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Volumn 4, Issue 5, 2006, Pages 395-405

New insights into the molecular biology and targeted therapy of cutaneous T-cell lymphomas;Neues zur molekularbiologie und zielgerichteten therapie des kutanen T-zell lymphoms

Author keywords

Cutaneous T cell lymphoma; Mycosis fungoides; S zary syndrome; Therapy; Tumor biology

Indexed keywords

ALEMTUZUMAB; BEXAROTENE; CD40 LIGAND; CHEMOKINE RECEPTOR CCR10; CHEMOKINE RECEPTOR CCR4; CYTOKINE; DENILEUKIN DIFTITOX; DNA; FAS ANTIGEN; FR 901228; GAMMA INTERFERON; HISTONE DEACETYLASE INHIBITOR; IMIQUIMOD; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 2; INTERLEUKIN 10; INTERLEUKIN 12; MONOCLONAL ANTIBODY; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1; STAT3 PROTEIN; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZANOLIMUMAB;

EID: 33646587683     PISSN: 16100379     EISSN: 16100387     Source Type: Journal    
DOI: 10.1111/j.1610-0387.2006.05982.x     Document Type: Review
Times cited : (22)

References (90)
  • 4
    • 1542615639 scopus 로고    scopus 로고
    • Immune surveillance in the skin: Mechanisms and clinical consequences
    • Kupper TS, Fuhlbrigge RC. Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol 2004; 4: 211-222.
    • (2004) Nat Rev Immunol , vol.4 , pp. 211-222
    • Kupper, T.S.1    Fuhlbrigge, R.C.2
  • 6
    • 20044391410 scopus 로고    scopus 로고
    • Circulating clonal CLA(+) and CD4(+) T cells in Sezary syndrome express the skin-homing chemokine receptors CCR4 and CCR10 as well as the lymph node-homing chemokine receptor CCR7
    • Sokolowska-Wojdylo M, Wenzel J, Gaffal E, Lenz J, Speuser P, Erdmann S, Abuzahra F, Bowman E, Roszkiewicz J, Bieber T, Tuting T. Circulating clonal CLA(+) and CD4(+) T cells in Sezary syndrome express the skin-homing chemokine receptors CCR4 and CCR10 as well as the lymph node-homing chemokine receptor CCR7. Br J Dermatol 2005; 152: 258-264.
    • (2005) Br J Dermatol , vol.152 , pp. 258-264
    • Sokolowska-Wojdylo, M.1    Wenzel, J.2    Gaffal, E.3    Lenz, J.4    Speuser, P.5    Erdmann, S.6    Abuzahra, F.7    Bowman, E.8    Roszkiewicz, J.9    Bieber, T.10    Tuting, T.11
  • 9
    • 0036069926 scopus 로고    scopus 로고
    • Clonal T cell receptor gamma-chain gene rearrangement by PCR-based GeneScan analysis in the skin and blood of patients with parapsoriasis and early-stage mycosis fungoides
    • Klemke CD, Dippel E, Dembinski A, Ponitz N, Assaf C, Hummel M, Stein H, Goerdt S. Clonal T cell receptor gamma-chain gene rearrangement by PCR-based GeneScan analysis in the skin and blood of patients with parapsoriasis and early-stage mycosis fungoides. J Pathol 2002; 197: 348-354.
    • (2002) J Pathol , vol.197 , pp. 348-354
    • Klemke, C.D.1    Dippel, E.2    Dembinski, A.3    Ponitz, N.4    Assaf, C.5    Hummel, M.6    Stein, H.7    Goerdt, S.8
  • 12
    • 11244307997 scopus 로고    scopus 로고
    • Early TCR-beta and TCR-gamma PCR detection of T-cell clonality indicates minimal tumor disease in lymph nodes of cutaneous T-cell lymphoma: Diagnostic and prognostic implications
    • Assaf C, Hummel M, Steinhoff M, Geilen CC, Orawa H, Stein H, Orfanos CE. Early TCR-beta and TCR-gamma PCR detection of T-cell clonality indicates minimal tumor disease in lymph nodes of cutaneous T-cell lymphoma: diagnostic and prognostic implications. Blood 2005; 105: 503-510.
    • (2005) Blood , vol.105 , pp. 503-510
    • Assaf, C.1    Hummel, M.2    Steinhoff, M.3    Geilen, C.C.4    Orawa, H.5    Stein, H.6    Orfanos, C.E.7
  • 13
    • 0038465916 scopus 로고    scopus 로고
    • Molecular immunoglobulin/T- cell receptor clonality analysis in cutaneous lymphoproliferations. Experience with the BIOMED-2 standardized polymerase chain reaction protocol
    • Sandberg Y, Heule F, Lam K, Lugtenburg PJ, Wolvers-Tettero IL, van Dongen JJ, Langerak AW. Molecular immunoglobulin/T- cell receptor clonality analysis in cutaneous lymphoproliferations. Experience with the BIOMED-2 standardized polymerase chain reaction protocol. Haematologica 2003; 88: 659-670.
    • (2003) Haematologica , vol.88 , pp. 659-670
    • Sandberg, Y.1    Heule, F.2    Lam, K.3    Lugtenburg, P.J.4    Wolvers-Tettero, I.L.5    Van Dongen, J.J.6    Langerak, A.W.7
  • 15
    • 10044282950 scopus 로고    scopus 로고
    • Assessment of T-cell clonality via T-cell receptor-gamma rearrangements in cutaneous T-cell-dominant infiltrates using polymerase chain reaction and single-stranded DNA conformational polymorphism assay
    • Chen M, Deng A, Crowson AN, Srinivasan M, Yearsley KH, Jewell S, Morrison C, Long S, Werling R, Magro C. Assessment of T-cell clonality via T-cell receptor-gamma rearrangements in cutaneous T-cell-dominant infiltrates using polymerase chain reaction and single-stranded DNA conformational polymorphism assay. Appl Immunohistochem Mol Morphol 2004; 12: 373-379.
    • (2004) Appl Immunohistochem Mol Morphol , vol.12 , pp. 373-379
    • Chen, M.1    Deng, A.2    Crowson, A.N.3    Srinivasan, M.4    Yearsley, K.H.5    Jewell, S.6    Morrison, C.7    Long, S.8    Werling, R.9    Magro, C.10
  • 16
    • 11144233984 scopus 로고    scopus 로고
    • Impaired CD40L signaling is a cause of defective IL-12 and TNF-alpha production in Sezary syndrome: Circumvention by hexameric soluble CD40L
    • French LE, Huard B, Wysocka M, Shane R, Contassot E, Arrighi JF, Piguet V, Calderara S, Rook AH. Impaired CD40L signaling is a cause of defective IL-12 and TNF-alpha production in Sezary syndrome: circumvention by hexameric soluble CD40L. Blood 2005; 105: 219-225.
    • (2005) Blood , vol.105 , pp. 219-225
    • French, L.E.1    Huard, B.2    Wysocka, M.3    Shane, R.4    Contassot, E.5    Arrighi, J.F.6    Piguet, V.7    Calderara, S.8    Rook, A.H.9
  • 20
    • 18644372264 scopus 로고    scopus 로고
    • Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigen-specific regulatory T cells
    • Maeda A, Schwarz A, Kernebeck K, Gross N, Aragane Y, Peritt D, Schwarz T. Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigen-specific regulatory T cells. J Immunol 2005; 174: 5968-5976.
    • (2005) J Immunol , vol.174 , pp. 5968-5976
    • Maeda, A.1    Schwarz, A.2    Kernebeck, K.3    Gross, N.4    Aragane, Y.5    Peritt, D.6    Schwarz, T.7
  • 22
    • 0034904078 scopus 로고    scopus 로고
    • Complete molecular remission during biologic response modifier therapy for Sezary syndrome is associated with enhanced helper T type 1 cytokine production and natural killer cell activity
    • Yoo EK, Cassin M, Lessin SR, Rook AH. Complete molecular remission during biologic response modifier therapy for Sezary syndrome is associated with enhanced helper T type 1 cytokine production and natural killer cell activity. J Am Acad Dermatol 2001; 45: 208-216.
    • (2001) J Am Acad Dermatol , vol.45 , pp. 208-216
    • Yoo, E.K.1    Cassin, M.2    Lessin, S.R.3    Rook, A.H.4
  • 23
    • 0037240524 scopus 로고    scopus 로고
    • Chromosomal abnormalities in relation to clinical disease in patients with cutaneous T-cell lymphoma: A 5-year follow-up study
    • Karenko L, Sarna S, Kahkonen M, Ranki A. Chromosomal abnormalities in relation to clinical disease in patients with cutaneous T-cell lymphoma: a 5-year follow-up study. Br J Dermatol 2003; 148: 55-64.
    • (2003) Br J Dermatol , vol.148 , pp. 55-64
    • Karenko, L.1    Sarna, S.2    Kahkonen, M.3    Ranki, A.4
  • 25
    • 4344715771 scopus 로고    scopus 로고
    • Multilineage progression of genetically unstable tumor subclones in cutaneous T-cell lymphoma
    • Rubben A, Kempf W, Kadin ME, Zimmermann DR, Burg G. Multilineage progression of genetically unstable tumor subclones in cutaneous T-cell lymphoma. Exp Dermatol 2004; 13: 472-483.
    • (2004) Exp Dermatol , vol.13 , pp. 472-483
    • Rubben, A.1    Kempf, W.2    Kadin, M.E.3    Zimmermann, D.R.4    Burg, G.5
  • 27
    • 0034803338 scopus 로고    scopus 로고
    • Shortened telomere length is demonstrated in T-cell subsets together with a pronounced increased telomerase activity in CD4 positive T cells from blood of patients with mycosis fungoides and parapsoriasis
    • Wu KD, Hansen ER. Shortened telomere length is demonstrated in T-cell subsets together with a pronounced increased telomerase activity in CD4 positive T cells from blood of patients with mycosis fungoides and parapsoriasis. Exp Dermatol 2001; 10: 329-336.
    • (2001) Exp Dermatol , vol.10 , pp. 329-336
    • Wu, K.D.1    Hansen, E.R.2
  • 29
    • 0033842372 scopus 로고    scopus 로고
    • Expression of Fas and Fas-ligand in primary cutaneous T-cell lymphoma (CTCL): Association between lack of Fas expression and aggressive types of CTCL
    • Zoi-Toli O, Vermeer MH, De Vries E, Van Beek P, Meijer CJ, Willemze R. Expression of Fas and Fas-ligand in primary cutaneous T-cell lymphoma (CTCL): association between lack of Fas expression and aggressive types of CTCL. Br J Dermatol 2000; 143: 313-319.
    • (2000) Br J Dermatol , vol.143 , pp. 313-319
    • Zoi-Toli, O.1    Vermeer, M.H.2    De Vries, E.3    Van Beek, P.4    Meijer, C.J.5    Willemze, R.6
  • 30
    • 0035725520 scopus 로고    scopus 로고
    • Decreased expression of fas (APO-1/CD95) on lesional CD4+ T lymphocytes in cutaneous T cell lymphomas: Correlations with blood data
    • Dereure O, Portales P, Clot J, Guilhou JJ. Decreased expression of fas (APO-1/CD95) on lesional CD4+ T lymphocytes in cutaneous T cell lymphomas: correlations with blood data. Br J Dermatol 2001; 145: 1031-1032.
    • (2001) Br J Dermatol , vol.145 , pp. 1031-1032
    • Dereure, O.1    Portales, P.2    Clot, J.3    Guilhou, J.J.4
  • 31
    • 0036280764 scopus 로고    scopus 로고
    • Infrequent Fas mutations but no Bax or p53 mutations in early mycosis fungoides: A possible mechanism for the accumulation of malignant T lymphocytes in the skin
    • Dereure O, Levi E, Vonderheid EC, Kadin ME. Infrequent Fas mutations but no Bax or p53 mutations in early mycosis fungoides: a possible mechanism for the accumulation of malignant T lymphocytes in the skin. J Invest Dermatol 2002; 118: 949-956.
    • (2002) J Invest Dermatol , vol.118 , pp. 949-956
    • Dereure, O.1    Levi, E.2    Vonderheid, E.C.3    Kadin, M.E.4
  • 33
    • 0037531758 scopus 로고    scopus 로고
    • Expression of apoptosis regulators in cutaneous T-cell lymphoma (CTCL) cells
    • Zhang CL, Kamarashev J, Qin JZ, Burg G, Dummer R, Dobbeling U. Expression of apoptosis regulators in cutaneous T-cell lymphoma (CTCL) cells. J Pathol 2003; 200: 249-254.
    • (2003) J Pathol , vol.200 , pp. 249-254
    • Zhang, C.L.1    Kamarashev, J.2    Qin, J.Z.3    Burg, G.4    Dummer, R.5    Dobbeling, U.6
  • 34
    • 0036682999 scopus 로고    scopus 로고
    • Engagement of ILT2/CD85j in Sezary syndrome cells inhibits their CD3/TCR signaling
    • Nikolova M, Musette P, Bagot M, Boumsell L, Bensussan A. Engagement of ILT2/CD85j in Sezary syndrome cells inhibits their CD3/TCR signaling. Blood 2002; 100: 1019-1025.
    • (2002) Blood , vol.100 , pp. 1019-1025
    • Nikolova, M.1    Musette, P.2    Bagot, M.3    Boumsell, L.4    Bensussan, A.5
  • 35
    • 16844371989 scopus 로고    scopus 로고
    • Resistance to activation-induced cell death and bystander cytotoxiciry via the Fas/Fas ligand pathway are implicated in the pathogenesis of cutaneous T cell lymphomas
    • Ni X, Zhang C, Talpur R, Duvic M. Resistance to activation-induced cell death and bystander cytotoxiciry via the Fas/Fas ligand pathway are implicated in the pathogenesis of cutaneous T cell lymphomas. J Invest Dermatol 2005; 124: 741-750.
    • (2005) J Invest Dermatol , vol.124 , pp. 741-750
    • Ni, X.1    Zhang, C.2    Talpur, R.3    Duvic, M.4
  • 36
    • 0035576116 scopus 로고    scopus 로고
    • CD8+ T cells in cutaneous T-cell lymphoma: Expression of cytotoxic proteins, Fas Ligand, and killing inhibitory receptors and their relationship with clinical behavior
    • Vermeer MH, van Doorn R, Dukers D, Bekkenk MW, Meijer CJ, Willemze R. CD8+ T cells in cutaneous T-cell lymphoma: expression of cytotoxic proteins, Fas Ligand, and killing inhibitory receptors and their relationship with clinical behavior. J Clin Oncol 2001; 19: 4322-4329.
    • (2001) J Clin Oncol , vol.19 , pp. 4322-4329
    • Vermeer, M.H.1    Van Doorn, R.2    Dukers, D.3    Bekkenk, M.W.4    Meijer, C.J.5    Willemze, R.6
  • 37
    • 0035138935 scopus 로고    scopus 로고
    • Dermal fibroblasts sustain proliferation of activated T cells via membrane-bound interleukin-15 upon long-term stimulation with tumor necrosis factor-alpha
    • Rappl G, Kapsokefalou A, Heuser C, Rossler M, Ugurel S, Tilgen W, Reinhold U, Abken H. Dermal fibroblasts sustain proliferation of activated T cells via membrane-bound interleukin-15 upon long-term stimulation with tumor necrosis factor-alpha. J Invest Dermatol 2001; 116: 102-109.
    • (2001) J Invest Dermatol , vol.116 , pp. 102-109
    • Rappl, G.1    Kapsokefalou, A.2    Heuser, C.3    Rossler, M.4    Ugurel, S.5    Tilgen, W.6    Reinhold, U.7    Abken, H.8
  • 38
    • 0034744479 scopus 로고    scopus 로고
    • The CD7(-) subset of CD4(+) memory T cells is prone to accelerated apoptosis that is prevented by interleukin-15 (IL-15)
    • Rappl G, Abken H, Hasselmann DO, Tilgen W, Ugurel S, Reinhold U. The CD7(-) subset of CD4(+) memory T cells is prone to accelerated apoptosis that is prevented by interleukin-15 (IL-15). Cell Death Differ 2001; 8: 395-402.
    • (2001) Cell Death Differ , vol.8 , pp. 395-402
    • Rappl, G.1    Abken, H.2    Hasselmann, D.O.3    Tilgen, W.4    Ugurel, S.5    Reinhold, U.6
  • 44
    • 33644755512 scopus 로고    scopus 로고
    • Down-regulating Constitutive Activation of the NFκB Canonical Pathway Overcomes the Resistance of Cutaneous T cell Lymphoma to Apoptosis
    • Sors A, Jean-Louis F, Pellet C, Laroche L, Dubertret L, Courtois G, Bachelez H, Michel L. Down-regulating Constitutive Activation of the NFκB Canonical Pathway Overcomes the Resistance of Cutaneous T cell Lymphoma to Apoptosis. Blood 2005; 107: 2354-63.
    • (2005) Blood , vol.107 , pp. 2354-2363
    • Sors, A.1    Jean-Louis, F.2    Pellet, C.3    Laroche, L.4    Dubertret, L.5    Courtois, G.6    Bachelez, H.7    Michel, L.8
  • 46
    • 0042744782 scopus 로고    scopus 로고
    • Mycosis fungoides shows concurrent deregulation of multiple genes involved in the TNF signaling pathway: An expression profile study
    • Tracey L, Villuendas R, Dotor AM, Spiteri I, Ortiz P, Garcia JF, Peralto JL, Lawler M, Piris MA. Mycosis fungoides shows concurrent deregulation of multiple genes involved in the TNF signaling pathway: an expression profile study. Blood 2003; 102: 1042-1050.
    • (2003) Blood , vol.102 , pp. 1042-1050
    • Tracey, L.1    Villuendas, R.2    Dotor, A.M.3    Spiteri, I.4    Ortiz, P.5    Garcia, J.F.6    Peralto, J.L.7    Lawler, M.8    Piris, M.A.9
  • 47
    • 4143079424 scopus 로고    scopus 로고
    • Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sezary syndrome identified by gene expression analysis
    • van Doorn R, Dijkman R, Vermeer MH, Out-Luiting JJ, van der Raaij-Helmer EM, Willemze R, Tensen CP. Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sezary syndrome identified by gene expression analysis. Cancer Res 2004; 64: 5578-5586.
    • (2004) Cancer Res , vol.64 , pp. 5578-5586
    • Van Doorn, R.1    Dijkman, R.2    Vermeer, M.H.3    Out-Luiting, J.J.4    Van Der Raaij-Helmer, E.M.5    Willemze, R.6    Tensen, C.P.7
  • 48
    • 0032897317 scopus 로고    scopus 로고
    • Retinoids synergize with interleukin-2 to augment IFN-gamma and interleukin-12 production by human peripheral blood mononuclear cells
    • Fox FE, Kubin M, Cassin M, Niu Z, Trinchieri G, Cooper KD, Rook AH. Retinoids synergize with interleukin-2 to augment IFN-gamma and interleukin-12 production by human peripheral blood mononuclear cells. J Interferon Cytokine Res 1999; 19: 407-415.
    • (1999) J Interferon Cytokine Res , vol.19 , pp. 407-415
    • Fox, F.E.1    Kubin, M.2    Cassin, M.3    Niu, Z.4    Trinchieri, G.5    Cooper, K.D.6    Rook, A.H.7
  • 50
    • 0034999546 scopus 로고    scopus 로고
    • Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma
    • Duvic M, Martin AG, Kim Y, Olsen E, Wood GS, Crowley CA, Yocum RC. Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma. Arch Dermatol 2001; 137: 581-593.
    • (2001) Arch Dermatol , vol.137 , pp. 581-593
    • Duvic, M.1    Martin, A.G.2    Kim, Y.3    Olsen, E.4    Wood, G.S.5    Crowley, C.A.6    Yocum, R.C.7
  • 51
    • 0035340844 scopus 로고    scopus 로고
    • Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: Multinational phase II-III trial results
    • Duvic M, Hymes K, Heald P, Breneman D, Martin AG, Myskowski P, Crowley C, Yocum RC. Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: multinational phase II-III trial results. J Clin Oncol 2001; 19: 2456-2471.
    • (2001) J Clin Oncol , vol.19 , pp. 2456-2471
    • Duvic, M.1    Hymes, K.2    Heald, P.3    Breneman, D.4    Martin, A.G.5    Myskowski, P.6    Crowley, C.7    Yocum, R.C.8
  • 53
    • 0036124124 scopus 로고    scopus 로고
    • Phase 1 and 2 trial of bexarotene gel for skin-directed treatment of patients with cutaneous T-cell lymphoma
    • Breneman D, Duvic M, Kuzel T, Yocum R, Truglia J, Stevens VJ. Phase 1 and 2 trial of bexarotene gel for skin-directed treatment of patients with cutaneous T-cell lymphoma. Arch Dermatol 2002; 138: 325-332.
    • (2002) Arch Dermatol , vol.138 , pp. 325-332
    • Breneman, D.1    Duvic, M.2    Kuzel, T.3    Yocum, R.4    Truglia, J.5    Stevens, V.J.6
  • 54
    • 0027394657 scopus 로고
    • The IL-2/IL-2 receptor system: A current overview
    • Taniguchi T, Minami Y. The IL-2/IL-2 receptor system: a current overview. Cell 1993; 73: 5-8.
    • (1993) Cell , vol.73 , pp. 5-8
    • Taniguchi, T.1    Minami, Y.2
  • 55
  • 56
    • 4143089253 scopus 로고    scopus 로고
    • Degree of CD25 expression in T-cell lymphoma is dependent on tissue site: Implications for targeted therapy
    • Jones D, Ibrahim S, Patel K, Luthra R, Duvic M, Medeiros LJ. Degree of CD25 expression in T-cell lymphoma is dependent on tissue site: implications for targeted therapy. Clin Cancer Res 2004; 10: 5587-5594.
    • (2004) Clin Cancer Res , vol.10 , pp. 5587-5594
    • Jones, D.1    Ibrahim, S.2    Patel, K.3    Luthra, R.4    Duvic, M.5    Medeiros, L.J.6
  • 57
    • 0028361965 scopus 로고
    • Differential expression of interleukin-2 receptors (alpha and beta chain) in mature lymphoid neoplasms
    • Nakase K, Kita K, Nasu K, Ueda T, Tanaka I, Shirakawa S, Tsudo M. Differential expression of interleukin-2 receptors (alpha and beta chain) in mature lymphoid neoplasms. Am J Hematol 1994; 46: 179-183.
    • (1994) Am J Hematol , vol.46 , pp. 179-183
    • Nakase, K.1    Kita, K.2    Nasu, K.3    Ueda, T.4    Tanaka, I.5    Shirakawa, S.6    Tsudo, M.7
  • 58
    • 0035017383 scopus 로고    scopus 로고
    • Constitutive STAT3-activation in Sezary syndrome: Tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells
    • Eriksen KW, Kaltoft K, Mikkelsen G, Nielsen M, Zhang Q, Geisler C, Nissen MH, Ropke C, Wasik MA, Odum N. Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells. Leukemia 2001; 15: 787-793.
    • (2001) Leukemia , vol.15 , pp. 787-793
    • Eriksen, K.W.1    Kaltoft, K.2    Mikkelsen, G.3    Nielsen, M.4    Zhang, Q.5    Geisler, C.6    Nissen, M.H.7    Ropke, C.8    Wasik, M.A.9    Odum, N.10
  • 61
    • 0346367061 scopus 로고    scopus 로고
    • Interleukin-2 receptor-directed therapies for cutaneous lymphomas
    • Foss FM, Waldmann TA. Interleukin-2 receptor-directed therapies for cutaneous lymphomas. Hematol Oncol Clin North Am 2003; 17: 1449-1458.
    • (2003) Hematol Oncol Clin North Am , vol.17 , pp. 1449-1458
    • Foss, F.M.1    Waldmann, T.A.2
  • 62
    • 22144495793 scopus 로고    scopus 로고
    • A phase-1 trial of bexarotene and denileukin diftitox in patients with relapsed or refractory cutaneous T-cell lymphoma
    • Foss F, Demierre MF, DiVenuti G. A phase-1 trial of bexarotene and denileukin diftitox in patients with relapsed or refractory cutaneous T-cell lymphoma. Blood 2005; 106: 454-457.
    • (2005) Blood , vol.106 , pp. 454-457
    • Foss, F.1    Demierre, M.F.2    DiVenuti, G.3
  • 63
    • 4644237391 scopus 로고    scopus 로고
    • Alemtuzumab in peripheral T-cell malignancies
    • Dearden C. Alemtuzumab in peripheral T-cell malignancies. Cancer Biother Radiopharm 2004; 19: 391-398.
    • (2004) Cancer Biother Radiopharm , vol.19 , pp. 391-398
    • Dearden, C.1
  • 64
    • 24344497929 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of leukaemias and lymphomas
    • Jacobs SA, Foon KA. Monoclonal antibody therapy of leukaemias and lymphomas. Expert Opin Biol Ther 2005; 5: 1225-1243.
    • (2005) Expert Opin Biol Ther , vol.5 , pp. 1225-1243
    • Jacobs, S.A.1    Foon, K.A.2
  • 65
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia
    • European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia
    • Osterborg A, Dyer MJ, Bunjes D, Pangalis GA, Bastion Y, Catovsky D, Mellstedt H. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol 1997; 15: 1567-1574.
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3    Pangalis, G.A.4    Bastion, Y.5    Catovsky, D.6    Mellstedt, H.7
  • 68
    • 3242816208 scopus 로고    scopus 로고
    • Cardiac toxicity of alemtuzumab in patients with mycosis fungoides/Sezary syndrome
    • Lenihan DJ, Alencar AJ, Yang D, Kurzrock R, Keating MJ, Duvic M. Cardiac toxicity of alemtuzumab in patients with mycosis fungoides/Sezary syndrome. Blood 2004; 104: 655-658.
    • (2004) Blood , vol.104 , pp. 655-658
    • Lenihan, D.J.1    Alencar, A.J.2    Yang, D.3    Kurzrock, R.4    Keating, M.J.5    Duvic, M.6
  • 69
    • 18544362669 scopus 로고    scopus 로고
    • No cardiac toxicity associated with alemtuzumab therapy for mycosis fungoides/Sezary syndrome
    • Lundin J, Kennedy B, Dearden C, Dyer MJ, Osterborg A. No cardiac toxicity associated with alemtuzumab therapy for mycosis fungoides/Sezary syndrome. Blood 2005; 105: 4148-4149.
    • (2005) Blood , vol.105 , pp. 4148-4149
    • Lundin, J.1    Kennedy, B.2    Dearden, C.3    Dyer, M.J.4    Osterborg, A.5
  • 71
    • 22344453419 scopus 로고    scopus 로고
    • Treatment of a patient with a nodal peripheral T-cell lymphoma (angioimmunoblastic T-Cell lymphoma) with a human monoclonal antibody against the CD4 antigen (Hu-Max-CD4)
    • Hagberg H, Pettersson M, Bjerner T, Enblad G. Treatment of a patient with a nodal peripheral T-cell lymphoma (angioimmunoblastic T-Cell lymphoma) with a human monoclonal antibody against the CD4 antigen (Hu-Max-CD4). Med Oncol 2005; 22: 191-194.
    • (2005) Med Oncol , vol.22 , pp. 191-194
    • Hagberg, H.1    Pettersson, M.2    Bjerner, T.3    Enblad, G.4
  • 72
    • 25444433301 scopus 로고    scopus 로고
    • Epigenetic plasticity of hematopoietic cells
    • Bonifer C. Epigenetic plasticity of hematopoietic cells. Cell Cycle 2005; 4: 211-214.
    • (2005) Cell Cycle , vol.4 , pp. 211-214
    • Bonifer, C.1
  • 73
    • 0034446542 scopus 로고    scopus 로고
    • DNA methylation, nuclear structure, gene expression and cancer
    • Leonhardt H, Cardoso MC. DNA methylation, nuclear structure, gene expression and cancer. J Cell Biochem Suppl 2000; Suppl 35: 78-83.
    • (2000) J Cell Biochem Suppl , Issue.35 SUPPL. , pp. 78-83
    • Leonhardt, H.1    Cardoso, M.C.2
  • 75
    • 0034837064 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylase as new anticancer agents
    • Jung M. Inhibitors of histone deacetylase as new anticancer agents. Curr Med Chem 2001; 8: 1505-1511.
    • (2001) Curr Med Chem , vol.8 , pp. 1505-1511
    • Jung, M.1
  • 76
    • 0036527775 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
    • Johnstone RW. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov 2002; 1: 287-299.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 287-299
    • Johnstone, R.W.1
  • 79
    • 0036889625 scopus 로고    scopus 로고
    • Arginine butyrate increases the cytotoxicity of DAB (389)IL-2 in leukemia and lymphoma cells by upregulation of IL-2Rbeta gene
    • Shao RH, Tian X, Gorgun G, Urbano AG, Foss FM. Arginine butyrate increases the cytotoxicity of DAB (389)IL-2 in leukemia and lymphoma cells by upregulation of IL-2Rbeta gene. Leuk Res 2002; 26: 1077-1083.
    • (2002) Leuk Res , vol.26 , pp. 1077-1083
    • Shao, R.H.1    Tian, X.2    Gorgun, G.3    Urbano, A.G.4    Foss, F.M.5
  • 80
    • 3342911554 scopus 로고    scopus 로고
    • Immune modulation and apoptosis induction: Two sides of the antitumoral activity of imiquimod
    • Schon MP, Schon M. Immune modulation and apoptosis induction: two sides of the antitumoral activity of imiquimod. Apoptosis 2004; 9: 291-298.
    • (2004) Apoptosis , vol.9 , pp. 291-298
    • Schon, M.P.1    Schon, M.2
  • 81
    • 2142692247 scopus 로고    scopus 로고
    • Imiquimod and the treatment of cutaneous T-cell proliferative diseases: At the threshold
    • Herbert WC. Imiquimod and the treatment of cutaneous T-cell proliferative diseases: at the threshold. Skinmed 2003; 2: 273-274.
    • (2003) Skinmed , vol.2 , pp. 273-274
    • Herbert, W.C.1
  • 82
    • 6044260163 scopus 로고    scopus 로고
    • Imiquimod 5 percent cream and the treatment of cutaneous malignancy
    • Navi D, Huntley A. Imiquimod 5 percent cream and the treatment of cutaneous malignancy. Dermatol Online J 2004; 10: 4.
    • (2004) Dermatol Online J , vol.10 , pp. 4
    • Navi, D.1    Huntley, A.2
  • 85
    • 10244242513 scopus 로고    scopus 로고
    • Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15
    • Wysocka M, Benoit BM, Newton S, Azzoni L, Montanet LJ, Rook AH. Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15. Blood 2004; 104: 4142-4149.
    • (2004) Blood , vol.104 , pp. 4142-4149
    • Wysocka, M.1    Benoit, B.M.2    Newton, S.3    Azzoni, L.4    Montanet, L.J.5    Rook, A.H.6
  • 86
    • 0242405667 scopus 로고    scopus 로고
    • Current status of cutaneous T-cell lymphoma: Molecular diagnosis, pathogenesis, therapy and future directions
    • Dippel E, Klemke CD, Goerdt S. Current status of cutaneous T-cell lymphoma: molecular diagnosis, pathogenesis, therapy and future directions. Onkologie 2003; 26: 477-483:
    • (2003) Onkologie , vol.26 , pp. 477-483
    • Dippel, E.1    Klemke, C.D.2    Goerdt, S.3
  • 89
    • 4544252694 scopus 로고    scopus 로고
    • Neoplastic stem cells in cutaneous lymphomas: Evidence and clinical implications
    • Gniadecki R. Neoplastic stem cells in cutaneous lymphomas: evidence and clinical implications. Arch Dermatol 2004; 140: 1156-1160.
    • (2004) Arch Dermatol , vol.140 , pp. 1156-1160
    • Gniadecki, R.1
  • 90
    • 18544390850 scopus 로고    scopus 로고
    • Do neoplastic stem cells underlie the pathogenesis of cutaneous lymphomas
    • Vonderheid EC, Matsui W. Do neoplastic stem cells underlie the pathogenesis of cutaneous lymphomas - Arch Dermatol 2005; 141: 641-642.
    • (2005) Arch Dermatol , vol.141 , pp. 641-642
    • Vonderheid, E.C.1    Matsui, W.2


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