Gastroprotective effect of heme-oxygenase 1/biliverdin/CO pathway in ethanol-induced gastric damage in mice

European Journal of Pharmacology

Volumn 642, Issue 1-3, 2010, Pages 140-145

  Gomes, Antoniella S ^a   Gadelha, Gemima G ^a   Lima, Samara J ^a   Garcia, Joyce A ^a   Medeiros, Jand Venes R ^a   Havt, Alexandre ^a   Lima, Aldo A ^a   Ribeiro, Ronaldo A ^a   Brito, Gerly Anne C ^a   Cunha, Fernando Q ^b   Souza, Marcellus H L P ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Biliverdin; CO; Ethanol; Gastric damage; HO 1

Indexed keywords

ALCOHOL; BILIRUBIN; BILIVERDIN; CARBON MONOXIDE; GLUTATHIONE; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; HEME OXYGENASE 1; HEMIN; MALONALDEHYDE; MANGANESE DERIVATIVE; MESSENGER RNA; PROTOPORPHYRIN ZINC; SODIUM CHLORIDE; PROTOPORPHYRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH INJURY; STOMACH MUCOSA; STOMACH PROTECTION; ANIMAL; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; STOMACH;

ANIMALS; BILIRUBIN; BILIVERDINE; CARBON MONOXIDE; ETHANOL; GASTRIC MUCOSA; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE; HEME OXYGENASE-1; HEMIN; MALE; MALONDIALDEHYDE; MICE; PROTOPORPHYRINS; STOMACH;

EID: 77954623301     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.05.023     Document Type: Article

References (32)

1. Amersi F., Nelson S.K., Shen X.D., Kato H., Melinek J., Kupiec-Weglinski J.W., Horwitz L.D., Busuttil R.W., Horwitz M.A. Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury. Proc. Natl Acad. Sci. 2002, 25:8915-8920.
2. Bauer M., Bauer I. Heme oxygenase-1: redox regulation and role in the hepatic response to oxidative stress. Antioxid. Redox Signal. 2002, 4:749-758.
3. Cho C.H., Pfeiffer C.J., Misra H.P. Ulcerogenic mechanism of ethanol and the action of sulphanilyl fluoride on the rat stomach in-vivo. J. Pharm. Pharmacol. 2001, 43:495-498.
4. Foresti R., Hoque M., Bains S., Green C.J., Motterlini R. Haem and nitric oxide: synergism in the modulation of the endothelial haem oxygenase-1 pathway. Biochem. J. 2003, 372:381-390.
5. Freitas A., Alves-Filho J.C., Secco D.D., Neto A.F., Ferreira S.H., Barja-Fidalgo C., Cunha F.Q. Heme oxygenase/carbon monoxide-biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation. Br. J. Pharmacol. 2006, 149:345-354.
6. Gottfried E.B., Korsten M.A., Lieber C.S. Alcohol-induced gastric and duodenal lesions in man. Am. J. Gastroenterol. 1978, 70:587-592.
7. Hegazi R.A., Rao K.N., Mayle A., Sepulveda A.R., Otterbein L.E., Plevy S.E. Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. J. Exp. Med. 2005, 19:1703-1713.
8. Helmer K.S., Suliburk J.W., Mercer D.W. Ketamine-induced gastroprotection during endotoxemia: role of heme-oxygenase-1. Dig. Dis. Sci. 2006, 51:1571-1581.
9. Ito M., Suzuki Y., Ishihara M., Suzuki Y. Anti-ulcer effects of antioxidants: effect of probucol. Eur. J. Pharmacol. 1998, 7:189-196.
10. Jonsson I.M., Verdrengh M., Brissler t.M., Lindblad S., Bokarewa M., Islander U., Carlsten H., Ohlsson C., Nandakumar K.S., Holmdahl R., Tarkowski A. Ethanol prevents development of destructive arthritis. Proc. Natl Acad. Sci. 2007, 104:258-263.
11. Kirkby K.A., Adin C.A. Products of heme oxygenase and their potential therapeutic applications. Am. J. Physiol. Ren. Physiol. 2006, 290:563-571.
12. Laine L. Endoscopic therapy for peptic ulcer hemorrhage: heater probe and alcohol injection. Gastroenterology 1991, 100:575-577.
13. Laine L., Weinstein W.M. Histology of alcoholic hemorrhagic gastritis: a prospective evaluation. Gastroenterology 1988, 94:1254-1262.
14. Lutnicki, Wrobel J., Ledwozyw A., Trebas-Pietras E. The effect of calcium ions on the intensity of peroxidation processes and the severity of ethanol-induced injury to the rat gastric mucosa. Arch. Vet. Pol. 1992, 32:125-132.
15. Maines M.D. The heme oxygenase system: a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 1997, 37:517-554.
16. Mancuso C. Heme oxygenase and its products in the nervous system. Antioxid. Redox Signal. 2004, 6:878-887.
17. Mihara M., Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem. 1978, 86:271-278.
18. Morita T., Perrella M.A., Lee M.E., Kourembanas S. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc. Natl Acad. Sci. 1995, 28:1475-1479.
19. Nath K.A. Heme oxygenase-1: a provenance for cytoprotective pathways in the kidney and other tissues. Kidney Int. 2006, 70:432-443.
20. Otterbein L.E., May A., Chin B.Y. Carbon monoxide increases macrophage bacterial clearance through Toll-like receptor (TLR) 4 expression. Cell. Mol. Biol. 2005, 3:433-440.
21. Ryter S.W., Otterbein L.E. Carbon monoxide in biology and medicine. Bioessays 2004, 26:270-280.
22. Ryter S.W., Tyrrell R.M. The heme synthesis and degradation pathways: role in oxidant sensitivity. Hemeoxygenase has both pro- and antioxidant properties. Free Radic. Biol. Med. 2000, 15:289-309.
23. Ryter S.W., Morse D., Choi A.M. Carbon monoxide and bilirubin: potential therapies for pulmonary/vascular injury and disease. Am. J. Respir. Cell Mol. Biol. 2007, 36:175-182.
24. Sedlak J., Lindsay R.H. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 1968, 25:1192-1205.
25. Szabo S., Trier J.S., Brown A., Schnoor J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 1985, 88:228-236.
26. Takahashi T., Morita K., Akagi R., Sassa S. Heme oxygenase-1: a novel therapeutic target in oxidative tissue injuries. Curr. Med. Chem. 2004, 11:1545-1561.
27. Tomaro M.L., Batlle A.M. Bilirubin: its role in cytoprotection against oxidative stress. Int. J. Biochem. Cell Biol. 2002, 34:216-220.
28. Ueda K., Ueyama T., Yoshida K., Kimura H., Ito T., Shimizu Y., Oka M., Tsuruo Y., Ichinose M. Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 295:460-469.
29. Varga C., Laszlo F., Fritz P., Cavicchi M., Lamarque D., Horvath K., Posa A., Berko A., Whittle B.J. Modulation by heme and zinc protoporphyrin of colonic heme oxygenase-1 and experimental inflammatory bowel disease in the rat. Eur. J. Pharmacol. 2007, 30:164-171.
30. Wagener F.A., Van Beurden H.E., Von den Hoff J.W., Adema G.J., Figdor C.G. The heme-heme oxygenase system: a molecular switch in wound healing. Blood 2003, 15:521-528.
31. Wang W.P., Guo X., Koo M.W., Wong B.C., Lam S.K., Ye Y.N., Cho C.H. Protective role of heme oxygenase-1 on trinitrobenzene sulfonic acid-induced colitis in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 2001, 281:586-594.
32. Yao P., Nussler A., Liu L., Hao L., Song F., Schirmeier A., Nussler N. Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways. J. Hepatol. 2007, 47:253-261.