Use of comprehensive screening methods to detect selective human CAR activators

Biochemical Pharmacology

Volumn 82, Issue 12, 2011, Pages 1994-2007

  Küblbeck, Jenni ^a   Laitinen, Tuomo ^a   Jyrkkärinne, Johanna ^a   Rousu, Timo ^b,c   Tolonen, Ari ^b,d   Abel, Tobias ^a   Kortelainen, Tanja ^a   Uusitalo, Jouko ^b   Korjamo, Timo ^b,e   Honkakoski, Paavo ^a   Molnár, Ferdinand ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b Novamass Ltd   (Finland)

^c UNIVERSITY OF OULU   (Finland)

^d Admescope Ltd   (Finland)

^e ORION CORPORATION   (Finland)

Author keywords

Agonist; Cell based assays; Human constitutive androstane receptor; Molecular modeling; Xenosensors

Indexed keywords

1,1,1 TRICHLORO 2 (2 CHLOROPHENYL) 2 (4 CHLOROPHENYL)ETHANE; 5 (3,4 DIEMTHOXY BENZYL) 3 PHENYL 4,5 DIHYDRO ISOXAZOLE; BETA NAPHTHOFLAVONE; CLOTRIMAZOLE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 3A4; DIETHYLSTILBESTROL; HYPERFORIN; MESSENGER RNA; METHOXYCHLOR; OMEPRAZOLE; PERMETHRIN; RIFAMPICIN; SR 12813; TRI 4 METHYL PHENYL PHOSPHATE; TRI PHENYL PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; MALE; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; MOLECULAR STRUCTURE; PROTEIN BINDING; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; REPRODUCIBILITY OF RESULTS; SMALL MOLECULE LIBRARIES;

EID: 80555149413     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.08.027     Document Type: Article

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