-
1
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-431, 1994.
-
(1994)
Nature
, vol.372
, pp. 425-431
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Leopold, L.4
Friedman, J.M.5
-
2
-
-
0017688670
-
Food intake, body weight gain, and body composition of the young obese (ob/ob) mouse
-
Lin P-Y, Romsos DR, Leveille GA. Food intake, body weight gain, and body composition of the young obese (ob/ob) mouse. J Nutr 107:1715-1723, 1977.
-
(1977)
J Nutr
, vol.107
, pp. 1715-1723
-
-
Lin, P.-Y.1
Romsos, D.R.2
Leveille, G.A.3
-
3
-
-
0018090686
-
Oxygen consumption and body fat content of young lean and obese (ob/ob) mice
-
Boissonneault GA, Hornshuh MJ, Simons JW, Romsos DR, Leveille GA. Oxygen consumption and body fat content of young lean and obese (ob/ob) mice. Proc Soc Exp Biol Med 157:402-406, 1978.
-
(1978)
Proc Soc Exp Biol Med
, vol.157
, pp. 402-406
-
-
Boissonneault, G.A.1
Hornshuh, M.J.2
Simons, J.W.3
Romsos, D.R.4
Leveille, G.A.5
-
4
-
-
0017364207
-
Thermogenic defect in pre-obese ob/ob mice
-
Trayhurn P, Thurlby P, James WPT. Thermogenic defect in pre-obese ob/ob mice. Nature 266:60-62, 1977.
-
(1977)
Nature
, vol.266
, pp. 60-62
-
-
Trayhurn, P.1
Thurlby, P.2
James, W.P.T.3
-
5
-
-
0017042247
-
The development of obesity, hyperinsulinemia, and hyperglycemia in ob/ob mice
-
Dubuc PU. The development of obesity, hyperinsulinemia, and hyperglycemia in ob/ob mice. Metabolism 25:1567-1574, 1976.
-
(1976)
Metabolism
, vol.25
, pp. 1567-1574
-
-
Dubuc, P.U.1
-
6
-
-
2642653233
-
Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice
-
Kulkarni RN, Wang Z-L, Wang R-M, Hurley JD, Smith DM, Ghatei MA, Withers DJ, Gardiner JV, Bailey CJ, Bloom SR. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest 100:2729-2736, 1997.
-
(1997)
J Clin Invest
, vol.100
, pp. 2729-2736
-
-
Kulkarni, R.N.1
Wang, Z.-L.2
Wang, R.-M.3
Hurley, J.D.4
Smith, D.M.5
Ghatei, M.A.6
Withers, D.J.7
Gardiner, J.V.8
Bailey, C.J.9
Bloom, S.R.10
-
7
-
-
0033582239
-
Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice
-
Seufert J, Kieffer TJ, Habener JF. Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice. Proc Natl Acad Sci USA 96:674-679, 1999.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 674-679
-
-
Seufert, J.1
Kieffer, T.J.2
Habener, J.F.3
-
8
-
-
0033974348
-
The adipoinsular axis: Effects of leptin on pancreatic cells
-
Kieffer TJ, Habener JF. The adipoinsular axis: Effects of leptin on pancreatic cells. Am J Physiol 278:E1-E14, 2000.
-
(2000)
Am J Physiol
, vol.278
-
-
Kieffer, T.J.1
Habener, J.F.2
-
10
-
-
0035525636
-
Leptin-deficient mice commence hypersecreting insulin in response to acetylcholine between 1 and 2 weeks of age
-
Lee J-W, Romsos DR. Leptin-deficient mice commence hypersecreting insulin in response to acetylcholine between 1 and 2 weeks of age. Exp Biol Med 226:906-911, 2001.
-
(2001)
Exp Biol Med
, vol.226
, pp. 906-911
-
-
Lee, J.-W.1
Romsos, D.R.2
-
11
-
-
0028921575
-
Enhanced sensitivity of pancreatic islets from preobese 2 week old ob/ob mice to neurohormonal stimulation of insulin secretion
-
Chen N-G, Romsos DR. Enhanced sensitivity of pancreatic islets from preobese 2 week old ob/ob mice to neurohormonal stimulation of insulin secretion. Endocrinology 136:505-511, 1995.
-
(1995)
Endocrinology
, vol.136
, pp. 505-511
-
-
Chen, N.-G.1
Romsos, D.R.2
-
12
-
-
0023525741
-
2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion
-
2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol Rev 67:1185-1248, 1987.
-
(1987)
Physiol Rev
, vol.67
, pp. 1185-1248
-
-
Prentki, M.1
Matschinsky, F.M.2
-
13
-
-
0024356031
-
Interaction between cholinergic agonists and enteric factors in the regulation of insulin
-
Zawalich WS, Zawalich KC, Rasmussen H. Interaction between cholinergic agonists and enteric factors in the regulation of insulin. Acta Endocrinol 120:702-707, 1989.
-
(1989)
Acta Endocrinol
, vol.120
, pp. 702-707
-
-
Zawalich, W.S.1
Zawalich, K.C.2
Rasmussen, H.3
-
14
-
-
0030955188
-
Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice
-
Chen N-G, Swick AG, Romsos DR. Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice. J Clin Invest 100:1174-1179, 1997.
-
(1997)
J Clin Invest
, vol.100
, pp. 1174-1179
-
-
Chen, N.-G.1
Swick, A.G.2
Romsos, D.R.3
-
15
-
-
0031915043
-
Effects of leptin on insulin secretion from isolated rat pancreatic islets
-
Ookuma M, Ookuma K, York DA. Effects of leptin on insulin secretion from isolated rat pancreatic islets. Diabetes 47:219-223, 1998.
-
(1998)
Diabetes
, vol.47
, pp. 219-223
-
-
Ookuma, M.1
Ookuma, K.2
York, D.A.3
-
16
-
-
0032169556
-
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B
-
Zhao AZ, Bornfeldt KE, Beavo JA. Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J Clin Invest 102:869-873, 1998.
-
(1998)
J Clin Invest
, vol.102
, pp. 869-873
-
-
Zhao, A.Z.1
Bornfeldt, K.E.2
Beavo, J.A.3
-
17
-
-
0030947582
-
Gonadotropin-releasing hormone and pituitary adenylate cyclase-activating polypeptide affect levels of cyclic adenosine 3′,5′ -monophosphate-dependent protein kinase A (PKA) subunits in the clonal gonadotrope αT3-1 cells: Evidence for cross-talk between PKA and protein kinase C pathways
-
Garrel G, McArdle CA, Hemmings BA, Counis R. Gonadotropin-releasing hormone and pituitary adenylate cyclase-activating polypeptide affect levels of cyclic adenosine 3′,5′ -monophosphate-dependent protein kinase A (PKA) subunits in the clonal gonadotrope αT3-1 cells: Evidence for cross-talk between PKA and protein kinase C pathways. Endocrinology 138:2259-2266, 1997.
-
(1997)
Endocrinology
, vol.138
, pp. 2259-2266
-
-
Garrel, G.1
McArdle, C.A.2
Hemmings, B.A.3
Counis, R.4
-
18
-
-
0032127896
-
+ channels in the rat insulinoma cell line CRI-G1
-
+ channels in the rat insulinoma cell line CRI-G1. J Physiol 510:47-61, 1998.
-
(1998)
J Physiol
, vol.510
, pp. 47-61
-
-
Harvey, J.1
Ashford, M.L.J.2
-
22
-
-
0027374488
-
Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
-
Yano H, Nakanishi S, Kimura K, Hanai N, Saitoh Y, Fukui Y, Nonomura Y, Matsuda Y. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem 268:25846-25856, 1993.
-
(1993)
J Biol Chem
, vol.268
, pp. 25846-25856
-
-
Yano, H.1
Nakanishi, S.2
Kimura, K.3
Hanai, N.4
Saitoh, Y.5
Fukui, Y.6
Nonomura, Y.7
Matsuda, Y.8
-
23
-
-
0014042613
-
Method for the isolation of intact islets of Langerhans from the rat pancreas
-
Lacy PE, Kostianovsky M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16:35-39, 1967.
-
(1967)
Diabetes
, vol.16
, pp. 35-39
-
-
Lacy, P.E.1
Kostianovsky, M.2
-
24
-
-
0023870117
-
Measurement of rat insulin ELISA with increased sensitivity, high accuracy and greater practicability than established radioimmunoassay
-
Kekow J, Ulrichs K, Muller-Ruchholtz W, Gross WL. Measurement of rat insulin ELISA with increased sensitivity, high accuracy and greater practicability than established radioimmunoassay. Diabetes 37:321-326, 1988.
-
(1988)
Diabetes
, vol.37
, pp. 321-326
-
-
Kekow, J.1
Ulrichs, K.2
Muller-Ruchholtz, W.3
Gross, W.L.4
-
25
-
-
0344357096
-
Glucagon-like peptide-1 stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line
-
Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF. Glucagon-like peptide-1 stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci USA 84:3434-3438, 1987.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 3434-3438
-
-
Drucker, D.J.1
Philippe, J.2
Mojsov, S.3
Chick, W.L.4
Habener, J.F.5
-
26
-
-
0023838544
-
Characterization of the receptor for glucagon-like peptide-1 (7-36) amide on rat insulinoma-derived cells
-
Göke R, Conlon JM. Characterization of the receptor for glucagon-like peptide-1 (7-36) amide on rat insulinoma-derived cells. J Endocrinol 116:357-362, 1988.
-
(1988)
J Endocrinol
, vol.116
, pp. 357-362
-
-
Göke, R.1
Conlon, J.M.2
-
27
-
-
0019842083
-
Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein
-
Seamon KB, Daly JW. Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein. J Biol Chem 256:9799-9801, 1981.
-
(1981)
J Biol Chem
, vol.256
, pp. 9799-9801
-
-
Seamon, K.B.1
Daly, J.W.2
-
28
-
-
0014873336
-
Effect of xanthine derivatives on lipolysis and on adenosine-3′,5′-monophosphate phosphodiesterase activity
-
Beavo JA, Rogers NL, Crofford OB, Hardman JG, Sutherland EW, Newman EV. Effect of xanthine derivatives on lipolysis and on adenosine-3′,5′-monophosphate phosphodiesterase activity. Mol Pharmacol 6:597-603, 1970.
-
(1970)
Mol Pharmacol
, vol.6
, pp. 597-603
-
-
Beavo, J.A.1
Rogers, N.L.2
Crofford, O.B.3
Hardman, J.G.4
Sutherland, E.W.5
Newman, E.V.6
-
29
-
-
0022454622
-
Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: A receptor for new cardiotonic drugs
-
Harrison SA, Reifsnyder DH, Gallis B, Cadd GG, Beavo JA. Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: A receptor for new cardiotonic drugs. Mol Pharmacol 29:506-514, 1986.
-
(1986)
Mol Pharmacol
, vol.29
, pp. 506-514
-
-
Harrison, S.A.1
Reifsnyder, D.H.2
Gallis, B.3
Cadd, G.G.4
Beavo, J.A.5
-
30
-
-
0031001932
-
Persistently enhanced sensitivity of pancreatic islets from ob/ob mice to PKC-stimulated insulin secretion
-
Chen N-G, Romsos DR. Persistently enhanced sensitivity of pancreatic islets from ob/ob mice to PKC-stimulated insulin secretion. Am J Physiol 272:E304-E311, 1997.
-
(1997)
Am J Physiol
, vol.272
-
-
Chen, N.-G.1
Romsos, D.R.2
-
31
-
-
0036097594
-
2+] elevation signals
-
2+] elevation signals. Diabetes 51:87-97, 2002.
-
(2002)
Diabetes
, vol.51
, pp. 87-97
-
-
Eto, K.1
Yamashita, T.2
Tsubamoto, Y.3
Terauchi, Y.4
Hirose, K.5
Kubota, N.6
Yamashita, S.7
Taka, J.8
Satoh, S.9
Sekihara, H.10
Tobe, K.11
Iino, M.12
Noda, M.13
Kimura, S.14
Kadowaki, T.15
-
32
-
-
0034457274
-
A link between insulin resistance and hyperinsulinemia: Inhibitors of phosphatidylinositol 3-kinase augment glucose-induced insulin secretion from islets of lean, but not obese, rats
-
Zawalich WS, Zawalich KC. A link between insulin resistance and hyperinsulinemia: Inhibitors of phosphatidylinositol 3-kinase augment glucose-induced insulin secretion from islets of lean, but not obese, rats. Endocrinology 141:3287-3295, 2000.
-
(2000)
Endocrinology
, vol.141
, pp. 3287-3295
-
-
Zawalich, W.S.1
Zawalich, K.C.2
-
33
-
-
0028958054
-
Differences in insulin secretion between the rat and mouse: Role of cAMP
-
Ma YH, Wang J, Rodd GG, Bolaffi JL, Grodsky GM. Differences in insulin secretion between the rat and mouse: Role of cAMP. Eurp J Endocrinol 132:370-376, 1995.
-
(1995)
Eurp J Endocrinol
, vol.132
, pp. 370-376
-
-
Ma, Y.H.1
Wang, J.2
Rodd, G.G.3
Bolaffi, J.L.4
Grodsky, G.M.5
-
34
-
-
0030036874
-
Regulation of insulin secretion by phosphoinositide-specific phospholipase C-protein kinase C activation
-
Zawalich WS. Regulation of insulin secretion by phosphoinositide-specific phospholipase C-protein kinase C activation. Diabetes Rev 4:160-176, 1996.
-
(1996)
Diabetes Rev
, vol.4
, pp. 160-176
-
-
Zawalich, W.S.1
-
35
-
-
0022528675
-
Abnormal regulation of insulin secretion in genetically obese (ob/ob) mouse
-
Black M, Heick HM, Bégin-Heick N. Abnormal regulation of insulin secretion in genetically obese (ob/ob) mouse. Biochem J 238:863-869, 1986.
-
(1986)
Biochem J
, vol.238
, pp. 863-869
-
-
Black, M.1
Heick, H.M.2
Bégin-Heick, N.3
-
36
-
-
0035125097
-
Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo
-
Cases JA, Gabriely I, Ma XH, Yang XM, Michaeli T, Fleischer N, Rossetti L, Barzilai N. Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo. Diabetes 50:348352, 2001.
-
(2001)
Diabetes
, vol.50
, pp. 348352
-
-
Cases, J.A.1
Gabriely, I.2
Ma, X.H.3
Yang, X.M.4
Michaeli, T.5
Fleischer, N.6
Rossetti, L.7
Barzilai, N.8
-
37
-
-
0031793899
-
Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans
-
Poitout V, Rouault C, Guerre-Millo M, Briaud I, Reach G. Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans. Endocrinology 139:822-826, 1998.
-
(1998)
Endocrinology
, vol.139
, pp. 822-826
-
-
Poitout, V.1
Rouault, C.2
Guerre-Millo, M.3
Briaud, I.4
Reach, G.5
-
38
-
-
0029955658
-
Wortmannin inhibits insulin secretion in pancreatic islets and β-TC3 cells independent of its inhibition of phosphatidylinositol 3-kinase
-
Gao Z-Y, Konrad RJ, Collins H, Matschinsky FM, Rothenberg PL, Wolf BA. Wortmannin inhibits insulin secretion in pancreatic islets and β-TC3 cells independent of its inhibition of phosphatidylinositol 3-kinase. Diabetes 45:854-862, 1996.
-
(1996)
Diabetes
, vol.45
, pp. 854-862
-
-
Gao, Z.-Y.1
Konrad, R.J.2
Collins, H.3
Matschinsky, F.M.4
Rothenberg, P.L.5
Wolf, B.A.6
-
39
-
-
0033747214
-
Leptin promotes invasiveness of kidney and colonic epithelial cells via phophoinositide 3-kinase-, rho-, and rac-dependent signaling pathways
-
Attoub S, Noe V, Pirola L, Bruyneel E, Chastre E, Mareel M, Wymann MP, Gespach C. Leptin promotes invasiveness of kidney and colonic epithelial cells via phophoinositide 3-kinase-, rho-, and rac-dependent signaling pathways, FASEB J 14:2329-2338, 2000.
-
(2000)
FASEB J
, vol.14
, pp. 2329-2338
-
-
Attoub, S.1
Noe, V.2
Pirola, L.3
Bruyneel, E.4
Chastre, E.5
Mareel, M.6
Wymann, M.P.7
Gespach, C.8
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