Sofalcone, a gastric mucosa protective agent, increases vascular endothelial growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cells

Biochemical and Biophysical Research Communications

Volumn 398, Issue 3, 2010, Pages 581-584

  Shibuya, Akiko ^a   Onda, Kenji ^a   Kawahara, Hirofumi ^a   Uchiyama, Yuka ^a   Nakayama, Hiroko ^a   Omi, Takamasa ^a   Nagaoka, Masayoshi ^a   Matsui, Hirofumi ^b   Hirano, Toshihiko ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Heme oxygenase 1; Rat gastric epithelial cells; Sofalcone; Vascular endothelial growth factor

Indexed keywords

BETA ACTIN; HEME OXYGENASE 1; PROTOPORPHYRIN TIN; SMALL INTERFERING RNA; SOFALCONE; TRANSCRIPTION FACTOR NRF2; VASCULOTROPIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INDUCTION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STOMACH EPITHELIUM; TIME;

ANIMALS; ANTI-ULCER AGENTS; CELL LINE; CHALCONES; CYTOPROTECTION; GASTRIC MUCOSA; GENE KNOCKDOWN TECHNIQUES; HEME OXYGENASE-1; NEOVASCULARIZATION, PHYSIOLOGIC; NF-E2-RELATED FACTOR 2; RATS; RNA, SMALL INTERFERING; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

RATTUS;

EID: 77955267856     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.06.124     Document Type: Article

References (17)

1. Muramatsu M., Tanaka M., Murakami S., Aihara H. Inhibition of 15-hydroxy prostaglandin dehydrogenase and increase of prostaglandin E2: effect of sofalcone on rat gastric mucosa. Life Sci. 1987, 41:315-322.
2. Kamiya S., Osaki T., Kumada J., Yamaguchi H., Taguchi H. Effect of sofalcone on adherence, production of vacuolating toxin, and induction of interleukin-8 secretion by Helicobacter pylori. J. Clin. Gastroenterol. 1997, 25(Suppl. 1):S172-S178.
3. Fujiwara Y., Higuchi K., Fukuda T., Watanabe T., Tominaga K., Arakawa T. Inhibitory effect of sofalcone on tumor necrosis factor-alpha and interleukin-1 beta production in human monocytes stimulated by Helicobacter pylori water extract. Drugs Exp. Clin. Res. 2001, 27:103-106.
4. Abraham N.G., Kappas A. Pharmacological and clinical aspects of heme oxygenase. Pharmacol. Rev. 2008, 60:79-127.
5. Aburaya M., Tanaka K., Hoshino T., Tsutsumi S., Suzuki K., Makise M., Akagi R., Mizushima T. Heme oxygenase-1 protects gastric mucosal cells against non-steroidal anti-inflammatory drugs. J. Biol. Chem. 2006, 281:33422-33432.
6. Ueda K., Ueyama T., Oka M., Ito T., Tsuruo Y., Ichinose M. Polaprezinc (Zinc L-carnosine) is a potent inducer of anti-oxidative stress enzyme, heme oxygenase (HO)-1 - a new mechanism of gastric mucosal protection. J. Pharmacol. Sci. 2009, 110:285-294.
7. Suemasu S., Tanaka K., Namba T., Ishihara T., Katsu T., Fujimoto M., Adachi H., Sobue G., Takeuchi K., Nakai A., Mizushima T. A role for HSP70 in protecting against indomethacin-induced gastric lesions. J. Biol. Chem. 2009, 284:19705-19715.
8. Tanaka H., Nakamura S., Onda K., Tazaki T., Hirano T. Sofalcone, an anti-ulcer chalcone derivative, suppresses inflammatory crosstalk between macrophages and adipocytes and adipocyte differentiation: implication of heme-oxygenase-1 induction. Biochem. Biophys. Res. Commun. 2009, 381:566-571.
9. Dudar G.K., D'Andrea L.D., Di Stasi R., Pedone C., Wallace J.L. A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 295:G374-G381.
10. Deng X., Szabo S., Khomenko T., Jadus M.R., Yoshida M. Gene therapy with adenoviral plasmids or naked DNA of vascular endothelial growth factor and platelet-derived growth factor accelerates healing of duodenal ulcer in rats. J. Pharmacol. Exp. Ther. 2004, 311:982-988.
11. Takahashi M., Maeda S., Ogura K., Terano A., Omata M. The possible role of vascular endothelial growth factor (VEGF) in gastric ulcer healing: effect of sofalcone on VEGF release in vitro. J. Clin. Gastroenterol. 1998, 27(Suppl. 1):S178-S182.
12. Dulak J., Jozkowicz A., Foresti R., Kasza A., Frick M., Huk I., Green C.J., Pachinger O., Weidinger F., Motterlini R. Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells. Antioxid. Redox. Signal 2002, 4:229-240.
13. Jozkowicz A., Huk I., Nigisch A., Weigel G., Weidinger F., Dulak J. Effect of prostaglandin-J(2) on VEGF synthesis depends on the induction of heme oxygenase-1. Antioxid. Redox. Signal 2002, 4:577-585.
14. Alam J., Cook J.L. Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway. Curr. Pharm. Des. 2003, 9:2499-2511.
15. Takagi T., Naito Y., Okada H., Ishii T., Mizushima K., Akagiri S., Adachi S., Handa O., Kokura S., Ichikawa H., Itoh K., Yamamoto M., Matsui H., Yoshikawa T. Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1. J. Pharmacol. Exp. Ther. 2009, 331:255-264.
16. Takahashi M., Kawabe T., Ogura K., Maeda S., Mikami Y., Kaneko N., Terano A., Omata M. Expression of vascular endothelial growth factor at the human gastric ulcer margin and in cultured gastric fibroblasts: a new angiogenic factor for gastric ulcer healing. Biochem. Biophys. Res. Commun. 1997, 234:493-498.
17. Morita K., Lee M.S., Her S. Possible relation of hemin-induced HO-1 expression to the upregulation of VEGF and BDNF mRNA levels in rat C6 glioma cells. J. Mol. Neurosci. 2009, 38:31-40.