Vascular CXCR4 expression - A novel antiangiogenic target in gastric cancer?

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Ingold, Barbara ^a   Simon, Eva ^a   Ungethüm, Ute ^a   Kuban, Ralf Jürgen ^a   Müller, Berit M ^a   Lupp, Amelie ^b   Neumann, Ulf ^a   Ebert, Matthias P A ^c   Denkert, Carsten ^a   Weichert, Wilko ^a,d   Schulz, Stefan ^b   Röcken, Christoph ^a,e  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; STROMAL CELL DERIVED FACTOR 1; ANGIOGENESIS INHIBITOR; CXCL12 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR; TUMOR PROTEIN;

ADULT; AGED; ANTIANGIOGENIC THERAPY; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; PROTEIN EXPRESSION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSLATION; SIGNAL TRANSDUCTION; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; TISSUE MICROARRAY; TUMOR VASCULARIZATION; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; MICROVASCULATURE; MIDDLE AGED; MORTALITY; STOMACH TUMOR; SURVIVAL RATE;

ANGIOGENESIS INHIBITORS; CHEMOKINE CXCL12; DRUG DELIVERY SYSTEMS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICROVESSELS; MIDDLE AGED; NEOPLASM PROTEINS; RECEPTORS, CXCR4; RECEPTORS, G-PROTEIN-COUPLED; STOMACH NEOPLASMS; SURVIVAL RATE;

EID: 77956332901     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010087     Document Type: Article

References (41)

1. Fenoglio-Preiser C, Carneiro F, Correa P, Guilford P, Lambert R, et al. (2000) Gastric carcinoma: In Hamilton S.R., Aaltonen L.A, eds. pp 39-52.
2. Dicken BJ, Saunders LD, Jhangri GS, de Gara C, Cass C, et al. (2004) Gastric cancer: establishing predictors of biologic behavior with use of population-based data. Ann Surg Oncol 11: 629-635.
3. Alberts SR, Cervantes A, van de Velde CJ (2003) Gastric cancer: epidemiology, pathology and treatment. Ann Oncol 14 Suppl 2: ii31-36.
4. Dorsam RT, Gutkind JS (2007) G-protein-coupled receptors and cancer. Nat Rev Cancer 7: 79-94.
5. Richard DE, Vouret-Craviari V, Pouyssegur J (2001) Angiogenesis and Gprotein- coupled receptors: signals that bridge the gap. Oncogene 20: 1556-1562.
6. Strieter RM, Burdick MD, Mestas J, Gomperts B, Keane MP, et al. (2006) Cancer CXC chemokine networks and tumour angiogenesis. Eur J Cancer 42: 768-778.
7. Smith CJ, Volkert WA, Hoffman TJ (2005) Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypes. Nucl Med Biol 32: 733-740.
8. Nagy A, Schally AV (2005) Targeting cytotoxic conjugates of somatostatin, luteinizing hormone-releasing hormone and bombesin to cancers expressing their receptors: a "smarter" chemotherapy. Curr Pharm Des 11: 1167-1180.
9. Nagy A, Plonowski A, Schally AV (2000) Stability of cytotoxic luteinizing hormone-releasing hormone conjugate (AN-152) containing doxorubicin 14-Ohemiglutarate in mouse and human serum in vitro: implications for the design of preclinical studies. Proc Natl Acad Sci U S A 97: 829-834.
10. Rocken C, Rohl FW, Diebler E, Lendeckel U, Pross M, et al. (2007) The angiotensin II/angiotensin II receptor system correlates with nodal spread in intestinal type gastric cancer. Cancer Epidemiol Biomarkers Prev 16: 1206-1212.
11. Lentsch AB (2002) The Duffy antigen/receptor for chemokines (DARC) and prostate cancer. A role as clear as black and white? FASEB J 16: 1093-1095.
12. Shen H, Schuster R, Stringer KF, Waltz SE, Lentsch AB (2006) The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growth. FASEB J 20: 59-64.
13. Thomas L (2005) Malaria gene linked to prostate-cancer incidence. Lancet Oncol 6: 266.
14. Horak CE, Mendoza A, Vega-Valle E, Albaugh M, Graff-Cherry C, et al. (2007) Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2. Cancer Res 67: 11751-11759.
15. Babbin BA, Lee WY, Parkos CA, Winfree LM, Akyildiz A, et al. (2006) Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptidereceptors. J Biol Chem 281: 19588-19599.
16. Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, et al. (2009) Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457: 608-611.
17. Vandercappellen J, Van Damme J, Struyf S (2008) The role of CXC chemokines and their receptors in cancer. Cancer Lett 267: 226-244.
18. Raman D, Baugher PJ, Thu YM, Richmond A (2007) Role of chemokines in tumor growth. Cancer Lett 256: 137-165.
19. Zlotnik A (2006) Involvement of chemokine receptors in organ-specific metastasis. Contrib Microbiol 13: 191-199.
20. Pierce KL, Premont RT, Lefkowitz RJ (2002) Seven-transmembrane receptors. Nat Rev Mol Cell Biol 3: 639-650.
21. Murdoch C (2000) CXCR4: chemokine receptor extraordinaire. Immunol Rev 177: 175-184.
22. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, et al. (1996) Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382: 635-638.
23. Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, et al. (1998) Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci USA 95: 9448-9453.
24. Muller A, Homey B, Soto H, Ge N, Catron D, et al. (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56.
25. Smith MC, Luker KE, Garbow JR, Prior JL, Jackson E, et al. (2004) CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res 64: 8604-8612.
26. Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, et al. (2002) Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res 62: 5930-5938.
27. Taichman RS, Cooper C, Keller ET, Pienta KJ, Taichman NS, et al. (2002) Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res 62: 1832-1837.
28. Phillips RJ, Burdick MD, Lutz M, Belperio JA, Keane MP, et al. (2003) The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am J Respir Crit Care Med 167: 1676-1686.
29. Schimanski CC, Schwald S, Simiantonaki N, Jayasinghe C, Gonner U, et al. (2005) Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer. Clin Cancer Res 11: 1743-1750.
30. Yasumoto K, Koizumi K, Kawashima A, Saitoh Y, Arita Y, et al. (2006) Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer. Cancer Res 66: 2181-2187.
31. Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, et al. (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121: 335-348.
32. Lee HJ, Kim SW, Kim HY, Li S, Yun HJ, et al. (2009) Chemokine receptor CXCR4 expression, function, and clinical implications in gastric cancer. Int J Oncol 34: 473-480.
33. Fischer T, Nagel F, Jacobs S, Stumm R, Schulz S (2008) Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2. PLoS ONE 3: e4069.
34. Yoshitake N, Fukui H, Yamagishi H, Sekikawa A, Fujii S, et al. (2008) Expression of SDF-1 alpha and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer. Br J Cancer 98: 1682-1689.
35. Saigusa S, Toiyama Y, Tanaka K, Yokoe T, Okugawa Y, et al. Stromal CXCR4 and CXCL12 Expression is Associated with Distant Recurrence and Poor Prognosis in Rectal Cancer After Chemoradiotherapy., Ann Surg Oncol.
36. Salcedo R, Oppenheim JJ (2003) Role of chemokines in angiogenesis: CXCL12/ SDF-1 and CXCR4 interaction, a key regulator of endothelial cell responses. Microcirculation 10: 359-370.
37. Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, et al. (2003) Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 425: 307-311.
38. Ingold B, Schulz S, Budczies J, Neumann U, Ebert PA, et al. (in press) The role of vascular CXCR4 expression in colorectal carcinoma.
39. Rempel SA, Dudas S, Ge S, Gutierrez JA (2000) Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin Cancer Res 6: 102-111.
40. Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, et al. (1998) Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 4: 844-847.
41. Moch H, Schraml P, Bubendorf L, Mirlacher M, Kononen J, et al. (1999) Highthroughput tissue microarray analysis to evaluate genes uncovered by cDNA microarray screening in renal cell carcinoma. Am J Pathol 154: 981-986.