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Volumn 60, Issue 12, 2011, Pages 1664-1672

Effects of leptin and adiponectin on pancreatic β-cell function

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ADIPONECTIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; LEPTIN; LEPTIN RECEPTOR;

EID: 81155137747     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2011.04.008     Document Type: Review
Times cited : (109)

References (81)
  • 3
    • 0030948734 scopus 로고    scopus 로고
    • + channels in pancreatic β-cells
    • T.J. Kieffer, R.S. Heller, and C.A. Leech Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells Diabetes 46 1997 1087 1093 (Pubitemid 27221014)
    • (1997) Diabetes , vol.46 , Issue.6 , pp. 1087-1093
    • Kieffer, T.J.1    Heller, R.S.2    Leech, C.A.3    Holz, G.G.4    Habener, J.F.5
  • 4
    • 67650245533 scopus 로고    scopus 로고
    • Inhibitory effects of leptin on pancreatic alpha-cell function
    • E. Tudur, L. Marroqu, and S. Soriano Inhibitory effects of leptin on pancreatic alpha-cell function Diabetes 58 2009 1616 1624
    • (2009) Diabetes , vol.58 , pp. 1616-1624
    • Tudur, E.1    Marroqu, L.2    Soriano, S.3
  • 5
    • 0031793899 scopus 로고    scopus 로고
    • Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans
    • DOI 10.1210/en.139.3.822
    • V. Poitout, C. Rouault, and M. Guerre-Millo Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans Endocrinology 139 1998 822 826 (Pubitemid 28510093)
    • (1998) Endocrinology , vol.139 , Issue.3 , pp. 822-826
    • Poitout, V.1    Rouault, C.2    Guerre-Millo, M.3    Briaud, I.4    Reach, G.5
  • 6
    • 0030965884 scopus 로고    scopus 로고
    • Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
    • V. Emilsson, Y.L. Liu, and M.A. Cawthorne Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion Diabetes 46 1997 313 316 (Pubitemid 27272267)
    • (1997) Diabetes , vol.46 , Issue.2 , pp. 313-316
    • Emilsson, V.1    Liu, Y.-L.2    Cawthorne, M.A.3    Morton, N.M.4    Davenport, M.5
  • 7
    • 0033974348 scopus 로고    scopus 로고
    • The adipoinsular axis: Effects of leptin on pancreatic beta-cells
    • T.J. Kieffer, and J.F. Habener The adipoinsular axis: effects of leptin on pancreatic beta-cells Am J Physiol Endocrinol Metab 278 2000 E1 E14
    • (2000) Am J Physiol Endocrinol Metab , vol.278
    • Kieffer, T.J.1    Habener, J.F.2
  • 9
    • 0032169556 scopus 로고    scopus 로고
    • Leptin inhibits insulin secretion by activation of phosphodiesterase 3B
    • A.Z. Zhao, K.E. Bornfeldt, and J.A. Beavo Leptin inhibits insulin secretion by activation of phosphodiesterase 3B J Clin Invest 102 1998 869 873 (Pubitemid 28419231)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.5 , pp. 869-873
    • Zhao, A.Z.1    Bornfeldt, K.E.2    Beavo, J.A.3
  • 10
    • 0030955188 scopus 로고    scopus 로고
    • Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice
    • N.G. Chen, A.G. Swick, and D.R. Romsos Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice J Clin Invest 100 1997 1174 1179 (Pubitemid 27386302)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.5 , pp. 1174-1179
    • Chen, N.-G.1    Swick, A.G.2    Romsos, D.R.3
  • 11
    • 0032530325 scopus 로고    scopus 로고
    • + channels in rat CRI-G1 insulin secreting cells
    • DOI 10.1111/j.1469-7793.1998.695bg.x
    • J. Harvey, and M.L. Ashford Insulin occludes leptin activation of ATP-sensitive K+ channels in rat CRI-G1 insulin secreting cells J Physiol 511 Pt 3 1998 695 706 (Pubitemid 28456900)
    • (1998) Journal of Physiology , vol.511 , Issue.3 , pp. 695-706
    • Harvey, J.1    Ashford, M.L.J.2
  • 15
    • 0037315210 scopus 로고    scopus 로고
    • Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway
    • J.W. Lee, A.G. Swick, and D.R. Romsos Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway Exp Biol Med (Maywood) 228 2003 175 182 (Pubitemid 36187924)
    • (2003) Experimental Biology and Medicine , vol.228 , Issue.2 , pp. 175-182
    • Lee, J.-W.1    Swick, A.G.2    Romsos, D.R.3
  • 19
    • 0038584871 scopus 로고    scopus 로고
    • Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression
    • DOI 10.1042/BJ20021812
    • G. da Silva Xavier, I. Leclerc, and A. Varadi Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression Biochem J 371 2003 761 774 (Pubitemid 36578875)
    • (2003) Biochemical Journal , vol.371 , Issue.3 , pp. 761-774
    • Da Silva Xavier, G.1    Leclerc, I.2    Varadi, A.3    Tsuboi, T.4    Moule, S.K.5    Rutter, G.A.6
  • 20
    • 2442691889 scopus 로고    scopus 로고
    • Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: Impact on glucose-stimulated insulin secretion
    • I. Leclerc, W.W. Woltersdorf, and G. da Silva Xavier Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion Am J Physiol Endocrinol Metab 286 2004 E1023 E1031
    • (2004) Am J Physiol Endocrinol Metab , vol.286
    • Leclerc, I.1    Woltersdorf, W.W.2    Da Silva Xavier, G.3
  • 22
    • 33644684253 scopus 로고    scopus 로고
    • Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic β-cells
    • DOI 10.2337/diabetes.54.12.3410
    • K. Laubner, T.J. Kieffer, and N.T. Lam Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells Diabetes 54 2005 3410 3417 (Pubitemid 43334330)
    • (2005) Diabetes , vol.54 , Issue.12 , pp. 3410-3417
    • Laubner, K.1    Kieffer, T.J.2    Lam, N.T.3    Niu, X.4    Jakob, F.5    Seufert, J.6
  • 23
    • 0031913829 scopus 로고    scopus 로고
    • Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat
    • DOI 10.2337/diabetes.47.3.358
    • A. Pick, J. Clark, and C. Kubstrup Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat Diabetes 47 1998 358 364 (Pubitemid 28104196)
    • (1998) Diabetes , vol.47 , Issue.3 , pp. 358-364
    • Pick, A.1    Clark, J.2    Kubstrup, C.3    Levisetti, M.4    Pugh, W.5    Bonner-Weir, S.6    Polonsky, K.S.7
  • 24
    • 0027947379 scopus 로고
    • Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships
    • Y. Lee, H. Hirose, and M. Ohneda Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships Proc Natl Acad Sci U S A 91 1994 10878 10882
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10878-10882
    • Lee, Y.1    Hirose, H.2    Ohneda, M.3
  • 25
    • 0034751343 scopus 로고    scopus 로고
    • Leptin increases the viability of isolated rat pancreatic islets by suppressing apoptosis
    • DOI 10.1210/en.142.11.4827
    • S. Okuya, K. Tanabe, and Y. Tanizawa Leptin increases the viability of isolated rat pancreatic islets by suppressing apoptosis Endocrinology 142 2001 4827 4830 (Pubitemid 33022358)
    • (2001) Endocrinology , vol.142 , Issue.11 , pp. 4827-4830
    • Okuya, S.1    Tanabe, K.2    Tanizawa, Y.3    Oka, Y.4
  • 27
    • 34948813565 scopus 로고    scopus 로고
    • Leptin decreases apoptosis and alters BCL-2: Bax ratio in clonal rodent pancreatic beta-cells
    • DOI 10.1002/dmrr.726
    • J.E. Brown, and S.J. Dunmore Leptin decreases apoptosis and alters BCL-2:Bax ratio in clonal rodent pancreatic beta-cells Diabetes Metab Res Rev 23 2007 497 502 (Pubitemid 47520908)
    • (2007) Diabetes/Metabolism Research and Reviews , vol.23 , Issue.6 , pp. 497-502
    • Brown, J.E.P.1    Dunmore, S.J.2
  • 28
    • 0031590853 scopus 로고    scopus 로고
    • Leptin induces proliferation of pancreatic β cell line MIN6 through activation of mitogen-activated protein kinase
    • DOI 10.1006/bbrc.1997.7894
    • K. Tanabe, S. Okuya, and Y. Tanizawa Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen-activated protein kinase Biochem Biophys Res Commun 241 1997 765 768 (Pubitemid 28036732)
    • (1997) Biochemical and Biophysical Research Communications , vol.241 , Issue.3 , pp. 765-768
    • Tanabe, K.1    Okuya, S.2    Tanizawa, Y.3    Matsutani, A.4    Oka, Y.5
  • 31
    • 44949143027 scopus 로고    scopus 로고
    • Glucose and leptin induce apoptosis in human β-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases
    • DOI 10.1096/fj.07-101824
    • K. Maedler, F.T. Schulthess, and C. Bielman Glucose and leptin induce apoptosis in human {beta}-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases FASEB J 22 2008 1905 1913 (Pubitemid 351811467)
    • (2008) FASEB Journal , vol.22 , Issue.6 , pp. 1905-1913
    • Maedler, K.1    Schulthess, F.T.2    Bielman, C.3    Berney, T.4    Bonny, C.5    Prentki, M.6    Donath, M.Y.7    Roduit, R.8
  • 34
    • 34548433579 scopus 로고    scopus 로고
    • Metabolic mechanisms of failure of intraportally transplanted pancreatic β-cells in rats: Role of lipotoxicity and prevention by leptin
    • DOI 10.2337/db07-0460
    • Y. Lee, M. Ravazzola, and B. Park Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin Diabetes 56 2007 2295 2301 (Pubitemid 47358236)
    • (2007) Diabetes , vol.56 , Issue.9 , pp. 2295-2301
    • Lee, Y.1    Ravazzola, M.2    Park, B.-H.3    Bashmakov, Y.K.4    Orci, L.5    Unger, R.H.6
  • 35
    • 0030871847 scopus 로고    scopus 로고
    • β-Cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy
    • K. Koyama, and G. Chen. M.Y. Wang beta-Cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy Diabetes 46 1997 1276 1280 (Pubitemid 27315275)
    • (1997) Diabetes , vol.46 , Issue.8 , pp. 1276-1280
    • Koyama, K.1    Chen, G.2    Wang, M.-Y.3    Lee, Y.4    Shimabukuro, M.5    Newgard, C.B.6    Unger, R.H.7
  • 36
    • 77950373635 scopus 로고    scopus 로고
    • Leptin therapy in insulin-deficient type i diabetes
    • M. Wang, L. Chen, and G.O. Clark Leptin therapy in insulin-deficient type I diabetes Proc Natl Acad Sci U S A 107 2010 4813 4819
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 4813-4819
    • Wang, M.1    Chen, L.2    Clark, G.O.3
  • 37
    • 77956022655 scopus 로고    scopus 로고
    • Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic {beta}-cell leptin signaling
    • S.L. Gray, C. Donald, and A. Jetha Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic {beta}-cell leptin signaling Endocrinology 151 2010 4178 4186
    • (2010) Endocrinology , vol.151 , pp. 4178-4186
    • Gray, S.L.1    Donald, C.2    Jetha, A.3
  • 38
    • 0033023472 scopus 로고    scopus 로고
    • Analysis of the relationship between fasting serum leptin levels and estimates of beta-cell function and insulin sensitivity in a population sample of 380 healthy young Caucasians
    • S.M. Echwald, J.O. Clausen, and T. Hansen Analysis of the relationship between fasting serum leptin levels and estimates of beta-cell function and insulin sensitivity in a population sample of 380 healthy young Caucasians Eur J Endocrinol 140 1999 180 185
    • (1999) Eur J Endocrinol , vol.140 , pp. 180-185
    • Echwald, S.M.1    Clausen, J.O.2    Hansen, T.3
  • 40
    • 33750970541 scopus 로고    scopus 로고
    • Correlation of plasma leptin and adiponectin with insulin sensitivity and beta-cell function in children - The Taipei Children Heart Study
    • Y.J. Hung, N.F. Chu, and S.C. Wang Correlation of plasma leptin and adiponectin with insulin sensitivity and beta-cell function in children - the Taipei Children Heart Study Int J Clin Pract 60 2006 1582 1587
    • (2006) Int J Clin Pract , vol.60 , pp. 1582-1587
    • Hung, Y.J.1    Chu, N.F.2    Wang, S.C.3
  • 41
    • 0034076315 scopus 로고    scopus 로고
    • Plasma insulin concentration is more tightly linked to plasma leptin concentration than is the body mass index
    • F. Abbasi, M. Carantoni, and T. McLaughlin Plasma insulin concentration is more tightly linked to plasma leptin concentration than is the body mass index Metab Clin Exp 49 2000 544 547 (Pubitemid 30196585)
    • (2000) Metabolism: Clinical and Experimental , vol.49 , Issue.4 , pp. 544-547
    • Abbasi, F.1    Carantoni, M.2    McLaughlin, T.3    Reaven, G.M.4
  • 42
    • 0031468011 scopus 로고    scopus 로고
    • Leptin - A regulator of islet function?: Its plasma levels correlate with glucagon and insulin secretion in healthy women
    • DOI 10.1016/S0026-0495(97)90152-9
    • B. Ahrn, and H. Larsson Leptin - a regulator of islet function? Its plasma levels correlate with glucagon and insulin secretion in healthy women Metab Clin Exp 46 1997 1477 1481 (Pubitemid 28053217)
    • (1997) Metabolism: Clinical and Experimental , vol.46 , Issue.12 , pp. 1477-1481
    • Ahren, B.1    Larsson, H.2
  • 46
    • 0031859766 scopus 로고    scopus 로고
    • Effect of hyperinsulinemia on plasma leptin concentrations and food intake in rats
    • S.J. Koopmans, M. Frolich, and E.H. Gribnau Effect of hyperinsulinemia on plasma leptin concentrations and food intake in rats Am J Physiol 274 1998 E998 E1001
    • (1998) Am J Physiol , vol.274
    • Koopmans, S.J.1    Frolich, M.2    Gribnau, E.H.3
  • 47
    • 0029157428 scopus 로고
    • Transient increase in obese gene expression after food intake or insulin administration
    • R. Saladin, P. De Vos, and M. Guerre-Millo Transient increase in obese gene expression after food intake or insulin administration Nature 377 1995 527 529
    • (1995) Nature , vol.377 , pp. 527-529
    • Saladin, R.1    De Vos, P.2    Guerre-Millo, M.3
  • 48
    • 33745197808 scopus 로고    scopus 로고
    • The role of leptin in leptin resistance and obesity
    • Y. Zhang, and P.J. Scarpace The role of leptin in leptin resistance and obesity Physiol Behav 88 2006 249 256
    • (2006) Physiol Behav , vol.88 , pp. 249-256
    • Zhang, Y.1    Scarpace, P.J.2
  • 49
    • 0842284789 scopus 로고    scopus 로고
    • Leptin effects on pancreatic beta-cell gene expression and function
    • J. Seufert Leptin effects on pancreatic beta-cell gene expression and function Diabetes 53 Suppl 1 2004 S152 S158
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Seufert, J.1
  • 50
    • 34547700630 scopus 로고    scopus 로고
    • Leptin and high-sensitivity C-reactive protein and their interaction in the metabolic syndrome in middle-aged subjects
    • DOI 10.1016/j.metabol.2007.04.019, PII S0026049507001564
    • O. Ukkola, and Y.A. Kesniemi Leptin and high-sensitivity C-reactive protein and their interaction in the metabolic syndrome in middle-aged subjects Metab Clin Exp 56 2007 1221 1227 (Pubitemid 47223262)
    • (2007) Metabolism: Clinical and Experimental , vol.56 , Issue.9 , pp. 1221-1227
    • Ukkola, O.1    Kesaniemi, Y.A.2
  • 51
    • 50649115441 scopus 로고    scopus 로고
    • Adiponectin and leptin are independently associated with insulin sensitivity, but not with insulin secretion or beta-cell function in overweight Hispanic adolescents
    • C. Koebnick, C.K. Roberts, and G.Q. Shaibi Adiponectin and leptin are independently associated with insulin sensitivity, but not with insulin secretion or beta-cell function in overweight Hispanic adolescents Horm Metab Res 40 2008 708 712
    • (2008) Horm Metab Res , vol.40 , pp. 708-712
    • Koebnick, C.1    Roberts, C.K.2    Shaibi, G.Q.3
  • 53
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • I. Shimomura, R.E. Hammer, and S. Ikemoto Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy Nature 401 1999 73 76
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3
  • 54
    • 33745781499 scopus 로고    scopus 로고
    • Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy
    • DOI 10.1210/jc.2005-1545
    • J.H. Lee, J.L. Chan, and E. Sourlas Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy J Clin Endocrinol Metab 91 2006 2605 2611 (Pubitemid 44024625)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.7 , pp. 2605-2611
    • Lee, J.H.1    Chan, J.L.2    Sourlas, E.3    Raptopoulos, V.4    Mantzoros, C.S.5
  • 56
    • 0034457883 scopus 로고    scopus 로고
    • In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
    • DOI 10.1210/en.141.7.2328
    • Y.B. Kim, S. Uotani, and D.D. Pierroz In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin Endocrinology 141 2000 2328 2339 (Pubitemid 32269051)
    • (2000) Endocrinology , vol.141 , Issue.7 , pp. 2328-2339
    • Kim, Y.-B.1    Uotani, S.2    Pierroz, D.D.3    Flier, J.S.4    Kahn, B.B.5
  • 58
    • 38149012112 scopus 로고    scopus 로고
    • Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: The effect of long-term leptin therapy
    • J.Y. Park, A.Y. Chong, and E.K. Cochran Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapy J Clin Endocrinol Metab 93 2008 26 31
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 26-31
    • Park, J.Y.1    Chong, A.Y.2    Cochran, E.K.3
  • 61
    • 69749086148 scopus 로고    scopus 로고
    • Enhanced weight loss with pramlintide/metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy
    • E. Ravussin, S.R. Smith, and J.A. Mitchell Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy Obesity (Silver Spring) 17 2009 1736 1743
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1736-1743
    • Ravussin, E.1    Smith, S.R.2    Mitchell, J.A.3
  • 62
    • 65249130126 scopus 로고    scopus 로고
    • The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia
    • K. Mulligan, H. Khatami, and J.M. Schwarz The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia J Clin Endocrinol Metab 94 2009 1137 1144
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1137-1144
    • Mulligan, K.1    Khatami, H.2    Schwarz, J.M.3
  • 63
    • 79956104781 scopus 로고    scopus 로고
    • Leptin replacement improves postprandial glycemia and insulin sensitivity in human immunodeficiency virus-infected lipoatrophic men treated with pioglitazone: A pilot study
    • F. Magkos, A. Brennan, and L. Sweeney Leptin replacement improves postprandial glycemia and insulin sensitivity in human immunodeficiency virus-infected lipoatrophic men treated with pioglitazone: a pilot study Metabolism 2010
    • (2010) Metabolism
    • Magkos, F.1    Brennan, A.2    Sweeney, L.3
  • 65
    • 77951256496 scopus 로고    scopus 로고
    • Regulation of beta-cell viability and gene expression by distinct agonist fragments of adiponectin
    • J.E. Brown, A.C. Conner, and J.E. Digby Regulation of beta-cell viability and gene expression by distinct agonist fragments of adiponectin Peptides 31 2010 944 949
    • (2010) Peptides , vol.31 , pp. 944-949
    • Brown, J.E.1    Conner, A.C.2    Digby, J.E.3
  • 66
    • 77958568034 scopus 로고    scopus 로고
    • Adiponectin-induced Erk and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion
    • N. Wijesekara, M. Krishnamurthy, and A. Bhattacharjee Adiponectin-induced Erk and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion J Biol Chem 2010
    • (2010) J Biol Chem
    • Wijesekara, N.1    Krishnamurthy, M.2    Bhattacharjee, A.3
  • 67
    • 1542284737 scopus 로고    scopus 로고
    • Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1
    • DOI 10.1007/s00125-003-1293-3
    • I. Rakatzi, H. Mueller, and O. Ritzeler Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1 Diabetologia 47 2004 249 258 (Pubitemid 38315361)
    • (2004) Diabetologia , vol.47 , Issue.2 , pp. 249-258
    • Rakatzi, I.1    Mueller, H.2    Ritzeler, O.3    Tennagels, N.4    Eckel, J.5
  • 68
    • 41849100299 scopus 로고    scopus 로고
    • Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration
    • M. Okamoto, M. Ohara-Imaizumi, and N. Kubota Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration Diabetologia 51 2008 827 835
    • (2008) Diabetologia , vol.51 , pp. 827-835
    • Okamoto, M.1    Ohara-Imaizumi, M.2    Kubota, N.3
  • 71
    • 21244487830 scopus 로고    scopus 로고
    • Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells
    • DOI 10.1016/j.lfs.2005.03.008, PII S0024320505003607
    • P. Huypens, K. Moens, and H. Heimberg Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells Life Sci 77 2005 1273 1282 (Pubitemid 40898325)
    • (2005) Life Sciences , vol.77 , Issue.11 , pp. 1273-1282
    • Huypens, P.1    Moens, K.2    Heimberg, H.3    Ling, Z.4    Pipeleers, D.5    Van De Casteele, M.6
  • 74
    • 64349119982 scopus 로고    scopus 로고
    • Plasma adiponectin and insulin sensitivity in overweight and normal-weight middle-aged premenopausal women
    • J. Jrime, T. Jrime, and S. Ring-Dimitriou Plasma adiponectin and insulin sensitivity in overweight and normal-weight middle-aged premenopausal women Metab Clin Exp 58 2009 638 643
    • (2009) Metab Clin Exp , vol.58 , pp. 638-643
    • Jrime, J.1    Jrime, T.2    Ring-Dimitriou, S.3
  • 75
    • 0842333086 scopus 로고    scopus 로고
    • Adiponectin in youth: Relationship to visceral adiposity, insulin sensitivity, and β-cell function
    • DOI 10.2337/diacare.27.2.547
    • F. Bacha, R. Saad, and N. Gungor Adiponectin in youth: relationship to visceral adiposity, insulin sensitivity, and beta-cell function Diabetes Care 27 2004 547 552 (Pubitemid 38174085)
    • (2004) Diabetes Care , vol.27 , Issue.2 , pp. 547-552
    • Bacha, F.1    Saad, R.2    Gungor, N.3    Arslanian, S.A.4
  • 77
    • 2542469144 scopus 로고    scopus 로고
    • Use and abuse of HOMA modeling
    • DOI 10.2337/diacare.27.6.1487
    • T.M. Wallace, J.C. Levy, and D.R. Matthews Use and abuse of HOMA modeling Diabetes Care 27 2004 1487 1495 (Pubitemid 38680001)
    • (2004) Diabetes Care , vol.27 , Issue.6 , pp. 1487-1495
    • Wallace, T.M.1    Levy, J.C.2    Matthews, D.R.3
  • 78
    • 46149088943 scopus 로고    scopus 로고
    • Differences in insulin sensitivity, pancreatic beta cell function and circulating adiponectin across glucose tolerance status in Thai obese and non-obese women
    • L. Chailurkit, S. Chanprasertyothin, and W. Jongjaroenprasert Differences in insulin sensitivity, pancreatic beta cell function and circulating adiponectin across glucose tolerance status in Thai obese and non-obese women Endocrine 33 2008 84 89
    • (2008) Endocrine , vol.33 , pp. 84-89
    • Chailurkit, L.1    Chanprasertyothin, S.2    Jongjaroenprasert, W.3
  • 79
    • 75149125704 scopus 로고    scopus 로고
    • Declining beta-cell compensation for insulin resistance in Hispanic women with recent gestational diabetes mellitus: Association with changes in weight, adiponectin, and C-reactive protein
    • A.H. Xiang, M. Kawakubo, and E. Trigo Declining beta-cell compensation for insulin resistance in Hispanic women with recent gestational diabetes mellitus: association with changes in weight, adiponectin, and C-reactive protein Diabetes Care 33 2010 396 401
    • (2010) Diabetes Care , vol.33 , pp. 396-401
    • Xiang, A.H.1    Kawakubo, M.2    Trigo, E.3
  • 80
    • 0017758766 scopus 로고
    • The effect of obesity on plasma triglycerides and fasting plasma IRI levels. Significance of insulinogenic index and glucose tolerance
    • K. Ichikawa, Y. Akanuma, and K. Kosaka The effect of obesity on plasma triglycerides and fasting plasma IRI levels. Significance of insulinogenic index and glucose tolerance Horm Metab Res 9 1977 429 430 (Pubitemid 8196627)
    • (1977) Hormone and Metabolic Research , vol.9 , Issue.5 , pp. 429-430
    • Ichikawa, K.1    Akanuma, Y.2    Kosaka, K.3    Kuzuya, N.4
  • 81
    • 70349782240 scopus 로고    scopus 로고
    • Low plasma adiponectin level, white blood cell count and Helicobacter pylori titre independently predict abnormal pancreatic beta-cell function
    • W. So, P.C. Tong, and G.T. Ko Low plasma adiponectin level, white blood cell count and Helicobacter pylori titre independently predict abnormal pancreatic beta-cell function Diabetes Res Clin Pract 86 2009 89 95
    • (2009) Diabetes Res Clin Pract , vol.86 , pp. 89-95
    • So, W.1    Tong, P.C.2    Ko, G.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.