Danese, S.2
  • 7
    • 79959369140 scopus 로고    scopus 로고
    • The sentinel role of the airway epithelium in asthma pathogenesis
    • Holgate ST. The sentinel role of the airway epithelium in asthma pathogenesis. Immunol Rev 2011;242:205-219.
    • (2011) Immunol Rev , vol.242 , pp. 205-219
    • Holgate, S.T.1
  • 8
    • 58149091806 scopus 로고    scopus 로고
    • The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity
    • Vaarala O, Atkinson MA, Neu J. The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity. Diabetes 2008;57:2555-2562.
    • (2008) Diabetes , vol.57 , pp. 2555-2562
    • Vaarala, O.1    Atkinson, M.A.2    Neu, J.3
  • 9
    • 8844222723 scopus 로고    scopus 로고
    • Cereal grains, legumes and diabetes
    • Venn BJ, Mann JI. Cereal grains, legumes and diabetes. Eur J Clin Nutr 2004; 58:1443-1461.
    • (2004) Eur J Clin Nutr , vol.58 , pp. 1443-1461
    • Venn, B.J.1    Mann, J.I.2
  • 10
    • 20744451860 scopus 로고    scopus 로고
    • Dietary fibres as "prebiotics": implications for colorectal cancer
    • Lim CC, Ferguson LR, Tannock GW. Dietary fibres as "prebiotics": implications for colorectal cancer. Mol Nutr Food Res 2005; 49:609-619.
    • (2005) Mol Nutr Food Res , vol.49 , pp. 609-619
    • Lim, C.C.1    Ferguson, L.R.2    Tannock, G.W.3
  • 12
    • 80052065175 scopus 로고    scopus 로고
    • Antibiotic overuse: stop the killing of beneficial bacteria
    • Blaser M. Antibiotic overuse: stop the killing of beneficial bacteria. Nature 2011; 476:393-394.
    • (2011) Nature , vol.476 , pp. 393-394
    • Blaser, M.1
  • 13
    • 79961202703 scopus 로고    scopus 로고
    • Commentary: paracetamol and asthma-lessons from the antibiotic hypothesis?
    • Shaheen SO. Commentary: paracetamol and asthma-lessons from the antibiotic hypothesis? Int J Epidemiol 2011;40:667-669.
    • (2011) Int J Epidemiol , vol.40 , pp. 667-669
    • Shaheen, S.O.1
  • 14
    • 0034241683 scopus 로고    scopus 로고
    • Family size, infection and atopy: the first decade of the "hygiene hypothesis"
    • Strachan D. Family size, infection and atopy: the first decade of the "hygiene hypothesis". Thorax 2000;55(Suppl.):S2-S10.
    • (2000) Thorax , vol.55 , Issue.SUPPL.
    • Strachan, D.1
  • 15
    • 0032974177 scopus 로고    scopus 로고
    • Fecal microflora in healthy infants born by different methods of delivery: permanent changes in intestinal flora after cesarean delivery
    • Gronlund MM, Lehtonen OP, Eerola E, Kero P. Fecal microflora in healthy infants born by different methods of delivery: permanent changes in intestinal flora after cesarean delivery. J Ped Gastroenterol Nutr 1999;28:19-25.
    • (1999) J Ped Gastroenterol Nutr , vol.28 , pp. 19-25
    • Gronlund, M.M.1    Lehtonen, O.P.2    Eerola, E.3    Kero, P.4
  • 16
    • 4344599461 scopus 로고    scopus 로고
    • Influence of mode of delivery on gut microbiota composition in seven year old children
    • Salminen S, Gibson GR, McCartney AL, Isolauri E. Influence of mode of delivery on gut microbiota composition in seven year old children. Gut 2004;53:1388-1389.
    • (2004) Gut , vol.53 , pp. 1388-1389
    • Salminen, S.1    Gibson, G.R.2    McCartney, A.L.3    Isolauri, E.4
  • 17
    • 79957574938 scopus 로고    scopus 로고
    • Moving pictures of the human microbiome
    • Caporaso JG, et al. Moving pictures of the human microbiome. Genome Biol 2011;12:R50.
    • (2011) Genome Biol , vol.12
    • Caporaso, J.G.1
  • 19
    • 85027927719 scopus 로고    scopus 로고
    • Enterotypes of the human gut microbiome
    • Arumugam M, et al. Enterotypes of the human gut microbiome. Nature 2011; 473:174-180.
    • (2011) Nature , vol.473 , pp. 174-180
    • Arumugam, M.1
  • 20
    • 80053618114 scopus 로고    scopus 로고
    • Linking long-term dietary patterns with gut microbial enterotypes
    • Wu GD, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science 2011;334:105-108.
    • (2011) Science , vol.334 , pp. 105-108
    • Wu, G.D.1
  • 22
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993;75:253-261.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 23
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
    • Sellon RK, et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun 1998;66:5224-5231.
    • (1998) Infect Immun , vol.66 , pp. 5224-5231
    • Sellon, R.K.1
  • 24
    • 35348857386 scopus 로고    scopus 로고
    • Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
    • Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci USA 2007;104:13780-13785.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 13780-13785
    • Frank, D.N.1    St Amand, A.L.2    Feldman, R.A.3    Boedeker, E.C.4    Harpaz, N.5    Pace, N.R.6
  • 25
    • 33750956239 scopus 로고    scopus 로고
    • Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis
    • Gophna U, Sommerfeld K, Gophna S, Doolittle WF, Veldhuyzen van Zanten SJO. Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis. J Clin Microbiol 2006;44:4136-4141.
    • (2006) J Clin Microbiol , vol.44 , pp. 4136-4141
    • Gophna, U.1    Sommerfeld, K.2    Gophna, S.3    Doolittle, W.F.4    Veldhuyzen van Zanten, S.J.O.5
  • 26
    • 30944466824 scopus 로고    scopus 로고
    • Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
    • Manichanh C, et al. Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut 2006;55:205-211.
    • (2006) Gut , vol.55 , pp. 205-211
    • Manichanh, C.1
  • 27
    • 70350666634 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by gut microbiota and chemoattractant receptor gpr43
    • Maslowski KM, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor gpr43. Nature 2009;461:1282-1286.
    • (2009) Nature , vol.461 , pp. 1282-1286
    • Maslowski, K.M.1
  • 28
    • 53349173070 scopus 로고    scopus 로고
    • Specific microbiota direct the differentiation of il-17-producing t-helper cells in the mucosa of the small intestine
    • Ivanov II, et al. Specific microbiota direct the differentiation of il-17-producing t-helper cells in the mucosa of the small intestine. Cell Host Microbe 2008;4:337-349.
    • (2008) Cell Host Microbe , vol.4 , pp. 337-349
    • Ivanov, I.I.1
  • 29
    • 79957576718 scopus 로고    scopus 로고
    • Nlrp6 inflammasome regulates colonic microbial ecology and risk for colitis
    • Elinav E, et al. Nlrp6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 2011;145:745-757.
    • (2011) Cell , vol.145 , pp. 745-757
    • Elinav, E.1
  • 30
    • 78649868190 scopus 로고    scopus 로고
    • Association between the use of antibiotics in the first year of life and pediatric inflammatory bowel disease
    • Shaw SY, Blanchard JF, Bernstein CN. Association between the use of antibiotics in the first year of life and pediatric inflammatory bowel disease. Am J Gastroenterol 2010;105:2687-2692.
    • (2010) Am J Gastroenterol , vol.105 , pp. 2687-2692
    • Shaw, S.Y.1    Blanchard, J.F.2    Bernstein, C.N.3
  • 31
    • 78651252504 scopus 로고    scopus 로고
    • Antibiotic use and inflammatory bowel diseases in childhood
    • Hviid A, Svanstrom H, Frisch M. Antibiotic use and inflammatory bowel diseases in childhood. Gut 2011;60:49-54.
    • (2011) Gut , vol.60 , pp. 49-54
    • Hviid, A.1    Svanstrom, H.2    Frisch, M.3
  • 32
    • 77649185148 scopus 로고    scopus 로고
    • Defining and analyzing geoepidemiology and human autoimmunity
    • Shapira Y, Agmon-Levin N, Shoenfeld Y. Defining and analyzing geoepidemiology and human autoimmunity. J Autoimmunity 2010;34:J168-J177.
    • (2010) J Autoimmunity , vol.34
    • Shapira, Y.1    Agmon-Levin, N.2    Shoenfeld, Y.3
  • 33
    • 77949272755 scopus 로고    scopus 로고
    • Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in nod mice
    • Lee AS, Gibson DL, Zhang Y, Sham HP, Vallance BA, Dutz JP. Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in nod mice. Diabetologia 2010; 53:741-748.
    • (2010) Diabetologia , vol.53 , pp. 741-748
    • Lee, A.S.1    Gibson, D.L.2    Zhang, Y.3    Sham, H.P.4    Vallance, B.A.5    Dutz, J.P.6
  • 34
    • 54549122338 scopus 로고    scopus 로고
    • Innate immunity and intestinal microbiota in the development of type 1 diabetes
    • Wen L, et al. Innate immunity and intestinal microbiota in the development of type 1 diabetes. Nature 2008;455:1109-1113.
    • (2008) Nature , vol.455 , pp. 1109-1113
    • Wen, L.1
  • 35
    • 34548036686 scopus 로고    scopus 로고
    • Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes
    • Kim HS, et al. Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes. Immunity 2007;27:321-333.
    • (2007) Immunity , vol.27 , pp. 321-333
    • Kim, H.S.1
  • 36
    • 77950250064 scopus 로고    scopus 로고
    • Metabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5
    • Vijay-Kumar M, et al. Metabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5. Science 2010;328:228-231.
    • (2010) Science , vol.328 , pp. 228-231
    • Vijay-Kumar, M.1
  • 37
    • 80052517464 scopus 로고    scopus 로고
    • Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (nod) mice
    • Alam C, et al. Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (nod) mice. Diabetologia 2011;54:1398-1406.
    • (2011) Diabetologia , vol.54 , pp. 1398-1406
    • Alam, C.1
  • 38
    • 74049161267 scopus 로고    scopus 로고
    • Influence of microbial environment on autoimmunity
    • Chervonsky AV. Influence of microbial environment on autoimmunity. Nat Immunol 2010;11:28-35.
    • (2010) Nat Immunol , vol.11 , pp. 28-35
    • Chervonsky, A.V.1
  • 39
    • 66449108669 scopus 로고    scopus 로고
    • Cd1d-dependent regulation of bacterial colonization in the intestine of mice
    • Nieuwenhuis EE, et al. Cd1d-dependent regulation of bacterial colonization in the intestine of mice. J Clin Invest 2009; 119:1241-1250.
    • (2009) J Clin Invest , vol.119 , pp. 1241-1250
    • Nieuwenhuis, E.E.1
  • 40
    • 70349468054 scopus 로고    scopus 로고
    • Nod2 is required for the regulation of commensal microbiota in the intestine
    • Petnicki-Ocwieja T, et al. Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci USA 2009;106:15813-15818.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 15813-15818
    • Petnicki-Ocwieja, T.1
  • 41
    • 44949127290 scopus 로고    scopus 로고
    • Effect of intestinal microbiota on the induction of regulatory cd25+ cd4+ t cells
    • Ishikawa H, et al. Effect of intestinal microbiota on the induction of regulatory cd25+ cd4+ t cells. Clin Exp Immunol 2008;153:127-135.
    • (2008) Clin Exp Immunol , vol.153 , pp. 127-135
    • Ishikawa, H.1
  • 42
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal th17 cells by segmented filamentous bacteria
    • Ivanov II, et al. Induction of intestinal th17 cells by segmented filamentous bacteria. Cell 2009;139:485-498.
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1
  • 43
    • 53349120339 scopus 로고    scopus 로고
    • Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine
    • Zaph C, et al. Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine. J Exp Med 2008;205:2191-2198.
    • (2008) J Exp Med , vol.205 , pp. 2191-2198
    • Zaph, C.1
  • 44
    • 77953302950 scopus 로고    scopus 로고
    • Inflammatory tendencies and overproduction of IL-17 in the colon of young NOD mice are counteracted with diet change
    • Alam C, Valkonen S, Palagani V, Jalava J, Eerola E, Hanninen A. Inflammatory tendencies and overproduction of IL-17 in the colon of young NOD mice are counteracted with diet change. Diabetes 2010;59:2237-2246.
    • (2010) Diabetes , vol.59 , pp. 2237-2246
    • Alam, C.1    Valkonen, S.2    Palagani, V.3    Jalava, J.4    Eerola, E.5    Hanninen, A.6
  • 45
    • 77949278571 scopus 로고    scopus 로고
    • Enhanced trafficking to the pancreatic lymph nodes and auto-antigen presentation capacity distinguishes peritoneal b lymphocytes in non-obese diabetic mice
    • Alam C, Valkonen S, Ohls S, Tornqvist K, Hanninen A. Enhanced trafficking to the pancreatic lymph nodes and auto-antigen presentation capacity distinguishes peritoneal b lymphocytes in non-obese diabetic mice. Diabetologia 2010;53:346-355.
    • (2010) Diabetologia , vol.53 , pp. 346-355
    • Alam, C.1    Valkonen, S.2    Ohls, S.3    Tornqvist, K.4    Hanninen, A.5
  • 48
    • 0033118675 scopus 로고    scopus 로고
    • From systemic t cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
    • Korganow A-S, et al. From systemic t cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 1999;10:451-461.
    • (1999) Immunity , vol.10 , pp. 451-461
    • Korganow, A.-S.1
  • 49
    • 0028603293 scopus 로고
    • Intestinal flora in early rheumatoid arthritis
    • Eerola E, et al. Intestinal flora in early rheumatoid arthritis. Rheumatology 1994;33:1030-1038.
    • (1994) Rheumatology , vol.33 , pp. 1030-1038
    • Eerola, E.1
  • 51
    • 79251522166 scopus 로고    scopus 로고
    • Diet and asthma: nutrition implications from prevention to treatment
    • Allan K, Devereux G. Diet and asthma: nutrition implications from prevention to treatment. J Am Dietetic Assoc 2011; 111:258-268.
    • (2011) J Am Dietetic Assoc , vol.111 , pp. 258-268
    • Allan, K.1    Devereux, G.2
  • 52
    • 79955606197 scopus 로고    scopus 로고
    • Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma
    • McLoughlin RM, Mills KHG. Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma. J Allerg Clin Immunol 2011; 127:1097-1107.
    • (2011) J Allerg Clin Immunol , vol.127 , pp. 1097-1107
    • McLoughlin, R.M.1    Mills, K.H.G.2
  • 53
    • 79955627107 scopus 로고    scopus 로고
    • Gut microbiota, probiotics, and vitamin d: interrelated exposures influencing allergy, asthma, and obesity?
    • Ly NP, Litonjua A, Gold DR, Celedon JC. Gut microbiota, probiotics, and vitamin d: interrelated exposures influencing allergy, asthma, and obesity? J Allerg Clin Immunol 2011;127:1087-1094.
    • (2011) J Allerg Clin Immunol , vol.127 , pp. 1087-1094
    • Ly, N.P.1    Litonjua, A.2    Gold, D.R.3    Celedon, J.C.4
  • 54
    • 33748333171 scopus 로고    scopus 로고
    • Low maternal vitamin e intake during pregnancy is associated with asthma in 5-year-old children
    • Devereux G, et al. Low maternal vitamin e intake during pregnancy is associated with asthma in 5-year-old children. Am J Respir Crit Care Med 2006;174:499-507.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 499-507
    • Devereux, G.1
  • 56
    • 77957113600 scopus 로고    scopus 로고
    • A large-scale, consortium-based genomewide association study of asthma
    • Moffatt MF, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010;363:1211-1221.
    • (2010) N Engl J Med , vol.363 , pp. 1211-1221
    • Moffatt, M.F.1
  • 57
    • 70349664159 scopus 로고    scopus 로고
    • Spdef is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
    • Chen G, et al. Spdef is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest 2009; 119:2914-2924.
    • (2009) J Clin Invest , vol.119 , pp. 2914-2924
    • Chen, G.1
  • 58
    • 77953442986 scopus 로고    scopus 로고
    • Foxa2 programs Th2 cell-mediated innate immunity in the developing lung
    • Chen G, et al. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol 2010;184:6133-6141.
    • (2010) J Immunol , vol.184 , pp. 6133-6141
    • Chen, G.1
  • 59
    • 74849096564 scopus 로고    scopus 로고
    • The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis
    • Holgate ST, Roberts G, Arshad HS, Howarth PH, Davies DE. The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis. Proc Am Thorac Soc 2009;6:655-659.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 655-659
    • Holgate, S.T.1    Roberts, G.2    Arshad, H.S.3    Howarth, P.H.4    Davies, D.E.5
  • 60
    • 36849031788 scopus 로고    scopus 로고
    • Epithelium dysfunction in asthma
    • Holgate ST. Epithelium dysfunction in asthma. J Allergy Clin Immunol 2007;120:1233-1244.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 1233-1244
    • Holgate, S.T.1
  • 61
    • 58149181699 scopus 로고    scopus 로고
    • Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress
    • Fitzpatrick AM, Teague WG, Holguin F, Yeh M, Brown LAS. Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress. J Allergy Clin Immunol 2009;123:146-152.e148.
    • (2009) J Allergy Clin Immunol , vol.123
    • Fitzpatrick, A.M.1    Teague, W.G.2    Holguin, F.3    Yeh, M.4    Brown, L.A.S.5
  • 62
    • 17144403499 scopus 로고    scopus 로고
    • Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    • Wark PAB, et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005;201:937-947.
    • (2005) J Exp Med , vol.201 , pp. 937-947
    • Wark, P.A.B.1
  • 63
    • 38049158195 scopus 로고    scopus 로고
    • Can inhaled corticosteroids influence the natural history of asthma?
    • Murray CS. Can inhaled corticosteroids influence the natural history of asthma? Curr Opin Allerg Clin Immunol 2008;8:77-81.
    • (2008) Curr Opin Allerg Clin Immunol , vol.8 , pp. 77-81
    • Murray, C.S.1
  • 64
    • 79959271087 scopus 로고    scopus 로고
    • Intestinal homeostasis and its breakdown in inflammatory bowel disease
    • Maloy KJ, Powrie F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 2011;474:298-306.
    • (2011) Nature , vol.474 , pp. 298-306
    • Maloy, K.J.1    Powrie, F.2
  • 65
    • 0023276469 scopus 로고
    • Short chain fatty acids in human large intestine, portal, hepatic and venous blood
    • Cummings JH, Pomare EW, Branch WJ, Naylor CP, Macfarlane GT. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 1987;28:1221-1227.
    • (1987) Gut , vol.28 , pp. 1221-1227
    • Cummings, J.H.1    Pomare, E.W.2    Branch, W.J.3    Naylor, C.P.4    Macfarlane, G.T.5
  • 66
    • 77957841535 scopus 로고    scopus 로고
    • Short-chain fatty acids and commensal microbiota in the faeces of severely malnourished children with cholera rehydrated with three different carbohydrates
    • Monira S, et al. Short-chain fatty acids and commensal microbiota in the faeces of severely malnourished children with cholera rehydrated with three different carbohydrates. Eur J Clin Nutr 2010;64:1116-1124.
    • (2010) Eur J Clin Nutr , vol.64 , pp. 1116-1124
    • Monira, S.1
  • 67
    • 85056037203 scopus 로고    scopus 로고
    • The impact of the level of the intestinal short chain fatty acids in inflammatory bowel disease patients versus healthy subjects
    • Huda-Faujan N, et al. The impact of the level of the intestinal short chain fatty acids in inflammatory bowel disease patients versus healthy subjects. Open Biochem J 2010;4:53-58.
    • (2010) Open Biochem J , vol.4 , pp. 53-58
    • Huda-Faujan, N.1
  • 68
    • 79957749035 scopus 로고    scopus 로고
    • The intestinal epithelial barrier in the control of homeostasis and immunity
    • Rescigno M. The intestinal epithelial barrier in the control of homeostasis and immunity. Trends Immunol 2011;32:256-264.
    • (2011) Trends Immunol , vol.32 , pp. 256-264
    • Rescigno, M.1
  • 69
    • 59549100692 scopus 로고    scopus 로고
    • Tight junctions at a glance
    • Balda MS, Matter K. Tight junctions at a glance. J Cell Sci 2008;121:3677-3682.
    • (2008) J Cell Sci , vol.121 , pp. 3677-3682
    • Balda, M.S.1    Matter, K.2
  • 71
    • 65249099918 scopus 로고    scopus 로고
    • Changes in gut microbiota control inflammation in obese mice through a mechanism involving glp-2-driven improvement of gut permeability
    • Cani PD, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving glp-2-driven improvement of gut permeability. Gut 2009;58:1091-1103.
    • (2009) Gut , vol.58 , pp. 1091-1103
    • Cani, P.D.1
  • 73
    • 0033214433 scopus 로고    scopus 로고
    • Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense
    • Wilson CL, et al. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 1999;286:113-117.
    • (1999) Science , vol.286 , pp. 113-117
    • Wilson, C.L.1
  • 74
    • 79251585301 scopus 로고    scopus 로고
    • Paneth cell defensins and the regulation of the microbiome: detente at mucosal surfaces
    • Salzman NH. Paneth cell defensins and the regulation of the microbiome: detente at mucosal surfaces. Gut microbes 2010; 1:401-406.
    • (2010) Gut microbes , vol.1 , pp. 401-406
    • Salzman, N.H.1
  • 75
    • 74049122536 scopus 로고    scopus 로고
    • Enteric defensins are essential regulators of intestinal microbial ecology
    • Salzman NH, et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 2010;11:76-83.
    • (2010) Nat Immunol , vol.11 , pp. 76-83
    • Salzman, N.H.1
  • 76
    • 34548130847 scopus 로고    scopus 로고
    • Reduced mucosal antimicrobial activity in crohn's disease of the colon
    • Nuding S, Fellermann K, Wehkamp J, Stange EF. Reduced mucosal antimicrobial activity in crohn's disease of the colon. Gut 2007;56:1240-1247.
    • (2007) Gut , vol.56 , pp. 1240-1247
    • Nuding, S.1    Fellermann, K.2    Wehkamp, J.3    Stange, E.F.4
  • 77
    • 79952748335 scopus 로고    scopus 로고
    • The two mucus layers of colon are organized by the muc2 mucin, whereas the outer layer is a legislator of host'äìmicrobial interactions
    • Johansson ME, Larsson JM, Hansson GC. The two mucus layers of colon are organized by the muc2 mucin, whereas the outer layer is a legislator of host'äìmicrobial interactions. Proc Natl Acad Sci USA 2011;108(Suppl.):4659-4665.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.SUPPL. , pp. 4659-4665
    • Johansson, M.E.1    Larsson, J.M.2    Hansson, G.C.3
  • 78
    • 79251581856 scopus 로고    scopus 로고
    • Importance and regulation of the colonic mucus barrier in a mouse model of colitis
    • Petersson J, et al. Importance and regulation of the colonic mucus barrier in a mouse model of colitis. Am J Physiol Gastrointest Liver Physiol 2011;300:G327-G333.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300
    • Petersson, J.1
  • 79
    • 33745746660 scopus 로고    scopus 로고
    • Muc2-deficient mice spontaneously develop colitis, indicating that muc2 is critical for colonic protection
    • Van der Sluis M, et al. Muc2-deficient mice spontaneously develop colitis, indicating that muc2 is critical for colonic protection. Gastroenterol 2006;131:117-129.
    • (2006) Gastroenterol , vol.131 , pp. 117-129
    • Van der Sluis, M.1
  • 80
    • 80655124696 scopus 로고    scopus 로고
    • The muc13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis
    • et al.
    • Sheng YH, et al. The muc13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Gut 2011.
    • (2011) Gut
    • Sheng, Y.H.1
  • 81
    • 80052278497 scopus 로고    scopus 로고
    • Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
    • Amar J, et al. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med 2011;3:559-572.
    • (2011) EMBO Mol Med , vol.3 , pp. 559-572
    • Amar, J.1
  • 82
    • 0034023665 scopus 로고    scopus 로고
    • Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon
    • Barcelo A, Claustre J, Moro F, Chayvialle JA, Cuber JC, Plaisancie P. Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon. Gut 2000; 46:218-224.
    • (2000) Gut , vol.46 , pp. 218-224
    • Barcelo, A.1    Claustre, J.2    Moro, F.3    Chayvialle, J.A.4    Cuber, J.C.5    Plaisancie, P.6
  • 83
    • 9244245819 scopus 로고    scopus 로고
    • Butyrate specifically modulates muc gene expression in intestinal epithelial goblet cells deprived of glucose
    • Gaudier E, et al. Butyrate specifically modulates muc gene expression in intestinal epithelial goblet cells deprived of glucose. Am J Physiol Gastrointest Liver Physiol 2004;287:G1168-G1174.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Gaudier, E.1
  • 84
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004;118:229-241.
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 85
    • 34948858508 scopus 로고    scopus 로고
    • Heat shock response in gastrointestinal tract
    • Sikora A, Grzesiuk E. Heat shock response in gastrointestinal tract. J Physiol Pharmacol 2007;58(Suppl.):43-62.
    • (2007) J Physiol Pharmacol , vol.58 , Issue.SUPPL. , pp. 43-62
    • Sikora, A.1    Grzesiuk, E.2
  • 86
    • 20144372886 scopus 로고    scopus 로고
    • Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72
    • Arvans DL, et al. Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72. AM J Physiol Gastrointest Liver Physiol 2005;288:G696-G704.
    • (2005) AM J Physiol Gastrointest Liver Physiol , vol.288
    • Arvans, D.L.1
  • 87
    • 0034837495 scopus 로고    scopus 로고
    • Short-chain fatty acids induce intestinal epithelial heat shock protein 25 expression in rats and iec 18 cells
    • Ren H, Musch MW, Kojima K, Boone D, Ma A, Chang EB. Short-chain fatty acids induce intestinal epithelial heat shock protein 25 expression in rats and iec 18 cells. Gastroenterology 2001;121:631-639.
    • (2001) Gastroenterology , vol.121 , pp. 631-639
    • Ren, H.1    Musch, M.W.2    Kojima, K.3    Boone, D.4    Ma, A.5    Chang, E.B.6
  • 88
    • 2342442430 scopus 로고    scopus 로고
    • Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease
    • Ott SJ, et al. Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut 2004;53:685-693.
    • (2004) Gut , vol.53 , pp. 685-693
    • Ott, S.J.1
  • 89
    • 0022623853 scopus 로고
    • Digestion and absorption of fiber carbohydrate in the colon
    • Fleming LL, Floch MH. Digestion and absorption of fiber carbohydrate in the colon. Am J Gastroeneterol 1986;81:507-511.
    • (1986) Am J Gastroeneterol , vol.81 , pp. 507-511
    • Fleming, L.L.1    Floch, M.H.2
  • 90
    • 0032535722 scopus 로고    scopus 로고
    • Identification and characterization of a monocarboxylate transporter (mct1) in pig and human colon: its potential to transport l-lactate as well as butyrate
    • Ritzhaupt A, Wood IS, Ellis A, Hosie KB, Shirazi-Beechey SP. Identification and characterization of a monocarboxylate transporter (mct1) in pig and human colon: its potential to transport l-lactate as well as butyrate. J Physiol 1998;513:719-732.
    • (1998) J Physiol , vol.513 , pp. 719-732
    • Ritzhaupt, A.1    Wood, I.S.2    Ellis, A.3    Hosie, K.B.4    Shirazi-Beechey, S.P.5
  • 91
    • 36549003678 scopus 로고    scopus 로고
    • Down-regulation of the monocarboxylate transporter 1 is involved in butyrate deficiency during intestinal inflammation
    • Thibault R, et al. Down-regulation of the monocarboxylate transporter 1 is involved in butyrate deficiency during intestinal inflammation. Gastroenterology 2007; 133:1916-1927.
    • (2007) Gastroenterology , vol.133 , pp. 1916-1927
    • Thibault, R.1
  • 92
    • 52949134856 scopus 로고    scopus 로고
    • Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability
    • Suzuki T, Yoshida S, Hara H. Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability. Br J Nutr 2008;100:297-305.
    • (2008) Br J Nutr , vol.100 , pp. 297-305
    • Suzuki, T.1    Yoshida, S.2    Hara, H.3
  • 93
    • 79251584066 scopus 로고    scopus 로고
    • Bifidobacteria can protect from enteropathogenic infection through production of acetate
    • Fukuda S, et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 2011;469:543-547.
    • (2011) Nature , vol.469 , pp. 543-547
    • Fukuda, S.1
  • 94
    • 34347223232 scopus 로고    scopus 로고
    • Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease
    • Tedelind S, Westberg F, Kjerruld M, Vidal A. Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease. World J Gastroenterol 2007;13:2826-2832.
    • (2007) World J Gastroenterol , vol.13 , pp. 2826-2832
    • Tedelind, S.1    Westberg, F.2    Kjerruld, M.3    Vidal, A.4
  • 95
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder K, Tschopp J. The inflammasomes. Cell 2010;140:821-832.
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 96
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in nod2 associated with susceptibility to crohn's disease
    • Ogura Y, et al. A frameshift mutation in nod2 associated with susceptibility to crohn's disease. Nature 2001;411:603-606.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1
  • 97
    • 77950002937 scopus 로고    scopus 로고
    • The nlrp3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    • Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD. The nlrp3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 2010;32:379-391.
    • (2010) Immunity , vol.32 , pp. 379-391
    • Zaki, M.H.1    Boyd, K.L.2    Vogel, P.3    Kastan, M.B.4    Lamkanfi, M.5    Kanneganti, T.D.6
  • 98
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the nalp3 inflammasome
    • Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the nalp3 inflammasome. Nature 2006;440:237-241.
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 99
    • 76249120134 scopus 로고    scopus 로고
    • Recognition of peptidoglycan from the microbiota by nod1 enhances systemic innate immunity
    • Clarke TB, Davis KM, Lysenko ES, Zhou AY, Yu Y, Weiser JN. Recognition of peptidoglycan from the microbiota by nod1 enhances systemic innate immunity. Nat Med 2010;16:228-231.
    • (2010) Nat Med , vol.16 , pp. 228-231
    • Clarke, T.B.1    Davis, K.M.2    Lysenko, E.S.3    Zhou, A.Y.4    Yu, Y.5    Weiser, J.N.6
  • 101
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005;122:107-118.
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 102
    • 79956311926 scopus 로고    scopus 로고
    • The toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • Round JL, et al. The toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 2011;332:974-977.
    • (2011) Science , vol.332 , pp. 974-977
    • Round, J.L.1
  • 103
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory t cells by indigenous clostridium species
    • Atarashi K, et al. Induction of colonic regulatory t cells by indigenous clostridium species. Science 2011;331:337-341.
    • (2011) Science , vol.331 , pp. 337-341
    • Atarashi, K.1
  • 104
    • 70349742524 scopus 로고    scopus 로고
    • The key role of segmented filamentous bacteria in the coordinated maturation of gut helper t cell responses
    • Gaboriau-Routhiau V, et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper t cell responses. Immunity 2009;31:677-689.
    • (2009) Immunity , vol.31 , pp. 677-689
    • Gaboriau-Routhiau, V.1
  • 105
    • 7944231342 scopus 로고    scopus 로고
    • Does the microbiota regulate immune responses outside the gut?
    • Noverr MC, Huffnagle GB. Does the microbiota regulate immune responses outside the gut? Trends Microbiol 2004;12:562-568.
    • (2004) Trends Microbiol , vol.12 , pp. 562-568
    • Noverr, M.C.1    Huffnagle, G.B.2
  • 106
    • 0035085791 scopus 로고    scopus 로고
    • Modulation of colonic barrier function by the composition of the commensal flora in the rat
    • Garcia-Lafuente A, Antolin M, Guarner F, Crespo E, Malagelada JR. Modulation of colonic barrier function by the composition of the commensal flora in the rat. Gut 2001;48:503-507.
    • (2001) Gut , vol.48 , pp. 503-507
    • Garcia-Lafuente, A.1    Antolin, M.2    Guarner, F.3    Crespo, E.4    Malagelada, J.R.5
  • 107
    • 0034831139 scopus 로고    scopus 로고
    • Probiotic bacteria enhance murine and human intestinal epithelial barrier function
    • Madsen K, et al. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology 2001; 121:580-591.
    • (2001) Gastroenterology , vol.121 , pp. 580-591
    • Madsen, K.1
  • 108
    • 0038460949 scopus 로고    scopus 로고
    • Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive escherichia coli (eiec)
    • Resta-Lenert S, Barrett KE. Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive escherichia coli (eiec). Gut 2003;52:988-997.
    • (2003) Gut , vol.52 , pp. 988-997
    • Resta-Lenert, S.1    Barrett, K.E.2
  • 109
    • 33846894974 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the probiotic effects of escherichia coli nissle 1917 involve zo-2 and pkczeta redistribution resulting in tight junction and epithelial barrier repair
    • Zyrek AA, Cichon C, Helms S, Enders C, Sonnenborn U, Schmidt MA. Molecular mechanisms underlying the probiotic effects of escherichia coli nissle 1917 involve zo-2 and pkczeta redistribution resulting in tight junction and epithelial barrier repair. Cell Microbiol 2007;9:804-816.
    • (2007) Cell Microbiol , vol.9 , pp. 804-816
    • Zyrek, A.A.1    Cichon, C.2    Helms, S.3    Enders, C.4    Sonnenborn, U.5    Schmidt, M.A.6
  • 110
    • 66149090738 scopus 로고    scopus 로고
    • Probiotic mixture vsl#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis
    • Mennigen R, et al. Probiotic mixture vsl#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol 2009;296:G1140-G1149.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296
    • Mennigen, R.1
  • 111
    • 33847770467 scopus 로고    scopus 로고
    • Effects of probiotic therapy in critically ill patients: a randomized, double-blind, placebo-controlled trial
    • Alberda C, et al. Effects of probiotic therapy in critically ill patients: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2007;85:816-823.
    • (2007) Am J Clin Nutr , vol.85 , pp. 816-823
    • Alberda, C.1
  • 112
    • 78650107219 scopus 로고    scopus 로고
    • Gut microbial diversity is reduced by the probiotic vsl#3 and correlates with decreased tnbs-induced colitis
    • Uronis J, et al. Gut microbial diversity is reduced by the probiotic vsl#3 and correlates with decreased tnbs-induced colitis. Inflamm Bowel Dis 2011;17:289-297.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 289-297
    • Uronis, J.1
  • 113
    • 38349078772 scopus 로고    scopus 로고
    • Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model
    • Martin FP, et al. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Mol Syst Biol 2008;4:157.
    • (2008) Mol Syst Biol , vol.4 , pp. 157
    • Martin, F.P.1
  • 114
    • 79957907960 scopus 로고    scopus 로고
    • Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an egfr-dependent mechanism
    • Yan F, et al. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an egfr-dependent mechanism. J Clin Invest 2011;121:2242-2253.
    • (2011) J Clin Invest , vol.121 , pp. 2242-2253
    • Yan, F.1
  • 116
    • 83655179316 scopus 로고    scopus 로고
    • A fermented formula in pre-term infants: clinical tolerance, gut microbiota, down-regulation of faecal calprotectin and up-regulation of faecal secretory iga
    • Campeotto F, et al. A fermented formula in pre-term infants: clinical tolerance, gut microbiota, down-regulation of faecal calprotectin and up-regulation of faecal secretory iga. Br J Nutr 2011;22:1-10.
    • (2011) Br J Nutr , vol.22 , pp. 1-10
    • Campeotto, F.1
  • 117
    • 33750228901 scopus 로고    scopus 로고
    • Probiotics and prebiotics in chronic inflammatory bowel disease
    • Ewaschuk J, Dueleman L. Probiotics and prebiotics in chronic inflammatory bowel disease. World J Gastroenterol 2006; 12:5941-5950.
    • (2006) World J Gastroenterol , vol.12 , pp. 5941-5950
    • Ewaschuk, J.1    Dueleman, L.2
  • 119
    • 79955025122 scopus 로고    scopus 로고
    • Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice
    • Goodman AL, et al. Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice. Proc Natl Acad Sci USA 2011;108:6252-6257.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 6252-6257
    • Goodman, A.L.1


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