Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): Role of PKC, MAPKs, and NF-κB

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 296, Issue 2, 2009, Pages

  Rafiee, Parvaneh ^a   Nelson, Victoria M ^a   Manley, Sharon ^a   Wellner, Michael ^a   Floer, Martin ^b   Binion, David G ^c   Shaker, Reza ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Gastroesophageal reflux disease; Interleukin 6; Interleukin 8

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CHELERYTHRINE; CURCUMIN; INTERLEUKIN 6; INTERLEUKIN 8; LONG CHAIN FATTY ACID COENZYME A LIGASE; MESSENGER RNA; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; EMBRYONIC STEM CELL; EPITHELIUM CELL; ESOPHAGUS DISEASE; GASTROESOPHAGEAL REFLUX; HUMAN; HUMAN CELL; INFLAMMATION; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

ANTHRACENES; ANTI-INFLAMMATORY AGENTS; BENZOPHENANTHRIDINES; CELL LINE; CURCUMIN; ENZYME ACTIVATION; EPITHELIAL CELLS; ESOPHAGUS; FLAVONOIDS; HUMANS; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; INTERLEUKIN-6; INTERLEUKIN-8; MITOGEN-ACTIVATED PROTEIN KINASES; MUCOUS MEMBRANE; NF-KAPPA B; PEPTIDES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PYRIDINES; SIGNAL TRANSDUCTION; TELOMERASE; TIME FACTORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 59449103458     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.90428.2008     Document Type: Article

References (33)

1. Andl CD, Mizushima T, Nakagawa H, Oyama K, Harada H, Chruma K, Herlyn M, Rustgi AK. Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo. J Biol Chem 278: 1824-1830, 2003.
2. Cheng L, Cao W, Behar J, Biancani P, Harnett KM. Inflammation induced changes in arachidonic acid metabolism in cat LES circular muscle. Am J Physiol Gastrointest Liver Physiol 288: G787-G797, 2005.
3. 2 impair esophageal ACh release in experimental esophagitis. Am J Physiol Gastrointest Liver Physiol 289: G418-G428, 2005.
4. Cho JW, Lee KS, Kim CW. Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets. Int J Mol Med 19: 469-474, 2007.
5. Corrado G, Zicari A, Cavaliere M, Rea P, Pacchiarotti C, Cerroni F, Pontieri G, Cardi E. Increased release of interleukin-6 by oesophageal mucosa in children with reflux oesophagitis. Eur J Gastroenterol Hepatol 11: 839-843, 1999.
6. Crookes PF, DeMeester TR. Ambulatory esophageal pH monitoring in patients with motility disorders. Dysphagia 11: 252-253, 1996.
7. D'Acquisto F, Iuvone T, Rombola L, Sautebin L, Di Rosa M, Car-nuccio R. Involvement of NF-kappaB in the regulation of cyclooxygen-ase-2 protein expression in LPS-stimulated J774 macrophages. FEBS Lett 418: 175-178, 1997.
8. Demeester TR, Johnson LF, Joseph GJ, Toscano MS, Hall AW, Skinner DB. Patterns of gastroesophageal reflux in health and disease. Ann Surg 184: 459-470, 1976.
9. Fang X, Yu S, Bast RC, Liu S, Xu HJ, Hu SX, LaPushin R, Claret FX, Aggarwal BB, Lu Y, Mills GB. Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells. J Biol Chem 279: 9653-9661, 2004.
10. Fitzgerald RC, Omary MB, Triadafilopoulos G. Altered sodium-hydrogen exchange activity is a mechanism for acid-induced hyperproliferation in Barrett's esophagus. Am J Physiol Gastrointest Liver Physiol 275: G47-G55, 1998.
11. Fitzgerald RC, Omary MB, Triadafilopoulos G. Dynamic effects of acid on Barrett's esophagus. An ex vivo proliferation and differentiation model. J Clin Invest 98: 2120-2128, 1996.
12. Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, Tsujikawa T, Fujiyama Y, Mitsuyama K, Sata M, Yamada M, Iwaoka Y, Kanke K, Hiraishi H, Hirayama K, Arai H, Yoshii S, Uchijima M, Nagata T, Koide Y. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gas-troenterol Hepatol 4: 1502-1506, 2006.
13. Harada H, Nakagawa H, Oyama K, Takaoka M, Andl CD, Jacob-meier B, von Werder A, Enders GH, Opitz OG, Rustgi AK. Telome-rase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation. Mol Cancer Res 1: 729-738, 2003.
14. Huang MT, Lou YR, Ma W, Newmark HL, Reuhl KR, Conney AH. Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. Cancer Res 54: 5841-5847, 1994.
15. Huang MT, Ma W, Lu YP, Chang RL, Fisher C, Manchand PS, Newmark HL, Conney AH. Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion. Carcinogenesis 16: 24932497, 1995.
16. Huang MT, Smart RC, Wong CQ, Conney AH. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 48: 5941-5946, 1988.
17. Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA. IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 14: 705-714,2001.
18. Isomoto H, Wang A, Mizuta Y, Akazawa Y, Ohba K, Omagari K, Miyazaki M, Murase K, Hayashi T, Inoue K, Murata I, Kohno S. Elevated levels of chemokines in esophageal mucosa of patients with reflux esophagitis. Am J Gastroenterol 98: 551-556, 2003.
19. Naka T, Nishimoto N, Kishimoto T. The paradigm of IL-6: from basic science to medicine. Arthritis Res 4, Suppl 3: S233-S242, 2002.
20. Nonn L, Duong D, Peehl DM. Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis 28: 1188-1196, 2007.
21. Orlando RC. Review article: oesophageal mucosal resistance. Aliment Pharmacol Ther 12: 191-197, 1998.
22. Orlando RC. The pathogenesis of gastroesophageal reflux disease: the relationship between epithelial defense, dysmotility, and acid exposure. Am J Gastroenterol 92: 3S-7S, 1997.
23. Ouatu-Lascar R, Fitzgerald RC, Triadafilopoulos G. Differentiation and proliferation in Barrett's esophagus and the effects of acid suppression. Gastroenterology 117: 327-335, 1999.
24. Pace F, Santalucia F, Bianchi Porro G. Natural history of gastro-oesophageal reflux disease without oesophagitis. Gut 32: 845-848, 1991.
25. Page K, Li J, Zhou L, Iasvovskaia S, Corbit KC, Soh JW, Weinstein IB, Brasier AR, Lin A, Hershenson MB. Regulation of airway epithelial cell NF-kappaB-dependent gene expression by protein kinase Cdelta. J Immunol 170: 5681-5689, 2003.
26. Rafiee P, Shi Y, Kong X, Pritchard KA Jr, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Su J, Baker JE. Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardiopro-tection. Circulation 106: 239-245, 2002.
27. Rafiee P, Theriot ME, Nelson VM, Heidemann J, Kanaa Y, Horowitz SA, Rogaczewski A, Johnson CP, Ali I, Shaker R, Binion DG. Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27. Am J Physiol Cell Physiol 291: C931-C945, 2006.
28. Reyes-Gordillo K, Segovia J, Shibayama M, Vergara P, Moreno MG, Muriel P. Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim Biophys Acta 1770: 989-996, 2007.
29. Rieder F, Cheng L, Harnett KM, Chak A, Cooper GS, Isenberg G, Ray M, Katz JA, Catanzaro A, O'Shea R, Post AB, Wong R, Sivak MV, McCormick T, Phillips M, West GA, Willis JE, Biancani P, Fiocchi C. Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Gastro-enterology 132: 154-165, 2007.
30. Romano M, Sironi M, Toniatti C, Polentarutti N, Fruscella P, Ghezzi P, Faggioni R, Luini W, van Hinsbergh V, Sozzani S, Bussolino F, Poli V, Ciliberto G, Mantovani A. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6: 315-325, 1997.
31. Souza RF, Shewmake K, Terada LS, Spechler SJ. Acid exposure activates the mitogen-activated protein kinase pathways in Barrett's esophagus. Gastroenterology 122: 299-307, 2002.
32. Surh Y. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat Res 428: 305-327, 1999.
33. G12Vinduces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction. Oncogene 23: 6760-6768, 2004.