Insulin occludes leptin activation of ATP-sensitive K+ channels in rat CRI-G1 insulin secreting cells

Journal of Physiology

Volumn 511, Issue 3, 1998, Pages 695-706

  Harvey, J ^a   Ashford, M L J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADENOSINE TRIPHOSPHATE; DIAZOXIDE; INSULIN; LEPTIN; PHOSPHATIDYLINOSITIDE; PHOSPHOTRANSFERASE; POTASSIUM CHANNEL; SOMATOMEDIN C; TOLBUTAMIDE; WORTMANNIN; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEEDBACK SYSTEM; HOMEOSTASIS; HYPERPOLARIZATION; INSULIN RELEASE; INSULINOMA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; RAT; SECRETORY CELL; CONCENTRATION (PARAMETERS); CRI G1 CELL LINE; ELECTROPHYSIOLOGY; EXPOSURE; HORMONE ACTION; INSULINOMA CELL LINE; PANCREAS ISLET BETA CELL; WHOLE CELL PATCH CLAMP;

ADENOSINE TRIPHOSPHATE; ANDROSTADIENES; ANIMALS; BINDING, COMPETITIVE; CHROMONES; DIABETES MELLITUS, TYPE 2; DIAZOXIDE; DRUG INTERACTIONS; ELECTRIC CONDUCTIVITY; ENZYME INHIBITORS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN ANTAGONISTS; INSULIN-LIKE GROWTH FACTOR I; ION CHANNEL GATING; LEPTIN; MEMBRANE POTENTIALS; MORPHOLINES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; PROTEINS; RATS; TOLBUTAMIDE; VASODILATOR AGENTS;

EID: 0032530325     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.695bg.x     Document Type: Article

References (35)

1. BERTI, L., KELLERER, M., CAPP, E. & HARING, H. U. (1997). Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubules: evidence for a PI3-kinase mediated effect. Diabetologia 40, 606-609.
2. CARRINGTON, C. A., RUBERY, E. D., PEARSON, E. C. & HALES, C. N. (1986). Five new insulin-producing cell lines with differing secretory properties. Journal of Endocrinology 109, 193-200.
3. COHEN, B., NOVICK, D. & RUBINSTEIN, M. (1996). Modulation of insulin activites by leptin. Science 274, 1185-1188.
4. EMILSSON, V., LIU, Y.-L., CAWTHORNE, M. A., MORTON, N. M. & DAVENPORT, M. (1997). Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 46, 313-316.
5. GAZZANO, H., HALBAN, P., PRENTKI, M., BALLOTTI, R., BRANDENBURG, D., FEHLMANN, M. & VAN OBBERGHEN, E. (1985). Identification of functional insulin receptors on membranes from an insulin-producing cell line (RINm5F). Biochemical Journal 226, 867-872.
6. GHILARDI, N. & SKODA, R. C. (1997). The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Molecular Endocrinology 11, 393-399.
7. HALAAS, J. L., GAJIWALA, K. S., MAFFEI, M., COHEN, S. L., CHAIT, B. T., RABINOWITZ, D., LALLIONE, R. L., BURLEY, S. K. & FREIDMAN, J. M. (1995). Weight reducing effects of the plasma-protein encoded by the obese gene. Science 269, 543-546.
8. HALES, C. N., BYRNE, C. D., PERRY, C. J. & WAREHAM, N. J. (1996). Measurement of insulin and proinsulin. Diabetes Reviews 4, 320-335.
9. HARBECK, M. C., LOUIE, D. C, HOWLAND, J., WOLF, B. A. & ROTHENBERG, P. L. (1996). Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta cells. Diabetes 45, 711-717.
10. HARVEY, J., MCKENNA, F., HERSON, P. S., SPANSWICK, D. & ASHFORD, M. L. J. (1997). Leptin activates ATP-sensitive potassium channels in the rat insulin secreting cell line, CRI-G1. Journal of Physiology 504, 527-535.
11. HUPPERTZ, C., SCHWARTZ, C., BECKER, W., HORN, F., HEINRICH, P. C. & JOOST, H. G. (1996). Comparison of the effects of insulin, PDGF, interleukin 6 and interferon-gamma on glucose transport in 3T3-LI cells: Lack of cross talk between tyrosine kinase receptors and JAK/STAT pathways. Diabetologia 39, 1432-1439.
12. IHLE, J. N. (1995). Cytokine receptor signalling. Nature 377, 591-594.
13. ISHIDA, K., MURAKAMI, T., MIZUNO, A., IIDA, M., KUWAJIMA, M. & SHIMA, K. (1997). Leptin suppresses basal insulin secretion from rat pancreatic islets. Regulatory Peptides 70, 179-182.
14. KEIFFER, T. J., HELLER, R. S. & HABENER, J. F. (1996). Leptin receptors expressed on pancreatic beta cells. Biochemical and Biophysical Research Communications 224, 522-527.
15. + channels in pancreatic beta cells. Diabetes 46, 1087-1093.
16. LECLERCQ-MEYER, V. & MALAISSE, W. J. (1997). Failure of leptin to counteract the effects of glucose on insulin and glucagon release by the perfused pancreas. Medical Science Research 25, 257-259.
17. LEE, G., PROENCA, R., MONTEZ, J. M., CARROLL, K. M., DARVISHZADEH, J. G., LEE, J. I. & FREIDMAN, J. M. (1995). Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632-635.
18. + channel present in rat cortical neurones. Journal of Physiology 488, 319-337.
19. MALMSTROM, R., TASKINEN, M. R., KARONEN, S. L. & YKIJARVINEN, H. (1996). Insulin increase in plasma leptin concentration in normal subjects and patients with NIDDM. Diabetologia 39, 993-996.
20. MIZUNO, T. M., BERGEN, H., FUNABASHI, T., KLEOPOULOS, S. P., ZHONG, Y. G., BAUMAN, W. A. & MOBBS, C. V. (1996). Obese gene expression-reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. Proceedings of the National Academy of Sciences of the USA 93, 3434-3438.
21. MYERS, M. G., GRAMMER, T. C., WANG, I. M., SUN, X. J., PIERCE, J. H., BLENIS, J. & WHITE, M. R. (1994) Insulin-receptor substrate-1 mediates phosphatidyinositol-3′-kinase and p70 (s6K) signalling during insulin, insulin-like growth factor-1 and interleukin-4 stimulation. Journal of Biological Chemistry 269, 28783-28789.
22. MYERS, M. G. & WHITE, M. F. (1996). Insulin signal transduction and the IRS proteins. Annual Review of Pharmacology and Toxicology 36, 615-658.
23. PELLEYMOUNTER, M. A., CULLEN, M. J., BAKER, M. B., HECHT, R., WINTERS, D., BOONE, T. & COLLINS, F. (1995). Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543.
24. POWIS, G., BONJOUKLIAN, R., BERGGREN, M. M., GALLEGOS, A., ABRAHAM, R., ASHENDEL, C., ZALKOW, L., MATTER, W. F., DODGE, J., GRINDLEY, G. & VLAHOS, C. J. (1994). Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Research 54, 2419-2423.
25. SHIRAISHI, I., IWAMOTO, Y., KUZUYA, A., MATSUDA, A. & KUMAKURA, S. (1991). Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance. Diabetologia 34, 737-741.
26. STEPHENS, L. R., JACKSON, T. R. & HAWKINS, P. T. (1993). Agonist-stimulated synthesis of phosphatidylinositol (3,4,5)-trisphosphate: a new intracellular signalling system. Biochimica et Biophysica Acta 1179, 27-75.
27. STURGESS, N. C., KOZLOWSKI, R. Z., CARRINGTON, C. A., HALES, C. N. & ASHFORD, M. L. J. (1988). Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line. British Journal of Pharmacology 95, 83-94.
28. TARTAGLIA, L. A., DEMSKI, M., WENG, X., DENG, N., CULPEPPER, J., DEVOS, R., RICHARDS, G. J., CAMPFIELD, L. A., CLARK, F. T., DEEDS, J., MUIR, C., SANKER, S., MORIARTY, A., MOORE, K. J., SMUTKO, J. S., MAYS, G. G., WOOLF, E. A., MONROE, C. A. & TEPPER, R. I. (1995). Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263-1271.
29. VELLOSO, L. A., FOLLI, F., SUN, X. J., WHITE, M. F., SAAD, M. J. A. & KAHN, R. (1996). Cross-talk between the insulin and angiotensin signalling systems. Proceeedings of the National Academy of Sciences of the USA 93, 12490-12495.
30. VLAHOS, C. J, MATTER, W. F, HUI, K. Y & BROWN, R. F. (1994). A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002). Journal of Biological Chemistry 269, 5241-5248.
31. WEIGLE, D. S., DUELL, P. B., CONNOR, W. E., STEINER, R. A., SOULES, M. R. & KUIJPER, J. L. (1997). Effects of fasting, refeeding and dietary fat restriction on plasma leptin levels. Journal of Clinical Endocrinology and Metabolism 82, 561-565.
32. WEILAND, M., BAHR, F., HOHNE, M., SCHURMANN, A., ZIEHM, D. & JOOST, H. G. (1991). The signalling potential of the receptors for insulin and insulin-like growth factor 1 (IGF-1) in 3T3-L1 adipocytes: comparison of glucose transport activity, induction of oncogenes c-fos, glucose transporter mRNA, and DNA synthesis. Journal of Cell Physiology 149, 428-435.
33. XU, G., HOWLAND, J. & ROTHENBERG, P. L. (1996). Insulin and secretagogues differentially regulate fluid-phase pinocytosis in insulin-secreting beta cells. Biochemical Journal 318, 623-629.
34. ZHANG, Y., PROENCA, R., MAFFEI, M., BARONE, M., LEOPOLD, L. & FREIDMAN, J. M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432.
35. ZVELEBIL, M. J., MACDOUGALL, L., LEEVERS, S., VOLINIA, S., VANHAESEBROECK, B., GOUT, I., PANAYOTOU, G., DOMIN, J., STEIN, R. & PAGES, F. (1996). Structural and functional diversity of phosphoinositide 3-kinase. Philosophical Transactions of the Royal Society B 351, 217-223.