메뉴 건너뛰기




Volumn 187, Issue 11, 2011, Pages 5983-5994

EphB receptors trigger Akt activation and suppress fas receptor-induced apoptosis in malignant T lymphocytes

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; EPHRIN B1; EPHRIN B2; EPHRIN RECEPTOR B3; EPHRIN RECEPTOR B6; FAS ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN KINASE B; PROTEIN TYROSINE KINASE;

EID: 82755187672     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003482     Document Type: Article
Times cited : (31)

References (85)
  • 1
    • 52749085175 scopus 로고    scopus 로고
    • Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia
    • Van Vlierberghe, P., R. Pieters, H. B. Beverloo, and J. P. Meijerink. 2008. Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia. Br. J. Haematol. 143: 153-168.
    • (2008) Br. J. Haematol. , vol.143 , pp. 153-168
    • Van Vlierberghe, P.1    Pieters, R.2    Beverloo, H.B.3    Meijerink, J.P.4
  • 2
    • 33646587683 scopus 로고    scopus 로고
    • New insights into the molecular biology and targeted therapy of cutaneous T-cell lymphomas
    • Klemke, C. D., S. Goerdt, D. Schrama, and J. C. Becker. 2006. New insights into the molecular biology and targeted therapy of cutaneous T-cell lymphomas. J. Dtsch. Dermatol. Ges. 4: 395-406.
    • (2006) J. Dtsch. Dermatol. Ges. , vol.4 , pp. 395-406
    • Klemke, C.D.1    Goerdt, S.2    Schrama, D.3    Becker, J.C.4
  • 3
    • 0030046322 scopus 로고    scopus 로고
    • Hypermethylationassociated inactivation indicates a tumor suppressor role for p15INK4B
    • Herman, J. G., J. Jen, A. Merlo, and S. B. Baylin. 1996. Hypermethylationassociated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res. 56: 722-727.
    • (1996) Cancer Res. , vol.56 , pp. 722-727
    • Herman, J.G.1    Jen, J.2    Merlo, A.3    Baylin, S.B.4
  • 5
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo, A., J. G. Herman, L. Mao, D. J. Lee, E. Gabrielson, P. C. Burger, S. B. Baylin, and D. Sidransky. 1995. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med. 1: 686-692.
    • (1995) Nat. Med. , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 7
    • 27944475340 scopus 로고    scopus 로고
    • Notch signaling in T-cell acute lymphoblastic leukemia
    • Weng, A. P., and A. Lau. 2005. Notch signaling in T-cell acute lymphoblastic leukemia. Future Oncol. 1: 511-519.
    • (2005) Future Oncol. , vol.1 , pp. 511-519
    • Weng, A.P.1    Lau, A.2
  • 9
    • 34250837539 scopus 로고    scopus 로고
    • The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for notch signaling
    • DOI 10.1158/0008-5472.CAN-06-4381
    • Malyukova, A., T. Dohda, N. von der Lehr, S. Akhoondi, M. Corcoran, M. Heyman, C. Spruck, D. Grandér, U. Lendahl, and O. Sangfelt. 2007. The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling. [Published erratum appears in 2008 Cancer Res. 68: 2051.] Cancer Res. 67: 5611-5616. (Pubitemid 46984990)
    • (2007) Cancer Research , vol.67 , Issue.12 , pp. 5611-5616
    • Malyukova, A.1    Dohda, T.2    Von Der, L.N.3    Akhondi, S.4    Corcoran, M.5    Heyman, M.6    Spruck, C.7    Grander, D.8    Lendahl, U.9    Sangfelt, O.10
  • 12
    • 34548058135 scopus 로고    scopus 로고
    • Cutaneous T-cell lymphoma: Molecular and cytogenetic findings
    • (Williston Park)
    • Sterry, W. 2007. Cutaneous T-cell lymphoma: molecular and cytogenetic findings. Oncology (Williston Park) 21(2 Suppl. 1): 13-17.
    • (2007) Oncology , vol.21 , Issue.2 SUPPL. 1 , pp. 13-17
    • Sterry, W.1
  • 15
    • 0037441884 scopus 로고    scopus 로고
    • Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas
    • DOI 10.1182/blood-2002-08-2434
    • Mao, X., G. Orchard, D. M. Lillington, R. Russell-Jones, B. D. Young, and S. J. Whittaker. 2003. Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas. Blood 101: 1513-1519. (Pubitemid 36182528)
    • (2003) Blood , vol.101 , Issue.4 , pp. 1513-1519
    • Mao, X.1    Orchard, G.2    Lillington, D.M.3    Russell-Jones, R.4    Young, B.D.5    Whittaker, S.J.6
  • 16
    • 0037531758 scopus 로고    scopus 로고
    • Expression of apoptosis regulators in cutaneous T-cell lymphoma (CTCL) cells
    • DOI 10.1002/path.1341
    • Zhang, C. L., J. Kamarashev, J. Z. Qin, G. Burg, R. Dummer, and U. Döbbeling. 2003. Expression of apoptosis regulators in cutaneous T-cell lymphoma (CTCL) cells. J. Pathol. 200: 249-254. (Pubitemid 36748034)
    • (2003) Journal of Pathology , vol.200 , Issue.2 , pp. 249-254
    • Zhang, C.-L.1    Kamarashev, J.2    Qin, J.-Z.3    Burg, G.4    Dummer, R.5    Dobbeling, U.6
  • 17
    • 27644535985 scopus 로고    scopus 로고
    • Immunotherapeutic strategies in acute lymphoblastic leukaemia relapsing after stem cell transplantation
    • DOI 10.1016/j.blre.2004.09.002, PII S0268960X04000517
    • Blair, A., N. J. Goulden, N. A. Libri, A. Oakhill, and D. H. Pamphilon. 2005. Immunotherapeutic strategies in acute lymphoblastic leukaemia relapsing after stem cell transplantation. Blood Rev. 19: 289-300. (Pubitemid 41571930)
    • (2005) Blood Reviews , vol.19 , Issue.6 , pp. 289-300
    • Blair, A.1    Goulden, N.J.2    Libri, N.A.3    Oakhill, A.4    Pamphilon, D.H.5
  • 18
    • 74049145806 scopus 로고    scopus 로고
    • Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia
    • Palomero, T., and A. Ferrando. 2009. Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia. Clin. Lymphoma Myeloma 9 (Suppl. 3): S205-S210.
    • (2009) Clin. Lymphoma Myeloma , vol.9 , Issue.SUPPL. 3
    • Palomero, T.1    Ferrando, A.2
  • 21
    • 25844450234 scopus 로고    scopus 로고
    • T cell-mediated graft-versus-leukemia reactions after allogeneic stem cell transplantation
    • DOI 10.1007/s00262-005-0681-6
    • Schetelig, J., A. Kiani, M. Schmitz, G. Ehninger, and M. Bornhäuser. 2005. T cell-mediated graft-versus-leukemia reactions after allogeneic stem cell transplantation. Cancer Immunol. Immunother. 54: 1043-1058. (Pubitemid 41396810)
    • (2005) Cancer Immunology, Immunotherapy , vol.54 , Issue.11 , pp. 1043-1058
    • Schetelig, J.1    Kiani, A.2    Schmitz, M.3    Ehninger, G.4    Bornhauser, M.5
  • 22
    • 41149109745 scopus 로고    scopus 로고
    • Signaling defects in anti-tumor T cells
    • DOI 10.1111/j.1600-065X.2008.00606.x
    • Frey, A. B., and N. Monu. 2008. Signaling defects in anti-tumor T cells. Immunol. Rev. 222: 192-205. (Pubitemid 351430368)
    • (2008) Immunological Reviews , vol.222 , Issue.1 , pp. 192-205
    • Frey, A.B.1    Monu, N.2
  • 25
    • 28344446374 scopus 로고    scopus 로고
    • A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis
    • DOI 10.1038/sj.onc.1208937, PII 1208937
    • Fang, W. B., D. M. Brantley-Sieders, M. A. Parker, A. D. Reith, and J. Chen. 2005. A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis. Oncogene 24: 7859-7868. (Pubitemid 41715192)
    • (2005) Oncogene , vol.24 , Issue.53 , pp. 7859-7868
    • Fang, W.B.1    Brantley-Sieders, D.M.2    Parker, M.A.3    Reith, A.D.4    Chen, J.5
  • 31
    • 77649114060 scopus 로고    scopus 로고
    • Eph receptors and ephrins in cancer: Bidirectional signalling and beyond
    • Pasquale, E. B. 2010. Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat. Rev. Cancer 10: 165-180.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 165-180
    • Pasquale, E.B.1
  • 33
    • 0029808699 scopus 로고    scopus 로고
    • Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments
    • Gale, N. W., A. Flenniken, D. C. Compton, N. Jenkins, N. G. Copeland, D. J. Gilbert, S. Davis, D. G. Wilkinson, and G. D. Yancopoulos. 1996. Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. Oncogene 13: 1343-1352. (Pubitemid 26343588)
    • (1996) Oncogene , vol.13 , Issue.6 , pp. 1343-1352
    • Gale, N.W.1    Flenniken, A.2    Compton, D.C.3    Jenkins, N.4    Copeland, N.G.5    Gilbert, D.J.6    Davis, S.7    Wilkinson, D.G.8    Yancopoulos, G.D.9
  • 34
    • 4644236647 scopus 로고    scopus 로고
    • Ephrins and their receptors: Binding versus biology
    • DOI 10.1080/15216540412331270076
    • Blits-Huizinga, C. T., C. M. Nelersa, A. Malhotra, and D. J. Liebl. 2004. Ephrins and their receptors: binding versus biology. IUBMB Life 56: 257-265. (Pubitemid 39272989)
    • (2004) IUBMB Life , vol.56 , Issue.5 , pp. 257-265
    • Blits-Huizinga, C.T.1    Nelersa, C.M.2    Malhotra, A.3    Liebl, D.J.4
  • 36
    • 73649128536 scopus 로고    scopus 로고
    • Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity
    • Qin, H., R. Noberini, X. Huan, J. Shi, E. B. Pasquale, and J. Song. 2010. Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity. J. Biol. Chem. 285: 644-654.
    • (2010) J. Biol. Chem. , vol.285 , pp. 644-654
    • Qin, H.1    Noberini, R.2    Huan, X.3    Shi, J.4    Pasquale, E.B.5    Song, J.6
  • 37
    • 0037040281 scopus 로고    scopus 로고
    • The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1
    • DOI 10.1074/jbc.M108011200
    • Freywald, A., N. Sharfe, and C. M. Roifman. 2002. The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. J. Biol. Chem. 277: 3823-3828. (Pubitemid 34968631)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.6 , pp. 3823-3828
    • Freywald, A.1    Sharfe, N.2    Roifman, C.M.3
  • 38
    • 0033956829 scopus 로고    scopus 로고
    • Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6
    • DOI 10.1016/S0014-5793(99)01793-7, PII S0014579399017937
    • Munthe, E., E. Rian, T. Holien, A. Rasmussen, F. O. Levy, and H. Aasheim. 2000. Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6. FEBS Lett. 466: 169-174. (Pubitemid 30050706)
    • (2000) FEBS Letters , vol.466 , Issue.1 , pp. 169-174
    • Munthe, E.1    Rian, E.2    Holien, T.3    Rasmussen, A.-M.4    Levy, F.O.5    Aasheim, H.-C.6
  • 39
    • 0036303033 scopus 로고    scopus 로고
    • Mechanisms and functions of Eph and ephrin signalling
    • DOI 10.1038/nrm856
    • Kullander, K., and R. Klein. 2002. Mechanisms and functions of Eph and ephrin signalling. Nat. Rev. Mol. Cell Biol. 3: 475-486. (Pubitemid 34733429)
    • (2002) Nature Reviews Molecular Cell Biology , vol.3 , Issue.7 , pp. 475-486
    • Kullander, K.1    Klein, R.2
  • 40
    • 35548948069 scopus 로고    scopus 로고
    • Cell-cell signaling via Eph receptors and ephrins
    • DOI 10.1016/j.ceb.2007.08.004, PII S0955067407001214, Cell to Cell Contact and Extracellular Matrix
    • Himanen, J. P., N. Saha, and D. B. Nikolov. 2007. Cell-cell signaling via Eph receptors and ephrins. Curr. Opin. Cell Biol. 19: 534-542. (Pubitemid 350016850)
    • (2007) Current Opinion in Cell Biology , vol.19 , Issue.5 , pp. 534-542
    • Himanen, J.-P.1    Saha, N.2    Nikolov, D.B.3
  • 41
    • 20344396123 scopus 로고    scopus 로고
    • Eph receptor signalling casts a wide net on cell behaviour
    • DOI 10.1038/nrm1662
    • Pasquale, E. B. 2005. Eph receptor signalling casts a wide net on cell behaviour. Nat. Rev. Mol. Cell Biol. 6: 462-475. (Pubitemid 40780558)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.6 , pp. 462-475
    • Pasquale, E.B.1
  • 42
    • 41149084179 scopus 로고    scopus 로고
    • Eph-Ephrin Bidirectional Signaling in Physiology and Disease
    • DOI 10.1016/j.cell.2008.03.011, PII S0092867408003863
    • Pasquale, E. B. 2008. Eph-ephrin bidirectional signaling in physiology and disease. Cell 133: 38-52. (Pubitemid 351442996)
    • (2008) Cell , vol.133 , Issue.1 , pp. 38-52
    • Pasquale, E.B.1
  • 43
    • 77957244402 scopus 로고    scopus 로고
    • Ephrins and Eph receptors in stem cells and cancer
    • Genander, M., and J. Frisén. 2010. Ephrins and Eph receptors in stem cells and cancer. Curr. Opin. Cell Biol. 22: 611-616.
    • (2010) Curr. Opin. Cell Biol. , vol.22 , pp. 611-616
    • Genander, M.1    Frisén, J.2
  • 44
    • 77950591484 scopus 로고    scopus 로고
    • Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia
    • Kuang, S. Q., H. Bai, Z. H. Fang, G. Lopez, H. Yang, W. Tong, Z. Z. Wang, and G. Garcia-Manero. 2010. Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia. Blood 115: 2412-2419.
    • (2010) Blood , vol.115 , pp. 2412-2419
    • Kuang, S.Q.1    Bai, H.2    Fang, Z.H.3    Lopez, G.4    Yang, H.5    Tong, W.6    Wang, Z.Z.7    Garcia-Manero, G.8
  • 45
    • 37349099726 scopus 로고    scopus 로고
    • EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions
    • DOI 10.1016/j.molimm.2007.09.019, PII S0161589007007717
    • Sharfe, N., M. Nikolic, L. Cimpeon, A. Van De Kratts, A. Freywald, and C. M. Roifman. 2008. EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions. Mol. Immunol. 45: 1208-1220. (Pubitemid 350299492)
    • (2008) Molecular Immunology , vol.45 , Issue.5 , pp. 1208-1220
    • Sharfe, N.1    Nikolic, M.2    Cimpeon, L.3    Van De, K.A.4    Freywald, A.5    Roifman, C.M.6
  • 46
    • 0037605875 scopus 로고    scopus 로고
    • Ephrin-A1 induces c-Cbl phosphorylation and Epha receptor down-regulation in T cells
    • Sharfe, N., A. Freywald, A. Toro, and C. M. Roifman. 2003. Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cells. J. Immunol. 170: 6024-6032. (Pubitemid 36682583)
    • (2003) Journal of Immunology , vol.170 , Issue.12 , pp. 6024-6032
    • Sharfe, N.1    Freywald, A.2    Toro, A.3    Roifman, C.M.4
  • 49
    • 17144449379 scopus 로고    scopus 로고
    • T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells
    • Shimoyama, M., H. Matsuoka, A. Tamekane, M. Ito, N. Iwata, R. Inoue, K. Chihara, A. Furuya, N. Hanai, and T. Matsui. 2000. T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells. Growth Factors 18: 63-78. (Pubitemid 30303655)
    • (2000) Growth Factors , vol.18 , Issue.1 , pp. 63-78
    • Shimoyama, M.1    Matsuoka, H.2    Tamekane, A.3    Ito, M.4    Nobuko, I.5    Inoue, R.6    Chihara, K.7    Furuya, A.8    Hanai, N.9    Matsui, T.10
  • 50
    • 0032891292 scopus 로고    scopus 로고
    • Expression of receptor tyrosine kinase HTK (hepatoma transmembrane kinase) and HTK ligand by human leukemia-lymphoma cell lines
    • Steube, K. G., C. Meyer, S. Habig, C. C. Uphoff, and H. G. Drexler. 1999. Expression of receptor tyrosine kinase HTK (hepatoma transmembrane kinase) and HTK ligand by human leukemia-lymphoma cell lines. Leuk. Lymphoma 33: 371-376. (Pubitemid 29196875)
    • (1999) Leukemia and Lymphoma , vol.33 , Issue.3-4 , pp. 371-376
    • Steube, K.G.1    Meyer, C.2    Habig, S.3    Uphoff, C.C.4    Drexler, H.G.5
  • 51
    • 40349085774 scopus 로고    scopus 로고
    • In human leukemia cells ephrin-B-induced invasive activity is supported by Lck and is associated with reassembling of lipid raft signaling complexes
    • DOI 10.1158/1541-7786.MCR-07-0047
    • Jiang, G., T. Freywald, J.Webster, D. Kozan, R. Geyer, J. DeCoteau, A. Narendran, and A. Freywald. 2008. In human leukemia cells ephrin-B-induced invasive activity is supported by Lck and is associated with reassembling of lipid raft signaling complexes. Mol. Cancer Res. 6: 291-305. (Pubitemid 351342417)
    • (2008) Molecular Cancer Research , vol.6 , Issue.2 , pp. 291-305
    • Jiang, G.1    Freywald, T.2    Webster, J.3    Kozan, D.4    Geyer, R.5    DeCoteau, J.6    Narendran, A.7    Freywald, A.8
  • 52
    • 73949090085 scopus 로고    scopus 로고
    • An impaired transendothelial migration potential of chronic lymphocytic leukemia (CLL) cells can be linked to ephrin-A4 expression
    • Trinidad, E. M., M. Ballesteros, J. Zuloaga, A. Zapata, and L. M. Alonso-Colmenar. 2009. An impaired transendothelial migration potential of chronic lymphocytic leukemia (CLL) cells can be linked to ephrin-A4 expression. Blood 114: 5081-5090.
    • (2009) Blood , vol.114 , pp. 5081-5090
    • Trinidad, E.M.1    Ballesteros, M.2    Zuloaga, J.3    Zapata, A.4    Alonso-Colmenar, L.M.5
  • 55
    • 23044489567 scopus 로고    scopus 로고
    • Recent advances on T-cell regulation by receptor tyrosine kinases
    • DOI 10.1097/01.moh.0000166497.26397.9f
    • Wu, J., and H. Luo. 2005. Recent advances on T-cell regulation by receptor tyrosine kinases. Curr. Opin. Hematol. 12: 292-297. (Pubitemid 41058393)
    • (2005) Current Opinion in Hematology , vol.12 , Issue.4 , pp. 292-297
    • Wu, J.1    Luo, H.2
  • 56
    • 0043074624 scopus 로고    scopus 로고
    • Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients
    • DOI 10.1002/art.11080
    • Luzina, I. G., S. P. Atamas, R. Wise, F. M. Wigley, J. Choi, H. Q. Xiao, and B. White. 2003. Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients. Arthritis Rheum. 48: 2262-2274. (Pubitemid 36959208)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.8 , pp. 2262-2274
    • Luzina, I.G.1    Atamas, S.P.2    Wise, R.3    Wigley, F.M.4    Choi, J.5    Xiao, H.Q.6    White, B.7
  • 59
    • 0042303323 scopus 로고    scopus 로고
    • The CD95 Type I/Type II model
    • DOI 10.1016/S1044-5323(03)00031-9
    • Barnhart, B. C., E. C. Alappat, and M. E. Peter. 2003. The CD95 type I/type II model. Semin. Immunol. 15: 185-193. (Pubitemid 38155825)
    • (2003) Seminars in Immunology , vol.15 , Issue.3 , pp. 185-193
    • Barnhart, B.C.1    Alappat, E.C.2    Peter, M.E.3
  • 60
    • 2442419137 scopus 로고    scopus 로고
    • Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application
    • DOI 10.1016/j.bbrc.2004.04.102, PII S0006291X04008575
    • Fox, B. P., and R. P. Kandpal. 2004. Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application. Biochem. Biophys. Res. Commun. 318: 882-892. (Pubitemid 38625856)
    • (2004) Biochemical and Biophysical Research Communications , vol.318 , Issue.4 , pp. 882-892
    • Fox, B.P.1    Kandpal, R.P.2
  • 61
    • 29244470819 scopus 로고    scopus 로고
    • Transcriptional silencing of EphB6 receptor tyrosine kinase in invasive breast carcinoma cells and detection of methylated promoter by methylation specific PCR
    • DOI 10.1016/j.bbrc.2005.11.174, PII S0006291X05027270
    • Fox, B. P., and R. P. Kandpal. 2006. Transcriptional silencing of EphB6 receptor tyrosine kinase in invasive breast carcinoma cells and detection of methylated promoter by methylation specific PCR. Biochem. Biophys. Res. Commun. 340: 268-276. (Pubitemid 41827676)
    • (2006) Biochemical and Biophysical Research Communications , vol.340 , Issue.1 , pp. 268-276
    • Fox, B.P.1    Kandpal, R.P.2
  • 62
    • 73949119120 scopus 로고    scopus 로고
    • Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: The therapeutic potential of Akt inhibition
    • Zhuang, J., S. F. Hawkins, M. A. Glenn, K. Lin, G. G. Johnson, A. Carter, J. C. Cawley, and A. R. Pettitt. 2010. Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition. Haematologica 95: 110-118.
    • (2010) Haematologica , vol.95 , pp. 110-118
    • Zhuang, J.1    Hawkins, S.F.2    Glenn, M.A.3    Lin, K.4    Johnson, G.G.5    Carter, A.6    Cawley, J.C.7    Pettitt, A.R.8
  • 63
    • 33746046785 scopus 로고    scopus 로고
    • Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways
    • DOI 10.1158/1535-7163.MCT-06-0076
    • Nyåkern, M., A. Cappellini, I. Mantovani, and A. M. Martelli. 2006. Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways. Mol. Cancer Ther. 5: 1559-1570. (Pubitemid 44070493)
    • (2006) Molecular Cancer Therapeutics , vol.5 , Issue.6 , pp. 1559-1570
    • Nyakern, M.1    Cappellini, A.2    Mantovani, I.3    Martelli, A.M.4
  • 64
    • 0038514192 scopus 로고    scopus 로고
    • Combined action of ERK and NFkappaB mediates the protective effect of phorbol ester on Fas-induced apoptosis in Jurkat cells
    • DOI 10.1074/jbc.M211556200
    • Engedal, N., and H. K. Blomhoff. 2003. Combined action of ERK and NF kappa B mediates the protective effect of phorbol ester on Fas-induced apoptosis in Jurkat cells. J. Biol. Chem. 278: 10934-10941. (Pubitemid 36792640)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.13 , pp. 10934-10941
    • Engedal, N.1    Blomhoff, H.K.2
  • 65
    • 54249110423 scopus 로고    scopus 로고
    • Dual acylation and lipid raft association of Src-family protein tyrosine kinases are required for SDF-1/ CXCL12-mediated chemotaxis in the Jurkat human T cell lymphoma cell line
    • Zaman, S. N., M. E. Resek, and S. M. Robbins. 2008. Dual acylation and lipid raft association of Src-family protein tyrosine kinases are required for SDF-1/ CXCL12-mediated chemotaxis in the Jurkat human T cell lymphoma cell line. J. Leukoc. Biol. 84: 1082-1091.
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 1082-1091
    • Zaman, S.N.1    Resek, M.E.2    Robbins, S.M.3
  • 70
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • DOI 10.1126/science.1106148
    • Sarbassov, D. D., D. A. Guertin, S. M. Ali, and D. M. Sabatini. 2005. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101. (Pubitemid 40262113)
    • (2005) Science , vol.307 , Issue.5712 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 71
    • 0037902498 scopus 로고    scopus 로고
    • + T cells
    • DOI 10.1034/j.1600-065X.2003.00019.x
    • Rincón, M., and G. Pedraza-Alva. 2003. JNK and p38 MAP kinases in CD4+ and CD8+ T cells. Immunol. Rev. 192: 131-142. (Pubitemid 36613329)
    • (2003) Immunological Reviews , vol.192 , pp. 131-142
    • Rincon, M.1    Pedraza-Alva, G.2
  • 72
    • 34648846176 scopus 로고    scopus 로고
    • Apoptosis during negative selection of autoreactive thymocytes
    • DOI 10.1016/j.coi.2007.06.001, PII S0952791507001045, Hematopoietic cell death/Immunogenetics/Transplantation
    • Sohn, S. J., J. Thompson, and A. Winoto. 2007. Apoptosis during negative selection of autoreactive thymocytes. Curr. Opin. Immunol. 19: 510-515. (Pubitemid 47464913)
    • (2007) Current Opinion in Immunology , vol.19 , Issue.5 , pp. 510-515
    • Sohn, S.J.1    Thompson, J.2    Winoto, A.3
  • 73
    • 0038004740 scopus 로고    scopus 로고
    • Targeting JNK for therapeutic benefit: From junk to gold?
    • DOI 10.1038/nrd1132
    • Manning, A. M., and R. J. Davis. 2003. Targeting JNK for therapeutic benefit: from junk to gold? Nat. Rev. Drug Discov. 2: 554-565. (Pubitemid 37361747)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.7 , pp. 554-565
    • Manning, A.M.1    Davis, R.J.2
  • 74
    • 0037307095 scopus 로고    scopus 로고
    • The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation
    • DOI 10.1034/j.1600-065X.2003.00015.x
    • Zamoyska, R., A. Basson, A. Filby, G. Legname, M. Lovatt, and B. Seddon. 2003. The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation. Immunol. Rev. 191: 107-118. (Pubitemid 36398852)
    • (2003) Immunological Reviews , vol.191 , pp. 107-118
    • Zamoyska, R.1    Basson, A.2    Filby, A.3    Legname, G.4    Lovatt, M.5    Seddon, B.6
  • 75
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • DOI 10.1038/378785a0
    • Cross, D. A., D. R. Alessi, P. Cohen, M. Andjelkovich, and B. A. Hemmings. 1995. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789. (Pubitemid 26004411)
    • (1995) Nature , vol.378 , Issue.6559 , pp. 785-789
    • Cross, D.A.E.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 76
    • 77953966202 scopus 로고    scopus 로고
    • Activation of EphA receptors on CD4+CD45RO+ memory cells stimulates migration
    • Holen, H. L., K. Nustad, and H. C. Aasheim. 2010. Activation of EphA receptors on CD4+CD45RO+ memory cells stimulates migration. J. Leukoc. Biol. 87: 1059-1068.
    • (2010) J. Leukoc. Biol. , vol.87 , pp. 1059-1068
    • Holen, H.L.1    Nustad, K.2    Aasheim, H.C.3
  • 77
    • 0036800761 scopus 로고    scopus 로고
    • EphB6 crosslinking results in costimulation of T cells
    • DOI 10.1172/JCI200215883
    • Luo, H., G. Yu, Y. Wu, and J. Wu. 2002. EphB6 crosslinking results in costimulation of T cells. J. Clin. Invest. 110: 1141-1150. (Pubitemid 35215895)
    • (2002) Journal of Clinical Investigation , vol.110 , Issue.8 , pp. 1141-1150
    • Luo, H.1    Yu, G.2    Wu, Y.3    Wu, J.4
  • 78
    • 0029780534 scopus 로고    scopus 로고
    • A new member of the Eph family of receptors that lacks protein tyrosine kinase activity
    • Gurniak, C. B., and L. J. Berg. 1996. A new member of the Eph family of receptors that lacks protein tyrosine kinase activity. Oncogene 13: 777-786. (Pubitemid 26312905)
    • (1996) Oncogene , vol.13 , Issue.4 , pp. 777-786
    • Gurniak, C.B.1    Berg, L.J.2
  • 80
    • 76249132650 scopus 로고    scopus 로고
    • The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells
    • Truitt, L., T. Freywald, J. DeCoteau, N. Sharfe, and A. Freywald. 2010. The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells. Cancer Res. 70: 1141-1153.
    • (2010) Cancer Res. , vol.70 , pp. 1141-1153
    • Truitt, L.1    Freywald, T.2    DeCoteau, J.3    Sharfe, N.4    Freywald, A.5
  • 81
    • 77957783252 scopus 로고    scopus 로고
    • Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells
    • Yang, N. Y., C. Fernandez, M. Richter, Z. Xiao, F. Valencia, D. A. Tice, and E. B. Pasquale. 2011. Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells. Cell Signal 23: 201-212.
    • (2011) Cell Signal , vol.23 , pp. 201-212
    • Yang, N.Y.1    Fernandez, C.2    Richter, M.3    Xiao, Z.4    Valencia, F.5    Tice, D.A.6    Pasquale, E.B.7
  • 82
    • 39049148397 scopus 로고    scopus 로고
    • Cellular FLICE-like inhibitory protein (C-FLIP): A novel target for cancer therapy
    • DOI 10.2174/156800908783497087
    • Safa, A. R., T. W. Day, and C. H. Wu. 2008. Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy. Curr. Cancer Drug Targets 8: 37-46. (Pubitemid 351237908)
    • (2008) Current Cancer Drug Targets , vol.8 , Issue.1 , pp. 37-46
    • Safa, A.R.1    Day, T.W.2    Wu, C.-H.3
  • 83
    • 79951516547 scopus 로고    scopus 로고
    • Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia
    • Paganin, M., and A. Ferrando. 2011. Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia. Blood Rev. 25: 83-90.
    • (2011) Blood Rev. , vol.25 , pp. 83-90
    • Paganin, M.1    Ferrando, A.2
  • 84
    • 69349095364 scopus 로고    scopus 로고
    • Anticancer strategies involving the vasculature
    • Heath, V. L., and R. Bicknell. 2009. Anticancer strategies involving the vasculature. Nat. Rev. Clin. Oncol. 6: 395-404.
    • (2009) Nat. Rev. Clin. Oncol. , vol.6 , pp. 395-404
    • Heath, V.L.1    Bicknell, R.2
  • 85
    • 76449104021 scopus 로고    scopus 로고
    • Molecular predictors of response to trastuzumab and lapatinib in breast cancer
    • Esteva, F. J., D. Yu, M. C. Hung, and G. N. Hortobagyi. 2010. Molecular predictors of response to trastuzumab and lapatinib in breast cancer. Nat. Rev. Clin. Oncol. 7: 98-107.
    • (2010) Nat. Rev. Clin. Oncol. , vol.7 , pp. 98-107
    • Esteva, F.J.1    Yu, D.2    Hung, M.C.3    Hortobagyi, G.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.