Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells

Autophagy

Volumn 7, Issue 12, 2011, Pages 1528-1545

  Zheng, Lin ^a   Terman, Alexei ^b   Hallbeck, Martin ^a,c   Dehvari, Nodi ^d,e   Cowburn, Richard F ^f   Benedikz, Eirikur ^d,g   Kågedal, Katarina ^a   Cedazo Minguez, Angel ^d   Marcusson, Jan ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

^e STOCKHOLM UNIVERSITY   (Sweden)

^f ASTRAZENECA R AND D   (Sweden)

^g UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Alzheimer disease; Amyloid precursor protein; Amyloid protein; Apoptosis; Autophagy; Lysosomes; Oxidative stress

Indexed keywords

3 METHYLADENINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AUTOPHAGY PROTEIN 5; GAMMA SECRETASE; MONOMER; OLIGOMER; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; AUTOPHAGY; BIOACCUMULATION; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPEROXIA; IMMUNOFLUORESCENCE MICROSCOPY; INHIBITION KINETICS; LYSOSOME; MUTATIONAL ANALYSIS; NERVE DEGENERATION; NEUROBLASTOMA CELL; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; UPREGULATION;

EID: 82855181494     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.7.12.18051     Document Type: Article

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