A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G1 cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors

FEBS Journal

Volumn 274, Issue 17, 2007, Pages 4440-4452

  Nakakuki, Masanori ^a   Shimano, Hitoshi ^a,c   Inoue, Noriyuki ^a   Tamura, Mariko ^a   Matsuzaka, Takashi ^a   Nakagawa, Yoshimi ^a   Yahagi, Naoya ^a   Toyoshima, Hideo ^a   Sato, Ryuichiro ^b   Yamada, Nobuhiro ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NONE   (Japan)

Author keywords

Cell growth; Cholesterol; Fatty acids; p21; p27

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PROTEIN P16INK4A; RETINOBLASTOMA PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CHO CELL; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; ENZYME ACTIVATION; FEMALE; FIBROBLAST; GROWTH INHIBITION; LIPOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; TISSUE REGENERATION; WILD TYPE;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIN-DEPENDENT KINASES; G1 PHASE; HUMANS; IMMUNOPRECIPITATION; LIPIDS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTEIN KINASE INHIBITORS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

CRICETULUS GRISEUS; MAMMALIA; MUS MUSCULUS;

EID: 34548131164     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2007.05973.x     Document Type: Article

References (43)

1. Brown MS Goldstein JL (1997) The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331 340.
2. Brown MS, Ye J, Rawson RB Goldstein JL (2000) Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100, 391 398.
3. Rawson RB (2003) Control of lipid metabolism by regulated intramembrane proteolysis of sterol regulatory element binding proteins (SREBPs). Biochem Soc Symp, 221 231.
4. Shimano H (2001) Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog Lipid Res 40, 439 452.
5. Horton JD, Goldstein JL Brown MS (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109, 1125 1131.
6. Shimomura I, Shimano H, Horton JD, Goldstein JL Brown MS (1997) Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest 99, 838 845.
7. Inoue N, Shimano H, Nakakuki M, Matsuzaka T, Nakagawa Y, Yamamoto T, Sato R, Takahashi A, Sone H, Yahagi N et al. (2005) Lipid synthetic transcription factor SREBP-1a activates p21WAF1/CIP1, a universal cyclin-dependent kinase inhibitor. Mol Cell Biol 25, 8938 8947.
8. Sato R, Okamoto A, Inoue J, Miyamoto W, Sakai Y, Emoto N, Shimano H Maeda M (2000) Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteins. J Biol Chem 275, 12497 12502.
9. Hirano Y, Yoshida M, Shimizu M Sato R (2001) Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway. J Biol Chem 276, 36431 36437.
10. Chen PL, Chen YM, Bookstein R Lee WH (1990) Genetic mechanisms of tumor suppression by the human p53 gene. Science 250, 1576 1580.
11. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW Vogelstein B (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817 825.
12. Shimano H, Yahagi N, Amemiya-Kudo M, Hasty AH, Osuga J, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Harada K et al. (1999) Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J Biol Chem 274, 35832 35839.
13. Kim JB, Spotts GD, Halvorsen YD, Shih HM, Ellenberger T, Towle HC Spiegelman BM (1995) Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol Cell Biol 15, 2582 2588.
14. Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K et al. (2002) Transcriptional activities of nuclear SREBP-1a-1c, and -2 to different target promoters of lipogenic and cholesterogenic genes. J Lipid Res 43, 1220 1235.
15. 1 phase progression: cycling on cue. Cell 79, 551 555.
16. Carrano AC, Eytan E, Hershko A Pagano M (1999) SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1, 193 199.
17. Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K Nakayama KI (2003) Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc Natl Acad Sci USA 100, 10231 10236.
18. 1 phase. Nat Cell Biol 6, 1229 1235.
19. 1 phase of the human cell cycle. Science 257, 1689 1694.
20. Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81, 323 330.
21. Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS Goldstein JL (1996) Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 98, 1575 1584.
22. Melchiorri C, Chieco P, Zedda AI, Coni P, Ledda-Columbano GM Columbano A (1993) Ploidy and nuclearity of rat hepatocytes after compensatory regeneration or mitogen-induced liver growth. Carcinogenesis 14, 1825 1830.
23. Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL Brown MS (2002) Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110, 489 500.
24. Chen HW, Heiniger HJ Kandutsch AA (1975) Relationship between sterol synthesis and DNA synthesis in phytohemagglutinin-stimulated mouse lymphocytes. Proc Natl Acad Sci USA 72, 1950 1954.
25. Zhou R-H, Yao M, Lee T-S, Zhu Y, Martins-Green M Shyy JY-J (2004) Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis. Circ Res 95, 471 478.
26. Du X, Kristiana I, Wong J Brown AJ (2006) Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: a link between a key cell proliferative pathway and membrane synthesis. Mol Biol Cell 17, 2735 2745.
27. Bengoechea-Alonso MT Ericsson J (2006) Cdk1/cyclin B-mediated phosphorylation stabilizes SREBP1 during mitosis. Cell Cycle 5, 1708 1718.
28. 2/M arrest induced by the TRC8 hereditary kidney cancer gene. Oncogene 26 (16 2263 2271.
29. Yahagi N, Shimano H, Hasty AH, Amemiya-Kudo M, Okazaki H, Tamura Y, Iizuka Y, Shionoiri F, Ohashi K, Osuga J et al. (1999) A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. J Biol Chem 274, 35840 35844.
30. Hannah VC, Ou J, Luong A, Goldstein JL Brown MS (2001) Unsaturated fatty acids down-regulate SREBP isoforms 1a and 1c by two mechanisms in HEK-293 cells. J Biol Chem 276, 4365 4372.
31. Bengoechea-Alonso MT, Punga T Ericsson J (2005) Hyperphosphorylation regulates the activity of SREBP1 during mitosis. Proc Natl Acad Sci USA 102, 11681 11686.
32. Kawabe Y, Imanaka T, Kodama T, Takano T Sato R (1998) Characterization of two Chinese hamster ovary cell lines expressing the COOH-terminal domains of sterol regulatory element-binding protein (SREBP)-1. Cell Struct Funct 23, 187 192.
33. Sundqvist A, Bengoechea-Alonso MTYeX, Lukiyanchuk V, Jin J, Harper JW Ericsson J (2005) Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF (Fbw7). Cell Metab 1, 379 391.
34. 1 to multiple cell cycles by lovastatin. Cancer Res 51, 3602 3609.
35. 1 to S phase in growth-stimulated rat FRTL-5 cells. J Biol Chem 272, 13 16.
36. Briggs MR, Yokoyama C, Wang X, Brown MS Goldstein JL (1993) Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence. J Biol Chem 268, 14490 14496.
37. Chu YW, Wang R, Schmid I Sakamoto KM (1999) Analysis with flow cytometry of green fluorescent protein expression in leukemic cells. Cytometry 36, 333 339.
38. Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K et al. (2001) Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol Cell Biol 21, 2991 3000.
39. 1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78, 67 74.
40. Wang X, Sato R, Brown MS, Hua X Goldstein JL (1994) SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77, 53 62.
41. Alessandrini A, Chiaur DS Pagano M (1997) Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation. Leukemia 11, 342 345.
42. Higgins GM Anderson RM (1931) Experimental pathology of the liver. Arch Pathol 12, 186 201.
43. Shimano H, Shimomura I, Hammer RE, Herz J, Goldstein JL, Brown MS Horton JD (1997) Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J Clin Invest 100, 2115 2124.