Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: Important pathogenetic steps in early and late stage of systemic scleroderma?

Matrix Biology

Volumn 24, Issue 7, 2005, Pages 459-468

  Brinckmann, J ^a   Kim, S ^c   Wu, J ^a   Reinhardt, D P ^b   Batmunkh, C ^a   Metzen, E ^a   Notbohm, H ^a   Bank, R A ^d   Krieg, T ^c   Hunzelmann, N ^c  

^a UNIVERSITY OF LÜBECK   (Germany)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF COLOGNE   (Germany)

^d TNO   (Netherlands)

Author keywords

Collagen; Cross link; Fibrosis; Hypoxia; Systemic scleroderma

Indexed keywords

ALDEHYDE; COLLAGEN TYPE 1; CYTOKINE; HYDROXYLYSINE ALDEHYDE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 4; LYSINE ALDEHYDE; MESSENGER RNA; PROCOLLAGEN LYSINE 2 OXOGLUTARATE 5 DIOXYGENASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; EXTRACELLULAR MATRIX; FIBROBLAST CULTURE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IMMUNOMODULATION; MEDIATOR; OXYGEN TENSION; PATHOGENESIS; PRIORITY JOURNAL; SCLERODERMA; SKIN; SKIN FIBROBLAST; STATISTICAL SIGNIFICANCE; SYSTEMIC SCLEROSIS;

CELL HYPOXIA; COLLAGEN; EXTRACELLULAR MATRIX; FIBROBLASTS; GENE EXPRESSION; HUMANS; INTERLEUKIN-1; INTERLEUKIN-4; PROCOLLAGEN-LYSINE, 2-OXOGLUTARATE 5-DIOXYGENASE; RECOMBINANT PROTEINS; RNA, MESSENGER; SCLERODERMA, SYSTEMIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 26644440414     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.matbio.2005.07.002     Document Type: Article

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