Apoptosis modulation as a promising target for treatment of systemic sclerosis

International Journal of Rheumatology

Volumn 2011, Issue , 2011, Pages

  Chabaud, Stéphane ^a   Moulin, Véronique J ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; CURCUMIN; ENDOTHELIAL CELL ANTIBODY; FAS ANTIGEN; FAS LIGAND; FLICE INHIBITORY PROTEIN; HYALURONIC ACID; INHIBITOR OF APOPTOSIS PROTEIN; INTERLEUKIN 4; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAD; PROTEIN KINASE B; RESVERATROL; THALIDOMIDE; THROMBIN; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; CELL HYPOXIA; CELL PROLIFERATION; CELL SUBPOPULATION; COLLAGEN SYNTHESIS; DISEASE COURSE; DNA DAMAGE; DRUG MECHANISM; DRUG SAFETY; ENDOTHELIUM CELL; EPITHELIUM CELL; FIBROBLAST; FIBROSIS; GENE DELETION; GENETIC TRANSCRIPTION; HUMAN; INFLAMMATION; LUNG FIBROSIS; LYMPHOCYTE; MODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REVIEW; SILICOSIS; SYSTEMIC SCLEROSIS; TH1 CELL; TH17 CELL; TH2 CELL;

EID: 81555227878     PISSN: 16879260     EISSN: 16879279     Source Type: Journal    
DOI: 10.1155/2011/495792     Document Type: Review

References (162)

1. Lonzetti L. S., Joyal F., Raynauld J. P., Roussin A., Goulet J. R., Rich R., Choquette D., Raymond Y., Sencal J. L., Updating the American College of Rheumatology preliminary classification criteria for systemic sclerosis: addition of severe nailfold capillaroscopy abnormalities markedly increases the sensitivity for limited scleroderma Arthritis and Rheumatism 2001 44 3 735 736 (Pubitemid 32234635)
2. Krishnan E., Furst D. E., Systemic sclerosis mortality in the United States: 19791998 European Journal of Epidemiology 2005 20 10 855 861 (Pubitemid 41622182)
3. Laing T. J., Gillespie B. W., Toth M. B., Mayes M. D., Gallavan R. H., Burns C. J., Johanns J. R., Cooper B. C., Keroack B. J., Wasko M. C. M., Lacey J. V., Schottenfeld D., Racial differences in scleroderma among women in Michigan Arthritis and Rheumatism 1997 40 4 734 742 (Pubitemid 27157581)
4. Bernatsky S., Hudson M., Panopalis P., Clarke A. E., Pope J., LeClercq S., Pierre Y. S., Baron M., Taillefer S. S., Markland J., Robinson D., Jones N., Khalidi N. A., Docherty P., Kaminska E., Abu-Hakima M., Masetto A., Smith C. D., Sutton E., Mathieu J. P., Ligier S., The cost of systemic sclerosis Arthritis Care and Research 2009 61 1 119 123
5. Arnett F. C., Howard R. F., Tan F., Moulds J. M., Bias W. B., Durban E., Cameron H. D., Paxton G., Hodge T. J., Weathers P. E., Reveille J. D., Increased prevalence of systemic sclerosis in a native American tribe in Oklahoma: association with an Amerindian HLA haplotype Arthritis and Rheumatism 1996 39 8 1362 1370 (Pubitemid 26270096)
6. Liakouli V., Manetti M., Pacini A., Tolusso B., Fatini C., Toscano A., Cipriani P., Guiducci S., Bazzichi L., Codullo V., Ruocco L., Dell'orso L., Carubbi F., Marrelli A., Abbate R., Bombardieri S., Ferraccioli G., Montecucco C., Valentini G., Matucci-Cerinic M., Ibba-Manneschi L., Giacomelli R., The 2670GA polymorphism in the FAS gene promoter region influences the susceptibility to systemic sclerosis Annals of the Rheumatic Diseases 2009 68 4 584 590
7. Garabrant D. H., Lacey J. V., Laing T. J., Gillespie B. W., Mayes M. D., Cooper B. C., Schottenfeld D., Scleroderma and solvent exposure among women American Journal of Epidemiology 2003 157 6 493 500 (Pubitemid 36292907)
8. Brinton L. A., Buckley L. M., Dvorkina O., Lubin J. H., Colton T., Murray M. C., Hoover R. N., Risk of connective tissue disorders among breast implant patients American Journal of Epidemiology 2004 160 7 619 627 (Pubitemid 39281841)
9. Lunardi C., Dolcino M., Peterlana D., Bason C., Navone R., Tamassia N., Beri R., Corrocher R., Puccetti A., Antibodies against human cytomegalovirus in the pathogenesis of systemic sclerosis: a gene array approach PLoS Medicine 2006 3 1 94 108 (Pubitemid 43200636)
10. Neidhart M., Kuchen S., Distler O., Brhlmann P., Michel B. A., Gay R. E., Gay S., Increased serum levels of antibodies against human cytomegalovirus and prevalence of autoantibodies in systemic sclerosis Arthritis and Rheumatism 1999 42 2 389 392 (Pubitemid 29072859)
11. Jimenez S. A., Artlett C. M., Microchimerism and systemic sclerosis Current Opinion in Rheumatology 2005 17 1 86 90 (Pubitemid 40075653)
12. Tamby M. C., Chanseaud Y., Guillevin L., Mouthon L., New insights into the pathogenesis of systemic sclerosis Autoimmunity Reviews 2003 2 3 152 157 (Pubitemid 37443852)
13. Corriveau M. P., Boufaied I., Lessard J., Chabaud S., Senécal J. L., Grodzicky T., Chartier S., Raymond Y., Moulin V. J., The fibrotic phenotype of systemic sclerosis fibroblasts varies with disease duration and severity of skin involvement: reconstitution of skin fibrosis development using a tissue engineering approach Journal of Pathology 2008 217 4 534 542
14. Abraham D. J., Varga J., Scleroderma: from cell and molecular mechanisms to disease models Trends in Immunology 2005 26 11 587 595 (Pubitemid 41726446)
15. Shi Y., Szalay M. G., Paskar L., Boyer M., Singh B., Green D. R., Activation-induced cell death in T cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation Journal of Immunology 1990 144 9 3326 3333 (Pubitemid 20146361)
16. Raff M. C., Social controls on cell survival and cell death Nature 1992 356 6368 397 400
17. Hetts S. W., To Die or not to die: an overview of apoptosis and its role in disease Journal of the American Medical Association 1998 279 4 300 307 (Pubitemid 28071022)
18. Savill J., Fadok V., Corpse clearance defines the meaning of cell death Nature 2000 407 6805 784 788
19. Kerr J. F., Wyllie A. H., Currie A. R., Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics British Journal of Cancer 1972 26 4 239 257
20. Raff M., Cell suicide for beginners Nature 1998 396 6707 119 122 (Pubitemid 28523602)
21. Cohen G. M., Caspases: the executioners of apoptosis Biochemical Journal 1997 326 1 1 16 (Pubitemid 27386911)
22. Kroemer G., Reed J. C., Mitochondrial control of cell death Nature Medicine 2000 6 5 513 519 (Pubitemid 30305900)
23. Adams J. M., Cory S., The Bcl-2 protein family: arbiters of cell survival Science 1998 281 5381 1322 1326 (Pubitemid 28406819)
24. Brenner C., Cadiou H., Vieira H. L. A., Zamzami N., Marzo I., Xie Z., Leber B., Andrews D., Duclohier H., Reed J. C., Kroemer G., Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator Oncogene 2000 19 3 329 336 (Pubitemid 30077332)
25. Taylor R. C., Cullen S. P., Martin S. J., Apoptosis: controlled demolition at the cellular level Nature Reviews Molecular Cell Biology 2008 9 3 231 241 (Pubitemid 351301823)
26. Subramanian R. R., Masters S. C., Zhang H., Fu H., Functional conservation of 14-3-3 isoforms in inhibiting Bad-induced apoptosis Experimental Cell Research 2001 271 1 142 151 (Pubitemid 33071001)
27. Liston P., Fong W. G., Korneluk R. G., The inhibitors of apoptosis: there is more to life than Bcl2 Oncogene 2003 22 53 8568 8580 (Pubitemid 38019194)
28. Deveraux Q. L., Reed J. C., IAP family proteins-Suppressors of apoptosis Genes and Development 1999 13 3 239 252 (Pubitemid 29095796)
29. Joza N., Susin S. A., Daugas E., Stanford W. L., Cho S. K., Li C. Y. J., Sasaki T., Elia A. J., Cheng H. Y. M., Ravagnan L., Ferri K. F., Zamzami N., Wakeham A., Hakem R., Yoshida H., Kong Y. Y., Mak T. W., Ziga-Pflcker J. C., Kroemer G., Penninger J. M., Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death Nature 2001 410 6828 549 554 (Pubitemid 32267191)
30. Ashkenazi A., Dixit V. M., Death receptors: signaling and modulation Science 1998 281 5381 1305 1308 (Pubitemid 28406815)
31. Thorburn A., Death receptor-induced cell killing Cellular Signalling 2004 16 2 139 144 (Pubitemid 37431163)
32. Wallach D., Varfolomeev E. E., Malinin N. L., Goltsev Y. V., Kovalenko A. V., Boldin M. P., Tumor necrosis factor receptor and Fas signaling mechanisms Annual Review of Immunology 1999 17 331 367 (Pubitemid 29241128)
33. Legler D. F., Micheau O., Doucey M. A., Tschopp J., Bron C., Recruitment of TNF receptor 1 to lipid rafts is essential for TNF -mediated NF- B activation Immunity 2003 18 5 655 664 (Pubitemid 36588582)
34. Chan F. K. M., Chun H. J., Zheng L., Siegel R. M., Bui K. L., Lenardo M. J., A domain in TNF receptors that mediates ligand-independent receptor assembty and signaling Science 2000 288 5475 2351 2354 (Pubitemid 30448156)
35. Siegel R. M., Frederiksen J. K., Zacharias D. A., Chan F. K. M., Johnson M., Lynch D., Tsien R. Y., Lenardo M. J., Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations Science 2000 288 5475 2354 2357 (Pubitemid 30448157)
36. Black R. A., Rauch C. T., Kozlosky C. J., Peschon J. J., Slack J. L., Wolfson M. F., Castner B. J., Stocking K. L., Reddy P., Srinivasan S., Nelson N., Boiani N., Schooley K. A., Gerhart M., Davis R., Fitzner J. N., Johnson R. S., Paxton R. J., March C. J., Cerretti D. P., A metalloproteinase disintegrin that releases tumour-necrosis factor- from cells Nature 1997 385 6618 729 733 (Pubitemid 27098094)
37. Wajant H., Pfizenmaier K., Scheurich P., Tumor necrosis factor signaling Cell Death and Differentiation 2003 10 1 45 65 (Pubitemid 36511832)
38. Wajant H., Pfizenmaier K., Scheurich P., Non-apoptotic Fas signaling Cytokine and Growth Factor Reviews 2003 14 1 53 66 (Pubitemid 36098431)
39. Aggarwal B. B., Signalling pathways of the TNF superfamily: a double-edged sword Nature Reviews Immunology 2003 3 9 745 756 (Pubitemid 41070815)
40. Scaffidi C., Fulda S., Srinivasan A., Friesen C., Li F., Tomaselli K. J., Debatin K. M., Krammer P. H., Peter M. E., Two CD95 (APO-1/Fas) signaling pathways EMBO Journal 1998 17 6 1675 1687 (Pubitemid 28119121)
41. Chinnalyan A. M., O'Rourke K., Tewari M., Dixit V. M., FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis Cell 1995 81 4 505 512
42. Scaffidi C., Schmitz I., Krammer P. H., Peter M. E., The role of c-FLIP in modulation of CD95-induced apoptosis Journal of Biological Chemistry 1999 274 3 1541 1548
43. Tschopp J., Irmler M., Thome M., Inhibition of Fas death signals by FLIPs Current Opinion in Immunology 1998 10 5 552 558 (Pubitemid 28479188)
44. Li H., Zhu H., Xu C. J., Yuan J., Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis Cell 1998 94 4 491 501 (Pubitemid 28391865)
45. Rubinfeld H., Seger R., The ERK cascade: a prototype of MAPK signaling Molecular Biotechnology 2005 31 2 151 174 (Pubitemid 41306584)
46. Dempsey P. W., Doyle S. E., He J. Q., Cheng G., The signaling adaptors and pathways activated by TNF superfamily Cytokine and Growth Factor Reviews 2003 14 3-4 193 209 (Pubitemid 36693141)
47. Krueger A., Baumann S., Krammer P. H., Kirchhoff S., FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis Molecular and Cellular Biology 2001 21 24 8247 8254 (Pubitemid 33108586)
48. Lieberman J., The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal Nature Reviews Immunology 2003 3 5 361 370 (Pubitemid 37323196)
49. Yang X., Stennicke H. R., Wang B., Green D. R., Jnicke R. U., Srinivasan A., Seth P., Salvesen G. S., Froelich C. J., Granzyme B mimics apical caspases: description of a unified pathway for trans-activation of executioner caspase-3 and -7 Journal of Biological Chemistry 1998 273 51 34278 34283 (Pubitemid 29008904)
50. Jiang H. Y., Wek S. A., McGrath B. C., Lu D., Hai T., Harding H. P., Wang X., Ron D., Cavener D. R., Wek R. C., Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response Molecular and Cellular Biology 2004 24 3 1365 1377 (Pubitemid 38112196)
51. Kogel D., Schomburg R., Schrmann T., Reimertz C., Knig H. G., Poppe M., Eckert A., Mller W. E., Prehn J. H. M., The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis Journal of Neurochemistry 2003 87 1 248 256 (Pubitemid 37210658)
52. Tabas I., Ron D., Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress Nature Cell Biology 2011 13 3 184 190
53. Majno G., Joris I., Apoptosis, oncosis, and necrosis: an overview of cell death American Journal of Pathology 1995 146 1 3 15
54. Galluzzi L., Kroemer G., Necroptosis: a specialized pathway of programmed necrosis Cell 2008 135 7 1161 1163
55. Cheng J., Zhou T., Liu C., Shapiro J. P., Brauer M. J., Kiefer M. C., Barr P. J., Mountz J. D., Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule Science 1994 263 5154 1759 1762 (Pubitemid 24131584)
56. Buhling F., Wille A., Rcken C., Wiesner O., Baier A., Mienecke I., Welte T., Pap T., Altered expression of membrane-bound and soluble CD95/Fas contributes to the resistance of fibrotic lung fibroblasts to FasL induced apoptosis Respiratory Research 2005 6
57. Tomokuni A., Otsuki T., Isozaki Y., Kita S., Ueki H., Kusaka M., Kishimoto T., Ueki A., Serum levels of soluble Fas ligand in patients with silicosis Clinical and Experimental Immunology 1999 118 3 441 444
58. Otsuki T., Hayashi H., Nishimura Y., Hyodo F., Maeda M., Kumagai N., Miura Y., Kusaka M., Uragami K., Dysregulation of autoimmunity caused by silica exposure and alteration of Fas-mediated apoptosis in T lymphocytes derived from silicosis patients International Journal of Immunopathology and Pharmacology 2011 24 1 Suppl 11S 16S
59. Tanaka T., Yoshimi M., Maeyama T., Hagimoto N., Kuwano K., Hara N., Resistance to Fas-mediated apoptosis in human lung fibroblast European Respiratory Journal 2002 20 2 359 368
60. Thannickal V. J., Horowitz J. C., Evolving concepts of apoptosis in idiopathic pulmonary fibrosis Proceedings of the American Thoracic Society 2006 3 4 350 356 (Pubitemid 43845412)
61. Budinger G. R. S., Mutlu G. M., Eisenbart J., Fuller A. C., Bellmeyer A. A., Baker C. M., Wilson M., Ridge K., Barrett T. A., Lee V. Y., Chandel N. S., Proapoptotic Bid is required for pulmonary fibrosis Proceedings of the National Academy of Sciences of the United States of America 2006 103 12 4604 4609
62. Kuwano K., Hagimoto N., Kawasaki M., Yatomi T., Nakamura N., Nagata S., Suda T., Kunitake R., Maeyama T., Miyazaki H., Hara N., Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis Journal of Clinical Investigation 1999 104 1 13 19 (Pubitemid 29534340)
63. Kuwano K., Miyazaki H., Hagimoto N., Kawasaki M., Fujita M., Kunitake R., Kaneko Y., Hara N., The involvement of Fas-Fas ligand pathway in fibrosing lung diseases American Journal of Respiratory Cell and Molecular Biology 1999 20 1 53 60 (Pubitemid 129504842)
64. Ates A., Kinikli G., Turgay M., Duman M., The levels of serum-soluble Fas in patients with rheumatoid arthritis and systemic sclerosis Clinical Rheumatology 2004 23 5 421 425 (Pubitemid 39386438)
65. Bianchi T., Bardazzi F., Patrizi A., Soluble fas levels in patients with systemic sclerosis Archives of Dermatological Research 2000 292 10 522 523 (Pubitemid 32112811)
66. Bogatkevich G. S., Gustilo E., Oates J. C., Feghali-Bostwick C., Harley R. A., Silver R. M., Ludwicka-Bradley A., Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts American Journal of Physiology, Lung Cellular and Molecular Physiology 2005 288 1 L190 L201 (Pubitemid 40023901)
67. Chabaud S., Corriveau M. -P., Grodzicky T., Senécal J. -L., Chartier S., Raymond Y., Moulin V. J., Decreased secretion of MMP by non-lesional late-stage scleroderma fibroblasts after selection via activation of the apoptotic fas-pathway Journal of Cellular Physiology 2011 226 7 1907 1914
68. Jelaska A., Korn J. H., Role of apoptosis and transforming growth factor 1 in fibroblast selection and activation in systemic sclerosis Arthritis and Rheumatism 2000 43 10 2230 2239
69. Santiago B., Galindo M., Rivero M., Pablos J. L., Decreased susceptibility to Fas-induced apoptosis of systemic sclerosis dermal fibroblasts Arthritis and Rheumatism 2001 44 7 1667 1676 (Pubitemid 32642230)
70. Yamamoto T., Yokozeki H., Nishioka K., Fas- and FasL-deficient mice are resistant to the induction of bleomycin-induced scleroderma Archives of Dermatological Research 2007 298 9 465 468 (Pubitemid 46144208)
71. Yamamoto T., Nishioka K., Possible role of apoptosis in the pathogenesis of bleomycin-induced scleroderma Journal of Investigative Dermatology 2004 122 1 44 50 (Pubitemid 38114637)
72. Alaibac M., Berti E., Chizzolini C., Fineschi S., Marzano A. V., Pigozzi B., Riboldi E., Sozzani S., Kuhn A., Role of cellular immunity in the pathogenesis of autoimmune skin diseases Clinical and Experimental Rheumatology 2006 24 1, supplement 40 S14 S19
73. Bendersky A., Markovits N., Bank I., V 9+ T cells in systemic sclerosis patients are numerically and functionally preserved and induce fibroblast apoptosis Immunobiology 2010 215 5 380 394
74. Atamas S. P., White B., The role of chemokines in the pathogenesis of scleroderma Current Opinion in Rheumatology 2003 15 6 772 777 (Pubitemid 38156306)
75. Giacomelli R., Cipriani P., Fulminis A., Barattelli G., Matucci-Cerinic M., D'Al S., Cifone G., Tonietti G., Circulating / T lymphocytes from systemic sclerosis (SSc) patients display a T helper (Th) 1 polarization Clinical and Experimental Immunology 2001 125 2 310 315 (Pubitemid 32758443)
76. De Palma R., Del Galdo F., Lupoli S., Altucci P., Abbate G., Valentini G., Peripheral T lymphocytes from patients with early systemic sclerosis co-cultured with autologous fibroblasts undergo an oligoclonal expansion similar to that occurring in the skin Clinical and Experimental Immunology 2006 144 1 169 176
77. Parel Y., Aurrand-Lions M., Scheja A., Dayer J. M., Roosnek E., Chizzolini C., Presence of CD4+CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis Arthritis and Rheumatism 2007 56 10 3459 3467 (Pubitemid 47585442)
78. Majone F., Olivieri S., Cozzi F., Montaldi A., Tonello M., Visentin M. S., Ciprian L., Ruffatti A., Increased apoptosis in circulating lymphocyte cultures of anti-RNA polymerase III positive patients with systemic sclerosis Rheumatology International 2009 29 8 891 895
79. Cipriani P., Fulminis A., Pingiotti E., Marrelli A., Liakouli V., Perricone R., Pignone A., Matucci-Cerinic M., Giacomelli R., Resistance to apoptosis in circulating / and / T lymphocytes from patients with systemic sclerosis Journal of Rheumatology 2006 33 10 2003 2014 (Pubitemid 44571874)
80. Fang Y., Yu S., Ellis J. S., Sharav T., Braley-Mullen H., Comparison of sensitivity of Th1, Th2, and Th17 cells to Fas-mediated apoptosis Journal of Leukocyte Biology 2011 87 6 1019 1028
81. Fang Y., Braley-Mullen H., Cultured murine thyroid epithelial cells expressing transgenic Fas-associated death domain-like interleukin-1 converting enzyme inhibitory protein are protected from Fas-mediated apoptosis Endocrinology 2008 149 7 3321 3329 (Pubitemid 351919618)
82. Fang Y., Wei Y., DeMarco V., Chen K., Sharp G. C., Braley-Mullen H., Murine FLIP transgene expressed on thyroid epithelial cells promotes resolution of granulomatous experimental autoimmune thyroiditis in DBA/1 mice American Journal of Pathology 2007 170 3 875 887 (Pubitemid 47339357)
83. Sgonc R., Gruschwitz M. S., Boeck G., Sepp N., Gruber J., Wick G., Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95 Arthritis and Rheumatism 2000 43 11 2550 2562
84. Ahmed S. S., Tan F. K., Arnett F. C., Jin L., Geng Y. J., Induction of apoptosis and fibrillin 1 expression in human dermal endothelial cells by scleroderma sera containing anti-endothelial cell antibodies Arthritis and Rheumatism 2006 54 7 2250 2262 (Pubitemid 44051083)
85. Lunardi C., Bason C., Navone R., Millo E., Damonte G., Corrocher R., Puccetti A., Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells Nature Medicine 2000 6 10 1183 1186
86. Barnes T. C., Spiller D. G., Anderson M. E., Edwards S. W., Moots R. J., Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis? Annals of the Rheumatic Diseases 2010 70 2 366 372
87. del Papa N., Quirici N., Scavullo C., Gianelli U., Corti L., Vitali C., Ferri C., Giuggioli D., Manfredi A., Maglione W., Onida F., Colaci M., Bosari S., Deliliers G. L., Antiendothelial cell antibodies induce apoptosis of bone marrow endothelial progenitors in systemic sclerosis Journal of Rheumatology 2010 37 10 2053 2063
88. Zhu S., Evans S., Yan B., Povsic T. J., Tapson V., Goldschmidt-Clermont P. J., Dong C., Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells Circulation 2008 118 21 2156 2165
89. Distler J. H.W., Akhmetshina A., Dees C., Jngel A., Strzl M., Gay S., Pisetsky D. S., Schett G., Distler O., Induction of apoptosis in circulating angiogenic cells by microparticles Arthritis and Rheumatism 2011 63 7 2067 2077
90. Distler J. H. W., Huber L. C., Gay S., Distler O., Pisetsky D. S., Microparticles as mediators of cellular cross-talk in inflammatory disease Autoimmunity 2006 39 8 683 690 (Pubitemid 44964371)
91. Bielecki M., Kowal K., Lapinska A., Chwiecko J., Skowronski J., Sierakowski S., Chyczewski L., Kowal-Bielecka O., Diminished production of TWEAK by the peripheral blood mononuclear cells is associated with vascular involvement in patients with systemic sclerosis Folia Histochemica et Cytobiologica 2009 47 3 465 469
92. Yanaba K., Yoshizaki A., Muroi E., Hara T., Ogawa F., Usui A., Hasegawa M., Fujimoto M., Takehara K., Sato S., Elevated circulating TWEAK levels in systemic sclerosis: association with lower frequency of pulmonary fibrosis Journal of Rheumatology 2009 36 8 1657 1662
93. Brinckmann J., Kim S., Wu J., Reinhardt D. P., Batmunkh C., Metzen E., Notbohm H., Bank R. A., Krieg T., Hunzelmann N., Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma? Matrix Biology 2005 24 7 459 468 (Pubitemid 41443273)
94. Beyer C., Schett G., Gay S., Distler O., Distler J. H., Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis Arthritis Research amp; Therapy 2009 11 2 220
95. Hagimoto N., Kuwano K., Nomoto Y., Kunitake R., Hara N., Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice American Journal of Respiratory Cell and Molecular Biology 1997 16 1 91 101 (Pubitemid 127497440)
96. Chapman H. A., A Fas pathway to pulmonary fibrosis Journal of Clinical Investigation 1999 104 1 1 2 (Pubitemid 29534337)
97. Hoyles R. K., Khan K., Shiwen X., Howat S. L., Lindahl G. E., Leoni P., Du Bois R. M., Wells A. U., Black C. M., Abraham D. J., Denton C. P., Fibroblast-specific perturbation of transforming growth factor signaling provides insight into potential pathogenic mechanisms of scleroderma-associated lung fibrosis: exaggerated response to alveolar epithelial injury in a novel mouse model Arthritis and Rheumatism 2008 58 4 1175 1188 (Pubitemid 351564021)
98. Kuwano K., Kunitake R., Kawasaki M., Nomoto Y., Hagimoto N., Nakanishi Y., Hara N., p21(Waf1/Cip1/Sdi1) and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis American Journal of Respiratory and Critical Care Medicine 1996 154 2 477 483 (Pubitemid 26269122)
99. Golan-Gerstl R., Wallach-Dayan S. B., Amir G., Breuer R., Epithelial cell apoptosis by Fas ligand-positive myofibroblasts in lung fibrosis American Journal of Respiratory Cell and Molecular Biology 2007 36 3 270 275 (Pubitemid 46365277)
100. Aden N., Shiwen X., Aden D., Black C., Nuttall A., Denton C. P., Leask A., Abraham D., Stratton R., Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer Rheumatology 2008 47 12 1754 1760
101. Aden N., Nuttall A., Shiwen X., De Winter P., Leask A., Black C. M., Denton C. P., Abraham D. J., Stratton R. J., Epithelial cells promote fibroblast activation via IL-1 in systemic sclerosis Journal of Investigative Dermatology 2010 130 9 2191 2200
102. Bellemare J., Roberge C. J., Bergeron D., Lopez-Vallé C. A., Roy M., Moulin V. J., Epidermis promotes dermal fibrosis: role in the pathogenesis of hypertrophic scars Journal of Pathology 2005 206 1 1 8 (Pubitemid 40613428)
103. Larochelle S., Langlois C., Thibault I., Lopez-Vallé C. A., Roy M., Moulin V., Sensitivity of myofibroblasts to H2O2-mediated apoptosis and their antioxidant cell network Journal of Cellular Physiology 2004 200 2 263 271 (Pubitemid 38880209)
104. Moulin V., Larochelle S., Langlois C., Thibault I., Lopez-Vallé C. A., Roy M., Normal skin wound and hypertrophic scar myofibroblasts have differential responses to apoptotic inductors Journal of Cellular Physiology 2004 198 3 350 358 (Pubitemid 38235030)
105. Kim J. Y., Kwok S. K., Hur K. H., Kim H. J., Kim N. S., Yoo S. A., Kim W. U., Cho C. S., Up-regulated macrophage migration inhibitory factor protects apoptosis of dermal fibroblasts in patients with systemic sclerosis Clinical and Experimental Immunology 2008 152 2 328 335 (Pubitemid 351520917)
106. Jun J. B., Kuechle M., Min J., Seung C. S., Kim G., Montenegro V., Korn J. H., Elkon K. B., Scleroderma fibroblasts demonstrate enhanced activation of Akt (protein kinase B) in situ Journal of Investigative Dermatology 2005 124 2 298 303 (Pubitemid 40175874)
107. Horowitz J. C., Rogers D. S., Sharma V., Vittal R., White E. S., Cui Z., Thannickal V. J., Combinatorial activation of FAK and AKT by transforming growth factor- 1 confers an anoikis-resistant phenotype to myofibroblasts Cellular Signalling 2007 19 4 761 771 (Pubitemid 46290691)
108. Mimura Y., Ihn H., Jinnin M., Asano Y., Yamane K., Tamaki K., Constitutive phosphorylation of focal adhesion kinase is involved in the myofibroblast differentiation of scleroderma fibroblasts Journal of Investigative Dermatology 2005 124 5 886 892 (Pubitemid 40629086)
109. Simonini G., Cerinic M. M., Generini S., Zoppi M., Anichini M., Cesaretti C., Pignone A., Falcini F., Lotti T., Cagnoni M., Oxidative stress in systemic sclerosis Molecular and Cellular Biochemistry 1999 196 1-2 85 91 (Pubitemid 29338782)
110. Avouac J., Borderie D., Ekindjian O. G., Kahan A., Allanore Y., High DNA oxidative damage in systemic sclerosis Journal of Rheumatology 2010 37 12 2540 2547
111. Jelaska A., Arakawa M., Broketa G., Korn J. H., Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts: increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts Arthritis and Rheumatism 1996 39 8 1338 1346 (Pubitemid 26270093)
112. Botstein G. R., Sherer G. K., Leroy E. C., Fibroblast selection in scleroderma. An alternative model of fibrosis Arthritis and Rheumatism 1982 25 2 189 195 (Pubitemid 12170277)
113. Needleman B. W., Ordonez J. V., Taramelli D., Alms W., Gayer K., Choi J., In vitro identification of a subpopulation of fibroblasts that produces high levels of collagen in scleroderma patients Arthritis and Rheumatism 1990 33 6 842 852 (Pubitemid 20205764)
114. Jun J. B., Kuechle M., Harlan J. M., Elkon K. B., Fibroblast and endothelial apoptosis in systemic sclerosis Current Opinion in Rheumatology 2003 15 6 756 760 (Pubitemid 38156303)
115. Shanahan W. R., Korn J. H., Cytotoxic activity of sera from scleroderma and other connective tissue diseases. Lack of cellular and disease specificity Arthritis and Rheumatism 1982 25 12 1391 1395 (Pubitemid 13202218)
116. Liu K., McDuffie E., Abrams S. I., Exposure of human primary colon carcinoma cells to anti-Fas interactions influences the emergence of pre-existing Fas-resistant metastatic subpopulations Journal of Immunology 2003 171 8 4164 4174 (Pubitemid 37238693)
117. de Palma R., D'aiuto E., Vettori S., Cuoppolo P., Abbate G., Valentini G., Peripheral T cells from patients with early systemic sclerosis kill autologous fibroblasts in co-culture: is T-cell response aimed to play a protective role? Rheumatology 2010 49 7 1257 1266
118. Laplante P., Sirois I., Raymond M. A., Kokta V., Béliveau A., Prat A., Pshezhetsky A. V., Hébert M. J., Caspase-3-mediated secretion of connective tissue growth factor by apoptotic endothelial cells promotes fibrosis Cell Death and Differentiation 2010 17 2 291 303
119. Holmes A., Abraham D. J., Sa S., Shiwen X., Black C. M., Leask A., CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling Journal of Biological Chemistry 2001 276 14 10594 10601 (Pubitemid 38089227)
120. Laplante P., Raymond M. A., Gagnon G., Vigneault N., Sasseville A. M. J., Langelier Y., Bernard M., Raymond Y., Hébert M. J., Novel fibrogenic pathways are activated in response to endothelial apoptosis: implications in the pathophysiology of systemic sclerosis Journal of Immunology 2005 174 9 5740 5749 (Pubitemid 40593217)
121. Nacu N., Luzina I. G., Highsmith K., Lockatell V., Pochetuhen K., Cooper Z. A., Gillmeister M. P., Todd N. W., Atamas S. P., macrophages Produce TGF- -induced ( -h3) following ingestion of apoptotic cells and regulate MMP14 levels and collagen turnover in fibroblasts Journal of Immunology 2008 180 7 5036 5044
122. Mimura Y., Ihn H., Jinnin M., Asano Y., Yamane K., Tamaki K., Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor- signaling in cultured scleroderma fibroblasts American Journal of Pathology 2005 166 5 1451 1463 (Pubitemid 40586515)
123. Moodley Y., Rigby P., Bundell C., Bunt S., Hayashi H., Misso N., McAnulty R., Laurent G., Scaffidi A., Thompson P., Knight D., Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36 American Journal of Pathology 2003 162 3 771 779 (Pubitemid 36237486)
124. Mott J. L., Kobayashi S., Bronk S. F., Gores G. J., mir-29 regulates Mcl-1 protein expression and apoptosis Oncogene 2007 26 42 6133 6140 (Pubitemid 47414372)
125. Maurer B., Stanczyk J., Jngel A., Akhmetshina A., Trenkmann M., Brock M., Kowal-Bielecka O., Gay R. E., Michel B. A., Distler J. H. W., Gay S., Distler O., MicroRNA-29, a key regulator of collagen expression in systemic sclerosis Arthritis and Rheumatism 2010 62 6 1733 1743
126. Mott J. L., Kurita S., Cazanave S. C., Bronk S. F., Werneburg N. W., Fernandez-Zapico M. E., Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB Journal of Cellular Biochemistry 2010 110 5 1155 1164
127. Koch A. E., Kronfeld-Harrington L. B., Szekanecz Z., Cho M., Haines G. K., Harlow L. A., Strieter R. M., Kunkel S. L., Massa M. C., Barr W. G., Jimenez S. A., In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis. Their role in early and late disease Pathobiology 1993 61 5-6 239 246 (Pubitemid 24007481)
128. Becvar R., Hulejov H., Braun M., tork J., Collagen degradation products and proinflammatory cytokines in systemic and localized scleroderma Folia Biologica 2007 53 2 66 68 (Pubitemid 46546780)
129. Horikawa M., Hasegawa M., Komura K., Hayakawa I., Yanaba K., Matsushita T., Takehara K., Sato S., Abnormal natural killer cell function in systemic sclerosis: altered cytokine production and defective killing activity Journal of Investigative Dermatology 2005 125 4 731 737
130. Kawaguchi Y., Hara M., Wright T. M., Endogenous IL-1 from systemic sclerosis fibroblasts induces IL-6 and PDGF-A Journal of Clinical Investigation 1999 103 9 1253 1260 (Pubitemid 29218295)
131. Sato S., Hasegawa M., Takehara K., Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis Journal of Dermatological Science 2001 27 2 140 146 (Pubitemid 32781022)
132. Xiao L. Z., Topley N., Ito T., Phillips A., Interleukin-6 regulation of transforming growth factor (TGF)- receptor compartmentalization and turnover enhances TGF- 1 signaling Journal of Biological Chemistry 2005 280 13 12239 12245
133. Moodley Y. P., Misso N. L. A., Scaffidi A. K., Fogel-Petrovic M., McAnulty R. J., Laurent G. J., Thompson P. J., Knight D. A., Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs American Journal of Respiratory Cell and Molecular Biology 2003 29 4 490 498 (Pubitemid 37222687)
134. Legembre P., Daburon S., Moreau P., Ichas F., De Giorgi F., Moreau J. F., Taupin J. L., Amplification of Fas-mediated apoptosis in type II cells via microdomain recruitment Molecular and Cellular Biology 2005 25 15 6811 6820 (Pubitemid 41023251)
135. Legembre P., Daburon S., Moreau P., Moreau J. F., Taupin J. L., Modulation of Fas-mediated apoptosis by lipid rafts in T lymphocytes Journal of Immunology 2006 176 2 716 720 (Pubitemid 43099665)
136. Ramaswamy M., Dumont C., Cruz A. C., Muppidi J. R., Gomez T. S., Billadeau D. D., Tybulewicz V. L. J., Siegel R. M., Cutting edge: Rac GTPases sensitize activated T cells to die via Fas Journal of Immunology 2007 179 10 6384 6388
137. Beneteau M., Pizon M., Chaigne-Delalande B., Daburon S., Moreau P., De Giorgi F., Ichas F., Rebillard A., Dimanche-Boitrel M. T., Taupin J. L., Moreau J. F., Legembre P., Localization of Fas/CD95 into the lipid rafts on down-modulation of the phosphatidylinositol 3-kinase signaling pathway Molecular
138. Muppidi J. R., Siegel R. M., Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death Nature Immunology 2004 5 2 182 189 (Pubitemid 38208360)
139. Aouad S. M., Cohen L. Y., Sharif-Askari E., Haddad E. K., Alam A., Sekaly R. P., Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death Journal of Immunology 2004 172 4 2316 2323 (Pubitemid 38182379)
140. Wei J., Bhattacharyya S., Tourtellotte W. G., Varga J., Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy Autoimmunity Reviews 2011 10 5 267 275
141. Shukla S., Fujita K. I., Xiao Q., Liao Z., Garfield S., Srinivasula S. M., A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface Apoptosis 2010 16 2 1 12
142. Varadhachary A. S., Edidin M., Hanlon A. M., Peter M. E., Krammer P. H., Salgame P., Phosphatidylinositol 3′-kinase blocks CD95 aggregation and caspase-8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD95 Journal of Immunology 2001 166 11 6564 6569 (Pubitemid 32467195)
143. Derk C. T., Associations of breast cancer development in patients with systemic sclerosis: an exploratory study Clinical Rheumatology 2007 26 10 1615 1619
144. Behjati S., Frank M. H., The effects of tamoxifen on immunity Current Medicinal Chemistry 2009 16 24 3076 3080
145. Shin S. M., Kim S. G., Inhibition of arachidonic acid and iron-induced mitochondrial dysfunction and apoptosis by oltipraz and novel 1,2-dithiole-3-thione congeners Molecular Pharmacology 2009 75 1 242 253
146. Ito T., Williams J. D., Fraser D. J., Phillips A. O., Hyaluronan regulates transforming growth factor- 1 receptor compartmentalization Journal of Biological Chemistry 2004 279 24 25326 25332 (Pubitemid 38756787)
147. Tourkina E., Richard M., Gz P., Bonner M., Pannu J., Harley R., Bernatchez P. N., Sessa W. C., Silver R. M., Hoffman S., Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo American Journal of Physiology, Lung Cellular and Molecular Physiology 2008 294 5 L843 L861
148. Qian N., Ueno T., Is dysfunction of caveolin-1 a link between systemic sclerosis and breast cancer, opening a window on both etiologies? Archives of Medical Research 2010 41 4 297 301
149. Tourkina E., Gooz P., Oates J. C., Ludwicka-Bradley A., Silver R. M., Hoffman S., Curcumin-induced apoptosis in scleroderma lung fibroblasts: role of protein kinase C American Journal of Respiratory Cell and Molecular Biology 2004 31 1 28 35 (Pubitemid 38888036)
150. Miller M., Chen S., Woodliff J., Kansra S., Curcumin (diferuloylmethane) inhibits cell proliferation, induces apoptosis, and decreases hormone levels and secretion in pituitary tumor cells Endocrinology 2008 149 8 4158 4167
151. Wang Z., Desmoulin S., Banerjee S., Kong D., Li Y., Deraniyagala R. L., Abbruzzese J., Sarkar F. H., Synergistic effects of multiple natural products in pancreatic cancer cells Life Sciences 2008 83 7-8 293 300
152. Majumdar A. P. N., Banerjee S., Nautiyal J., Patel B. B., Patel V., Du J., Yu Y., Elliott A. A., Levi E., Sarkar F. H., Curcumin synergizes with resveratrol to inhibit colon cancer Nutrition and Cancer 2009 61 4 544 553
153. Singh S., Khar A., Biological effects of curcumin and its role in cancer chemoprevention and therapy Anti-Cancer Agents in Medicinal Chemistry 2006 6 3 259 270 (Pubitemid 43796643)
154. Singh N., Shrivastav A., Sharma R. K., Curcumin induces caspase and calpain-dependent apoptosis in HT29 human colon cancer cells Molecular Medicine Reports 2009 2 4 627 631
155. Fulda S., Modulation of apoptosis by natural products for cancer therapy Planta Medica 2011 76 11 1075 1079
156. Fulda S., Debatin K. M., Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review Cancer Detection and Prevention 2006 30 3 217 223 (Pubitemid 44163050)
157. Simonini G., Alberto P., Sergio G., Fernanda F., Marco M. C., Emerging potentials for an antioxidant therapy as a new approach to the treatment of systemic sclerosis Toxicology 2000 155 1-3 1 15 (Pubitemid 32056309)
158. Lee E. S., Kim Y. A., Kwon H. J., Bang D., Lee S., Sohn S., Thalidomide upregulates macrophage inflammatory protein-1 in a herpes simplex virus-induced Behet's disease-like animal model Archives of Dermatological Research 2004 296 4 175 181 (Pubitemid 39371412)
159. Yasui K., Kobayashi N., Yamazaki T., Agematsu K., Thalidomide as an immunotherapeutic agent: the effects on neutrophil-mediated inflammation Current Pharmaceutical Design 2005 11 3 395 401 (Pubitemid 40277865)
160. Gockel H. R., Lgering A., Heidemann J., Schmidt M., Domschke W., Kucharzik T., Lgering N., Thalidomide Induces Apoptosis in Human Monocytes by Using a Cytochrome c-Dependent Pathway Journal of Immunology 2004 172 8 5103 5109 (Pubitemid 38456439)
161. Huber S. A., Kupperman J., Newell M. K., Estradiol prevents and testosterone promotes Fas-dependent apoptosis in CD4+ Th2 cells by altering Bcl 2 expression Lupus 1999 8 5 384 387 (Pubitemid 29378019)
162. Ghobrial I. M., Witzig T. E., Adjei A. A., Targeting apoptosis pathways in cancer therapy Ca-A Cancer Journal for Clinicians 2005 55 3 178 194 (Pubitemid 40826487)