Vγ9+ γδ T cells in systemic sclerosis patients are numerically and functionally preserved and induce fibroblast apoptosis

Immunobiology

Volumn 215, Issue 5, 2010, Pages 380-394

  Bendersky, Anna ^a,b   Markovits, Noa ^a   Bank, I ^a,c  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

T cells; Apoptosis; Progressive systemic sclerosis; Scleroderma; Tumor necrosis factor

Indexed keywords

INTERLEUKIN 2; ISOPENTENYL DIPHOSPHATE; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; LYMPHOCYTE ANTIGEN RECEPTOR; T CELL RECEPTOR VGAMMA9, HUMAN; T-CELL RECEPTOR VGAMMA9, HUMAN;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL CONTACT; CELL DISRUPTION; CELL EXPANSION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; EX VIVO STUDY; FEMALE; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOPATHOGENESIS; INTERSTITIAL LUNG DISEASE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PRESERVATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SYSTEMIC SCLEROSIS; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; COCULTURE; FIBROBLAST; IMMUNOLOGY; LYMPHOCYTE COUNT; METABOLISM; MIDDLE AGED; T LYMPHOCYTE;

ADULT; AGED; APOPTOSIS; CELL DIVISION; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; FEMALE; FIBROBLASTS; HUMANS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SCLERODERMA, SYSTEMIC; T-LYMPHOCYTES;

EID: 77950933199     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2009.05.012     Document Type: Article

References (52)

1. American College of Rheumatology for SSc Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Arthritis Rheum. 1980, 23:581-590.
2. Abraham D.J., Varga J. Scleroderma: from cell and molecular mechanisms to disease models. Trends Immunol. 2005, 26:587-595. (Epub 2005 September 2015).
3. Ali Z., Shao L., Halliday L., Reichenberg A., Hintz M., Jomaa H., Chen Z.W. Prolonged (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-driven antimicrobial and cytotoxic responses of pulmonary and systemic Vgamma2Vdelta2T cells in macaques. J. Immunol. 2007, 179:8287-8296.
4. Aliprantis A.O., Wang J., Fathman J.W., Lemaire R., Dorfman D.M., Lafyatis R., Glimcher L.H. Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc. Natl. Acad. Sci. USA 2007, 104:2827-2830.
5. Bai S., Liu H., Chen K.H., Eksarko P., Perlman H., Moore T.L., Pope R.M. NF-kappaB-regulated expression of cellular FLIP protects rheumatoid arthritis synovial fibroblasts from tumor necrosis factor alpha-mediated apoptosis. Arthritis Rheum. 2004, 50:3844-3855.
6. Bank I., Cohen L., Kneller A., De Rosbo N.K., Book M., Ben-Nun A. Aberrant T-cell receptor signalling of interferon-gamma- and tumour necrosis factor-alpha-producing cytotoxic CD8+ Vdelta1/Vbeta16T cells in a patient with chronic neutropenia. Scand. J. Immunol. 2003, 58:89-98.
7. Bank I., DePinho R.A., Brenner M.B., Cassimeris J., Alt F.W., Chess L. A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature 1986, 322:179-181.
8. Bhogal R.K., Stoica C.M., McGaha T.L., Bona C.A. Molecular aspects of regulation of collagen gene expression in fibrosis. J. Clin. Immunol. 2005, 25:592-603.
9. Boin F., De Fanis U., Bartlett S.J., Wigley F.M., Rosen A., Casolaro V. T cell polarization identifies distinct clinical phenotypes in scleroderma lung disease. Arthritis Rheum. 2008, 58:1165-1174.
10. Braun R.K., Ferrick C., Neubauer P., Sjoding M., Sterner-Kock A., Kock M., Putney L., Ferrick D.A., Hyde D.M., Love R.B. IL-17 producing gammadelta T cells are required for a controlled inflammatory response after bleomycin-induced lung injury. Inflammation 2008, 31:167-179.
11. Brenner M.B., McLean J., Dialynas D.P., Strominger J.L., Smith J.A., Owen F.L., Seidman J.G., Ip S., Rosen F., Krangel M.S. Identification of a putative second T-cell receptor. Nature 1986, 322:145-149.
12. Carbone L.D., Warrington K.J., Barrow K.D., Pugazhenthi M., Watsky M.A., Somes G., Ingels J., Postlethwaite A.E. Pamidronate infusion in patients with systemic sclerosis results in changes in blood mononuclear cell cytokine profiles. Clin. Exp. Immunol. 2006, 146:371-380.
13. Chizzolini C. T lymphocyte and fibroblast interactions: the case of skin involvement in systemic sclerosis and other examples. Springer Semin. Immunopathol. 1999, 21:431-450.
14. Collins R.A., Werling D., Duggan S.E., Bland A.P., Parsons K.R., Howard C.J. Gammadelta T cells present antigen to CD4+ alphabeta T cells. J. Leukoc. Biol. 1998, 63:707-714.
15. de Ledinghen V., Barreiro P., Foucher J., Labarga P., Castera L., Vispo M.E., Bernard P.H., Martin-Carbonero L., Neau D., Garcia-Gasco P., Merrouche W., Soriano V. Liver fibrosis on account of chronic hepatitis C is more severe in HIV-positive than HIV-negative patients despite antiretroviral therapy. J. Viral Hepat. 2008, 15:427-433.
16. Dieli F., Vermijlen D., Fulfaro F., Caccamo N., Meraviglia S., Cicero G., Roberts A., Buccheri S., D'Asaro M., Gebbia N., Salerno A., Eberl M., Hayday A.C. Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer Res. 2007, 67:7450-7457.
17. Dyugovskaya L., Hirsh M., Ginsburg H. Phenotypic profile and functional characterization of rat lymph node-derived gammadelta T cells: implication in the immune response to cytomegalovirus. Immunology 2003, 108:129-136.
18. Enders P.J., Yin C., Martini F., Evans P.S., Propp N., Poccia F., Pauza C.D. HIV-mediated gammadelta T cell depletion is specific for Vgamma2+ cells expressing the Jgamma1.2 segment. AIDS Res. Hum. Retroviruses 2003, 19:21-29.
19. Garcia V.E., Sieling P.A., Gong J., Barnes P.F., Uyemura K., Tanaka Y., Bloom B.R., Morita C.T., Modlin R.L. Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens. J. Immunol. 1997, 159:1328-1335.
20. Giacomelli R., Cipriani P., Fulminis A., Barattelli G., Matucci-Cerinic M., D'Alo S., Cifone G., Tonietti G. Circulating gamma/delta T lymphocytes from systemic sclerosis (SSc) patients display a T helper (Th) 1 polarization. Clin. Exp. Immunol. 2001, 125:310-315.
21. Giacomelli R., Matucci-Cerinic M., Cipriani P., Ghersetich I., Lattanzio R., Pavan A., Pignone A., Cagnoni M.L., Lotti T., Tonietti G. Circulating Vdelta1+ T cells are activated and accumulate in the skin of systemic sclerosis patients. Arthritis Rheum. 1998, 41:327-334.
22. Hayday A.C. [gamma][delta] cells: a right time and a right place for a conserved third way of protection. Annu. Rev. Immunol. 2000, 18:975-1026.
23. Hintz M., Reichenberg A., Altincicek B., Bahr U., Gschwind R.M., Kollas A.K., Beck E., Wiesner J., Eberl M., Jomaa H. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Lett. 2001, 509:317-322.
24. Holcombe R.F., Baethge B.A., Wolf R.E., Betzing K.W., Stewart R.M. Natural killer cells and gamma delta T cells in scleroderma: relationship to disease duration and anti-Scl-70 antibodies. Ann. Rheum. Dis. 1995, 54:69-72.
25. Huang D., Shen Y., Qiu L., Chen C.Y., Shen L., Estep J., Hunt R., Vasconcelos D., Du G., Aye P., Lackner A.A., Larsen M.H., Jacobs W.R., Haynes B.F., Letvin N.L., Chen Z.W. Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection. Infect. Immun. 2008, 76:426-436.
26. Jelaska A., Korn J.H. Role of apoptosis and transforming growth factor beta1 in fibroblast selection and activation in systemic sclerosis. Arthritis Rheum. 2000, 43:2230-2239.
27. Jun J.B., Kuechle M., Harlan J.M., Elkon K.B. Fibroblast and endothelial apoptosis in systemic sclerosis. Curr. Opin. Rheumatol. 2003, 15:756-760.
28. Kahari V.M., Chen Y.Q., Su M.W., Ramirez F., Uitto J. Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels. J. Clin. Invest. 1990, 86:1489-1495.
29. Kato Y., Tanaka Y., Hayashi M., Okawa K., Minato N. Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens. J. Immunol. 2006, 177:877-884.
30. Lafyatis R. Targeting fibrosis in systemic sclerosis. Endocr. Metab. Immune Disord. Drug Targets 2006, 6:395-400.
31. Lockhart E., Green A.M., Flynn J.L. IL-17 production is dominated by gammadelta T cells rather than CD4T cells during Mycobacterium tuberculosis infection. J. Immunol. 2006, 177:4662-4669.
32. Maeda S., Chang L., Li Z.W., Luo J.L., Leffert H., Karin M. IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity 2003, 19:725-737.
33. Morel J., Audo R., Hahne M., Combe B. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phosphatidylinositol 3-kinase/Akt. J. Biol. Chem. 2005, 280:15709-15718.
34. Morita C.T., Beckman E.M., Bukowski J.F., Tanaka Y., Band H., Bloom B.R., Golan D.E., Brenner M.B. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells. Immunity 1995, 3:495-507.
35. Morita C.T., Jin C., Sarikonda G., Wang H. Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. Immunol. Rev. 2007, 215:59-76.
36. Rajagopalan S., Zordan T., Tsokos G.C., Datta S.K. Pathogenic anti-DNA autoantibody-inducing T helper cell lines from patients with active lupus nephritis: isolation of CD4-8- T helper cell lines that express the gamma delta T-cell antigen receptor. Proc. Natl. Acad. Sci. USA 1990, 87:7020-7024.
37. Rincon-Orozco B., Kunzmann V., Wrobel P., Kabelitz D., Steinle A., Herrmann T. Activation of V gamma 9V delta 2T cells by NKG2D. J. Immunol. 2005, 175:2144-2151.
38. Rothenfusser S., Buchwald A., Kock S., Ferrone S., Fisch P. Missing HLA class I expression on Daudi cells unveils cytotoxic and proliferative responses of human gammadelta T lymphocytes. Cell. Immunol. 2002, 215:32-44.
39. Simonian P.L., Roark C.L., Diaz del Valle F., Palmer B.E., Douglas I.S., Ikuta K., Born W.K., O'Brien R.L., Fontenot A.P. Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis. J. Immunol. 2006, 177:4436-4443.
40. Temkin V., Karin M. From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey. Immunol. Rev. 2007, 220:8-21.
41. Tengstrand B., Ernestam S., Engvall I.L., Rydvald Y., Hafstrom I. TNF blockade in rheumatoid arthritis can cause severe fibrosing alveolitis. Six case reports. Lakartidningen 2005, 102. 3788-3790, 3793.
42. Wang L., Das H., Kamath A., Bukowski J.F. Human V gamma 2V delta 2T cells produce IFN-gamma and TNF-alpha with an on/off/on cycling pattern in response to live bacterial products. J. Immunol. 2001, 167:6195-6201.
43. Weissenbach J., Zeevi M., Landau T., Revel M. Identification of the translation products of human fibroblast interferon mRNA in reticulocyte lysates. Eur. J. Biochem. 1979, 98:1-8.
44. White B., Korn J.H., Piela-Smith T.H. Preferential adherence of human gamma delta, CD8+, and memory T cells to fibroblasts. J. Immunol. 1994, 152:4912-4918.
45. Workalemahu G., Foerster M., Kroegel C. Expression and synthesis of fibroblast growth factor-9 in human gammadelta T-lymphocytes. Response to isopentenyl pyrophosphate and TGF-beta1/IL-15. J. Leukoc. Biol. 2004, 75:657-663.
46. Workalemahu G., Foerster M., Kroegel C., Braun R.K. Human gamma delta-T lymphocytes express and synthesize connective tissue growth factor: effect of IL-15 and TGF-beta 1 and comparison with alpha beta-T lymphocytes. J. Immunol. 2003, 170:153-157.
47. Wu H., Wang Y M., Wang Y., Hu M., Zhang G.Y., Knight J.F., Harris D.C., Alexander S.I. Depletion of gammadelta T cells exacerbates murine adriamycin nephropathy. J. Am. Soc. Nephrol. 2007, 18:1180-1189.
48. Wynn T. Cellular and molecular mechanisms of fibrosis. J. Pathol. 2008, 214:199-210.
49. Wynn T.A. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J. Clin. Invest. 2007, 117:524-529.
50. Yin Z., Chen C., Szabo S.J., Glimcher L.H., Ray A., Craft J. T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells. J. Immunol. 2002, 168:1566-1571.
51. Yurovsky V.V., Sutton P.A., Schulze D.H., Wigley F.M., Wise R.A., Howard R.F., White B. Expansion of selected V delta 1+ gamma delta T cells in systemic sclerosis patients. J. Immunol. 1994, 153:881-891.
52. Zheng B., Marinova E., Han J., Tan T.H., Han S. Cutting edge: gamma delta T cells provide help to B cells with altered clonotypes and are capable of inducing Ig gene hypermutation. J. Immunol. 2003, 171:4979-4983.