Synthesis and evaluation of estrogen agonism of diaryl 4,5- dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: A compound set forming a 4D molecular library

Journal of Medicinal Chemistry

Volumn 51, Issue 12, 2008, Pages 3562-3571

  Pulkkinen, Juha T ^a   Honkakoski, Paavo ^a   Peräkylä, Mikael ^a   Berczi, Istvan ^b   Laatikainen, Reino ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1,7 DIPHENYLHEPTANE 2,4 DIONE; 1,8 DIPHENYLOCTANE 3,5 DIONE; 2 HYDROXY 1,7 DIPHENYLHEPTAN 4 ONE; 2 METHOXY 1,7 DIPHENYLHEPTAN 4 ONE; 3 (DIMETHYL LAMBDA4 SULFANYLIDENE) 1,7 DIPHENYLHEPTANE 2,4 DIONE; 3,5 DIPHENETHYL 4,5 DIHYDROISOXAZOLE; 4 (DIMETHYL LAMBDA4 SULFANYLIDENE) 1,7 DIPHENYLHEPTANE 3,5 DIONE; 4 HYDROXY 1,6 DIPHENYLHEXAN 2 ONE; 4 METHOXY 5 NAPHTHALEN 2 YL 1 PHENYLPENTAN 2 ONE; 5 (4 FLUOROBENZYL) 3 (2 HYDROXYPHENETHYL) 4,5 DIHYDROISOXAZOLE; 5 (4 FLUOROBENZYL) 3 (4 HYDROXYPHENETHYL) 4,5 DIHYDROISOXAZOLE; 5 (4 FLUOROBENZYL) 3 DIPHENETHYL 4,5 DIHYDROISOXAZOLE; 5 (4 HYDROXYBENZYL) 3 (2 HYDROXYPHENETHYL) 4,5 DIHYDROISOXAZOLE; 5 (4 HYDROXYBENZYL) 3 (4 HYDROXYPHENETHYL) 4,5 DIHYDROISOXAZOLE; 5 (4 HYDROXYBENZYL) 3 PHENETHYL 4,5 DIHYDROISOXAZOLE; 5 BENZYL 3 [2 (2 HYDROXYPHENYL)ETHYL] 4,5 DIHYDROISOXAZOLE; 5 BENZYL 3 [2 (3 HYDROXYPHENYL)ETHYL] 4,5 DIHYDROISOXAZOLE; 5 BENZYL 3 [2 (4 HYDROXYPHENYL)ETHYL] 4,5 DIHYDROISOXAZOLE; 5 BENZYL 3 PHENETHYL 4,5 DIHYDROISOXAZOLE; 5 HYDROXY 6 (4 FLUOROPHENYL) 1 PHENYLHEXAN 3 ONE; 5 METHOXY 6 NAPHTHALEN 2 YL 1 PHENYLHEXAN 3 ONE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN;

ARTICLE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESTROGEN ACTIVITY; HUMAN; HUMAN CELL; MOLECULAR LIBRARY; MOLECULAR MODEL; RECEPTOR UPREGULATION;

BINDING SITES; CELL LINE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HUMANS; ISOXAZOLES; KETONES; LIGANDS; MODELS, MOLECULAR; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 45749150002     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8001795     Document Type: Article

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