TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

Nature Medicine

Volumn 12, Issue 1, 2006, Pages 107-113

  Nakagawa, Yoshimi ^a   Shimano, Hitoshi ^a   Yoshikawa, Tomohiro ^a   Ide, Tomohiro ^a   Tamura, Mariko ^a   Furusawa, Mika ^a   Yamamoto, Takashi ^a   Inoue, Noriyuki ^a   Matsuzaka, Takashi ^a   Takahashi, Akimitsu ^a   Hasty, Alyssa H ^b   Suzuki, Hiroaki ^a   Sone, Hirohito ^a   Toyoshima, Hideo ^a   Yahagi, Naoya ^a   Yamada, Nobuhiro ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3BETA; HELIX LOOP HELIX PROTEIN; HEXOKINASE; HEXOKINASE ISOENZYME; INSULIN; INSULIN INDUCED GENE 1; INSULIN RECEPTOR SUBSTRATE 2; ISOENZYME; LIVER PROTEIN; PROTEIN KINASE B; STREPTOZOCIN; TRANSCRIPTION FACTOR E3; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIABETES MELLITUS; E BOX ELEMENT; ENZYME PHOSPHORYLATION; GENE CONTROL; GENETIC TRANSCRIPTION; GLUCOSE BLOOD LEVEL; GLYCOGEN SYNTHESIS; IN VIVO STUDY; LIPOGENESIS; LIVER CELL CULTURE; LIVER FUNCTION; METABOLISM; MOLECULAR CLONING; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; TRANSACTIVATION;

ADENOVIRIDAE; ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BLOOD GLUCOSE; BLOTTING, NORTHERN; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; CLONING, MOLECULAR; DIABETES MELLITUS; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3; GREEN FLUORESCENT PROTEINS; HEPATOCYTES; HEXOKINASE; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PHOSPHOPROTEINS; PHOSPHORYLATION; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; STREPTOZOCIN; TIME FACTORS; TRANS-ACTIVATION (GENETICS);

ADENOVIRIDAE; ANIMALIA;

EID: 30044437308     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1334     Document Type: Article

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