Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells

Circulation

Volumn 118, Issue 21, 2008, Pages 2156-2165

  Zhu, Shoukang ^a   Evans, Sarah ^b   Yan, Bin ^b   Povsic, Thomas J ^b   Tapson, Victor ^b   Goldschmidt Clermont, Pascal J ^a   Dong, Chunming ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Angiogenesis; Antibodies; Apoptosis; Endothelial progenitor cells; Scleroderma

Indexed keywords

BIM PROTEIN; IMMUNOGLOBULIN G; PROTEIN KINASE B; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHRL1;

ADULT; APOPTOSIS; ARTICLE; COLONY FORMING UNIT; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL CULTURE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; SCLERODERMA; SIGNAL TRANSDUCTION; STEM CELL; TRANSCRIPTION REGULATION; UPREGULATION;

ADULT; AGED; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; ENDOTHELIAL CELLS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOGLOBULIN G; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REGENERATION; SCLERODERMA, SYSTEMIC; SERUM; STEM CELLS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 57449114150     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.108.787200     Document Type: Article

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