Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice

Journal of Biological Chemistry

Volumn 286, Issue 47, 2011, Pages 40835-40846

  Kumadaki, Shin ^a   Karasawa, Tadayoshi ^a   Matsuzaka, Takashi ^a   Ema, Masatsugu ^a   Nakagawa, Yoshimi ^a   Nakakuki, Masanori ^a   Saito, Ryo ^a   Yahagi, Naoya ^a   Iwasaki, Hitoshi ^a   Sone, Hirohito ^a   Takekoshi, Kazuhiro ^a   Yatoh, Shigeru ^a   Kobayashi, Kazuto ^a   Takahashi, Akimitsu ^a   Suzuki, Hiroaki ^a   Takahashi, Satoru ^a   Yamada, Nobuhiro ^a   Shimano, Hitoshi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR GROWTH; CULTURED CELL; CYCLIN E; DIACYLGLYCEROL ACYLTRANSFERASES; FATTY ACID SYNTHESIS; GROWTH REGULATORS; IN-VIVO; IN-VIVO EXPERIMENTS; LIPID METABOLISMS; LIPID SYNTHESIS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; STEROL REGULATORY ELEMENT-BINDING PROTEINS; SUBSTRATE RECOGNITION; TARGET GENES; UBIQUITIN LIGASES;

CYTOLOGY; DEGRADATION; FATTY ACIDS; GENE EXPRESSION; GLYCEROL; GROWTH KINETICS; MAMMALS; METABOLISM; PHYSIOLOGY; PROTEINS;

BIOSYNTHESIS;

F BOX AND WD REPEAT DOMAIN CONTAINING 7ALPHA; KRUPPEL LIKE FACTOR 5; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD36 GENE; CELL NUCLEUS; CONTROLLED STUDY; DIACYLGLYCEROL ACYLTRANSFERASE 1 GENE; FAT SPECIFIC PROTEIN 27 GENE; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FATTY ACID TRANSPORT; FATTY LIVER; GAIN OF FUNCTION MUTATION; GENE; GENE EXPRESSION; IN VIVO STUDY; LIPID METABOLISM; LIPID STORAGE; LOSS OF FUNCTION MUTATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; TRIACYLGLYCEROL SYNTHESIS;

ANIMALS; CELL CYCLE; CELL PROLIFERATION; F-BOX PROTEINS; FATTY LIVER; FENOFIBRATE; GENE KNOCKDOWN TECHNIQUES; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; PPAR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UBIQUITIN-PROTEIN LIGASES;

MUS;

EID: 81755171440     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.235283     Document Type: Article

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