Estradiol prevents and testosterone promotes Fas-dependent apoptosis in CD4+ Th2 cells by altering Bcl 2 expression

Lupus

Volumn 8, Issue 5, 1999, Pages 384-387

  Huber, S A ^a   Kupperman, J ^a   Newell, M K ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

Apoptosis; Estradiol; Myocarditis; Testosterone

Indexed keywords

CD4 ANTIGEN; CHROMIUM 51; ESTRADIOL; FAS ANTIGEN; PROTEIN BCL 2; TESTOSTERONE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CLONE; CELL PROTECTION; CONTROLLED STUDY; COXSACKIE VIRUS B3; CYTOLYSIS; GENETIC TRANSFECTION; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING;

EID: 0032795930     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/096120339900800511     Document Type: Article

References (24)

1. Lockshin MD. Why women? J Am Med Womens Assoc 1998; 53: 4-8.
2. Lou H, Kodama T, Zhao YJ et al. Inhibition of transplant coronary arteriosclerosis in rabbits by chronic estradiol treatment is associated with abolition of MHC class II antigen expression. Circulation 1996; 94: 3355-3361.
3. Wira CR, Rossoll RM. Antigen-presenting cells in the female reproductive tract: influence of sex hormones on antigen presentation in the vagina. Immunology 1995; 84: 505-508.
4. Run MF, Bi Y, D'Alonzo R et al. Effect of estrogens on IL-1beta promoter activity. J Steroid Biochem Mol Biol 1998; 66: 203-210
5. Fox HS, Bond BL, Parslow TG. Estrogen regulates the IFN-gamma promoter. J Immunol 1991; 146: 4362-4367.
6. Wang Y, Campbell HD, Young IG. Sex hormones and dexamethasone modulate inter-leukin-5 gene expression in T lymphocytes. J Steroid Biochem Mol Biol 1993; 44: 203-210.
7. Gilmore W, Weiner LP, Correale J. Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects. J Immunol 1997; 158: 446-451.
8. Correale J, Arias M, Gilmore W. Steroid hormone regulation of cytokine secretion by proteolipid protein-specific CD4 + T cell clones isolated from multiple sclerosis patients and normal control subjects. J Immunol 1998; 161: 3365-3374.
9. Toda I, Wickham LA, Sullivan DA. Gender and androgen treatment influence the expression of proto-oncogenes and apoptotic factors in lacrimal and salivary tissue of MRL/1pr mice. Clin Immunol Immunopathol 1998; 86: 159-71.
10. Garcia-Segura LM, Cardona-Gomez P, Naptolin F et al. Estradiol upregulates Bcl 2 expression in adult brain neurons. Neuroreport 1998; 9: 593-597.
11. Evans MJ, MacLaughlin S, Malvin RD et al. Estrogen decreases in vitro apoptosis of peripheral blood mononuclear cells from women with normal menstrual cycles and decreases TNF-alpha production in SLE but not in normal cultures. Clin Immunol Immunopathol 1997; 82: 258-262.
12. Watanabe-Fukunaga R, Brannan CI, Copeland NG et al. Lymphoproliferative disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992; 356: 314.
13. Huber SA, Gauntt CJ, Sakkinen P. Enteroviruses and myocarditis: Viral pathogenesis through replication, cytokine induction and immunopathogenicity. Adv Virus Res 1998; 51: 35-80.
14. Woodruff J. Viral myocarditis. Am J Pathol 1980; 101: 425-483.
15. Lyden D, Huber S. Aggravation of coxsackievirus group B type 3-induced myocarditis and increase in cellular immunity to myocyte antigens in pregnant BALB/c mice and animals treated with progesterone. Cell Immunol 1984; 87: 462-472.
16. Lyden DC, Olszweski J, Feran M et al. Coxsackievirus B3-induced myocarditis. Effects of sex steroids on viremia and infectivity of cardiocytes. Am J Pathol 1987; 126: 432-438.
17. Huber S, Lodge P. Coxsackievirus B3 myocarditis in Balb/c mice: evidence for autoimmunity to myocyte antigens. Am J Path 1984; 116: 21.
18. Huber S, Pfaeffle B. Differential Th1 and Th2 cell responses in male and female BALB/c mice infected with Coxsackievirus Group B Type 3. J Virol 1994; 68: 5126-5132.
19. Hofmann-Lehmann R, Holznagel R, Lutz H. Female cats have lower rates of apoptosis in peripheral blood lymphocytes than male cats: correlation with estradiol-17beta, but not with progesterone blood levels. Vet Immunol Immunopathol 1988; 65: 151-160.
20. Cutolo M, Sulli A, Seriolo B et al. Estrogens, the immune response and autoimmunity. Clin Exp Rheumatol 1995; 13: 217-226.
21. Kretz-Rommel A, Rubin R. Persistence of autoreactive T cell drive is required to elicit anti-chromatin antibodies in a murine model of drug-induced lupus. J Immunol 1999; 162: 813-820.
22. Suda T, Nagata S. Why do defects in the Fas-Fas ligand system cause autoimmunity? J Allergy Clin Immunol 1997; 100: S97-101.
23. Carlsten H, Nilsson N. Jonsson R et al. Estrogen accelerates immune complex glomerulonephritis but ameliorates T cell-mediated vasculitis and sialadenitis in autoimmune MLR 1pr/1pr mice. Cell Immunol 1992; 144: 190-202.
24. Erbach GT, Bahr JM. Enhancement of in vivo humoral immunity by estrogen: permissive effect of a thymic factor. Endocrinology 1991; 128: 1352-1358.