Constitutive phosphorylation of focal adhesion kinase is involved in the myofibroblast differentiation of scleroderma fibroblasts

Journal of Investigative Dermatology

Volumn 124, Issue 5, 2005, Pages 886-892

  Mimura, Yoshihiro ^a   Ihn, Hironobu ^a   Jinnin, Masatoshi ^a   Asano, Yoshihide ^a   Yamane, Kenichi ^a   Tamaki, Kunihiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Focal adhesion kinase; Scleroderma fibroblasts; smooth muscle actin

Indexed keywords

4 AMINO 5 (4 CHLOROPHENYL) 7 BUTYLPYRAZOLO[3,4 D]PYRIMIDINE; ALPHA SMOOTH MUSCLE ACTIN; ENZYME INHIBITOR; FOCAL ADHESION KINASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ARTICLE; AUTOCRINE EFFECT; CELL CULTURE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; MYOFIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SCLERODERMA; SIGNAL TRANSDUCTION;

EID: 18244368698     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23701.x     Document Type: Article

References (52)

1. Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K: Increased expression levels of integrin αvβ5 on scleroderma fibroblasts. Am J Pathol 164:1275-1292, 2004
2. Barry ST, Critchley DR: The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-δ to focal adhesions. J Cell Sci 107:2033-2045, 1994
3. Border WA, Noble NA: Transforming growth factor β in tissue fibrosis. N Engl J Med 331:1286-1292, 1994
4. Brunet CL, Sharpe PM, Ferguson MWJ: Inhibition of TGF-β3 (but not TGF-β1 or TGF-β2) activity prevents normal and mouse embryonic palate fusion. Int J Dev Biol 39:345-355, 1995
5. Buckingham RB, Prince RK, Rodnan GP: Progressive systemic sclerosis (PSS, scleroderma) dermal fibroblasts synthesize increased amounts of glycosaminoglycan. J Lab Clin Med 101:659-669, 1983
6. Burridge K, Turner CE, Romer LH: Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: A role in cytoskeletal assembly. J Cell Biol 119:893-903, 1992
7. Calalb MB, Polte TR, Hanks SK: Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for src family kinases. Mol Cell Biol 15:954-963, 1995
8. Chan PY, Kanner SB, Whitney G, Aruffo A: A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK. J Biol Chem 269:20567-20574, 1994
9. Chen HC, Appeddu PA, Isoda H, Guan JL: Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. J Biol Chem 271:26329-26334, 1996
10. Chrzanowska-Wodnicka M, Burridge K: Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation. J Cell Sci 107:3643-3654, 1994
11. Darby I, Skalli O, Gabbiani G: α-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest 63:21-29, 1990
12. Eide BL, Turck CW, Escobedo JA: Identification of Tyr-397 as the primary site of tyrosine phosphorylation and pp60src association in the focal adhesion kinase, pp125FAK. Mol Cell Biol 15:2819-2827, 1995
13. Falanga V, Greenberg AS, Ochoa SM, Roberts AB, Falabella A, Yamaguchi Y: Stimulation of collagen synthesis by anabolic steroid stanozol. J Invest Dermatol 111:1193-1197, 1998
14. Finlay GA, Thannickal VJ, Fanburg BL, Paulson KE: Transforming growth factor-β 1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor. J Biol Chem 275:27650-27656, 2000
15. Fleischmajer R, Perlish JS, Krieg T: Variability in collagen and fibronectin synthesis by scleroderma fibroblasts in primary culture. J Invest Dermatol 76:400-403, 1981
16. Guan JL, Shalloway D: Regulation of pp125FAK both by cellular adhesion and by oncogenic transformation. Nature 358:690-692, 1992
17. Hanks SK, Calalb MB, Harper MC, Patel SK: Focal adhesion protein tyrosine kinase phosphorylated in response to cell spreading on fibronectin. Proc Natl Acad Sci USA 89:8487-8489, 1992
18. Hassell TM, Page RC, Narayanan AS, Cooper CG: Diphenylhydantoin (dilantin) gingival hyperplasia: Drug-induced abnormality of connective tissue, Proc Natl Acad Sci USA 73:2909-2912, 1976
19. Heino J, Ignotz RA, Hemler ME, Crouse C, Massagué J: Regulation of cell adhesion receptors by transforming growth factor-β. Concomitant regulation of integrins that share a common β1 subunit. J Biol Chem 264: 380-388, 1989
20. Hynes RO: Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 69:11-25, 1992
21. Ignotz RA, Massagué J: Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 261:4337-4345, 1986
22. Ihn H, Tamaki K: Mitogenic activity of dermatofibrosarcoma protuberans is mediated via an extracellular signal related kinase dependent pathway. J Invest Dermatol 119:954-960, 2002
23. Ihn H, Yamane K, Asano Y, Kubo M, Tamaki K: IL-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase-dependent pathway. J Immunol 168: 1895-1902, 2002
24. Ihn H, Yamane K, Kubo M, Tamaki K: Blockade of endogenous transforming growth factor β signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor β receptors. Arthritis Rheum 44:474-480, 2001
25. Jimenez SA, Feldman G, Bashey RI, Bienkowski R, Rosenbloom J: Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts. Biochem J 237:837-843, 1986
26. Kahari VM, Sandberg M, Kalimo H, Vuorio T, Vuorio E: Identification of fibroblasts responsible for increased collagen production in localized scleroderma by in situ hybridization. Invest Dermatol 90:664-670, 1988
27. Kinsella MB, Smith EA, Miller KS, LeRoy EC, Silver RM: Spontaneous production of fibronectin by alveolar macrophages in patients with scleroderma. Arthritis Rheum 32:577-583, 1989
28. Kirk TZ, Mark ME, Chua CC, Chua BH, Mayes MD: Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloproteinase (TIMP-1) with two forms of TIMP-1. J Biol Chem 270:3423-3428, 1995
29. Kornberg L, Earp HS, Parsons JT, Schaller MD, Juliano RL: Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J Biol Chem 267:23439-23442, 1992
30. Kumagai N, Morii N, Fujisawa K, Nemoto Y, Narumiya S: ADP-ribosylation of Rho p21 inhibits lysophosphatidic acidinduced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. J Biol Chem 268:24535-24538, 1993
31. LeRoy EC: Increased collagen synthesis by scleroderma skin fibroblasts in vitro: A possible defect in the regulation or activation of the scleroderma fibroblast. J Clin Invest 54:880-889, 1974
32. Lipfert L, Haimovich B, Schaller MD, Cobb BS, Parsons JT, Brugge JS: Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets. J Cell Biol 119:905-912, 1992
33. Ludwicka A, Trojanowska M, Smith EA, et al: Growth and characterization of fibroblasts obtained from bronchoalveolar lavage of patients with scleroderma. J Rheumatol 19:1716-1723, 1992
34. Massague J: The trasnforming growth facor-β family. Annu Rev Cell Biol 6: 597-641, 1990
35. Matsumoto K, Matsumoto K, Nakamura T, Kramer RH: Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J Biol Chem 269:31807-31813, 1994
36. Peltonen J, Hsiao LL, Jaakkola S, et al: Activation of collagen gene expression in keloids: Co-localization of type I and VI collagen and transforming growth factor-β1 mRNA. J Invest Dermatol 97:240-248, 1991
37. Peltonen J, Kahari L, Uitto J, Jimenez SA: Increased expression of type VI collagen genes in systemic sclerosis. Arthritis Rheum 33:1829-1835, 1990
38. Polte TR, Naftilan AJ, Hanks SK: Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II. J Cell Biochem 55:106-119, 1994
39. Rankin S, Rozengurt E: Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. J Biol Chem 269:704-710, 1994
40. Ridley AJ, Hall A: Signal transduction pathways regulating Rho-mediated stress fiber formation: Requirement for a tyrosine kinase. EMBO J 13:2600-2610, 1994
41. Sappino AP, Schurch W, Gabbiani G: Differentiation repertoire of fibroblastic cells: Expression of cytoskeletal proteins as marker of phenotypic modulations. Lab Invest 63:144-161, 1990
42. Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT: The autophosphorylation site of the focal adhesion kinase, pp125FAK: A high affinity binding site for pp60src. Mol Cell Biol 14:1680-1688, 1994
43. Schwartz MA, Schaller MD, Ginsberg MH: Integrins: Emerging paradigms of signal transduction. Annu Rev Cell Dev Biol 11:549-599, 1995
44. Seufferlein T, Rozengurt E: Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin and p130. J Biol Chem 269: 9345-9351, 1994
45. Sinnett-Smith J, Zachary I, Valverde AM, Rozengurt E: Bombesin stimulation of pp125 focal adhesion kinase tyrosine phosphorylation. J Biol Chem 268: 14261-14268, 1993
46. Thannickal VJ, Aldweib KD, Rajan T, Fanburg BL: Upregulated expression of fibroblast growth factor (FGF) receptors by transforming growth factor-β1 (TGF-β1) mediates enhanced mitogenic responses to FGFs in cultured human lung fibroblasts. Biochem Biophys Res Commun 251:437-441, 1998
47. 2-generating NADH oxidase in human lung fibroblasts by transforming growth factor β1. J Biol Chem 270:30334-30338, 1995
48. Thannickal VJ, Lee DY, White ES, et al: Myofibroblast differentiation by transforming growth factor-β1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase. J Biol Chem 278:12384-12389, 2003
49. Uitto J, Bauer EA, Eisen AZ: Scleroderma: Increased biosynthesis of triple-helical type I and type III procollagens associated with unaltered expression of collagenase by skin fibroblasts in culture. J Clin Invest 64:921-930, 1979
50. Uitto J, Perejda AJ, Abergel RP, Chu ML, Ramirez F: Altered steady-state ratio of type I/III procollagen mRNAs correlates with selectively increased type I procollagen biosynthesis in cultured keloid fibroblasts. Proc Natl Acad Sci USA 82:5935-5939, 1985
51. Zachary I, Sinnett-Smith J, Rozengurt E: Bombesin, vasopressin and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate. J Biol Chem 267:19031-19034, 1992
52. Zhang K, Rekhter MD, Gordon D, Phan SH: Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study. Am J Pathol 145:114-125, 1994