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Volumn 279, Issue 4, 1998, Pages 300-307

To Die or not to die: An overview of apoptosis and its role in disease

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ADENOSINE TRIPHOSPHATE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; AMYLOID BETA PROTEIN; ANTINUCLEAR ANTIBODY; CELL SURFACE PROTEIN; CYTOCHROME C; CYTOKINE; DNA; DOPAMINE; ENDONUCLEASE; FAS LIGAND; GROWTH FACTOR; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLSERINE; PRESENILIN 2; PROTEIN BAX; PROTEIN P53; PROTEINASE; REACTIVE OXYGEN METABOLITE; RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SELEGILINE; SUPEROXIDE DISMUTASE; T LYMPHOCYTE RECEPTOR; THROMBOSPONDIN; UNINDEXED DRUG; VIRUS PROTEIN;

EID: 0032573853     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.279.4.300     Document Type: Review
Times cited : (481)

References (78)
  • 1
    • 0015383455 scopus 로고
    • Apoptosis: A basic biologic phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biologic phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26: 239-257.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 2
    • 0025283961 scopus 로고
    • Developmental cell death: Morphological diversity and multiple mechanisms
    • Clarke PGH. Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol. 1990;181:195-213.
    • (1990) Anat Embryol , vol.181 , pp. 195-213
    • Clarke, P.G.H.1
  • 3
    • 0000948987 scopus 로고
    • Cellular injury and cellular death
    • Cotran RS, Kumar V, Robbins SL, eds. Philadelphia, Pa: WB Saunders Co
    • Cotran RS, Kumar V, Robbins SL. Cellular injury and cellular death. In: Cotran RS, Kumar V, Robbins SL, eds. Pathologic Basis of Disease. 5th ed. Philadelphia, Pa: WB Saunders Co; 1994:1-34.
    • (1994) Pathologic Basis of Disease. 5th Ed. , pp. 1-34
    • Cotran, R.S.1    Kumar, V.2    Robbins, S.L.3
  • 4
    • 0028891783 scopus 로고
    • Apoptosis, oncosis, and necrosis: An overview of cell death
    • Majno G, Joris I. Apoptosis, oncosis, and necrosis: an overview of cell death. Am J Pathol. 1995; 146:3-15.
    • (1995) Am J Pathol , vol.146 , pp. 3-15
    • Majno, G.1    Joris, I.2
  • 5
    • 0029328602 scopus 로고
    • bcl-2, a novel regulator of cell death
    • Hockenbery DM. bcl-2, a novel regulator of cell death. Bioessays. 1995;17:631-638.
    • (1995) Bioessays , vol.17 , pp. 631-638
    • Hockenbery, D.M.1
  • 6
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science. 1995;267:1456-1462.
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 8
    • 0028929328 scopus 로고
    • Mechanisms and genes of cellular suicide
    • Steller H. Mechanisms and genes of cellular suicide. Science 1995;267:1445-1449.
    • (1995) Science , vol.267 , pp. 1445-1449
    • Steller, H.1
  • 9
    • 0027172322 scopus 로고
    • Molecular regulation of apoptosis: Genetic controls on cell death
    • Williams GT, Smith CA. Molecular regulation of apoptosis: genetic controls on cell death. Cell. 1993 74:777-779.
    • (1993) Cell , vol.74 , pp. 777-779
    • Williams, G.T.1    Smith, C.A.2
  • 10
    • 0028326952 scopus 로고
    • An evolutionary perspective on apoptosis
    • Vaux DL, Haecker G, Strasser A. An evolutionary perspective on apoptosis. Cell. 1994;76:777-779.
    • (1994) Cell , vol.76 , pp. 777-779
    • Vaux, D.L.1    Haecker, G.2    Strasser, A.3
  • 11
    • 0025255636 scopus 로고
    • Genetic mosaic analysis of ced-3 and ced-4, two genes that control programmed cell death in the nematode C elegans
    • Yuan J-Y, Horvitz RH. Genetic mosaic analysis of ced-3 and ced-4, two genes that control programmed cell death in the nematode C elegans. Dev Biol. 1990;138:33-41.
    • (1990) Dev Biol , vol.138 , pp. 33-41
    • Yuan, J.-Y.1    Horvitz, R.H.2
  • 12
    • 0026582702 scopus 로고
    • Caenorhabditis elegans gene ced-9 protects cells from programmed cell death
    • Hengartner MO, Ellis RE, Horvitz RH. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature. 1992;356:494-499.
    • (1992) Nature , vol.356 , pp. 494-499
    • Hengartner, M.O.1    Ellis, R.E.2    Horvitz, R.H.3
  • 13
    • 0031034997 scopus 로고    scopus 로고
    • Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death
    • Chinnaiyan AM, O'Rourke K, Lane BR, Dixit VM. Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science. 1997; 275:1122-1126.
    • (1997) Science , vol.275 , pp. 1122-1126
    • Chinnaiyan, A.M.1    O'Rourke, K.2    Lane, B.R.3    Dixit, V.M.4
  • 14
    • 0031020227 scopus 로고    scopus 로고
    • Interaction and regulation of subcellular localization of CED-4 by CED-9
    • Wu D, Wallen HD, Nuñez G. Interaction and regulation of subcellular localization of CED-4 by CED-9. Science. 1997;275:1126-1129.
    • (1997) Science , vol.275 , pp. 1126-1129
    • Wu, D.1    Wallen, H.D.2    Nuñez, G.3
  • 15
    • 0031019739 scopus 로고    scopus 로고
    • Interactions between the C elegans cell-death regulators CED-9 and CED-4
    • Spector MS, Desnoyers S, Hoeppner DJ, Hengartner MO. Interactions between the C elegans cell-death regulators CED-9 and CED-4. Nature. 1997;385:653-656.
    • (1997) Nature , vol.385 , pp. 653-656
    • Spector, M.S.1    Desnoyers, S.2    Hoeppner, D.J.3    Hengartner, M.O.4
  • 16
    • 0029007855 scopus 로고
    • The TNF receptor 1-associated protein TRADD signals cell death and NF-kB activation
    • Hsu H, Xiong J, Goeddel DV. The TNF receptor 1-associated protein TRADD signals cell death and NF-kB activation. Cell. 1995;81:495-504.
    • (1995) Cell , vol.81 , pp. 495-504
    • Hsu, H.1    Xiong, J.2    Goeddel, D.V.3
  • 17
    • 0029026548 scopus 로고
    • FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
    • Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 1995;81:505-512.
    • (1995) Cell , vol.81 , pp. 505-512
    • Chinnaiyan, A.M.1    O'Rourke, K.2    Tewari, M.3    Dixit, V.M.4
  • 18
    • 0029054725 scopus 로고
    • RIP: A novel protein containing a death domain that interacts with FAS/APO-1 (CD95) in yeast and causes cell death
    • Stanger BZ, Leder P, Lee T-H, et al. RIP: A novel protein containing a death domain that interacts with FAS/APO-1 (CD95) in yeast and causes cell death. Cell 1995;81:513-523.
    • (1995) Cell , vol.81 , pp. 513-523
    • Stanger, B.Z.1    Leder, P.2    Lee, T.-H.3
  • 19
    • 0030032106 scopus 로고    scopus 로고
    • TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
    • Hsu H, Shu H-B, Pan M-G, Goeddel DV. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 1996;84:299-308.
    • (1996) Cell , vol.84 , pp. 299-308
    • Hsu, H.1    Shu, H.-B.2    Pan, M.-G.3    Goeddel, D.V.4
  • 20
    • 0030011398 scopus 로고    scopus 로고
    • Involvement of MACH, a Novel MORT1/ FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
    • Boldin MP, Goncharov TM, Goltsev YV, Wallach D. Involvement of MACH, a Novel MORT1/ FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death. Cell. 1996;85:803-815.
    • (1996) Cell , vol.85 , pp. 803-815
    • Boldin, M.P.1    Goncharov, T.M.2    Goltsev, Y.V.3    Wallach, D.4
  • 21
    • 15844412409 scopus 로고    scopus 로고
    • FLICE, a novel FADD-homologous ICE/CED-3-Iike protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
    • Muzio M, Chinnaiyan AM, Kischkel FC, et al. FLICE, a novel FADD-homologous ICE/CED-3-Iike protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell. 1996;85:817-827.
    • (1996) Cell , vol.85 , pp. 817-827
    • Muzio, M.1    Chinnaiyan, A.M.2    Kischkel, F.C.3
  • 22
    • 0028927607 scopus 로고
    • The Fas death factor
    • Nagata S, Golstein P. The Fas death factor. Science. 1995;267:1449-1456.
    • (1995) Science , vol.267 , pp. 1449-1456
    • Nagata, S.1    Golstein, P.2
  • 23
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • Nagata S. Apoptosis by death factor. Cell. 1997; 88:355-365.
    • (1997) Cell , vol.88 , pp. 355-365
    • Nagata, S.1
  • 24
    • 0029939945 scopus 로고    scopus 로고
    • The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance
    • Van Parijs L, Ibraghimov A, Abbas AK. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity. 1996;4:321-328.
    • (1996) Immunity , vol.4 , pp. 321-328
    • Van Parijs, L.1    Ibraghimov, A.2    Abbas, A.K.3
  • 25
    • 0029961719 scopus 로고    scopus 로고
    • Die and let live: Eliminating dangerous lymphocytes
    • Abbas AK. Die and let live: eliminating dangerous lymphocytes. Cell. 1996;84:655-657.
    • (1996) Cell , vol.84 , pp. 655-657
    • Abbas, A.K.1
  • 26
    • 0026504147 scopus 로고
    • Social controls on cell survival and cell death
    • Raff MC. Social controls on cell survival and cell death. Nature. 1992;356:397-400.
    • (1992) Nature , vol.356 , pp. 397-400
    • Raff, M.C.1
  • 27
    • 0029965136 scopus 로고    scopus 로고
    • The molecular biology of apoptosis
    • Vaux DL, Strasser A. The molecular biology of apoptosis. Proc Nat Acad Sci USA. 1996;93:2239-2244.
    • (1996) Proc Nat Acad Sci USA , vol.93 , pp. 2239-2244
    • Vaux, D.L.1    Strasser, A.2
  • 29
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirements for DATP and cytochrome c
    • Liu X, Kim CN, Yang J, et al. Induction of apoptotic program in cell-free extracts: requirements for DATP and cytochrome c. Cell. 1996;86: 147-157.
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3
  • 30
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 1997;90:405-413.
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 31
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by bcl-2: Release of cytochrome c from mitochondria blocked
    • Yang J, Liu X, Bhalla K, et al. Prevention of apoptosis by bcl-2: release of cytochrome c from mitochondria blocked. Science. 1997;275:1129-1132.
    • (1997) Science , vol.275 , pp. 1129-1132
    • Yang, J.1    Liu, X.2    Bhalla, K.3
  • 32
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for bcl-2 regulation of apoptosis
    • Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for bcl-2 regulation of apoptosis. Science. 1997;275:1132-1136.
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 33
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoeitic cell survival and cooperates with c-myc to immortalize pre-β cells
    • Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoeitic cell survival and cooperates with c-myc to immortalize pre-β cells. Nature. 1988; 335:440-442.
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 34
    • 0028915454 scopus 로고
    • Regulation of lymphocyte survival by the bcl-2 gene family
    • Cory S. Regulation of lymphocyte survival by the bcl-2 gene family. Ann Rev Immunol. 1995;13: 513-543.
    • (1995) Ann Rev Immunol , vol.13 , pp. 513-543
    • Cory, S.1
  • 35
    • 0030740251 scopus 로고    scopus 로고
    • CED-4 - The third horseman of apoptosis
    • Vaux DL. CED-4 - the third horseman of apoptosis. Cell. 1997;90:389-390.
    • (1997) Cell , vol.90 , pp. 389-390
    • Vaux, D.L.1
  • 36
    • 0030979773 scopus 로고    scopus 로고
    • Double identity for proteins of the bcl-2 family
    • Reed JC. Double identity for proteins of the bcl-2 family. Nature. 1997;387:773-776.
    • (1997) Nature , vol.387 , pp. 773-776
    • Reed, J.C.1
  • 37
    • 0030584079 scopus 로고    scopus 로고
    • Apoptosis meets signal transduction: Elimination of a BAD influence
    • Gajewski TF, Thompson CB. Apoptosis meets signal transduction: elimination of a BAD influence. Cell. 1996;87:589-592.
    • (1996) Cell , vol.87 , pp. 589-592
    • Gajewski, T.F.1    Thompson, C.B.2
  • 38
    • 9844257587 scopus 로고    scopus 로고
    • Inhibition of Bax channel-forming activity by bcl-2
    • Antonsson B, Conti F, Ciavatta A, et al. Inhibition of Bax channel-forming activity by bcl-2. Science. 1997;277:370-372.
    • (1997) Science , vol.277 , pp. 370-372
    • Antonsson, B.1    Conti, F.2    Ciavatta, A.3
  • 39
    • 0031034563 scopus 로고    scopus 로고
    • Controlling cell death
    • Golstein P. Controlling cell death. Science. 1997; 275:1081-1082.
    • (1997) Science , vol.275 , pp. 1081-1082
    • Golstein, P.1
  • 41
    • 0031465443 scopus 로고    scopus 로고
    • Conversion of Bcl-2 to a BAX-like death effector by caspases
    • Cheng E, Kirsch DG, Clem R, et al. Conversion of Bcl-2 to a BAX-like death effector by caspases. Science. 1997;278:1966-1968.
    • (1997) Science , vol.278 , pp. 1966-1968
    • Cheng, E.1    Kirsch, D.G.2    Clem, R.3
  • 42
    • 0028288510 scopus 로고
    • Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
    • Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med. 1994; 179:1317-1330.
    • (1994) J Exp Med , vol.179 , pp. 1317-1330
    • Casciola-Rosen, L.A.1    Anhalt, G.2    Rosen, A.3
  • 43
    • 0028791690 scopus 로고
    • Unraveling immune privilege
    • Streilein JW. Unraveling immune privilege. Science. 1995;270:1158-1159.
    • (1995) Science , vol.270 , pp. 1158-1159
    • Streilein, J.W.1
  • 44
    • 0028879109 scopus 로고
    • Fas ligand-induced apoptosis as a mechanism of immune privilege
    • Griffith TS, Brunner T, Fletcher SM, et al. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science. 1995;270:1189-1192.
    • (1995) Science , vol.270 , pp. 1189-1192
    • Griffith, T.S.1    Brunner, T.2    Fletcher, S.M.3
  • 45
    • 0028864778 scopus 로고
    • A role for CD95 ligand in preventing graft rejection
    • Bellgrau D, Gold D, Selawry H, et al. A role for CD95 ligand in preventing graft rejection. Nature. 1995;377:630-632.
    • (1995) Nature , vol.377 , pp. 630-632
    • Bellgrau, D.1    Gold, D.2    Selawry, H.3
  • 46
    • 0030890588 scopus 로고    scopus 로고
    • Cell death mediators in autoimmune diabetes - No shortage of suspects
    • Benoist C, Mathis D. Cell death mediators in autoimmune diabetes - no shortage of suspects. Cell. 1997;89:1-3.
    • (1997) Cell , vol.89 , pp. 1-3
    • Benoist, C.1    Mathis, D.2
  • 47
    • 0030017476 scopus 로고    scopus 로고
    • Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice
    • Lau HT, Yu M, Fontana A, Stoeckert CJ Jr. Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice. Science. 1996;273:109-112.
    • (1996) Science , vol.273 , pp. 109-112
    • Lau, H.T.1    Yu, M.2    Fontana, A.3    Stoeckert Jr., C.J.4
  • 48
    • 0030890721 scopus 로고    scopus 로고
    • The role of Fas in autoimmune diabetes
    • Chernovsky AV, Wang Y, Wong, FS, et al. The role of Fas in autoimmune diabetes. Cell. 1997;89: 17-24.
    • (1997) Cell , vol.89 , pp. 17-24
    • Chernovsky, A.V.1    Wang, Y.2    Wong, F.S.3
  • 49
    • 0031034933 scopus 로고    scopus 로고
    • Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis
    • Giordano C, Stassi G, De Maria R, et al. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. Science. 1997; 275:960-963.
    • (1997) Science , vol.275 , pp. 960-963
    • Giordano, C.1    Stassi, G.2    De Maria, R.3
  • 50
    • 0029976410 scopus 로고    scopus 로고
    • A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection
    • Rodriguez I, Matsuura K, Khatib K, Reed JC, Nagata S, Vassalli P. A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection. J Exp Med. 1996;183:1031-1036.
    • (1996) J Exp Med , vol.183 , pp. 1031-1036
    • Rodriguez, I.1    Matsuura, K.2    Khatib, K.3    Reed, J.C.4    Nagata, S.5    Vassalli, P.6
  • 51
    • 0030250572 scopus 로고    scopus 로고
    • ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis
    • Roquet N, Pages J-C, Molina T, Briand P, Joulin V. ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis. Curr Biol. 1996;6:1192-1195.
    • (1996) Curr Biol , vol.6 , pp. 1192-1195
    • Roquet, N.1    Pages, J.-C.2    Molina, T.3    Briand, P.4    Joulin, V.5
  • 52
    • 0029006893 scopus 로고
    • Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity
    • Rieux-Laucat F, Le Deist F, Hivroz C, et al. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science. 1995;268:1347-1349.
    • (1995) Science , vol.268 , pp. 1347-1349
    • Rieux-Laucat, F.1    Le Deist, F.2    Hivroz, C.3
  • 53
    • 0029025441 scopus 로고
    • Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
    • Fisher GH, Rosenberg FJ, Straus SE, et al. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell. 1995;81:935-946.
    • (1995) Cell , vol.81 , pp. 935-946
    • Fisher, G.H.1    Rosenberg, F.J.2    Straus, S.E.3
  • 54
    • 0029802697 scopus 로고    scopus 로고
    • Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity
    • Drappa J, Vaishnaw AK, Sullivan KE, Chu JL, Elkon KB. Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity. N Engl J Med. 1996;335:1643-1649.
    • (1996) N Engl J Med , vol.335 , pp. 1643-1649
    • Drappa, J.1    Vaishnaw, A.K.2    Sullivan, K.E.3    Chu, J.L.4    Elkon, K.B.5
  • 55
    • 0028025563 scopus 로고
    • Apoptosis in cancer therapy: Crossing the threshold
    • Fisher DE. Apoptosis in cancer therapy: crossing the threshold. Cell. 1994;78:539-542.
    • (1994) Cell , vol.78 , pp. 539-542
    • Fisher, D.E.1
  • 56
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 58
    • 0031038137 scopus 로고    scopus 로고
    • Bax suppresses tumorigenesis and stimulates apoptosis in vivo
    • Yin C, Knudson CM, Korsmeyer SJ, Van Dyke T. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature. 1997;385:637-640.
    • (1997) Nature , vol.385 , pp. 637-640
    • Yin, C.1    Knudson, C.M.2    Korsmeyer, S.J.3    Van Dyke, T.4
  • 59
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • Rampino N, Yamamoto H, Ionov Y, et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science. 1997;275:967-969.
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3
  • 60
    • 10544232277 scopus 로고    scopus 로고
    • Melanoma cell expression of Fas (Apo-1/CD95) ligand: Implications for tumor immune escape
    • Hahne M, Rimoldi D, Schroter M, et al. Melanoma cell expression of Fas (Apo-1/CD95) ligand: implications for tumor immune escape. Science. 1996;274:1363-1366.
    • (1996) Science , vol.274 , pp. 1363-1366
    • Hahne, M.1    Rimoldi, D.2    Schroter, M.3
  • 61
    • 16144363507 scopus 로고    scopus 로고
    • Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells - A mechanism of immune evasion?
    • Strand S, Hofmann WJ, Hug H, et al. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells - a mechanism of immune evasion? Nat Med. 1996;2:1361-1366.
    • (1996) Nat Med , vol.2 , pp. 1361-1366
    • Strand, S.1    Hofmann, W.J.2    Hug, H.3
  • 62
    • 0028946358 scopus 로고
    • Calcium-mediated cell injury and cell death
    • Trump BF, Berezesky IK. Calcium-mediated cell injury and cell death. FASEB J. 1995;9:219-228.
    • (1995) FASEB J , vol.9 , pp. 219-228
    • Trump, B.F.1    Berezesky, I.K.2
  • 63
    • 0029910954 scopus 로고    scopus 로고
    • Similarity of neuronal cell injury and death in AIDS dementia and focal cerebral ischemia: Potential treatment with NMDA open-channel blockers and nitric oxide-related species
    • Lipton SA. Similarity of neuronal cell injury and death in AIDS dementia and focal cerebral ischemia: potential treatment with NMDA open-channel blockers and nitric oxide-related species. Brain Pathol. 1996;6:507-517.
    • (1996) Brain Pathol , vol.6 , pp. 507-517
    • Lipton, S.A.1
  • 64
    • 0029614765 scopus 로고
    • Neural apoptosis
    • Bredesen DE. Neural apoptosis. Ann Neurol. 1995;38:839-851.
    • (1995) Ann Neurol , vol.38 , pp. 839-851
    • Bredesen, D.E.1
  • 65
    • 0030756459 scopus 로고    scopus 로고
    • bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Kostic V, Jackson-Lewis V, de Bilbao F, Dubois-Dauphin M, Przedborski S. bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. Science. 1997;277:559-562.
    • (1997) Science , vol.277 , pp. 559-562
    • Kostic, V.1    Jackson-Lewis, V.2    De Bilbao, F.3    Dubois-Dauphin, M.4    Przedborski, S.5
  • 66
    • 0029671219 scopus 로고    scopus 로고
    • Interfering with apoptosis: Ca2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3
    • Vito P, Lacana E, D'Adamio L. Interfering with apoptosis: Ca2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science. 1996;271:521-525.
    • (1996) Science , vol.271 , pp. 521-525
    • Vito, P.1    Lacana, E.2    D'Adamio, L.3
  • 67
    • 10544224542 scopus 로고    scopus 로고
    • Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
    • Wolozin B, Iwasaki K, Vito P, et al. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science. 1996;274:1710-1713.
    • (1996) Science , vol.274 , pp. 1710-1713
    • Wolozin, B.1    Iwasaki, K.2    Vito, P.3
  • 68
    • 0029860523 scopus 로고    scopus 로고
    • Amyloid beta peptide of Alzheimer's disease downregulates bcl-2 and upregulates box expression in human neurons
    • Paradis E, Douillard H, Koutroumanis M, Goodyer C, LeBlanc A. Amyloid beta peptide of Alzheimer's disease downregulates bcl-2 and upregulates box expression in human neurons. J Neurosci. 1996;16:7533-7539.
    • (1996) J Neurosci , vol.16 , pp. 7533-7539
    • Paradis, E.1    Douillard, H.2    Koutroumanis, M.3    Goodyer, C.4    LeBlanc, A.5
  • 69
    • 0029751104 scopus 로고    scopus 로고
    • Oxidative stress and the pathogenesis of Parkinson's disease
    • Jenner P, Olanow CW. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology. 1996;47:S161-S170.
    • (1996) Neurology , vol.47
    • Jenner, P.1    Olanow, C.W.2
  • 70
    • 0031013141 scopus 로고    scopus 로고
    • Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons
    • Tompkins MM, Basgall EJ, Zamrini E, Hill WD. Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons. Am J Pathol. 1997;150:119-131.
    • (1997) Am J Pathol , vol.150 , pp. 119-131
    • Tompkins, M.M.1    Basgall, E.J.2    Zamrini, E.3    Hill, W.D.4
  • 71
    • 0029731378 scopus 로고    scopus 로고
    • Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration
    • Tatton WG, Chalmers-Redman RM. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration. Neurology. 1996;47: S171-S183.
    • (1996) Neurology , vol.47
    • Tatton, W.G.1    Chalmers-Redman, R.M.2
  • 72
    • 10244254975 scopus 로고    scopus 로고
    • Apoptosis in myocytes in end-stage heart failure
    • Narula J, Haider N, Virmani R, et al. Apoptosis in myocytes in end-stage heart failure. N Engl J Med. 1996;335:1182-1189.
    • (1996) N Engl J Med , vol.335 , pp. 1182-1189
    • Narula, J.1    Haider, N.2    Virmani, R.3
  • 73
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:493-501.
    • (1992) J Cell Biol , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 74
    • 0030766192 scopus 로고    scopus 로고
    • Apoptosis in the failing human heart
    • Olivetti G, Abbi R, Quaini F, et al. Apoptosis in the failing human heart. N Engl J Med. 1997;336: 1131-1141.
    • (1997) N Engl J Med , vol.336 , pp. 1131-1141
    • Olivetti, G.1    Abbi, R.2    Quaini, F.3
  • 75
    • 0029799092 scopus 로고    scopus 로고
    • Apoptosis in the heart
    • Colucci WS. Apoptosis in the heart. N Engl J Med. 1996;335:1224-1226.
    • (1996) N Engl J Med , vol.335 , pp. 1224-1226
    • Colucci, W.S.1
  • 76
    • 0029836032 scopus 로고    scopus 로고
    • Evidence of apoptosis in arrhythmogenic right ventricular dysplasia
    • Mallat A, Tedgui A, Fontaliran F, et al. Evidence of apoptosis in arrhythmogenic right ventricular dysplasia. N Engl J Med. 1996;335:1190-1196.
    • (1996) N Engl J Med , vol.335 , pp. 1190-1196
    • Mallat, A.1    Tedgui, A.2    Fontaliran, F.3
  • 77
    • 0029068871 scopus 로고
    • Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
    • Nicholson DW, Ali A, Thornberry NA, et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995;376:37-43.
    • (1995) Nature , vol.376 , pp. 37-43
    • Nicholson, D.W.1    Ali, A.2    Thornberry, N.A.3
  • 78
    • 0344188096 scopus 로고    scopus 로고
    • An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
    • Bischoff JR, Kirn DH, Williams A, et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science. 1996;274: 373-376.
    • (1996) Science , vol.274 , pp. 373-376
    • Bischoff, J.R.1    Kirn, D.H.2    Williams, A.3


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